Sleep and cognition in aging dogs. A polysomnographic study

Autores
Mondino, Alejandra; Catanzariti, Magaly Belén; Mateos, Diego Martín; Khan, Michael; Ludwig, Claire; Kis, Anna; Gruen, Margaret E.; Olby, Natasha J.
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Sleep is fundamental for cognitive homeostasis, especially in senior populations since clearance of amyloid beta (key in the pathophysiology of Alzheimer’s disease) occurs during sleep. Some electroencephalographic characteristics of sleep and wakefulness have been considered a hallmark of dementia. Owners of dogs with canine cognitive dysfunction syndrome (a canine analog to Alzheimer’s disease) report that their dogs suer from di culty sleeping. The aim of this study was to quantify age-related changes in the sleep-wakefulness cycle macrostructure and electroencephalographic features in senior dogs and to correlate them with their cognitive performance. Methods: We performed polysomnographic recordings in 28 senior dogs during a 2 h afternoon nap. Percentage of time spent in wakefulness, drowsiness, NREM, and REM sleep, as well as latency to the three sleep states were calculated. Spectral power, coherence, and Lempel Ziv Complexity of the brain oscillations were estimated. Finally, cognitive performance was evaluated by means of the Canine Dementia Scale Questionnaire and a battery of cognitive tests. Correlations between age, cognitive performance and sleep-wakefulness cycle macrostructure and electroencephalographic features were calculated. Results: Dogs with higher dementia scores and with worse performance in a problem-solving task spent less time in NREM and REM sleep. Additionally, quantitative electroencephalographic analyses showed dierences in dogs associated with age or cognitive performance, some of them reflecting shallower sleep in more aected dogs. Discussion: Polysomnographic recordings in dogs can detect sleep-wakefulness cycle changes associated with dementia. Further studies should evaluate polysomnography’s potential clinical use to monitor the progression of canine cognitive dysfunction syndrome.
Fil: Mondino, Alejandra. North Carolina State University; Estados Unidos
Fil: Catanzariti, Magaly Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; Argentina
Fil: Mateos, Diego Martín. Universidad Autonoma de Entre Rios. Facultad de Ciencia y Tecnologia. Departamento de Fisica.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; Argentina
Fil: Khan, Michael. North Carolina State University; Estados Unidos
Fil: Ludwig, Claire. North Carolina State University; Estados Unidos
Fil: Kis, Anna. No especifíca;
Fil: Gruen, Margaret E.. North Carolina State University; Estados Unidos
Fil: Olby, Natasha J.. North Carolina State University; Estados Unidos
Materia
NREM SLEEP
REM SLEEP
CANINE COGNITIVE DYSFUNCTION SYNDROME
QUANTITATIVE EEG
POWER SPECTRUM
COHERENCE
COMPLEXITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/255740
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sleep and cognition in aging dogs. A polysomnographic studyMondino, AlejandraCatanzariti, Magaly BelénMateos, Diego MartínKhan, MichaelLudwig, ClaireKis, AnnaGruen, Margaret E.Olby, Natasha J.NREM SLEEPREM SLEEPCANINE COGNITIVE DYSFUNCTION SYNDROMEQUANTITATIVE EEGPOWER SPECTRUMCOHERENCECOMPLEXITYhttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1Introduction: Sleep is fundamental for cognitive homeostasis, especially in senior populations since clearance of amyloid beta (key in the pathophysiology of Alzheimer’s disease) occurs during sleep. Some electroencephalographic characteristics of sleep and wakefulness have been considered a hallmark of dementia. Owners of dogs with canine cognitive dysfunction syndrome (a canine analog to Alzheimer’s disease) report that their dogs suer from di culty sleeping. The aim of this study was to quantify