Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome

Autores
Tellado, Matías Nicolás; Maglietti, Felipe Horacio; Michinski, Sebastián Diego; Marshall, Guillermo Ricardo; Signori, Emanuela
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Oral malignant melanoma is the most common, but aggressive oral cancer in dogs with poor prognosis. Electrochemotherapy (ECT) has therapeutic potential in such tumors as effective local treatment. Therefore, the aim of this prospective clinical study was to evaluate treatment effectiveness of ECT in as first line treatment for canine oral malignant melanoma, and search for factors influencing treatment outcome. Sixty-seven canines with primary oral malignant melanoma, non-candidates for first-line therapy, were enrolled. All dogs received ECT and follow-up exams for the span of two years. Based on RECIST criteria, the objective response rate was 100%, 89.5%, 57.7%, and 36.4%, in stage I, II, III and IV, respectively. Only patients in stage I, II and III with partial or complete response improved their quality of life. The median time to progression was 11, 7, 4 and 4 months, and median survival time after the treatment was 16.5, 9.0, 7.5 and 4.5 months, for patients in stage I, II, III and IV, respectively. Significantly better was local response in stage I and II disease (p = 0.0013), without the bone involvement (p = 0.043) Electrochemotherapy is effective local treatment of oral canine malignant melanoma when no alternative treatment is available. Better response is expected in stage I and II patients with tumors without bone involvement.
Fil: Tellado, Matías Nicolás. No especifíca;
Fil: Maglietti, Felipe Horacio. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Michinski, Sebastián Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Fil: Marshall, Guillermo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Fil: Signori, Emanuela. Centre National de la Recherche Scientifique; Francia
Materia
CANCER
DOG
ELECTROCHEMOTHERAPY
ELECTROPORATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/146362
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcomeTellado, Matías NicolásMaglietti, Felipe HoracioMichinski, Sebastián DiegoMarshall, Guillermo RicardoSignori, EmanuelaCANCERDOGELECTROCHEMOTHERAPYELECTROPORATIONhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Oral malignant melanoma is the most common, but aggressive oral cancer in dogs with poor prognosis. Electrochemotherapy (ECT) has therapeutic potential in such tumors as effective local treatment. Therefore, the aim of this prospective clinical study was to evaluate treatment effectiveness of ECT in as first line treatment for canine oral malignant melanoma, and search for factors influencing treatment outcome. Sixty-seven canines with primary oral malignant melanoma, non-candidates for first-line therapy, were enrolled. All dogs received ECT and follow-up exams for the span of two years. Based on RECIST criteria, the objective response rate was 100%, 89.5%, 57.7%, and 36.4%, in stage I, II, III and IV, respectively. Only patients in stage I, II and III with partial or complete response improved their quality of life. The median time to progression was 11, 7, 4 and 4 months, and median survival time after the treatment was 16.5, 9.0, 7.5 and 4.5 months, for patients in stage I, II, III and IV, respectively. Significantly better was local response in stage I and II disease (p = 0.0013), without the bone involvement (p = 0.043) Electrochemotherapy is effective local treatment of oral canine malignant melanoma when no alternative treatment is available. Better response is expected in stage I and II patients with tumors without bone involvement.Fil: Tellado, Matías Nicolás. No especifíca;Fil: Maglietti, Felipe Horacio. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Michinski, Sebastián Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; ArgentinaFil: Marshall, Guillermo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; ArgentinaFil: Signori, Emanuela. Centre National de la Recherche Scientifique; FranciaAssoc Radiology & Oncology2020-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/146362Tellado, Matías Nicolás; Maglietti, Felipe Horacio; Michinski, Sebastián Diego; Marshall, Guillermo Ricardo; Signori, Emanuela; Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome; Assoc Radiology & Oncology; Radiology And Oncology; 54; 1; 3-2020; 68-781318-2099CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2478/raon-2020-0014info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:58:40Zoai:ri.conicet.gov.ar:11336/146362instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:58:41.142CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome
title Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome
spellingShingle Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome
Tellado, Matías Nicolás
CANCER
DOG
ELECTROCHEMOTHERAPY
ELECTROPORATION
title_short Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome
title_full Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome
