On-line enantioseparation of chlorpheniramine using β-cyclodextrin and carbon nanotubes after multivariate optimization

Autores
Acosta, Maria Gimena; Silva, Raúl Alejandro; Gil, Raul Andres; Gomez, Roxana; Fernandez, Liliana Patricia
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Multiwalled carbon nanotubes are evaluated here as solid phase extraction (SPE) sorbent aiming to (±)-chlorpheniramine (CPA) enantioresolution with fluorimetric detection. β-cyclodextrin (CD) was added to the racemate and solutions with HCl and sodium dodecyl sulfate (SDS) in different proportions were assayed as eluents to achieve the separation between both enantiomers. The overall methodology involved a flow injection (FI) strategy enabling high sample throughput and low reagents consumption making it suitable for drug routine quality control. An adequate enantioresolution (2.08) with satisfactory responses for both (R)-CPA (peak area = 285) and (S)-CPA (peak area = 380) was achieved applying the proposed FI-SPE strategy under the optimized conditions [β-CD] = 1.0 mmol L-1, [HCl] = 1.0 x 10-2 mol L-1, [SDS] = 4.0 x 10-4 mol L-1 and eluent flow rate = 8.0 rpm.
Fil: Acosta, Maria Gimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; Argentina
Fil: Gil, Raul Andres. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Gomez, Roxana. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica;
Fil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Materia
CARBON NANOTUBES
FLOW INJECTION ANALYSIS
MULTIVARIATE OPTIMIZATION
ON-LINE ENANTIORESOLUTION
Β-CYCLODEXTRIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/1083

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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling On-line enantioseparation of chlorpheniramine using β-cyclodextrin and carbon nanotubes after multivariate optimizationAcosta, Maria GimenaSilva, Raúl AlejandroGil, Raul AndresGomez, RoxanaFernandez, Liliana PatriciaCARBON NANOTUBESFLOW INJECTION ANALYSISMULTIVARIATE OPTIMIZATIONON-LINE ENANTIORESOLUTIONΒ-CYCLODEXTRINhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Multiwalled carbon nanotubes are evaluated here as solid phase extraction (SPE) sorbent aiming to (±)-chlorpheniramine (CPA) enantioresolution with fluorimetric detection. β-cyclodextrin (CD) was added to the racemate and solutions with HCl and sodium dodecyl sulfate (SDS) in different proportions were assayed as eluents to achieve the separation between both enantiomers. The overall methodology involved a flow injection (FI) strategy enabling high sample throughput and low reagents consumption making it suitable for drug routine quality control. An adequate enantioresolution (2.08) with satisfactory responses for both (R)-CPA (peak area = 285) and (S)-CPA (peak area = 380) was achieved applying the proposed FI-SPE strategy under the optimized conditions [β-CD] = 1.0 mmol L-1, [HCl] = 1.0 x 10-2 mol L-1, [SDS] = 4.0 x 10-4 mol L-1 and eluent flow rate = 8.0 rpm.Fil: Acosta, Maria Gimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; ArgentinaFil: Gil, Raul Andres. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Gomez, Roxana. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica;Fil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaElsevier Science2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/octet-streamapplication/pdfhttp://hdl.handle.net/11336/1083Acosta, Maria Gimena; Silva, Raúl Alejandro; Gil, Raul Andres; Gomez, Roxana; Fernandez, Liliana Patricia; On-line enantioseparation of chlorpheniramine using β-cyclodextrin and carbon nanotubes after multivariate optimization; Elsevier Science; Talanta; 105; 2-2013; 167-1720039-9140enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.talanta.2012.11.045info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0039914012009897info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:16Zoai:ri.conicet.gov.ar:11336/1083instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:16.524CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv On-line enantioseparation of chlorpheniramine using β-cyclodextrin and carbon nanotubes after multivariate optimization
title On-line enantioseparation of chlorpheniramine using β-cyclodextrin and carbon nanotubes after multivariate optimization
spellingShingle On-line enantioseparation of chlorpheniramine using β-cyclodextrin and carbon nanotubes after multivariate optimization
Acosta, Maria Gimena
CARBON NANOTUBES
FLOW INJECTION ANALYSIS
