Biliary secretion and hepatic oxidative stress in animals fed with linoleic acid conjugates (CLA)

Autores
González, Marcela; Tomatis, Vanesa Marisa; Illesca, Paola Guadalupe; Andreoli, Maria Florencia; Bernal, Claudio Adrian
Año de publicación
2008
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The purpose of this work was to investigate the effects of CLA at two levels (7 and 20%) of dietary fat on biliary secretion and oxidative stress in liver of rats. Animals were divided in four groups and fed with diets, supplemented or not with CLA during 30 days. After this time, we analyzed “in vivo” bile flow by canulation of bile duct and collecting bile during 1 hour. In bile, we evaluated biliary acids, proteins, phospholipids and cholesterol concentrations. Furthermore, we determinate in liver homogenates oxidative stress parameters. The results of this experiment demonstrated that at both dietary fat levels, CLA increased bile flow (40% and more than 50% in recommended and high fat levels, respectively). This was accompanied by an increase in biliary acids and protein secretion rates without significant changes in oxidative stress parameters. It can be concluded that at both dietary fat levels CLA increases the fractional bile flow dependent of biliary acids. This can be related with peroxisomal proliferative activity of CLA that, stimulating β-oxidation, could produce a bigger flow of Acetil-Co A which is a precursor of bile acids synthesis.
Fil: González, Marcela. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Tomatis, Vanesa Marisa. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Illesca, Paola Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Andreoli, Maria Florencia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bernal, Claudio Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Materia
conjugated linoleic acid
biliary secretion
bile flow
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/102157
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Biliary secretion and hepatic oxidative stress in animals fed with linoleic acid conjugates (CLA)González, MarcelaTomatis, Vanesa MarisaIllesca, Paola GuadalupeAndreoli, Maria FlorenciaBernal, Claudio Adrianconjugated linoleic acidbiliary secretionbile flowhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The purpose of this work was to investigate the effects of CLA at two levels (7 and 20%) of dietary fat on biliary secretion and oxidative stress in liver of rats. Animals were divided in four groups and fed with diets, supplemented or not with CLA during 30 days. After this time, we analyzed “in vivo” bile flow by canulation of bile duct and collecting bile during 1 hour. In bile, we evaluated biliary acids, proteins, phospholipids and cholesterol concentrations. Furthermore, we determinate in liver homogenates oxidative stress parameters. The results of this experiment demonstrated that at both dietary fat levels, CLA increased bile flow (40% and more than 50% in recommended and high fat levels, respectively). This was accompanied by an increase in biliary acids and protein secretion rates without significant changes in oxidative stress parameters. It can be concluded that at both dietary fat levels CLA increases the fractional bile flow dependent of biliary acids. This can be related with peroxisomal proliferative activity of CLA that, stimulating β-oxidation, could produce a bigger flow of Acetil-Co A which is a precursor of bile acids synthesis.Fil: González, Marcela. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaFil: Tomatis, Vanesa Marisa. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaFil: Illesca, Paola Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaFil: Andreoli, Maria Florencia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bernal, Claudio Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaSociedad Argentina de Nutrición2008-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/102157González, Marcela; Tomatis, Vanesa Marisa; Illesca, Paola Guadalupe; Andreoli, Maria Florencia; Bernal, Claudio Adrian; Biliary secretion and hepatic oxidative stress in animals fed with linoleic acid conjugates (CLA); Sociedad Argentina de Nutrición; Actualización en Nutricion; 9; 12-2008; 43-501667-8052CONICET DigitalCONICETspainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:22:48Zoai:ri.conicet.gov.ar:11336/102157instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:22:48.489CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Biliary secretion and hepatic oxidative stress in animals fed with linoleic acid conjugates (CLA)
title Biliary secretion and hepatic oxidative stress in animals fed with linoleic acid conjugates (CLA)
spellingShingle Biliary secretion and hepatic oxidative stress in animals fed with linoleic acid conjugates (CLA)
González, Marcela
conjugated linoleic acid
biliary secretion
bile flow
