Surgical Strategies for Epilepsy in Developing Countries: Experience with SEEG in Temporal Lobe Epilepsy

Autores
Oddo, Silvia Andrea; Giagante, Brenda; Kochen, Sara Silvia
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: In this work we present the evidence that in a developing country, it is possible toperform surgical treatment for drug resistant temporal lobe epilepsy patients, including those casesthat require SEEG, with a similar outcome than in developed countries.Methods: We selected 19 consecutive drug resistant temporal lobe epilepsy patients, whounderwent SEEG evaluation at El Cruce Hospital from 2014 to 2019. SEEG is performed due tofailure to localize the Epileptogenic Zone (EZ) with non-invasive methods, when the hypothesis ofEZ are suspected to involve extra temporal areas, negative MRI, suspected bilateral onset, bilateralhippocampal lesion, or with discrepancies between MRI findings and scalp Video-EEG monitoring.The implantation scheme was planned based on the EZ hypothesis, based on scalp Video-EEG,especially ictal clinical semiology, neuroimaging data and neuropsychological results. Between 6and 12 multilead electrodes per patient were implanted, in temporal and extra temporal areas.Results: Thirteen patients (68.4%) with unilateral EZ were found eligible for surgery after SEEG.Seven patients underwent a mesial temporal region resection (left N=3, right n=4). One patientunderwent a frontotemporal corticectomy, one patient an insulectomy. Because of the pandemicsituation, four patients are on a list for surgery. Six patients were formally excluded from surgerybecause of the bilateral (seizures originating independently or concomitantly in both temporallobes) or multifocal origin of their seizures.Conclusion: According to the results obtained in this case analysis, we consider SEEG to be anappropriate method to define EZ in patients with drug-resistant temporal epilepsy and thesubsequent indication for surgery. We hope to encourage the multiplication of epilepsy surgerycenters in the region that have specialist staff and financial resources. Despite the high costs, it isachievable development with the same quality as that carried out in developed countries.
Fil: Oddo, Silvia Andrea. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
Fil: Giagante, Brenda. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Kochen, Sara Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Temporal lobe epilepsy
Stereoelectroencephalography
Epilepsy surgery
Ictal clinical semiology
Ictal electrical semiology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/217311

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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Surgical Strategies for Epilepsy in Developing Countries: Experience with SEEG in Temporal Lobe EpilepsyOddo, Silvia AndreaGiagante, BrendaKochen, Sara SilviaTemporal lobe epilepsyStereoelectroencephalographyEpilepsy surgeryIctal clinical semiologyIctal electrical semiologyhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: In this work we present the evidence that in a developing country, it is possible toperform surgical treatment for drug resistant temporal lobe epilepsy patients, including those casesthat require SEEG, with a similar outcome than in developed countries.Methods: We selected 19 consecutive drug resistant temporal lobe epilepsy patients, whounderwent SEEG evaluation at El Cruce Hospital from 2014 to 2019. SEEG is performed due tofailure to localize the Epileptogenic Zone (EZ) with non-invasive methods, when the hypothesis ofEZ are suspected to involve extra temporal areas, negative MRI, suspected bilateral onset, bilateralhippocampal lesion, or with discrepancies between MRI findings and scalp Video-EEG monitoring.The implantation scheme was planned based on the EZ hypothesis, based on scalp Video-EEG,especially ictal clinical semiology, neuroimaging data and neuropsychological results. Between 6and 12 multilead electrodes per patient were implanted, in temporal and extra temporal areas.Results: Thirteen patients (68.4%) with unilateral EZ were found eligible for surgery after SEEG.Seven patients underwent a mesial temporal region resection (left N=3, right n=4). One patientunderwent a frontotemporal corticectomy, one patient an insulectomy. Because of the pandemicsituation, four patients are on a list for surgery. Six patients were formally excluded from surgerybecause of the bilateral (seizures originating independently or concomitantly in both temporallobes) or multifocal origin of their seizures.Conclusion: According to the results obtained in this case analysis, we consider SEEG to be anappropriate method to define EZ in patients with drug-resistant temporal epilepsy and thesubsequent indication for surgery. We hope to encourage the multiplication of epilepsy surgerycenters in the region that have specialist staff and financial resources. Despite the high costs, it isachievable development with the same quality as that carried out in developed countries.Fil: Oddo, Silvia Andrea. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; ArgentinaFil: Giagante, Brenda. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; ArgentinaFil: Kochen, Sara Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaRemedy Publications2021-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/217311Oddo, Silvia Andrea; Giagante, Brenda; Kochen, Sara Silvia; Surgical Strategies for Epilepsy in Developing Countries: Experience with SEEG in Temporal Lobe Epilepsy; Remedy Publications; Annals of Epilepsy and Seizures; 3; 1014; 12-2021; 1-102644-0458CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.remedypublications.com/open-access/surgical-strategies-for-epilepsy-in-developing-countries-experience-with-seeg-8288.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:52Zoai:ri.conicet.gov.ar:11336/217311instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:52.86CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Surgical Strategies for Epilepsy in Developing Countries: Experience with SEEG in Temporal Lobe Epilepsy
title Surgical Strategies for Epilepsy in Developing Countries: Experience with SEEG in Temporal Lobe Epilepsy
spellingShingle Surgical Strategies for Epilepsy in Developing Countries: Experience with SEEG in Temporal Lobe Epilepsy
Oddo, Silvia Andrea
Temporal lobe epilepsy
Stereoelectroencephalography
Epilepsy surgery
Ictal clinical semiology
Ictal electrical semiology
