Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans

Autores
Tempesti, Tomas Cristian; Alvarez, María Gabriela; de Araújo, Marcelo Francisco; Catunda Júnior, Francisco Eduardo Aragão; de Carvalho, Mário Geraldo; Durantini, Edgardo Néstor
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this study, a novel quercetin derivative bearing a trifluoromethyl group was synthesized by the nucleophilic aromatic substitution reaction between rutin and 2-chloro-5-(trifluoromethyl)-1,3-dinitrobenzene in basic medium. This synthetic quercetin showed antifungal activity against Candida albicans cultures. The results indicated a remarkable increase in the biological activity of this compound as compared to rutin.
Fil: Tempesti, Tomas Cristian. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Alvarez, María Gabriela. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de Araújo, Marcelo Francisco. Universidade Federal do Rio de Janeiro; Brasil
Fil: Catunda Júnior, Francisco Eduardo Aragão. Universidade Federal do Rio de Janeiro; Brasil
Fil: de Carvalho, Mário Geraldo. Universidade Federal do Rio de Janeiro; Brasil
Fil: Durantini, Edgardo Néstor. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Antifungal Activity
Candida Albicans
Flavonoid
Quercetin
Rutin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/62845
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicansTempesti, Tomas CristianAlvarez, María Gabrielade Araújo, Marcelo FranciscoCatunda Júnior, Francisco Eduardo Aragãode Carvalho, Mário GeraldoDurantini, Edgardo NéstorAntifungal ActivityCandida AlbicansFlavonoidQuercetinRutinhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In this study, a novel quercetin derivative bearing a trifluoromethyl group was synthesized by the nucleophilic aromatic substitution reaction between rutin and 2-chloro-5-(trifluoromethyl)-1,3-dinitrobenzene in basic medium. This synthetic quercetin showed antifungal activity against Candida albicans cultures. The results indicated a remarkable increase in the biological activity of this compound as compared to rutin.Fil: Tempesti, Tomas Cristian. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Alvarez, María Gabriela. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: de Araújo, Marcelo Francisco. Universidade Federal do Rio de Janeiro; BrasilFil: Catunda Júnior, Francisco Eduardo Aragão. Universidade Federal do Rio de Janeiro; BrasilFil: de Carvalho, Mário Geraldo. Universidade Federal do Rio de Janeiro; BrasilFil: Durantini, Edgardo Néstor. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaBirkhauser Boston Inc2012-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/62845Tempesti, Tomas Cristian; Alvarez, María Gabriela; de Araújo, Marcelo Francisco; Catunda Júnior, Francisco Eduardo Aragão; de Carvalho, Mário Geraldo; et al.; Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans; Birkhauser Boston Inc; Medicinal Chemistry Research; 21; 9; 9-2012; 2217-22221054-25231554-8120CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00044-011-9750-xinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00044-011-9750-xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-29T11:41:47Zoai:ri.conicet.gov.ar:11336/62845instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-29 11:41:47.985CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans
title Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans
spellingShingle Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans
Tempesti, Tomas Cristian
Antifungal Activity
Candida Albicans
Flavonoid
Quercetin
Rutin
title_short Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans
title_full Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans
title_fullStr Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans
title_full_unstemmed Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans
title_sort Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans
dc.creator.none.fl_str_mv Tempesti, Tomas Cristian
Alvarez, María Gabriela
de Araújo, Marcelo Francisco
Catunda Júnior, Francisco Eduardo Aragão
de Carvalho, Mário Geraldo
Durantini, Edgardo Néstor
author Tempesti, Tomas Cristian
author_facet Tempesti, Tomas Cristian
Alvarez, María Gabriela
de Araújo, Marcelo Francisco
Catunda Júnior, Francisco Eduardo Aragão
de Carvalho, Mário Geraldo
Durantini, Edgardo Néstor
author_role author
author2 Alvarez, María Gabriela
de Araújo, Marcelo Francisco
Catunda Júnior, Francisco Eduardo Aragão
de Carvalho, Mário Geraldo
Durantini, Edgardo Néstor
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Antifungal Activity
Candida Albicans
Flavonoid
Quercetin
Rutin
topic Antifungal Activity
Candida Albicans
Flavonoid
Quercetin
Rutin
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In this study, a novel quercetin derivative bearing a trifluoromethyl group was synthesized by the nucleophilic aromatic substitution reaction between rutin and 2-chloro-5-(trifluoromethyl)-1,3-dinitrobenzene in basic medium. This synthetic quercetin showed antifungal activity against Candida albicans cultures. The results indicated a remarkable increase in the biological activity of this compound as compared to rutin.
Fil: Tempesti, Tomas Cristian. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Alvarez, María Gabriela. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de Araújo, Marcelo Francisco. Universidade Federal do Rio de Janeiro; Brasil
Fil: Catunda Júnior, Francisco Eduardo Aragão. Universidade Federal do Rio de Janeiro; Brasil
Fil: de Carvalho, Mário Geraldo. Universidade Federal do Rio de Janeiro; Brasil
Fil: Durantini, Edgardo Néstor. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description In this study, a novel quercetin derivative bearing a trifluoromethyl group was synthesized by the nucleophilic aromatic substitution reaction between rutin and 2-chloro-5-(trifluoromethyl)-1,3-dinitrobenzene in basic medium. This synthetic quercetin showed antifungal activity against Candida albicans cultures. The results indicated a remarkable increase in the biological activity of this compound as compared to rutin.
publishDate 2012
dc.date.none.fl_str_mv 2012-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/62845
Tempesti, Tomas Cristian; Alvarez, María Gabriela; de Araújo, Marcelo Francisco; Catunda Júnior, Francisco Eduardo Aragão; de Carvalho, Mário Geraldo; et al.; Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans; Birkhauser Boston Inc; Medicinal Chemistry Research; 21; 9; 9-2012; 2217-2222
1054-2523
1554-8120
CONICET Digital
CONICET
url http://hdl.handle.net/11336/62845
identifier_str_mv Tempesti, Tomas Cristian; Alvarez, María Gabriela; de Araújo, Marcelo Francisco; Catunda Júnior, Francisco Eduardo Aragão; de Carvalho, Mário Geraldo; et al.; Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans; Birkhauser Boston Inc; Medicinal Chemistry Research; 21; 9; 9-2012; 2217-2222
1054-2523
1554-8120
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00044-011-9750-x
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00044-011-9750-x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Birkhauser Boston Inc
publisher.none.fl_str_mv Birkhauser Boston Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1847426321606508544
score 13.10058

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