The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics

Autores
Virmani, T.; Urbano Suarez, Francisco Jose; Bisagno, Veronica; Garcia Rill, Edgar
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this review, we discuss first an example of one of the symptoms of PD, freezing of gait (FOG), then we will turn to the use of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) to treat PD, and the original studies that led to identification of the PPN as one source of locomotor control and why stimulation frequency is critical, and then describe the intrinsic properties of PPN neurons that require beta/gamma stimulation in order to fully activate all types of PPN neurons. Finally, we will describe recent findings on the proteomic and molecular consequences of gamma band activity in PPN neurons, with emphasis on the potential neuroepigenetic sequelae. These considerations will provide essential information for the appropriate refining and testing of PPN DBS as a potential therapy for PD, as well as alternative options.
Fil: Virmani, T.. University of Arkansas for Medical Sciences; Estados Unidos
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
Fil: Garcia Rill, Edgar. University of Arkansas for Medical Sciences; Estados Unidos
Materia
AROUSAL
DEEP BRAIN STIMULATION
F-ACTIN
HISTONE DEACETYLASE
N- AND P/Q-TYPE CALCIUM CHANNELS
REM SLEEP
TRICHOSTATIN A
WAKING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/162966
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The pedunculopontine nucleus: From posture and locomotion to neuroepigeneticsVirmani, T.Urbano Suarez, Francisco JoseBisagno, VeronicaGarcia Rill, EdgarAROUSALDEEP BRAIN STIMULATIONF-ACTINHISTONE DEACETYLASEN- AND P/Q-TYPE CALCIUM CHANNELSREM SLEEPTRICHOSTATIN AWAKINGhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In this review, we discuss first an example of one of the symptoms of PD, freezing of gait (FOG), then we will turn to the use of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) to treat PD, and the original studies that led to identification of the PPN as one source of locomotor control and why stimulation frequency is critical, and then describe the intrinsic properties of PPN neurons that require beta/gamma stimulation in order to fully activate all types of PPN neurons. Finally, we will describe recent findings on the proteomic and molecular consequences of gamma band activity in PPN neurons, with emphasis on the potential neuroepigenetic sequelae. These considerations will provide essential information for the appropriate refining and testing of PPN DBS as a potential therapy for PD, as well as alternative options.Fil: Virmani, T.. University of Arkansas for Medical Sciences; Estados UnidosFil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; ArgentinaFil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; ArgentinaFil: Garcia Rill, Edgar. University of Arkansas for Medical Sciences; Estados UnidosAIMS Press2019-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/162966Virmani, T.; Urbano Suarez, Francisco Jose; Bisagno, Veronica; Garcia Rill, Edgar; The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics; AIMS Press; AIMS Neuroscience; 6; 4; 9-2019; 219-2302373-7972CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3934/Neuroscience.2019.4.219info:eu-repo/semantics/altIdentifier/url/http://www.aimspress.com/article/10.3934/Neuroscience.2019.4.219info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:18:53Zoai:ri.conicet.gov.ar:11336/162966instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:18:53.688CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics
title The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics
spellingShingle The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics
Virmani, T.
AROUSAL
DEEP BRAIN STIMULATION
F-ACTIN
HISTONE DEACETYLASE
N- AND P/Q-TYPE CALCIUM CHANNELS
REM SLEEP
TRICHOSTATIN A
WAKING
title_short The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics
title_full The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics
title_fullStr The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics
title_full_unstemmed The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics
title_sort The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics
dc.creator.none.fl_str_mv Virmani, T.
Urbano Suarez, Francisco Jose
Bisagno, Veronica
Garcia Rill, Edgar
author Virmani, T.
author_facet Virmani, T.
Urbano Suarez, Francisco Jose
Bisagno, Veronica
Garcia Rill, Edgar
author_role author
author2 Urbano Suarez, Francisco Jose
Bisagno, Veronica
Garcia Rill, Edgar
author2_role author
author
author
dc.subject.none.fl_str_mv AROUSAL
DEEP BRAIN STIMULATION
F-ACTIN
HISTONE DEACETYLASE
N- AND P/Q-TYPE CALCIUM CHANNELS
REM SLEEP
TRICHOSTATIN A
WAKING
topic AROUSAL
DEEP BRAIN STIMULATION
F-ACTIN
HISTONE DEACETYLASE
N- AND P/Q-TYPE CALCIUM CHANNELS
REM SLEEP
TRICHOSTATIN A
WAKING
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In this review, we discuss first an example of one of the symptoms of PD, freezing of gait (FOG), then we will turn to the use of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) to treat PD, and the original studies that led to identification of the PPN as one source of locomotor control and why stimulation frequency is critical, and then describe the intrinsic properties of PPN neurons that require beta/gamma stimulation in order to fully activate all types of PPN neurons. Finally, we will describe recent findings on the proteomic and molecular consequences of gamma band activity in PPN neurons, with emphasis on the potential neuroepigenetic sequelae. These considerations will provide essential information for the appropriate refining and testing of PPN DBS as a potential therapy for PD, as well as alternative options.
Fil: Virmani, T.. University of Arkansas for Medical Sciences; Estados Unidos
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
Fil: Garcia Rill, Edgar. University of Arkansas for Medical Sciences; Estados Unidos
description In this review, we discuss first an example of one of the symptoms of PD, freezing of gait (FOG), then we will turn to the use of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) to treat PD, and the original studies that led to identification of the PPN as one source of locomotor control and why stimulation frequency is critical, and then describe the intrinsic properties of PPN neurons that require beta/gamma stimulation in order to fully activate all types of PPN neurons. Finally, we will describe recent findings on the proteomic and molecular consequences of gamma band activity in PPN neurons, with emphasis on the potential neuroepigenetic sequelae. These considerations will provide essential information for the appropriate refining and testing of PPN DBS as a potential therapy for PD, as well as alternative options.
publishDate 2019
dc.date.none.fl_str_mv 2019-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/162966
Virmani, T.; Urbano Suarez, Francisco Jose; Bisagno, Veronica; Garcia Rill, Edgar; The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics; AIMS Press; AIMS Neuroscience; 6; 4; 9-2019; 219-230
2373-7972
CONICET Digital
CONICET
url http://hdl.handle.net/11336/162966
identifier_str_mv Virmani, T.; Urbano Suarez, Francisco Jose; Bisagno, Veronica; Garcia Rill, Edgar; The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics; AIMS Press; AIMS Neuroscience; 6; 4; 9-2019; 219-230
2373-7972
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3934/Neuroscience.2019.4.219
info:eu-repo/semantics/altIdentifier/url/http://www.aimspress.com/article/10.3934/Neuroscience.2019.4.219
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv AIMS Press
publisher.none.fl_str_mv AIMS Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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