Closed-loop control of epilepsy by transcranial electrical stimulation

Autores
Berényi, Antal; Belluscio, Mariano Andres; Mao, Dun; Buzsáki, György
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Many neurological and psychiatric diseases are associated with clinically detectable, altered brain dynamics. The aberrant brain activity, in principle, can be restored through electrical stimulation. In epilepsies, abnormal patterns emerge intermittently, and therefore, a closed-loop feedback brain control that leaves other aspects of brain functions unaffected is desirable. Here, we demonstrate that seizure-triggered, feedback transcranial electrical stimulation (TES) can dramatically reduce spike-and-wave episodes in a rodent model of generalized epilepsy. Closed-loop TES can be an effective clinical tool to reduce pathological brain patterns in drug-resistant patients.
Fil: Berényi, Antal. Rutgers University; Estados Unidos. University of New York; Estados Unidos. University of Szeged; Hungría
Fil: Belluscio, Mariano Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Rutgers University; Estados Unidos
Fil: Mao, Dun. Rutgers University; Estados Unidos
Fil: Buzsáki, György. Rutgers University; Estados Unidos. University of New York; Estados Unidos
Materia
Oscillations
Epilepsy
Electrical stimulation
Cortex
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/196992
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/196992
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Closed-loop control of epilepsy by transcranial electrical stimulationBerényi, AntalBelluscio, Mariano AndresMao, DunBuzsáki, GyörgyOscillationsEpilepsyElectrical stimulationCortexhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Many neurological and psychiatric diseases are associated with clinically detectable, altered brain dynamics. The aberrant brain activity, in principle, can be restored through electrical stimulation. In epilepsies, abnormal patterns emerge intermittently, and therefore, a closed-loop feedback brain control that leaves other aspects of brain functions unaffected is desirable. Here, we demonstrate that seizure-triggered, feedback transcranial electrical stimulation (TES) can dramatically reduce spike-and-wave episodes in a rodent model of generalized epilepsy. Closed-loop TES can be an effective clinical tool to reduce pathological brain patterns in drug-resistant patients.Fil: Berényi, Antal. Rutgers University; Estados Unidos. University of New York; Estados Unidos. University of Szeged; HungríaFil: Belluscio, Mariano Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Rutgers University; Estados UnidosFil: Mao, Dun. Rutgers University; Estados UnidosFil: Buzsáki, György. Rutgers University; Estados Unidos. University of New York; Estados UnidosAmerican Association for the Advancement of Science2012-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/196992Berényi, Antal; Belluscio, Mariano Andres; Mao, Dun; Buzsáki, György; Closed-loop control of epilepsy by transcranial electrical stimulation; American Association for the Advancement of Science; Science; 337; 6095; 8-2012; 735-7370036-8075CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencemag.org/content/337/6095/735.abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1126/science.1223154info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:29:32Zoai:ri.conicet.gov.ar:11336/196992instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:29:32.813CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Closed-loop control of epilepsy by transcranial electrical stimulation
title Closed-loop control of epilepsy by transcranial electrical stimulation
spellingShingle Closed-loop control of epilepsy by transcranial electrical stimulation
Berényi, Antal
Oscillations
Epilepsy
Electrical stimulation
Cortex
title_short Closed-loop control of epilepsy by transcranial electrical stimulation
title_full Closed-loop control of epilepsy by transcranial electrical stimulation
title_fullStr Closed-loop control of epilepsy by transcranial electrical stimulation
title_full_unstemmed Closed-loop control of epilepsy by transcranial electrical stimulation
title_sort Closed-loop control of epilepsy by transcranial electrical stimulation
dc.creator.none.fl_str_mv Berényi, Antal
Belluscio, Mariano Andres
Mao, Dun
Buzsáki, György
author Berényi, Antal
author_facet Berényi, Antal
Belluscio, Mariano Andres
Mao, Dun
Buzsáki, György
author_role author
author2 Belluscio, Mariano Andres
Mao, Dun
Buzsáki, György
author2_role author
author
author
dc.subject.none.fl_str_mv Oscillations
Epilepsy
Electrical stimulation
Cortex
topic Oscillations
Epilepsy
Electrical stimulation
Cortex
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Many neurological and psychiatric diseases are associated with clinically detectable, altered brain dynamics. The aberrant brain activity, in principle, can be restored through electrical stimulation. In epilepsies, abnormal patterns emerge intermittently, and therefore, a closed-loop feedback brain control that leaves other aspects of brain functions unaffected is desirable. Here, we demonstrate that seizure-triggered, feedback transcranial electrical stimulation (TES) can dramatically reduce spike-and-wave episodes in a rodent model of generalized epilepsy. Closed-loop TES can be an effective clinical tool to reduce pathological brain patterns in drug-resistant patients.
Fil: Berényi, Antal. Rutgers University; Estados Unidos. University of New York; Estados Unidos. University of Szeged; Hungría
Fil: Belluscio, Mariano Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Rutgers University; Estados Unidos
Fil: Mao, Dun. Rutgers University; Estados Unidos
Fil: Buzsáki, György. Rutgers University; Estados Unidos. University of New York; Estados Unidos
description Many neurological and psychiatric diseases are associated with clinically detectable, altered brain dynamics. The aberrant brain activity, in principle, can be restored through electrical stimulation. In epilepsies, abnormal patterns emerge intermittently, and therefore, a closed-loop feedback brain control that leaves other aspects of brain functions unaffected is desirable. Here, we demonstrate that seizure-triggered, feedback transcranial electrical stimulation (TES) can dramatically reduce spike-and-wave episodes in a rodent model of generalized epilepsy. Closed-loop TES can be an effective clinical tool to reduce pathological brain patterns in drug-resistant patients.
publishDate 2012
dc.date.none.fl_str_mv 2012-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/196992
Berényi, Antal; Belluscio, Mariano Andres; Mao, Dun; Buzsáki, György; Closed-loop control of epilepsy by transcranial electrical stimulation; American Association for the Advancement of Science; Science; 337; 6095; 8-2012; 735-737
0036-8075
CONICET Digital
CONICET
url http://hdl.handle.net/11336/196992
identifier_str_mv Berényi, Antal; Belluscio, Mariano Andres; Mao, Dun; Buzsáki, György; Closed-loop control of epilepsy by transcranial electrical stimulation; American Association for the Advancement of Science; Science; 337; 6095; 8-2012; 735-737
0036-8075
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencemag.org/content/337/6095/735.abstract
info:eu-repo/semantics/altIdentifier/doi/10.1126/science.1223154
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for the Advancement of Science
publisher.none.fl_str_mv American Association for the Advancement of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083434866278400
score 13.22299

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