Effects of dietary cis and trans unsaturated and saturated fatty acids on the glucose metabolites and enzymes of rats

Autores
Bernal, Claudio Adrian; Rovira, Jordi; Colandré, María; Cussó, Roser; Cadefau, Joan A.
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the present study was to examine whether the level of dietary cis fatty acid (c FA), or the isomers (trans or cis) and/or the saturation of the fatty acids at high dietary fat levels altered the intracellular glucose metabolites and certain regulatory enzyme activities in the skeletal muscle and liver of rats. The animals were fed for 30 d on either a recommended control diet (7% c FA, w/w) or a high-fat diet (20% fatty acids, w/w). The high-fat diet was enriched with either c FA, trans fatty acid (t FA), a moderate proportion of saturated fatty acid (MSFA), or a high proportion of saturated fatty acid (HSFA). The most striking findings were observed in the gastrocnemius muscle with a HSFA diet. There was a significant increase in glucose-6-phosphate (306 %), glucose-1-phosphate (245 %), fructose-6-phosphate (400 %), fructose-1,6-bisphosphate (86 %), glyceraldehyde- 3-phosphate (38 %), pyruvate (341 %), lactate (325 %), citrate (79 %) and the bisphosphorylated sugars as compared with the cFA diet. These changes were paralleled by an increase in muscle triacylglycerol content (49 %) and a decrease in glucose (39 %). In addition, the amount of cFA and the other types of fatty acid (i.e. tFA and MSFA) led to no great differences in glucose metabolism as compared with the respective control group. These data support the hypothesis that glucose changes induced by a HSFA diet are a multifaceted abnormality. Glucose and lactate transport and intracellular glucose metabolism could be the key biochemical defects involved in this detrimental effect on glucose metabolism.
Fil: Bernal, Claudio Adrian. Universidad Nacional del Litoral; Argentina
Fil: Rovira, Jordi. Universidad de Barcelona; España
Fil: Colandré, María. Universidad Nacional del Litoral; Argentina
Fil: Cussó, Roser. Universidad de Barcelona; España
Fil: Cadefau, Joan A.. Universidad de Barcelona; España
Materia
Trans fatty acidsm
Saturated fatty acids
Dietary fat
Glucose metabolism
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/106742
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/106742
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Effects of dietary cis and trans unsaturated and saturated fatty acids on the glucose metabolites and enzymes of ratsBernal, Claudio AdrianRovira, JordiColandré, MaríaCussó, RoserCadefau, Joan A.Trans fatty acidsmSaturated fatty acidsDietary fatGlucose metabolismhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The aim of the present study was to examine whether the level of dietary cis fatty acid (c FA), or the isomers (trans or cis) and/or the saturation of the fatty acids at high dietary fat levels altered the intracellular glucose metabolites and certain regulatory enzyme activities in the skeletal muscle and liver of rats. The animals were fed for 30 d on either a recommended control diet (7% c FA, w/w) or a high-fat diet (20% fatty acids, w/w). The high-fat diet was enriched with either c FA, trans fatty acid (t FA), a moderate proportion of saturated fatty acid (MSFA), or a high proportion of saturated fatty acid (HSFA). The most striking findings were observed in the gastrocnemius muscle with a HSFA diet. There was a significant increase in glucose-6-phosphate (306 %), glucose-1-phosphate (245 %), fructose-6-phosphate (400 %), fructose-1,6-bisphosphate (86 %), glyceraldehyde- 3-phosphate (38 %), pyruvate (341 %), lactate (325 %), citrate (79 %) and the bisphosphorylated sugars as compared with the cFA diet. These changes were paralleled by an increase in muscle triacylglycerol content (49 %) and a decrease in glucose (39 %). In addition, the amount of cFA and the other types of fatty acid (i.e. tFA and MSFA) led to no great differences in glucose metabolism as compared with the respective control group. These data support the hypothesis that glucose changes induced by a HSFA diet are a multifaceted abnormality. Glucose and lactate transport and intracellular glucose metabolism could be the key biochemical defects involved in this detrimental effect on glucose metabolism.Fil: Bernal, Claudio Adrian. Universidad Nacional del Litoral; ArgentinaFil: Rovira, Jordi. Universidad de Barcelona; EspañaFil: Colandré, María. Universidad Nacional del Litoral; ArgentinaFil: Cussó, Roser. Universidad de Barcelona; EspañaFil: Cadefau, Joan A.. Universidad de Barcelona; EspañaCambridge University Press2006-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/106742Bernal, Claudio Adrian; Rovira, Jordi; Colandré, María; Cussó, Roser; Cadefau, Joan A.; Effects of dietary cis and trans unsaturated and saturated fatty acids on the glucose metabolites and enzymes of rats; Cambridge University Press; British Journal of Nutrition; 95; 5; 12-2006; 947-9540007-1145CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1079/BJN20061756info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:04:53Zoai:ri.conicet.gov.ar:11336/106742instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:04:53.739CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of dietary cis and trans unsaturated and saturated fatty acids on the glucose metabolites and enzymes of rats
title Effects of dietary cis and trans unsaturated and saturated fatty acids on the glucose metabolites and enzymes of rats
spellingShingle Effects of dietary cis and trans unsaturated and saturated fatty acids on the glucose metabolites and enzymes of rats
Bernal, Claudio Adrian
Trans fatty acidsm
Saturated fatty acids
Dietary fat
Glucose metabolism
title_short Effects of dietary cis and trans unsaturated and saturated fatty acids on the glucose metabolites and enzymes of rats
title_full Effects of dietary cis and trans unsaturated and saturated fatty acids on the glucose metabolites and enzymes of rats
title_fullStr Effects of dietary cis and trans unsaturated and saturated fatty acids on the glucose metabolites and enzymes of rats
title_full_unstemmed Effects of dietary cis and trans unsaturated and saturated fatty acids on the glucose metabolites and enzymes of rats
title_sort Effects of dietary cis and trans unsaturated and saturated fatty acids on the glucose metabolites and enzymes of rats
dc.creator.none.fl_str_mv Bernal, Claudio Adrian
Rovira, Jordi
Colandré, María
Cussó, Roser
Cadefau, Joan A.
