Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: Relevance to schizophrenia and bipolar disorder

Autores
D'Onofrio, Stasia; Kezunovic, Nebojsa; Hyde, James; Luster, Brennon; Messias, Erick; Urbano Suarez, Francisco Jose; Garcia Rill, Edgar
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) expression was reported in a series of postmortem studies. These disorders are also characterized by sleep dysregulation, suggesting a role for the reticular activating system (RAS). The discovery of gamma-band activity in the pedunculopontine nucleus (PPN), the cholinergic arm of the RAS, revealed that such activity was mediated by high-threshold calcium channels that are regulated by NCS-1.We hypothesized that NCS-1 normally regulates gamma-band oscillations through these calcium channels and that excessive levels of NCS-1, such as would be expected with overexpression, decrease gammaband activity. We found that PPN neurons in rat brain slices manifested gamma-band oscillations that were increased by low levels of NCS-1 but suppressed by high levels of NCS-1.Our results suggest that NCS-1 overexpression may be responsible for the decrease in gamma-band activity present in at least some schizophrenia and bipolar disorder patients.
Fil: D'Onofrio, Stasia. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Kezunovic, Nebojsa. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Hyde, James. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Luster, Brennon. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Messias, Erick. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Garcia Rill, Edgar. University Of Arkansas For Medical Sciences; Estados Unidos
Materia
Arousal
Bipolar Disorder
P/Q-Type Calcium Channels
Rem Sleep
Schizophrenia
Waking
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/39915
Acceder
id CONICETDig_048d08eb6484407dadb1fcff8e196e60
oai_identifier_str oai:ri.conicet.gov.ar:11336/39915
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: Relevance to schizophrenia and bipolar disorderD'Onofrio, StasiaKezunovic, NebojsaHyde, JamesLuster, BrennonMessias, ErickUrbano Suarez, Francisco JoseGarcia Rill, EdgarArousalBipolar DisorderP/Q-Type Calcium ChannelsRem SleepSchizophreniaWakinghttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) expression was reported in a series of postmortem studies. These disorders are also characterized by sleep dysregulation, suggesting a role for the reticular activating system (RAS). The discovery of gamma-band activity in the pedunculopontine nucleus (PPN), the cholinergic arm of the RAS, revealed that such activity was mediated by high-threshold calcium channels that are regulated by NCS-1.We hypothesized that NCS-1 normally regulates gamma-band oscillations through these calcium channels and that excessive levels of NCS-1, such as would be expected with overexpression, decrease gammaband activity. We found that PPN neurons in rat brain slices manifested gamma-band oscillations that were increased by low levels of NCS-1 but suppressed by high levels of NCS-1.Our results suggest that NCS-1 overexpression may be responsible for the decrease in gamma-band activity present in at least some schizophrenia and bipolar disorder patients.Fil: D'Onofrio, Stasia. University Of Arkansas For Medical Sciences; Estados UnidosFil: Kezunovic, Nebojsa. University Of Arkansas For Medical Sciences; Estados UnidosFil: Hyde, James. University Of Arkansas For Medical Sciences; Estados UnidosFil: Luster, Brennon. University Of Arkansas For Medical Sciences; Estados UnidosFil: Messias, Erick. University Of Arkansas For Medical Sciences; Estados UnidosFil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Garcia Rill, Edgar. University Of Arkansas For Medical Sciences; Estados UnidosAmerican Physiological Society2015-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39915D'Onofrio, Stasia; Kezunovic, Nebojsa; Hyde, James; Luster, Brennon; Messias, Erick; et al.; Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: Relevance to schizophrenia and bipolar disorder; American Physiological Society; Journal of Neurophysiology; 113; 3; 2-2015; 709-7190022-3077CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://jn.physiology.org/content/113/3/709.longinfo:eu-repo/semantics/altIdentifier/doi/10.1152/jn.00828.2014info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312873/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:01:54Zoai:ri.conicet.gov.ar:11336/39915instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:01:54.811CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: Relevance to schizophrenia and bipolar disorder
title Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: Relevance to schizophrenia and bipolar disorder
spellingShingle Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: Relevance to schizophrenia and bipolar disorder
D'Onofrio, Stasia
