Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs

Autores
Monte Mor Rangel, Marcelo; Calazans Menescal Linhares, Laís; Duro de Oliveira, Krishna; Ota Hisayasu Suzuki, Daniela; Maglietti, Felipe Horacio; Barboza de Nardi, Andrigo
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Local treatment of canine urothelial carcinoma (UC) of the bladder is a challenge. More than 90% of the cases invade the muscular layer, more than 50% develop on bladder sites with a difficult surgical approach and often requiring radical surgical procedures. This study aims to evaluate the safety and feasibility of electrochemotherapy (ECT) with intravenous bleomycin (BLM) as a local therapy for bladder UC. This prospective study included 21 dogs with spontaneous bladder UC. Regional/distant metastases and neoplastic infiltration of the serosa was considered the main exclusion criteria. We had no deaths during ECT or in the immediate postoperative period, and no suture dehiscence. Most dogs (19/21) developed mild adverse effects, whereas two dogs developed ureteral stenosis. Complete response (CR) was achieved in 62% of the cases (13/21), while partial response (PR) was achieved in 24% (5/21). The median survival and disease-free survival times were 284 and 270 days, respectively. Overall survival was significantly better in the dogs who achieved a CR. In conclusion, ECT was well-tolerated in dogs with UC, demonstrating its safety and feasibility. These data pave the way for new studies aimed at evaluating the effectiveness of ECT in canine bladder UC as a translational model for human disease.
Fil: Monte Mor Rangel, Marcelo. No especifíca;
Fil: Calazans Menescal Linhares, Laís. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Duro de Oliveira, Krishna. No especifíca;
Fil: Ota Hisayasu Suzuki, Daniela. Universidade Federal de Santa Catarina; Brasil
Fil: Maglietti, Felipe Horacio. Instituto Universidad de la Fundación "Héctor Barceló"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barboza de Nardi, Andrigo. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Materia
electroporation
canine
tumor
veterinary
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/229310
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/229310
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogsMonte Mor Rangel, MarceloCalazans Menescal Linhares, LaísDuro de Oliveira, KrishnaOta Hisayasu Suzuki, DanielaMaglietti, Felipe HoracioBarboza de Nardi, Andrigoelectroporationcaninetumorveterinaryhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Local treatment of canine urothelial carcinoma (UC) of the bladder is a challenge. More than 90% of the cases invade the muscular layer, more than 50% develop on bladder sites with a difficult surgical approach and often requiring radical surgical procedures. This study aims to evaluate the safety and feasibility of electrochemotherapy (ECT) with intravenous bleomycin (BLM) as a local therapy for bladder UC. This prospective study included 21 dogs with spontaneous bladder UC. Regional/distant metastases and neoplastic infiltration of the serosa was considered the main exclusion criteria. We had no deaths during ECT or in the immediate postoperative period, and no suture dehiscence. Most dogs (19/21) developed mild adverse effects, whereas two dogs developed ureteral stenosis. Complete response (CR) was achieved in 62% of the cases (13/21), while partial response (PR) was achieved in 24% (5/21). The median survival and disease-free survival times were 284 and 270 days, respectively. Overall survival was significantly better in the dogs who achieved a CR. In conclusion, ECT was well-tolerated in dogs with UC, demonstrating its safety and feasibility. These data pave the way for new studies aimed at evaluating the effectiveness of ECT in canine bladder UC as a translational model for human disease.Fil: Monte Mor Rangel, Marcelo. No especifíca;Fil: Calazans Menescal Linhares, Laís. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Duro de Oliveira, Krishna. No especifíca;Fil: Ota Hisayasu Suzuki, Daniela. Universidade Federal de Santa Catarina; BrasilFil: Maglietti, Felipe Horacio. Instituto Universidad de la Fundación "Héctor Barceló"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Barboza de Nardi, Andrigo. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilNature2023-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/229310Monte Mor Rangel, Marcelo; Calazans Menescal Linhares, Laís; Duro de Oliveira, Krishna; Ota Hisayasu Suzuki, Daniela; Maglietti, Felipe Horacio; et al.; Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs; Nature; Scientific Reports; 13; 1; 12-2023; 1-152045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-023-45433-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:21Zoai:ri.conicet.gov.ar:11336/229310instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:21.534CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs
title Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs
spellingShingle Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs
Monte Mor Rangel, Marcelo
electroporation
canine
tumor
