Fatty acid metabolism in liver and muscle is strongly modulated by photoperiod in Fischer 344 rats

Autores
Ruiz de Azua, Maria Josefina; Manocchio, Francesca; Cruz Carrión, Álvaro; Arola Arnal, Anna; Torres Fuentes, Cristina; Bernal, Claudio Adrian; Sain, Juliana; Suarez, Manuel
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Circadian and seasonal variations produce variations in physiological processes throughout the day and the year, respectively. In this sense, both the light and the moment of feeding are strong modulators of the central and peripheral clocks. However, little is known about its influence on certain metabolic parameters and on the composition of liver and muscle fatty acids (FA). In the present study, 24 Fischer 344 rats were exposed for 11 weeks to different photoperiods, L6, L12 and L18, with 6, 12 and 18 h of light/day, respectively. They were fed a standard diet. Serum metabolic parameters, gene expression of liver enzymes and gastrocnemius muscle involved in the synthesis, elongation, desaturation and β-oxidation of FA were analyzed. We have found that exposure to different hours of light has a clear effect on FA composition and gene expression in the liver. Mainly, the biosynthesis of unsaturated FA was altered in the L18 animals with respect to those exposed to L12, while the L6 did not show significant changes. At the muscle level, differences were observed in the concentration of mono and polyunsaturated FA. A multivariate analysis confirmed the differences between L12 and L18 in a significant way. We conclude that exposure to long days produces changes in the composition of liver and muscle FA, as well as changes in the gene expression of oxidative enzymes compared to exposure to L12, which could be a consequence of different seasonal eating patterns.
Fil: Ruiz de Azua, Maria Josefina. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;
Fil: Manocchio, Francesca. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;
Fil: Cruz Carrión, Álvaro. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;
Fil: Arola Arnal, Anna. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;
Fil: Torres Fuentes, Cristina. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;
Fil: Bernal, Claudio Adrian. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Sain, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Suarez, Manuel. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;
Materia
CHRONONUTRITION
FATTY ACID PROFILE
METABOLISM
SEASONALITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/218250
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/218250
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fatty acid metabolism in liver and muscle is strongly modulated by photoperiod in Fischer 344 ratsRuiz de Azua, Maria JosefinaManocchio, FrancescaCruz Carrión, ÁlvaroArola Arnal, AnnaTorres Fuentes, CristinaBernal, Claudio AdrianSain, JulianaSuarez, ManuelCHRONONUTRITIONFATTY ACID PROFILEMETABOLISMSEASONALITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Circadian and seasonal variations produce variations in physiological processes throughout the day and the year, respectively. In this sense, both the light and the moment of feeding are strong modulators of the central and peripheral clocks. However, little is known about its influence on certain metabolic parameters and on the composition of liver and muscle fatty acids (FA). In the present study, 24 Fischer 344 rats were exposed for 11 weeks to different photoperiods, L6, L12 and L18, with 6, 12 and 18 h of light/day, respectively. They were fed a standard diet. Serum metabolic parameters, gene expression of liver enzymes and gastrocnemius muscle involved in the synthesis, elongation, desaturation and β-oxidation of FA were analyzed. We have found that exposure to different hours of light has a clear effect on FA composition and gene expression in the liver. Mainly, the biosynthesis of unsaturated FA was altered in the L18 animals with respect to those exposed to L12, while the L6 did not show significant changes. At the muscle level, differences were observed in the concentration of mono and polyunsaturated FA. A multivariate analysis confirmed the differences between L12 and L18 in a significant way. We conclude that exposure to long days produces changes in the composition of liver and muscle FA, as well as changes in the gene expression of oxidative enzymes compared to exposure to L12, which could be a consequence of different seasonal eating patterns.Fil: Ruiz de Azua, Maria Josefina. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;Fil: Manocchio, Francesca. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;Fil: Cruz Carrión, Álvaro. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;Fil: Arola Arnal, Anna. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;Fil: Torres Fuentes, Cristina. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;Fil: Bernal, Claudio Adrian. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Sain, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaFil: Suarez, Manuel. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;Elsevier Science SA2023-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/218250Ruiz de Azua, Maria Josefina; Manocchio, Francesca; Cruz Carrión, Álvaro; Arola Arnal, Anna; Torres Fuentes, Cristina; et al.; Fatty acid metabolism in liver and muscle is strongly modulated by photoperiod in Fischer 344 rats; Elsevier Science SA; Journal of Photochemistry and Photobiology B: Biology; 238; 112621; 1-2023; 1-151011-1344CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1011134422002366info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphotobiol.2022.112621info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:48:15Zoai:ri.conicet.gov.ar:11336/218250instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:48:16.129CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fatty acid metabolism in liver and muscle is strongly modulated by photoperiod in Fischer 344 rats
title Fatty acid metabolism in liver and muscle is strongly modulated by photoperiod in Fischer 344 rats
spellingShingle Fatty acid metabolism in liver and muscle is strongly modulated by photoperiod in Fischer 344 rats
Ruiz de Azua, Maria Josefina