title_short Biliary secretion and hepatic oxidative stress in animals fed with linoleic acid conjugates (CLA)
title_full Biliary secretion and hepatic oxidative stress in animals fed with linoleic acid conjugates (CLA)
title_fullStr Biliary secretion and hepatic oxidative stress in animals fed with linoleic acid conjugates (CLA)
title_full_unstemmed Biliary secretion and hepatic oxidative stress in animals fed with linoleic acid conjugates (CLA)
title_sort Biliary secretion and hepatic oxidative stress in animals fed with linoleic acid conjugates (CLA)
dc.creator.none.fl_str_mv González, Marcela
Tomatis, Vanesa Marisa
Illesca, Paola Guadalupe
Andreoli, Maria Florencia
Bernal, Claudio Adrian
author González, Marcela
author_facet González, Marcela
Tomatis, Vanesa Marisa
Illesca, Paola Guadalupe
Andreoli, Maria Florencia
Bernal, Claudio Adrian
author_role author
author2 Tomatis, Vanesa Marisa
Illesca, Paola Guadalupe
Andreoli, Maria Florencia
Bernal, Claudio Adrian
author2_role author
author
author
author
dc.subject.none.fl_str_mv conjugated linoleic acid
biliary secretion
bile flow
topic conjugated linoleic acid
biliary secretion
bile flow
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The purpose of this work was to investigate the effects of CLA at two levels (7 and 20%) of dietary fat on biliary secretion and oxidative stress in liver of rats. Animals were divided in four groups and fed with diets, supplemented or not with CLA during 30 days. After this time, we analyzed “in vivo” bile flow by canulation of bile duct and collecting bile during 1 hour. In bile, we evaluated biliary acids, proteins, phospholipids and cholesterol concentrations. Furthermore, we determinate in liver homogenates oxidative stress parameters. The results of this experiment demonstrated that at both dietary fat levels, CLA increased bile flow (40% and more than 50% in recommended and high fat levels, respectively). This was accompanied by an increase in biliary acids and protein secretion rates without significant changes in oxidative stress parameters. It can be concluded that at both dietary fat levels CLA increases the fractional bile flow dependent of biliary acids. This can be related with peroxisomal proliferative activity of CLA that, stimulating β-oxidation, could produce a bigger flow of Acetil-Co A which is a precursor of bile acids synthesis.
Fil: González, Marcela. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Tomatis, Vanesa Marisa. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Illesca, Paola Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Andreoli, Maria Florencia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bernal, Claudio Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
description The purpose of this work was to investigate the effects of CLA at two levels (7 and 20%) of dietary fat on biliary secretion and oxidative stress in liver of rats. Animals were divided in four groups and fed with diets, supplemented or not with CLA during 30 days. After this time, we analyzed “in vivo” bile flow by canulation of bile duct and collecting bile during 1 hour. In bile, we evaluated biliary acids, proteins, phospholipids and cholesterol concentrations. Furthermore, we determinate in liver homogenates oxidative stress parameters. The results of this experiment demonstrated that at both dietary fat levels, CLA increased bile flow (40% and more than 50% in recommended and high fat levels, respectively). This was accompanied by an increase in biliary acids and protein secretion rates without significant changes in oxidative stress parameters. It can be concluded that at both dietary fat levels CLA increases the fractional bile flow dependent of biliary acids. This can be related with peroxisomal proliferative activity of CLA that, stimulating β-oxidation, could produce a bigger flow of Acetil-Co A which is a precursor of bile acids synthesis.
publishDate 2008
dc.date.none.fl_str_mv 2008-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/102157
González, Marcela; Tomatis, Vanesa Marisa; Illesca, Paola Guadalupe; Andreoli, Maria Florencia; Bernal, Claudio Adrian; Biliary secretion and hepatic oxidative stress in animals fed with linoleic acid conjugates (CLA); Sociedad Argentina de Nutrición; Actualización en Nutricion; 9; 12-2008; 43-50
1667-8052
CONICET Digital
CONICET
url http://hdl.handle.net/11336/102157
identifier_str_mv González, Marcela; Tomatis, Vanesa Marisa; Illesca, Paola Guadalupe; Andreoli, Maria Florencia; Bernal, Claudio Adrian; Biliary secretion and hepatic oxidative stress in animals fed with linoleic acid conjugates (CLA); Sociedad Argentina de Nutrición; Actualización en Nutricion; 9; 12-2008; 43-50
1667-8052
CONICET Digital
CONICET
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Nutrición
publisher.none.fl_str_mv Sociedad Argentina de Nutrición
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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