veterinary
title_short Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs
title_full Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs
title_fullStr Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs
title_full_unstemmed Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs
title_sort Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs
dc.creator.none.fl_str_mv Monte Mor Rangel, Marcelo
Calazans Menescal Linhares, Laís
Duro de Oliveira, Krishna
Ota Hisayasu Suzuki, Daniela
Maglietti, Felipe Horacio
Barboza de Nardi, Andrigo
author Monte Mor Rangel, Marcelo
author_facet Monte Mor Rangel, Marcelo
Calazans Menescal Linhares, Laís
Duro de Oliveira, Krishna
Ota Hisayasu Suzuki, Daniela
Maglietti, Felipe Horacio
Barboza de Nardi, Andrigo
author_role author
author2 Calazans Menescal Linhares, Laís
Duro de Oliveira, Krishna
Ota Hisayasu Suzuki, Daniela
Maglietti, Felipe Horacio
Barboza de Nardi, Andrigo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv electroporation
canine
tumor
veterinary
topic electroporation
canine
tumor
veterinary
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Local treatment of canine urothelial carcinoma (UC) of the bladder is a challenge. More than 90% of the cases invade the muscular layer, more than 50% develop on bladder sites with a difficult surgical approach and often requiring radical surgical procedures. This study aims to evaluate the safety and feasibility of electrochemotherapy (ECT) with intravenous bleomycin (BLM) as a local therapy for bladder UC. This prospective study included 21 dogs with spontaneous bladder UC. Regional/distant metastases and neoplastic infiltration of the serosa was considered the main exclusion criteria. We had no deaths during ECT or in the immediate postoperative period, and no suture dehiscence. Most dogs (19/21) developed mild adverse effects, whereas two dogs developed ureteral stenosis. Complete response (CR) was achieved in 62% of the cases (13/21), while partial response (PR) was achieved in 24% (5/21). The median survival and disease-free survival times were 284 and 270 days, respectively. Overall survival was significantly better in the dogs who achieved a CR. In conclusion, ECT was well-tolerated in dogs with UC, demonstrating its safety and feasibility. These data pave the way for new studies aimed at evaluating the effectiveness of ECT in canine bladder UC as a translational model for human disease.
Fil: Monte Mor Rangel, Marcelo. No especifíca;
Fil: Calazans Menescal Linhares, Laís. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Duro de Oliveira, Krishna. No especifíca;
Fil: Ota Hisayasu Suzuki, Daniela. Universidade Federal de Santa Catarina; Brasil
Fil: Maglietti, Felipe Horacio. Instituto Universidad de la Fundación "Héctor Barceló"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barboza de Nardi, Andrigo. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
description Local treatment of canine urothelial carcinoma (UC) of the bladder is a challenge. More than 90% of the cases invade the muscular layer, more than 50% develop on bladder sites with a difficult surgical approach and often requiring radical surgical procedures. This study aims to evaluate the safety and feasibility of electrochemotherapy (ECT) with intravenous bleomycin (BLM) as a local therapy for bladder UC. This prospective study included 21 dogs with spontaneous bladder UC. Regional/distant metastases and neoplastic infiltration of the serosa was considered the main exclusion criteria. We had no deaths during ECT or in the immediate postoperative period, and no suture dehiscence. Most dogs (19/21) developed mild adverse effects, whereas two dogs developed ureteral stenosis. Complete response (CR) was achieved in 62% of the cases (13/21), while partial response (PR) was achieved in 24% (5/21). The median survival and disease-free survival times were 284 and 270 days, respectively. Overall survival was significantly better in the dogs who achieved a CR. In conclusion, ECT was well-tolerated in dogs with UC, demonstrating its safety and feasibility. These data pave the way for new studies aimed at evaluating the effectiveness of ECT in canine bladder UC as a translational model for human disease.
publishDate 2023
dc.date.none.fl_str_mv 2023-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/229310
Monte Mor Rangel, Marcelo; Calazans Menescal Linhares, Laís; Duro de Oliveira, Krishna; Ota Hisayasu Suzuki, Daniela; Maglietti, Felipe Horacio; et al.; Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs; Nature; Scientific Reports; 13; 1; 12-2023; 1-15
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/229310
identifier_str_mv Monte Mor Rangel, Marcelo; Calazans Menescal Linhares, Laís; Duro de Oliveira, Krishna; Ota Hisayasu Suzuki, Daniela; Maglietti, Felipe Horacio; et al.; Evaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs; Nature; Scientific Reports; 13; 1; 12-2023; 1-15
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-023-45433-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269339593474048
score 13.13397

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