CHRONONUTRITION
FATTY ACID PROFILE
METABOLISM
SEASONALITY
title_short Fatty acid metabolism in liver and muscle is strongly modulated by photoperiod in Fischer 344 rats
title_full Fatty acid metabolism in liver and muscle is strongly modulated by photoperiod in Fischer 344 rats
title_fullStr Fatty acid metabolism in liver and muscle is strongly modulated by photoperiod in Fischer 344 rats
title_full_unstemmed Fatty acid metabolism in liver and muscle is strongly modulated by photoperiod in Fischer 344 rats
title_sort Fatty acid metabolism in liver and muscle is strongly modulated by photoperiod in Fischer 344 rats
dc.creator.none.fl_str_mv Ruiz de Azua, Maria Josefina
Manocchio, Francesca
Cruz Carrión, Álvaro
Arola Arnal, Anna
Torres Fuentes, Cristina
Bernal, Claudio Adrian
Sain, Juliana
Suarez, Manuel
author Ruiz de Azua, Maria Josefina
author_facet Ruiz de Azua, Maria Josefina
Manocchio, Francesca
Cruz Carrión, Álvaro
Arola Arnal, Anna
Torres Fuentes, Cristina
Bernal, Claudio Adrian
Sain, Juliana
Suarez, Manuel
author_role author
author2 Manocchio, Francesca
Cruz Carrión, Álvaro
Arola Arnal, Anna
Torres Fuentes, Cristina
Bernal, Claudio Adrian
Sain, Juliana
Suarez, Manuel
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHRONONUTRITION
FATTY ACID PROFILE
METABOLISM
SEASONALITY
topic CHRONONUTRITION
FATTY ACID PROFILE
METABOLISM
SEASONALITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Circadian and seasonal variations produce variations in physiological processes throughout the day and the year, respectively. In this sense, both the light and the moment of feeding are strong modulators of the central and peripheral clocks. However, little is known about its influence on certain metabolic parameters and on the composition of liver and muscle fatty acids (FA). In the present study, 24 Fischer 344 rats were exposed for 11 weeks to different photoperiods, L6, L12 and L18, with 6, 12 and 18 h of light/day, respectively. They were fed a standard diet. Serum metabolic parameters, gene expression of liver enzymes and gastrocnemius muscle involved in the synthesis, elongation, desaturation and β-oxidation of FA were analyzed. We have found that exposure to different hours of light has a clear effect on FA composition and gene expression in the liver. Mainly, the biosynthesis of unsaturated FA was altered in the L18 animals with respect to those exposed to L12, while the L6 did not show significant changes. At the muscle level, differences were observed in the concentration of mono and polyunsaturated FA. A multivariate analysis confirmed the differences between L12 and L18 in a significant way. We conclude that exposure to long days produces changes in the composition of liver and muscle FA, as well as changes in the gene expression of oxidative enzymes compared to exposure to L12, which could be a consequence of different seasonal eating patterns.
Fil: Ruiz de Azua, Maria Josefina. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;
Fil: Manocchio, Francesca. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;
Fil: Cruz Carrión, Álvaro. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;
Fil: Arola Arnal, Anna. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;
Fil: Torres Fuentes, Cristina. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;
Fil: Bernal, Claudio Adrian. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Sain, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Suarez, Manuel. Departamento de Bioquimica y Biotecnologia ; Facultad de Quimica y Enologia ; Universitat Rovira I Virgili;
description Circadian and seasonal variations produce variations in physiological processes throughout the day and the year, respectively. In this sense, both the light and the moment of feeding are strong modulators of the central and peripheral clocks. However, little is known about its influence on certain metabolic parameters and on the composition of liver and muscle fatty acids (FA). In the present study, 24 Fischer 344 rats were exposed for 11 weeks to different photoperiods, L6, L12 and L18, with 6, 12 and 18 h of light/day, respectively. They were fed a standard diet. Serum metabolic parameters, gene expression of liver enzymes and gastrocnemius muscle involved in the synthesis, elongation, desaturation and β-oxidation of FA were analyzed. We have found that exposure to different hours of light has a clear effect on FA composition and gene expression in the liver. Mainly, the biosynthesis of unsaturated FA was altered in the L18 animals with respect to those exposed to L12, while the L6 did not show significant changes. At the muscle level, differences were observed in the concentration of mono and polyunsaturated FA. A multivariate analysis confirmed the differences between L12 and L18 in a significant way. We conclude that exposure to long days produces changes in the composition of liver and muscle FA, as well as changes in the gene expression of oxidative enzymes compared to exposure to L12, which could be a consequence of different seasonal eating patterns.
publishDate 2023
dc.date.none.fl_str_mv 2023-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/218250
Ruiz de Azua, Maria Josefina; Manocchio, Francesca; Cruz Carrión, Álvaro; Arola Arnal, Anna; Torres Fuentes, Cristina; et al.; Fatty acid metabolism in liver and muscle is strongly modulated by photoperiod in Fischer 344 rats; Elsevier Science SA; Journal of Photochemistry and Photobiology B: Biology; 238; 112621; 1-2023; 1-15
1011-1344
CONICET Digital
CONICET
url http://hdl.handle.net/11336/218250
identifier_str_mv Ruiz de Azua, Maria Josefina; Manocchio, Francesca; Cruz Carrión, Álvaro; Arola Arnal, Anna; Torres Fuentes, Cristina; et al.; Fatty acid metabolism in liver and muscle is strongly modulated by photoperiod in Fischer 344 rats; Elsevier Science SA; Journal of Photochemistry and Photobiology B: Biology; 238; 112621; 1-2023; 1-15
1011-1344
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1011134422002366
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphotobiol.2022.112621
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science SA
publisher.none.fl_str_mv Elsevier Science SA
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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