Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome
- Autores
- Tellado, Matías Nicolás; Maglietti, Felipe Horacio; Michinski, Sebastián Diego; Marshall, Guillermo Ricardo; Signori, Emanuela
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Oral malignant melanoma is the most common, but aggressive oral cancer in dogs with poor prognosis. Electrochemotherapy (ECT) has therapeutic potential in such tumors as effective local treatment. Therefore, the aim of this prospective clinical study was to evaluate treatment effectiveness of ECT in as first line treatment for canine oral malignant melanoma, and search for factors influencing treatment outcome. Sixty-seven canines with primary oral malignant melanoma, non-candidates for first-line therapy, were enrolled. All dogs received ECT and follow-up exams for the span of two years. Based on RECIST criteria, the objective response rate was 100%, 89.5%, 57.7%, and 36.4%, in stage I, II, III and IV, respectively. Only patients in stage I, II and III with partial or complete response improved their quality of life. The median time to progression was 11, 7, 4 and 4 months, and median survival time after the treatment was 16.5, 9.0, 7.5 and 4.5 months, for patients in stage I, II, III and IV, respectively. Significantly better was local response in stage I and II disease (p = 0.0013), without the bone involvement (p = 0.043) Electrochemotherapy is effective local treatment of oral canine malignant melanoma when no alternative treatment is available. Better response is expected in stage I and II patients with tumors without bone involvement.
Fil: Tellado, Matías Nicolás. No especifíca;
Fil: Maglietti, Felipe Horacio. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Michinski, Sebastián Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Fil: Marshall, Guillermo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Fil: Signori, Emanuela. Centre National de la Recherche Scientifique; Francia - Materia
-
CANCER
DOG
ELECTROCHEMOTHERAPY
ELECTROPORATION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/146362
Ver los metadatos del registro completo
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Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcomeTellado, Matías NicolásMaglietti, Felipe HoracioMichinski, Sebastián DiegoMarshall, Guillermo RicardoSignori, EmanuelaCANCERDOGELECTROCHEMOTHERAPYELECTROPORATIONhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Oral malignant melanoma is the most common, but aggressive oral cancer in dogs with poor prognosis. Electrochemotherapy (ECT) has therapeutic potential in such tumors as effective local treatment. Therefore, the aim of this prospective clinical study was to evaluate treatment effectiveness of ECT in as first line treatment for canine oral malignant melanoma, and search for factors influencing treatment outcome. Sixty-seven canines with primary oral malignant melanoma, non-candidates for first-line therapy, were enrolled. All dogs received ECT and follow-up exams for the span of two years. Based on RECIST criteria, the objective response rate was 100%, 89.5%, 57.7%, and 36.4%, in stage I, II, III and IV, respectively. Only patients in stage I, II and III with partial or complete response improved their quality of life. The median time to progression was 11, 7, 4 and 4 months, and median survival time after the treatment was 16.5, 9.0, 7.5 and 4.5 months, for patients in stage I, II, III and IV, respectively. Significantly better was local response in stage I and II disease (p = 0.0013), without the bone involvement (p = 0.043) Electrochemotherapy is effective local treatment of oral canine malignant melanoma when no alternative treatment is available. Better response is expected in stage I and II patients with tumors without bone involvement.Fil: Tellado, Matías Nicolás. No especifíca;Fil: Maglietti, Felipe Horacio. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Michinski, Sebastián Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; ArgentinaFil: Marshall, Guillermo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; ArgentinaFil: Signori, Emanuela. Centre National de la Recherche Scientifique; FranciaAssoc Radiology & Oncology2020-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/146362Tellado, Matías Nicolás; Maglietti, Felipe Horacio; Michinski, Sebastián Diego; Marshall, Guillermo Ricardo; Signori, Emanuela; Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome; Assoc Radiology & Oncology; Radiology And Oncology; 54; 1; 3-2020; 68-781318-2099CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2478/raon-2020-0014info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:40Zoai:ri.conicet.gov.ar:11336/146362instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:41.193CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome |
title |
Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome |
spellingShingle |
Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome Tellado, Matías Nicolás CANCER DOG ELECTROCHEMOTHERAPY ELECTROPORATION |
title_short |
Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome |
title_full |
Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome |
title_fullStr |
Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome |
title_full_unstemmed |
Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome |
title_sort |
Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome |
dc.creator.none.fl_str_mv |
Tellado, Matías Nicolás Maglietti, Felipe Horacio Michinski, Sebastián Diego Marshall, Guillermo Ricardo Signori, Emanuela |
author |
Tellado, Matías Nicolás |
author_facet |
Tellado, Matías Nicolás Maglietti, Felipe Horacio Michinski, Sebastián Diego Marshall, Guillermo Ricardo Signori, Emanuela |
author_role |
author |
author2 |
Maglietti, Felipe Horacio Michinski, Sebastián Diego Marshall, Guillermo Ricardo Signori, Emanuela |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
CANCER DOG ELECTROCHEMOTHERAPY ELECTROPORATION |
topic |
CANCER DOG ELECTROCHEMOTHERAPY ELECTROPORATION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Oral malignant melanoma is the most common, but aggressive oral cancer in dogs with poor prognosis. Electrochemotherapy (ECT) has therapeutic potential in such tumors as effective local treatment. Therefore, the aim of this prospective clinical study was to evaluate treatment effectiveness of ECT in as first line treatment for canine oral malignant melanoma, and search for factors influencing treatment outcome. Sixty-seven canines with primary oral malignant melanoma, non-candidates for first-line therapy, were enrolled. All dogs received ECT and follow-up exams for the span of two years. Based on RECIST criteria, the objective response rate was 100%, 89.5%, 57.7%, and 36.4%, in stage I, II, III and IV, respectively. Only patients in stage I, II and III with partial or complete response improved their quality of life. The median time to progression was 11, 7, 4 and 4 months, and median survival time after the treatment was 16.5, 9.0, 7.5 and 4.5 months, for patients in stage I, II, III and IV, respectively. Significantly better was local response in stage I and II disease (p = 0.0013), without the bone involvement (p = 0.043) Electrochemotherapy is effective local treatment of oral canine malignant melanoma when no alternative treatment is available. Better response is expected in stage I and II patients with tumors without bone involvement. Fil: Tellado, Matías Nicolás. No especifíca; Fil: Maglietti, Felipe Horacio. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Michinski, Sebastián Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina Fil: Marshall, Guillermo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina Fil: Signori, Emanuela. Centre National de la Recherche Scientifique; Francia |
description |
Oral malignant melanoma is the most common, but aggressive oral cancer in dogs with poor prognosis. Electrochemotherapy (ECT) has therapeutic potential in such tumors as effective local treatment. Therefore, the aim of this prospective clinical study was to evaluate treatment effectiveness of ECT in as first line treatment for canine oral malignant melanoma, and search for factors influencing treatment outcome. Sixty-seven canines with primary oral malignant melanoma, non-candidates for first-line therapy, were enrolled. All dogs received ECT and follow-up exams for the span of two years. Based on RECIST criteria, the objective response rate was 100%, 89.5%, 57.7%, and 36.4%, in stage I, II, III and IV, respectively. Only patients in stage I, II and III with partial or complete response improved their quality of life. The median time to progression was 11, 7, 4 and 4 months, and median survival time after the treatment was 16.5, 9.0, 7.5 and 4.5 months, for patients in stage I, II, III and IV, respectively. Significantly better was local response in stage I and II disease (p = 0.0013), without the bone involvement (p = 0.043) Electrochemotherapy is effective local treatment of oral canine malignant melanoma when no alternative treatment is available. Better response is expected in stage I and II patients with tumors without bone involvement. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/146362 Tellado, Matías Nicolás; Maglietti, Felipe Horacio; Michinski, Sebastián Diego; Marshall, Guillermo Ricardo; Signori, Emanuela; Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome; Assoc Radiology & Oncology; Radiology And Oncology; 54; 1; 3-2020; 68-78 1318-2099 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/146362 |
identifier_str_mv |
Tellado, Matías Nicolás; Maglietti, Felipe Horacio; Michinski, Sebastián Diego; Marshall, Guillermo Ricardo; Signori, Emanuela; Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome; Assoc Radiology & Oncology; Radiology And Oncology; 54; 1; 3-2020; 68-78 1318-2099 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.2478/raon-2020-0014 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Assoc Radiology & Oncology |
publisher.none.fl_str_mv |
Assoc Radiology & Oncology |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269359817359360 |
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13.13397 |