author Bernal, Claudio Adrian
author_facet Bernal, Claudio Adrian
Rovira, Jordi
Colandré, María
Cussó, Roser
Cadefau, Joan A.
author_role author
author2 Rovira, Jordi
Colandré, María
Cussó, Roser
Cadefau, Joan A.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Trans fatty acidsm
Saturated fatty acids
Dietary fat
Glucose metabolism
topic Trans fatty acidsm
Saturated fatty acids
Dietary fat
Glucose metabolism
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The aim of the present study was to examine whether the level of dietary cis fatty acid (c FA), or the isomers (trans or cis) and/or the saturation of the fatty acids at high dietary fat levels altered the intracellular glucose metabolites and certain regulatory enzyme activities in the skeletal muscle and liver of rats. The animals were fed for 30 d on either a recommended control diet (7% c FA, w/w) or a high-fat diet (20% fatty acids, w/w). The high-fat diet was enriched with either c FA, trans fatty acid (t FA), a moderate proportion of saturated fatty acid (MSFA), or a high proportion of saturated fatty acid (HSFA). The most striking findings were observed in the gastrocnemius muscle with a HSFA diet. There was a significant increase in glucose-6-phosphate (306 %), glucose-1-phosphate (245 %), fructose-6-phosphate (400 %), fructose-1,6-bisphosphate (86 %), glyceraldehyde- 3-phosphate (38 %), pyruvate (341 %), lactate (325 %), citrate (79 %) and the bisphosphorylated sugars as compared with the cFA diet. These changes were paralleled by an increase in muscle triacylglycerol content (49 %) and a decrease in glucose (39 %). In addition, the amount of cFA and the other types of fatty acid (i.e. tFA and MSFA) led to no great differences in glucose metabolism as compared with the respective control group. These data support the hypothesis that glucose changes induced by a HSFA diet are a multifaceted abnormality. Glucose and lactate transport and intracellular glucose metabolism could be the key biochemical defects involved in this detrimental effect on glucose metabolism.
Fil: Bernal, Claudio Adrian. Universidad Nacional del Litoral; Argentina
Fil: Rovira, Jordi. Universidad de Barcelona; España
Fil: Colandré, María. Universidad Nacional del Litoral; Argentina
Fil: Cussó, Roser. Universidad de Barcelona; España
Fil: Cadefau, Joan A.. Universidad de Barcelona; España
description The aim of the present study was to examine whether the level of dietary cis fatty acid (c FA), or the isomers (trans or cis) and/or the saturation of the fatty acids at high dietary fat levels altered the intracellular glucose metabolites and certain regulatory enzyme activities in the skeletal muscle and liver of rats. The animals were fed for 30 d on either a recommended control diet (7% c FA, w/w) or a high-fat diet (20% fatty acids, w/w). The high-fat diet was enriched with either c FA, trans fatty acid (t FA), a moderate proportion of saturated fatty acid (MSFA), or a high proportion of saturated fatty acid (HSFA). The most striking findings were observed in the gastrocnemius muscle with a HSFA diet. There was a significant increase in glucose-6-phosphate (306 %), glucose-1-phosphate (245 %), fructose-6-phosphate (400 %), fructose-1,6-bisphosphate (86 %), glyceraldehyde- 3-phosphate (38 %), pyruvate (341 %), lactate (325 %), citrate (79 %) and the bisphosphorylated sugars as compared with the cFA diet. These changes were paralleled by an increase in muscle triacylglycerol content (49 %) and a decrease in glucose (39 %). In addition, the amount of cFA and the other types of fatty acid (i.e. tFA and MSFA) led to no great differences in glucose metabolism as compared with the respective control group. These data support the hypothesis that glucose changes induced by a HSFA diet are a multifaceted abnormality. Glucose and lactate transport and intracellular glucose metabolism could be the key biochemical defects involved in this detrimental effect on glucose metabolism.
publishDate 2006
dc.date.none.fl_str_mv 2006-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/106742
Bernal, Claudio Adrian; Rovira, Jordi; Colandré, María; Cussó, Roser; Cadefau, Joan A.; Effects of dietary cis and trans unsaturated and saturated fatty acids on the glucose metabolites and enzymes of rats; Cambridge University Press; British Journal of Nutrition; 95; 5; 12-2006; 947-954
0007-1145
CONICET Digital
CONICET
url http://hdl.handle.net/11336/106742
identifier_str_mv Bernal, Claudio Adrian; Rovira, Jordi; Colandré, María; Cussó, Roser; Cadefau, Joan A.; Effects of dietary cis and trans unsaturated and saturated fatty acids on the glucose metabolites and enzymes of rats; Cambridge University Press; British Journal of Nutrition; 95; 5; 12-2006; 947-954
0007-1145
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1079/BJN20061756
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980166313181184
score 12.993085

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