Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors

Autores
Olaiz, Nahuel Manuel; Suárez, Cecilia Ana; Risk, Marcelo; Molina, Fernando Víctor; Marshall, Guillermo Ricardo
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Electrochemical reactions in the electrochemical treatment of tumors (EChT) induce extreme pH changes and, consequently, protein electrodenaturation fronts intimately related to tumor destruction. Here we introduce a new in vitro EChT collagen-macronutrient gel (CMG) model to study protein electrodenaturation fronts as a mean of assessing EChT effectiveness. Our CMG model shows that from an initial uniform condition two electrodenaturation fronts evolve expanding towards each other until collision. Moreover, electrodenaturation front tracking reveals that the front grows under a diffusion-controlled regime. Based on this evidence it is possible, in principle, to predict the time needed for tumor destruction without compromising healthy tissue. These results are consistent with those previously obtained with in vivo and in vitro EChT modeling. In contrast to previous simpler in vitro models, our CMG model represents a better structural and chemical approximation to a real tissue thus providing a better tool for validation of new in silico EChT models aimed at a more accurate prediction of tissue destruction level.
Fil: Olaiz, Nahuel Manuel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación. Ciencias Computacionales de la Vida, Simulación y Sistemas Complejos; Argentina
Fil: Suárez, Cecilia Ana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación. Ciencias Computacionales de la Vida, Simulación y Sistemas Complejos; Argentina
Fil: Risk, Marcelo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación. Ciencias Computacionales de la Vida, Simulación y Sistemas Complejos; Argentina
Fil: Molina, Fernando Víctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Marshall, Guillermo Ricardo. University of Manchester; Reino Unido
Materia
Electrochemical Treatment
Electrodenaturation
In Vitro Models
Tumors
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/53839
Acceder
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network_acronym_str CONICETDig
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spelling Tracking protein electrodenaturation fronts in the electrochemical treatment of tumorsOlaiz, Nahuel ManuelSuárez, Cecilia AnaRisk, MarceloMolina, Fernando VíctorMarshall, Guillermo RicardoElectrochemical TreatmentElectrodenaturationIn Vitro ModelsTumorshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1Electrochemical reactions in the electrochemical treatment of tumors (EChT) induce extreme pH changes and, consequently, protein electrodenaturation fronts intimately related to tumor destruction. Here we introduce a new in vitro EChT collagen-macronutrient gel (CMG) model to study protein electrodenaturation fronts as a mean of assessing EChT effectiveness. Our CMG model shows that from an initial uniform condition two electrodenaturation fronts evolve expanding towards each other until collision. Moreover, electrodenaturation front tracking reveals that the front grows under a diffusion-controlled regime. Based on this evidence it is possible, in principle, to predict the time needed for tumor destruction without compromising healthy tissue. These results are consistent with those previously obtained with in vivo and in vitro EChT modeling. In contrast to previous simpler in vitro models, our CMG model represents a better structural and chemical approximation to a real tissue thus providing a better tool for validation of new in silico EChT models aimed at a more accurate prediction of tissue destruction level.Fil: Olaiz, Nahuel Manuel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación. Ciencias Computacionales de la Vida, Simulación y Sistemas Complejos; ArgentinaFil: Suárez, Cecilia Ana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación. Ciencias Computacionales de la Vida, Simulación y Sistemas Complejos; ArgentinaFil: Risk, Marcelo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación. Ciencias Computacionales de la Vida, Simulación y Sistemas Complejos; ArgentinaFil: Molina, Fernando Víctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Marshall, Guillermo Ricardo. University of Manchester; Reino UnidoElsevier Science Inc2010-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53839Olaiz, Nahuel Manuel; Suárez, Cecilia Ana; Risk, Marcelo; Molina, Fernando Víctor; Marshall, Guillermo Ricardo; Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors; Elsevier Science Inc; Electrochemistry Communications; 12; 1; 1-2010; 94-971388-2481CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1388248109005426info:eu-repo/semantics/altIdentifier/doi/10.1016/j.elecom.2009.10.044info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:51Zoai:ri.conicet.gov.ar:11336/53839instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:52.021CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors
title Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors
spellingShingle Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors
Olaiz, Nahuel Manuel
Electrochemical Treatment
Electrodenaturation
In Vitro Models
Tumors
title_short Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors
title_full Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors
title_fullStr Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors
title_full_unstemmed Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors
title_sort Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors
dc.creator.none.fl_str_mv Olaiz, Nahuel Manuel
Suárez, Cecilia Ana
Risk, Marcelo
Molina, Fernando Víctor
Marshall, Guillermo Ricardo
author Olaiz, Nahuel Manuel
author_facet Olaiz, Nahuel Manuel
Suárez, Cecilia Ana
Risk, Marcelo
Molina, Fernando Víctor
Marshall, Guillermo Ricardo
author_role author
author2 Suárez, Cecilia Ana
Risk, Marcelo
Molina, Fernando Víctor
Marshall, Guillermo Ricardo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Electrochemical Treatment
Electrodenaturation
In Vitro Models
Tumors
topic Electrochemical Treatment
Electrodenaturation
In Vitro Models
Tumors
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Electrochemical reactions in the electrochemical treatment of tumors (EChT) induce extreme pH changes and, consequently, protein electrodenaturation fronts intimately related to tumor destruction. Here we introduce a new in vitro EChT collagen-macronutrient gel (CMG) model to study protein electrodenaturation fronts as a mean of assessing EChT effectiveness. Our CMG model shows that from an initial uniform condition two electrodenaturation fronts evolve expanding towards each other until collision. Moreover, electrodenaturation front tracking reveals that the front grows under a diffusion-controlled regime. Based on this evidence it is possible, in principle, to predict the time needed for tumor destruction without compromising healthy tissue. These results are consistent with those previously obtained with in vivo and in vitro EChT modeling. In contrast to previous simpler in vitro models, our CMG model represents a better structural and chemical approximation to a real tissue thus providing a better tool for validation of new in silico EChT models aimed at a more accurate prediction of tissue destruction level.
Fil: Olaiz, Nahuel Manuel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación. Ciencias Computacionales de la Vida, Simulación y Sistemas Complejos; Argentina
Fil: Suárez, Cecilia Ana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación. Ciencias Computacionales de la Vida, Simulación y Sistemas Complejos; Argentina
Fil: Risk, Marcelo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación. Ciencias Computacionales de la Vida, Simulación y Sistemas Complejos; Argentina
Fil: Molina, Fernando Víctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Marshall, Guillermo Ricardo. University of Manchester; Reino Unido
description Electrochemical reactions in the electrochemical treatment of tumors (EChT) induce extreme pH changes and, consequently, protein electrodenaturation fronts intimately related to tumor destruction. Here we introduce a new in vitro EChT collagen-macronutrient gel (CMG) model to study protein electrodenaturation fronts as a mean of assessing EChT effectiveness. Our CMG model shows that from an initial uniform condition two electrodenaturation fronts evolve expanding towards each other until collision. Moreover, electrodenaturation front tracking reveals that the front grows under a diffusion-controlled regime. Based on this evidence it is possible, in principle, to predict the time needed for tumor destruction without compromising healthy tissue. These results are consistent with those previously obtained with in vivo and in vitro EChT modeling. In contrast to previous simpler in vitro models, our CMG model represents a better structural and chemical approximation to a real tissue thus providing a better tool for validation of new in silico EChT models aimed at a more accurate prediction of tissue destruction level.
publishDate 2010
dc.date.none.fl_str_mv 2010-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/53839
Olaiz, Nahuel Manuel; Suárez, Cecilia Ana; Risk, Marcelo; Molina, Fernando Víctor; Marshall, Guillermo Ricardo; Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors; Elsevier Science Inc; Electrochemistry Communications; 12; 1; 1-2010; 94-97
1388-2481
CONICET Digital
CONICET
url http://hdl.handle.net/11336/53839
identifier_str_mv Olaiz, Nahuel Manuel; Suárez, Cecilia Ana; Risk, Marcelo; Molina, Fernando Víctor; Marshall, Guillermo Ricardo; Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors; Elsevier Science Inc; Electrochemistry Communications; 12; 1; 1-2010; 94-97
1388-2481
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1388248109005426
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.elecom.2009.10.044
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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