age-related changes in the sleep-wakefulness cycle macrostructure and electroencephalographic features in senior dogs and to correlate them with their cognitive performance. Methods: We performed polysomnographic recordings in 28 senior dogs during a 2 h afternoon nap. Percentage of time spent in wakefulness, drowsiness, NREM, and REM sleep, as well as latency to the three sleep states were calculated. Spectral power, coherence, and Lempel Ziv Complexity of the brain oscillations were estimated. Finally, cognitive performance was evaluated by means of the Canine Dementia Scale Questionnaire and a battery of cognitive tests. Correlations between age, cognitive performance and sleep-wakefulness cycle macrostructure and electroencephalographic features were calculated. Results: Dogs with higher dementia scores and with worse performance in a problem-solving task spent less time in NREM and REM sleep. Additionally, quantitative electroencephalographic analyses showed dierences in dogs associated with age or cognitive performance, some of them reflecting shallower sleep in more aected dogs. Discussion: Polysomnographic recordings in dogs can detect sleep-wakefulness cycle changes associated with dementia. Further studies should evaluate polysomnography’s potential clinical use to monitor the progression of canine cognitive dysfunction syndrome.Fil: Mondino, Alejandra. North Carolina State University; Estados UnidosFil: Catanzariti, Magaly Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; ArgentinaFil: Mateos, Diego Martín. Universidad Autonoma de Entre Rios. Facultad de Ciencia y Tecnologia. Departamento de Fisica.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; ArgentinaFil: Khan, Michael. North Carolina State University; Estados UnidosFil: Ludwig, Claire. North Carolina State University; Estados UnidosFil: Kis, Anna. No especifíca;Fil: Gruen, Margaret E.. North Carolina State University; Estados UnidosFil: Olby, Natasha J.. North Carolina State University; Estados UnidosFrontiers Media2023-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/255740Mondino, Alejandra; Catanzariti, Magaly Belén; Mateos, Diego Martín; Khan, Michael; Ludwig, Claire; et al.; Sleep and cognition in aging dogs. A polysomnographic study; Frontiers Media; Frontiers in Veterinary Science; 10; 4-2023; 1-162297-1769CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fvets.2023.1151266/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fvets.2023.1151266info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:23Zoai:ri.conicet.gov.ar:11336/255740instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:23.962CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sleep and cognition in aging dogs. A polysomnographic study
title Sleep and cognition in aging dogs. A polysomnographic study
spellingShingle Sleep and cognition in aging dogs. A polysomnographic study
Mondino, Alejandra
NREM SLEEP
REM SLEEP
CANINE COGNITIVE DYSFUNCTION SYNDROME
QUANTITATIVE EEG
POWER SPECTRUM
COHERENCE
COMPLEXITY
title_short Sleep and cognition in aging dogs. A polysomnographic study
title_full Sleep and cognition in aging dogs. A polysomnographic study
title_fullStr Sleep and cognition in aging dogs. A polysomnographic study
title_full_unstemmed Sleep and cognition in aging dogs. A polysomnographic study
title_sort Sleep and cognition in aging dogs. A polysomnographic study
dc.creator.none.fl_str_mv Mondino, Alejandra
Catanzariti, Magaly Belén
Mateos, Diego Martín
Khan, Michael
Ludwig, Claire
Kis, Anna
Gruen, Margaret E.
Olby, Natasha J.
author Mondino, Alejandra
author_facet Mondino, Alejandra
Catanzariti, Magaly Belén
Mateos, Diego Martín
Khan, Michael
Ludwig, Claire
Kis, Anna
Gruen, Margaret E.
Olby, Natasha J.
author_role author
author2 Catanzariti, Magaly Belén
Mateos, Diego Martín
Khan, Michael
Ludwig, Claire
Kis, Anna
Gruen, Margaret E.