MULTIVARIATE OPTIMIZATION
ON-LINE ENANTIORESOLUTION
Β-CYCLODEXTRIN
title_short On-line enantioseparation of chlorpheniramine using β-cyclodextrin and carbon nanotubes after multivariate optimization
title_full On-line enantioseparation of chlorpheniramine using β-cyclodextrin and carbon nanotubes after multivariate optimization
title_fullStr On-line enantioseparation of chlorpheniramine using β-cyclodextrin and carbon nanotubes after multivariate optimization
title_full_unstemmed On-line enantioseparation of chlorpheniramine using β-cyclodextrin and carbon nanotubes after multivariate optimization
title_sort On-line enantioseparation of chlorpheniramine using β-cyclodextrin and carbon nanotubes after multivariate optimization
dc.creator.none.fl_str_mv Acosta, Maria Gimena
Silva, Raúl Alejandro
Gil, Raul Andres
Gomez, Roxana
Fernandez, Liliana Patricia
author Acosta, Maria Gimena
author_facet Acosta, Maria Gimena
Silva, Raúl Alejandro
Gil, Raul Andres
Gomez, Roxana
Fernandez, Liliana Patricia
author_role author
author2 Silva, Raúl Alejandro
Gil, Raul Andres
Gomez, Roxana
Fernandez, Liliana Patricia
author2_role author
author
author
author
dc.subject.none.fl_str_mv CARBON NANOTUBES
FLOW INJECTION ANALYSIS
MULTIVARIATE OPTIMIZATION
ON-LINE ENANTIORESOLUTION
Β-CYCLODEXTRIN
topic CARBON NANOTUBES
FLOW INJECTION ANALYSIS
MULTIVARIATE OPTIMIZATION
ON-LINE ENANTIORESOLUTION
Β-CYCLODEXTRIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Multiwalled carbon nanotubes are evaluated here as solid phase extraction (SPE) sorbent aiming to (±)-chlorpheniramine (CPA) enantioresolution with fluorimetric detection. β-cyclodextrin (CD) was added to the racemate and solutions with HCl and sodium dodecyl sulfate (SDS) in different proportions were assayed as eluents to achieve the separation between both enantiomers. The overall methodology involved a flow injection (FI) strategy enabling high sample throughput and low reagents consumption making it suitable for drug routine quality control. An adequate enantioresolution (2.08) with satisfactory responses for both (R)-CPA (peak area = 285) and (S)-CPA (peak area = 380) was achieved applying the proposed FI-SPE strategy under the optimized conditions [β-CD] = 1.0 mmol L-1, [HCl] = 1.0 x 10-2 mol L-1, [SDS] = 4.0 x 10-4 mol L-1 and eluent flow rate = 8.0 rpm.
Fil: Acosta, Maria Gimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; Argentina
Fil: Gil, Raul Andres. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Gomez, Roxana. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica;
Fil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
description Multiwalled carbon nanotubes are evaluated here as solid phase extraction (SPE) sorbent aiming to (±)-chlorpheniramine (CPA) enantioresolution with fluorimetric detection. β-cyclodextrin (CD) was added to the racemate and solutions with HCl and sodium dodecyl sulfate (SDS) in different proportions were assayed as eluents to achieve the separation between both enantiomers. The overall methodology involved a flow injection (FI) strategy enabling high sample throughput and low reagents consumption making it suitable for drug routine quality control. An adequate enantioresolution (2.08) with satisfactory responses for both (R)-CPA (peak area = 285) and (S)-CPA (peak area = 380) was achieved applying the proposed FI-SPE strategy under the optimized conditions [β-CD] = 1.0 mmol L-1, [HCl] = 1.0 x 10-2 mol L-1, [SDS] = 4.0 x 10-4 mol L-1 and eluent flow rate = 8.0 rpm.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/1083
Acosta, Maria Gimena; Silva, Raúl Alejandro; Gil, Raul Andres; Gomez, Roxana; Fernandez, Liliana Patricia; On-line enantioseparation of chlorpheniramine using β-cyclodextrin and carbon nanotubes after multivariate optimization; Elsevier Science; Talanta; 105; 2-2013; 167-172
0039-9140
url http://hdl.handle.net/11336/1083
identifier_str_mv Acosta, Maria Gimena; Silva, Raúl Alejandro; Gil, Raul Andres; Gomez, Roxana; Fernandez, Liliana Patricia; On-line enantioseparation of chlorpheniramine using β-cyclodextrin and carbon nanotubes after multivariate optimization; Elsevier Science; Talanta; 105; 2-2013; 167-172
0039-9140
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.talanta.2012.11.045
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0039914012009897
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/octet-stream
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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