Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device

Autores
Luján, Emmanuel; Schinca, Herman; Olaiz, Nahuel Manuel; Urquiza, Santiago Adrian; Molina, Fernando Víctor; Turjanski, Pablo Guillermo; Marshall, Guillermo Ricardo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Electrolytic ablation (EA), a medical treatment used in solid tumor ablation due to its minimum side effects and low cost, consists in the passage of a low constant electric current through two or more electrodes inserted in the tissue thus inducing pH fronts that produce tumor necrosis. Combined with a recently introduced one-probe two electrode device (OPTED) this procedure results in a minimally invasive treatment. Despite its success, EA has drawbacks such as the difficulties in determining the optimum dose-response relationship between the applied current, treatment time and necrotized tumor volume (NTV) and choosing a reliable dose parameter. In this work, a theoretical model is introduced describing the EA/OPTED as an electrolytic process and the underlying electrochemical reactions through the Nernst-Planck equations for ion transport. Model results show that the coulomb dosage is a reliable dose parameter and predicts an optimal dose-response relationship for a given tumor size subjected to an EA/OPTED, considering the optimum as the minimum coulomb dosage necessary to achieve total tumor destruction while minimizing healthy tissue damage. Moreover, it predicts a nonlinear relationship between coulomb dosage and NTV, dosage and NTV scaling as Q1.4. Consequently, these results could have a significant impact on dose planning methodology aimed at improving the effectiveness of the electrolytic ablation.
Fil: Luján, Emmanuel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Fil: Schinca, Herman. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; Argentina
Fil: Olaiz, Nahuel Manuel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Fil: Urquiza, Santiago Adrian. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; Argentina
Fil: Molina, Fernando Víctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Turjanski, Pablo Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; Argentina
Fil: Marshall, Guillermo Ricardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Materia
ELECTROCHEMICAL TREATMENT
ELECTROLYTIC ABLATION
IN SILICO MODELS
IN VITRO MODELS
PH FRONT TRACKING
TUMORS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/94606
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/94606
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode deviceLuján, EmmanuelSchinca, HermanOlaiz, Nahuel ManuelUrquiza, Santiago AdrianMolina, Fernando VíctorTurjanski, Pablo GuillermoMarshall, Guillermo RicardoELECTROCHEMICAL TREATMENTELECTROLYTIC ABLATIONIN SILICO MODELSIN VITRO MODELSPH FRONT TRACKINGTUMORShttps://purl.org/becyt/ford/2.3https://purl.org/becyt/ford/2https://purl.org/becyt/ford/2.3https://purl.org/becyt/ford/2Electrolytic ablation (EA), a medical treatment used in solid tumor ablation due to its minimum side effects and low cost, consists in the passage of a low constant electric current through two or more electrodes inserted in the tissue thus inducing pH fronts that produce tumor necrosis. Combined with a recently introduced one-probe two electrode device (OPTED) this procedure results in a minimally invasive treatment. Despite its success, EA has drawbacks such as the difficulties in determining the optimum dose-response relationship between the applied current, treatment time and necrotized tumor volume (NTV) and choosing a reliable dose parameter. In this work, a theoretical model is introduced describing the EA/OPTED as an electrolytic process and the underlying electrochemical reactions through the Nernst-Planck equations for ion transport. Model results show that the coulomb dosage is a reliable dose parameter and predicts an optimal dose-response relationship for a given tumor size subjected to an EA/OPTED, considering the optimum as the minimum coulomb dosage necessary to achieve total tumor destruction while minimizing healthy tissue damage. Moreover, it predicts a nonlinear relationship between coulomb dosage and NTV, dosage and NTV scaling as Q1.4. Consequently, these results could have a significant impact on dose planning methodology aimed at improving the effectiveness of the electrolytic ablation.Fil: Luján, Emmanuel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; ArgentinaFil: Schinca, Herman. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; ArgentinaFil: Olaiz, Nahuel Manuel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; ArgentinaFil: Urquiza, Santiago Adrian. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; ArgentinaFil: Molina, Fernando Víctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Turjanski, Pablo Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; ArgentinaFil: Marshall, Guillermo Ricardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; ArgentinaPergamon-Elsevier Science Ltd2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/94606Luján, Emmanuel; Schinca, Herman; Olaiz, Nahuel Manuel; Urquiza, Santiago Adrian; Molina, Fernando Víctor; et al.; Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device; Pergamon-Elsevier Science Ltd; Electrochimica Acta; 186; 12-2015; 494-5030013-4686CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0013468615307283info:eu-repo/semantics/altIdentifier/doi/10.1016/j.electacta.2015.10.147info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:55Zoai:ri.conicet.gov.ar:11336/94606instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:55.678CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device
title Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device
spellingShingle Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device