title_short Surgical Strategies for Epilepsy in Developing Countries: Experience with SEEG in Temporal Lobe Epilepsy
title_full Surgical Strategies for Epilepsy in Developing Countries: Experience with SEEG in Temporal Lobe Epilepsy
title_fullStr Surgical Strategies for Epilepsy in Developing Countries: Experience with SEEG in Temporal Lobe Epilepsy
title_full_unstemmed Surgical Strategies for Epilepsy in Developing Countries: Experience with SEEG in Temporal Lobe Epilepsy
title_sort Surgical Strategies for Epilepsy in Developing Countries: Experience with SEEG in Temporal Lobe Epilepsy
dc.creator.none.fl_str_mv Oddo, Silvia Andrea
Giagante, Brenda
Kochen, Sara Silvia
author Oddo, Silvia Andrea
author_facet Oddo, Silvia Andrea
Giagante, Brenda
Kochen, Sara Silvia
author_role author
author2 Giagante, Brenda
Kochen, Sara Silvia
author2_role author
author
dc.subject.none.fl_str_mv Temporal lobe epilepsy
Stereoelectroencephalography
Epilepsy surgery
Ictal clinical semiology
Ictal electrical semiology
topic Temporal lobe epilepsy
Stereoelectroencephalography
Epilepsy surgery
Ictal clinical semiology
Ictal electrical semiology
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: In this work we present the evidence that in a developing country, it is possible toperform surgical treatment for drug resistant temporal lobe epilepsy patients, including those casesthat require SEEG, with a similar outcome than in developed countries.Methods: We selected 19 consecutive drug resistant temporal lobe epilepsy patients, whounderwent SEEG evaluation at El Cruce Hospital from 2014 to 2019. SEEG is performed due tofailure to localize the Epileptogenic Zone (EZ) with non-invasive methods, when the hypothesis ofEZ are suspected to involve extra temporal areas, negative MRI, suspected bilateral onset, bilateralhippocampal lesion, or with discrepancies between MRI findings and scalp Video-EEG monitoring.The implantation scheme was planned based on the EZ hypothesis, based on scalp Video-EEG,especially ictal clinical semiology, neuroimaging data and neuropsychological results. Between 6and 12 multilead electrodes per patient were implanted, in temporal and extra temporal areas.Results: Thirteen patients (68.4%) with unilateral EZ were found eligible for surgery after SEEG.Seven patients underwent a mesial temporal region resection (left N=3, right n=4). One patientunderwent a frontotemporal corticectomy, one patient an insulectomy. Because of the pandemicsituation, four patients are on a list for surgery. Six patients were formally excluded from surgerybecause of the bilateral (seizures originating independently or concomitantly in both temporallobes) or multifocal origin of their seizures.Conclusion: According to the results obtained in this case analysis, we consider SEEG to be anappropriate method to define EZ in patients with drug-resistant temporal epilepsy and thesubsequent indication for surgery. We hope to encourage the multiplication of epilepsy surgerycenters in the region that have specialist staff and financial resources. Despite the high costs, it isachievable development with the same quality as that carried out in developed countries.
Fil: Oddo, Silvia Andrea. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
Fil: Giagante, Brenda. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Kochen, Sara Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Introduction: In this work we present the evidence that in a developing country, it is possible toperform surgical treatment for drug resistant temporal lobe epilepsy patients, including those casesthat require SEEG, with a similar outcome than in developed countries.Methods: We selected 19 consecutive drug resistant temporal lobe epilepsy patients, whounderwent SEEG evaluation at El Cruce Hospital from 2014 to 2019. SEEG is performed due tofailure to localize the Epileptogenic Zone (EZ) with non-invasive methods, when the hypothesis ofEZ are suspected to involve extra temporal areas, negative MRI, suspected bilateral onset, bilateralhippocampal lesion, or with discrepancies between MRI findings and scalp Video-EEG monitoring.The implantation scheme was planned based on the EZ hypothesis, based on scalp Video-EEG,especially ictal clinical semiology, neuroimaging data and neuropsychological results. Between 6and 12 multilead electrodes per patient were implanted, in temporal and extra temporal areas.Results: Thirteen patients (68.4%) with unilateral EZ were found eligible for surgery after SEEG.Seven patients underwent a mesial temporal region resection (left N=3, right n=4). One patientunderwent a frontotemporal corticectomy, one patient an insulectomy. Because of the pandemicsituation, four patients are on a list for surgery. Six patients were formally excluded from surgerybecause of the bilateral (seizures originating independently or concomitantly in both temporallobes) or multifocal origin of their seizures.Conclusion: According to the results obtained in this case analysis, we consider SEEG to be anappropriate method to define EZ in patients with drug-resistant temporal epilepsy and thesubsequent indication for surgery. We hope to encourage the multiplication of epilepsy surgerycenters in the region that have specialist staff and financial resources. Despite the high costs, it isachievable development with the same quality as that carried out in developed countries.
publishDate 2021
dc.date.none.fl_str_mv 2021-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/217311
Oddo, Silvia Andrea; Giagante, Brenda; Kochen, Sara Silvia; Surgical Strategies for Epilepsy in Developing Countries: Experience with SEEG in Temporal Lobe Epilepsy; Remedy Publications; Annals of Epilepsy and Seizures; 3; 1014; 12-2021; 1-10
2644-0458
CONICET Digital
CONICET
url http://hdl.handle.net/11336/217311
identifier_str_mv Oddo, Silvia Andrea; Giagante, Brenda; Kochen, Sara Silvia; Surgical Strategies for Epilepsy in Developing Countries: Experience with SEEG in Temporal Lobe Epilepsy; Remedy Publications; Annals of Epilepsy and Seizures; 3; 1014; 12-2021; 1-10
2644-0458
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.remedypublications.com/open-access/surgical-strategies-for-epilepsy-in-developing-countries-experience-with-seeg-8288.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Remedy Publications
publisher.none.fl_str_mv Remedy Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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