title_fullStr Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome
title_full_unstemmed Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome
title_sort Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome
dc.creator.none.fl_str_mv Tellado, Matías Nicolás
Maglietti, Felipe Horacio
Michinski, Sebastián Diego
Marshall, Guillermo Ricardo
Signori, Emanuela
author Tellado, Matías Nicolás
author_facet Tellado, Matías Nicolás
Maglietti, Felipe Horacio
Michinski, Sebastián Diego
Marshall, Guillermo Ricardo
Signori, Emanuela
author_role author
author2 Maglietti, Felipe Horacio
Michinski, Sebastián Diego
Marshall, Guillermo Ricardo
Signori, Emanuela
author2_role author
author
author
author
dc.subject.none.fl_str_mv CANCER
DOG
ELECTROCHEMOTHERAPY
ELECTROPORATION
topic CANCER
DOG
ELECTROCHEMOTHERAPY
ELECTROPORATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Oral malignant melanoma is the most common, but aggressive oral cancer in dogs with poor prognosis. Electrochemotherapy (ECT) has therapeutic potential in such tumors as effective local treatment. Therefore, the aim of this prospective clinical study was to evaluate treatment effectiveness of ECT in as first line treatment for canine oral malignant melanoma, and search for factors influencing treatment outcome. Sixty-seven canines with primary oral malignant melanoma, non-candidates for first-line therapy, were enrolled. All dogs received ECT and follow-up exams for the span of two years. Based on RECIST criteria, the objective response rate was 100%, 89.5%, 57.7%, and 36.4%, in stage I, II, III and IV, respectively. Only patients in stage I, II and III with partial or complete response improved their quality of life. The median time to progression was 11, 7, 4 and 4 months, and median survival time after the treatment was 16.5, 9.0, 7.5 and 4.5 months, for patients in stage I, II, III and IV, respectively. Significantly better was local response in stage I and II disease (p = 0.0013), without the bone involvement (p = 0.043) Electrochemotherapy is effective local treatment of oral canine malignant melanoma when no alternative treatment is available. Better response is expected in stage I and II patients with tumors without bone involvement.
Fil: Tellado, Matías Nicolás. No especifíca;
Fil: Maglietti, Felipe Horacio. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Michinski, Sebastián Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Fil: Marshall, Guillermo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Fil: Signori, Emanuela. Centre National de la Recherche Scientifique; Francia
description Oral malignant melanoma is the most common, but aggressive oral cancer in dogs with poor prognosis. Electrochemotherapy (ECT) has therapeutic potential in such tumors as effective local treatment. Therefore, the aim of this prospective clinical study was to evaluate treatment effectiveness of ECT in as first line treatment for canine oral malignant melanoma, and search for factors influencing treatment outcome. Sixty-seven canines with primary oral malignant melanoma, non-candidates for first-line therapy, were enrolled. All dogs received ECT and follow-up exams for the span of two years. Based on RECIST criteria, the objective response rate was 100%, 89.5%, 57.7%, and 36.4%, in stage I, II, III and IV, respectively. Only patients in stage I, II and III with partial or complete response improved their quality of life. The median time to progression was 11, 7, 4 and 4 months, and median survival time after the treatment was 16.5, 9.0, 7.5 and 4.5 months, for patients in stage I, II, III and IV, respectively. Significantly better was local response in stage I and II disease (p = 0.0013), without the bone involvement (p = 0.043) Electrochemotherapy is effective local treatment of oral canine malignant melanoma when no alternative treatment is available. Better response is expected in stage I and II patients with tumors without bone involvement.
publishDate 2020
dc.date.none.fl_str_mv 2020-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/146362
Tellado, Matías Nicolás; Maglietti, Felipe Horacio; Michinski, Sebastián Diego; Marshall, Guillermo Ricardo; Signori, Emanuela; Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome; Assoc Radiology & Oncology; Radiology And Oncology; 54; 1; 3-2020; 68-78
1318-2099
CONICET Digital
CONICET
url http://hdl.handle.net/11336/146362
identifier_str_mv Tellado, Matías Nicolás; Maglietti, Felipe Horacio; Michinski, Sebastián Diego; Marshall, Guillermo Ricardo; Signori, Emanuela; Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome; Assoc Radiology & Oncology; Radiology And Oncology; 54; 1; 3-2020; 68-78
1318-2099
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2478/raon-2020-0014
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Assoc Radiology & Oncology
publisher.none.fl_str_mv Assoc Radiology & Oncology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613747422789632
score 13.070432

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