Arousal
Bipolar Disorder
P/Q-Type Calcium Channels
Rem Sleep
Schizophrenia
Waking
title_short Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: Relevance to schizophrenia and bipolar disorder
title_full Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: Relevance to schizophrenia and bipolar disorder
title_fullStr Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: Relevance to schizophrenia and bipolar disorder
title_full_unstemmed Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: Relevance to schizophrenia and bipolar disorder
title_sort Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: Relevance to schizophrenia and bipolar disorder
dc.creator.none.fl_str_mv D'Onofrio, Stasia
Kezunovic, Nebojsa
Hyde, James
Luster, Brennon
Messias, Erick
Urbano Suarez, Francisco Jose
Garcia Rill, Edgar
author D'Onofrio, Stasia
author_facet D'Onofrio, Stasia
Kezunovic, Nebojsa
Hyde, James
Luster, Brennon
Messias, Erick
Urbano Suarez, Francisco Jose
Garcia Rill, Edgar
author_role author
author2 Kezunovic, Nebojsa
Hyde, James
Luster, Brennon
Messias, Erick
Urbano Suarez, Francisco Jose
Garcia Rill, Edgar
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Arousal
Bipolar Disorder
P/Q-Type Calcium Channels
Rem Sleep
Schizophrenia
Waking
topic Arousal
Bipolar Disorder
P/Q-Type Calcium Channels
Rem Sleep
Schizophrenia
Waking
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) expression was reported in a series of postmortem studies. These disorders are also characterized by sleep dysregulation, suggesting a role for the reticular activating system (RAS). The discovery of gamma-band activity in the pedunculopontine nucleus (PPN), the cholinergic arm of the RAS, revealed that such activity was mediated by high-threshold calcium channels that are regulated by NCS-1.We hypothesized that NCS-1 normally regulates gamma-band oscillations through these calcium channels and that excessive levels of NCS-1, such as would be expected with overexpression, decrease gammaband activity. We found that PPN neurons in rat brain slices manifested gamma-band oscillations that were increased by low levels of NCS-1 but suppressed by high levels of NCS-1.Our results suggest that NCS-1 overexpression may be responsible for the decrease in gamma-band activity present in at least some schizophrenia and bipolar disorder patients.
Fil: D'Onofrio, Stasia. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Kezunovic, Nebojsa. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Hyde, James. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Luster, Brennon. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Messias, Erick. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Garcia Rill, Edgar. University Of Arkansas For Medical Sciences; Estados Unidos
description Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) expression was reported in a series of postmortem studies. These disorders are also characterized by sleep dysregulation, suggesting a role for the reticular activating system (RAS). The discovery of gamma-band activity in the pedunculopontine nucleus (PPN), the cholinergic arm of the RAS, revealed that such activity was mediated by high-threshold calcium channels that are regulated by NCS-1.We hypothesized that NCS-1 normally regulates gamma-band oscillations through these calcium channels and that excessive levels of NCS-1, such as would be expected with overexpression, decrease gammaband activity. We found that PPN neurons in rat brain slices manifested gamma-band oscillations that were increased by low levels of NCS-1 but suppressed by high levels of NCS-1.Our results suggest that NCS-1 overexpression may be responsible for the decrease in gamma-band activity present in at least some schizophrenia and bipolar disorder patients.
publishDate 2015
dc.date.none.fl_str_mv 2015-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39915
D'Onofrio, Stasia; Kezunovic, Nebojsa; Hyde, James; Luster, Brennon; Messias, Erick; et al.; Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: Relevance to schizophrenia and bipolar disorder; American Physiological Society; Journal of Neurophysiology; 113; 3; 2-2015; 709-719
0022-3077
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39915
identifier_str_mv D'Onofrio, Stasia; Kezunovic, Nebojsa; Hyde, James; Luster, Brennon; Messias, Erick; et al.; Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: Relevance to schizophrenia and bipolar disorder; American Physiological Society; Journal of Neurophysiology; 113; 3; 2-2015; 709-719
0022-3077
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://jn.physiology.org/content/113/3/709.long
info:eu-repo/semantics/altIdentifier/doi/10.1152/jn.00828.2014
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312873/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842979981248954368
score 12.993085

Publicaciones similares