Olby, Natasha J.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv NREM SLEEP
REM SLEEP
CANINE COGNITIVE DYSFUNCTION SYNDROME
QUANTITATIVE EEG
POWER SPECTRUM
COHERENCE
COMPLEXITY
topic NREM SLEEP
REM SLEEP
CANINE COGNITIVE DYSFUNCTION SYNDROME
QUANTITATIVE EEG
POWER SPECTRUM
COHERENCE
COMPLEXITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Introduction: Sleep is fundamental for cognitive homeostasis, especially in senior populations since clearance of amyloid beta (key in the pathophysiology of Alzheimer’s disease) occurs during sleep. Some electroencephalographic characteristics of sleep and wakefulness have been considered a hallmark of dementia. Owners of dogs with canine cognitive dysfunction syndrome (a canine analog to Alzheimer’s disease) report that their dogs suer from di culty sleeping. The aim of this study was to quantify age-related changes in the sleep-wakefulness cycle macrostructure and electroencephalographic features in senior dogs and to correlate them with their cognitive performance. Methods: We performed polysomnographic recordings in 28 senior dogs during a 2 h afternoon nap. Percentage of time spent in wakefulness, drowsiness, NREM, and REM sleep, as well as latency to the three sleep states were calculated. Spectral power, coherence, and Lempel Ziv Complexity of the brain oscillations were estimated. Finally, cognitive performance was evaluated by means of the Canine Dementia Scale Questionnaire and a battery of cognitive tests. Correlations between age, cognitive performance and sleep-wakefulness cycle macrostructure and electroencephalographic features were calculated. Results: Dogs with higher dementia scores and with worse performance in a problem-solving task spent less time in NREM and REM sleep. Additionally, quantitative electroencephalographic analyses showed dierences in dogs associated with age or cognitive performance, some of them reflecting shallower sleep in more aected dogs. Discussion: Polysomnographic recordings in dogs can detect sleep-wakefulness cycle changes associated with dementia. Further studies should evaluate polysomnography’s potential clinical use to monitor the progression of canine cognitive dysfunction syndrome.
Fil: Mondino, Alejandra. North Carolina State University; Estados Unidos
Fil: Catanzariti, Magaly Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; Argentina
Fil: Mateos, Diego Martín. Universidad Autonoma de Entre Rios. Facultad de Ciencia y Tecnologia. Departamento de Fisica.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; Argentina
Fil: Khan, Michael. North Carolina State University; Estados Unidos
Fil: Ludwig, Claire. North Carolina State University; Estados Unidos
Fil: Kis, Anna. No especifíca;
Fil: Gruen, Margaret E.. North Carolina State University; Estados Unidos
Fil: Olby, Natasha J.. North Carolina State University; Estados Unidos
description Introduction: Sleep is fundamental for cognitive homeostasis, especially in senior populations since clearance of amyloid beta (key in the pathophysiology of Alzheimer’s disease) occurs during sleep. Some electroencephalographic characteristics of sleep and wakefulness have been considered a hallmark of dementia. Owners of dogs with canine cognitive dysfunction syndrome (a canine analog to Alzheimer’s disease) report that their dogs suer from di culty sleeping. The aim of this study was to quantify age-related changes in the sleep-wakefulness cycle macrostructure and electroencephalographic features in senior dogs and to correlate them with their cognitive performance. Methods: We performed polysomnographic recordings in 28 senior dogs during a 2 h afternoon nap. Percentage of time spent in wakefulness, drowsiness, NREM, and REM sleep, as well as latency to the three sleep states were calculated. Spectral power, coherence, and Lempel Ziv Complexity of the brain oscillations were estimated. Finally, cognitive performance was evaluated by means of the Canine Dementia Scale Questionnaire and a battery of cognitive tests. Correlations between age, cognitive performance and sleep-wakefulness cycle macrostructure and electroencephalographic features were calculated. Results: Dogs with higher dementia scores and with worse performance in a problem-solving task spent less time in NREM and REM sleep. Additionally, quantitative electroencephalographic analyses showed dierences in dogs associated with age or cognitive performance, some of them reflecting shallower sleep in more aected dogs. Discussion: Polysomnographic recordings in dogs can detect sleep-wakefulness cycle changes associated with dementia. Further studies should evaluate polysomnography’s potential clinical use to monitor the progression of canine cognitive dysfunction syndrome.
publishDate 2023
dc.date.none.fl_str_mv 2023-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/255740
Mondino, Alejandra; Catanzariti, Magaly Belén; Mateos, Diego Martín; Khan, Michael; Ludwig, Claire; et al.; Sleep and cognition in aging dogs. A polysomnographic study; Frontiers Media; Frontiers in Veterinary Science; 10; 4-2023; 1-16
2297-1769
CONICET Digital
CONICET
url http://hdl.handle.net/11336/255740
identifier_str_mv Mondino, Alejandra; Catanzariti, Magaly Belén; Mateos, Diego Martín; Khan, Michael; Ludwig, Claire; et al.; Sleep and cognition in aging dogs. A polysomnographic study; Frontiers Media; Frontiers in Veterinary Science; 10; 4-2023; 1-16
2297-1769
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fvets.2023.1151266/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fvets.2023.1151266
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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