Luján, Emmanuel
ELECTROCHEMICAL TREATMENT
ELECTROLYTIC ABLATION
IN SILICO MODELS
IN VITRO MODELS
PH FRONT TRACKING
TUMORS
title_short Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device
title_full Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device
title_fullStr Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device
title_full_unstemmed Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device
title_sort Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device
dc.creator.none.fl_str_mv Luján, Emmanuel
Schinca, Herman
Olaiz, Nahuel Manuel
Urquiza, Santiago Adrian
Molina, Fernando Víctor
Turjanski, Pablo Guillermo
Marshall, Guillermo Ricardo
author Luján, Emmanuel
author_facet Luján, Emmanuel
Schinca, Herman
Olaiz, Nahuel Manuel
Urquiza, Santiago Adrian
Molina, Fernando Víctor
Turjanski, Pablo Guillermo
Marshall, Guillermo Ricardo
author_role author
author2 Schinca, Herman
Olaiz, Nahuel Manuel
Urquiza, Santiago Adrian
Molina, Fernando Víctor
Turjanski, Pablo Guillermo
Marshall, Guillermo Ricardo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ELECTROCHEMICAL TREATMENT
ELECTROLYTIC ABLATION
IN SILICO MODELS
IN VITRO MODELS
PH FRONT TRACKING
TUMORS
topic ELECTROCHEMICAL TREATMENT
ELECTROLYTIC ABLATION
IN SILICO MODELS
IN VITRO MODELS
PH FRONT TRACKING
TUMORS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.3
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/2.3
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Electrolytic ablation (EA), a medical treatment used in solid tumor ablation due to its minimum side effects and low cost, consists in the passage of a low constant electric current through two or more electrodes inserted in the tissue thus inducing pH fronts that produce tumor necrosis. Combined with a recently introduced one-probe two electrode device (OPTED) this procedure results in a minimally invasive treatment. Despite its success, EA has drawbacks such as the difficulties in determining the optimum dose-response relationship between the applied current, treatment time and necrotized tumor volume (NTV) and choosing a reliable dose parameter. In this work, a theoretical model is introduced describing the EA/OPTED as an electrolytic process and the underlying electrochemical reactions through the Nernst-Planck equations for ion transport. Model results show that the coulomb dosage is a reliable dose parameter and predicts an optimal dose-response relationship for a given tumor size subjected to an EA/OPTED, considering the optimum as the minimum coulomb dosage necessary to achieve total tumor destruction while minimizing healthy tissue damage. Moreover, it predicts a nonlinear relationship between coulomb dosage and NTV, dosage and NTV scaling as Q1.4. Consequently, these results could have a significant impact on dose planning methodology aimed at improving the effectiveness of the electrolytic ablation.
Fil: Luján, Emmanuel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Fil: Schinca, Herman. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; Argentina
Fil: Olaiz, Nahuel Manuel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Fil: Urquiza, Santiago Adrian. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; Argentina
Fil: Molina, Fernando Víctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Turjanski, Pablo Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; Argentina
Fil: Marshall, Guillermo Ricardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
description Electrolytic ablation (EA), a medical treatment used in solid tumor ablation due to its minimum side effects and low cost, consists in the passage of a low constant electric current through two or more electrodes inserted in the tissue thus inducing pH fronts that produce tumor necrosis. Combined with a recently introduced one-probe two electrode device (OPTED) this procedure results in a minimally invasive treatment. Despite its success, EA has drawbacks such as the difficulties in determining the optimum dose-response relationship between the applied current, treatment time and necrotized tumor volume (NTV) and choosing a reliable dose parameter. In this work, a theoretical model is introduced describing the EA/OPTED as an electrolytic process and the underlying electrochemical reactions through the Nernst-Planck equations for ion transport. Model results show that the coulomb dosage is a reliable dose parameter and predicts an optimal dose-response relationship for a given tumor size subjected to an EA/OPTED, considering the optimum as the minimum coulomb dosage necessary to achieve total tumor destruction while minimizing healthy tissue damage. Moreover, it predicts a nonlinear relationship between coulomb dosage and NTV, dosage and NTV scaling as Q1.4. Consequently, these results could have a significant impact on dose planning methodology aimed at improving the effectiveness of the electrolytic ablation.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/94606
Luján, Emmanuel; Schinca, Herman; Olaiz, Nahuel Manuel; Urquiza, Santiago Adrian; Molina, Fernando Víctor; et al.; Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device; Pergamon-Elsevier Science Ltd; Electrochimica Acta; 186; 12-2015; 494-503
0013-4686
CONICET Digital
CONICET
url http://hdl.handle.net/11336/94606
identifier_str_mv Luján, Emmanuel; Schinca, Herman; Olaiz, Nahuel Manuel; Urquiza, Santiago Adrian; Molina, Fernando Víctor; et al.; Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device; Pergamon-Elsevier Science Ltd; Electrochimica Acta; 186; 12-2015; 494-503
0013-4686
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0013468615307283
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.electacta.2015.10.147
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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