Extrahippocampal Desynchronization in Nonlesional Temporal Lobe Epilepsy

Autores
Pastor, Jesús; Navarrete, Eduardo G.; Sola, Rafael G.; Ortega, Guillermo José
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Although temporal lobe epilepsy (TLE) is traditionally associated with both hypersynchronous activity in the form of interictalepileptic discharges and hippocampal sclerosis, recent findings suggest that desynchronization also plays a central role in thedynamics of this pathology. The objective of this work is to show the imbalance existing between mesial activities in patientssuffering from mesial TLE, with normal mesial structures. Foramen ovale recordings from six patients with mesial TLE and one with lateral TLE were analyzed through a cluster analysis and synchronization matrices. None of the patients present findings in the MRI presurgical evaluation. Numerical analysis was carried out in three different situations: awake and sleep interictal and also during the preictal stage. High levels of desynchronization ipsilateral to the epileptic side were present in mesial TLE patients. Lowlevels of desynchronization were present in the lateral TLE patient during the interictal stage and almost zero in the preictal stage. Implications of these findings in relation with seizure spreading are discussed.
Fil: Pastor, Jesús. Hospital Universitario and Instituto de Investigacion La Princesa; España
Fil: Navarrete, Eduardo G.. Hospital Universitario and Instituto de Investigacion La Princesa; España
Fil: Sola, Rafael G.. Hospital Universitario and Instituto de Investigacion La Princesa; España
Fil: Ortega, Guillermo José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
epilepsy
synchornization
seizure
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/194458
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/194458
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Extrahippocampal Desynchronization in Nonlesional Temporal Lobe EpilepsyPastor, JesúsNavarrete, Eduardo G.Sola, Rafael G.Ortega, Guillermo Joséepilepsysynchornizationseizurehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Although temporal lobe epilepsy (TLE) is traditionally associated with both hypersynchronous activity in the form of interictalepileptic discharges and hippocampal sclerosis, recent findings suggest that desynchronization also plays a central role in thedynamics of this pathology. The objective of this work is to show the imbalance existing between mesial activities in patientssuffering from mesial TLE, with normal mesial structures. Foramen ovale recordings from six patients with mesial TLE and one with lateral TLE were analyzed through a cluster analysis and synchronization matrices. None of the patients present findings in the MRI presurgical evaluation. Numerical analysis was carried out in three different situations: awake and sleep interictal and also during the preictal stage. High levels of desynchronization ipsilateral to the epileptic side were present in mesial TLE patients. Lowlevels of desynchronization were present in the lateral TLE patient during the interictal stage and almost zero in the preictal stage. Implications of these findings in relation with seizure spreading are discussed.Fil: Pastor, Jesús. Hospital Universitario and Instituto de Investigacion La Princesa; EspañaFil: Navarrete, Eduardo G.. Hospital Universitario and Instituto de Investigacion La Princesa; EspañaFil: Sola, Rafael G.. Hospital Universitario and Instituto de Investigacion La Princesa; EspañaFil: Ortega, Guillermo José. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaHindawi Publishing Corporation2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/194458Pastor, Jesús; Navarrete, Eduardo G.; Sola, Rafael G.; Ortega, Guillermo José; Extrahippocampal Desynchronization in Nonlesional Temporal Lobe Epilepsy; Hindawi Publishing Corporation; Epilepsy Research and Treatment; 2012; 1-2012; 1-92090-1348CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ert/2012/823683/info:eu-repo/semantics/altIdentifier/doi/10.1155/2012/823683info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:25:17Zoai:ri.conicet.gov.ar:11336/194458instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:25:17.555CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Extrahippocampal Desynchronization in Nonlesional Temporal Lobe Epilepsy
title Extrahippocampal Desynchronization in Nonlesional Temporal Lobe Epilepsy
spellingShingle Extrahippocampal Desynchronization in Nonlesional Temporal Lobe Epilepsy
Pastor, Jesús
epilepsy
synchornization
seizure
title_short Extrahippocampal Desynchronization in Nonlesional Temporal Lobe Epilepsy
title_full Extrahippocampal Desynchronization in Nonlesional Temporal Lobe Epilepsy
title_fullStr Extrahippocampal Desynchronization in Nonlesional Temporal Lobe Epilepsy
title_full_unstemmed Extrahippocampal Desynchronization in Nonlesional Temporal Lobe Epilepsy
title_sort Extrahippocampal Desynchronization in Nonlesional Temporal Lobe Epilepsy
dc.creator.none.fl_str_mv Pastor, Jesús
Navarrete, Eduardo G.
Sola, Rafael G.
Ortega, Guillermo José
author Pastor, Jesús
author_facet Pastor, Jesús
Navarrete, Eduardo G.
Sola, Rafael G.
Ortega, Guillermo José
author_role author
author2 Navarrete, Eduardo G.
Sola, Rafael G.
Ortega, Guillermo José
author2_role author
author
author
dc.subject.none.fl_str_mv epilepsy
synchornization
seizure
topic epilepsy
synchornization
seizure
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Although temporal lobe epilepsy (TLE) is traditionally associated with both hypersynchronous activity in the form of interictalepileptic discharges and hippocampal sclerosis, recent findings suggest that desynchronization also plays a central role in thedynamics of this pathology. The objective of this work is to show the imbalance existing between mesial activities in patientssuffering from mesial TLE, with normal mesial structures. Foramen ovale recordings from six patients with mesial TLE and one with lateral TLE were analyzed through a cluster analysis and synchronization matrices. None of the patients present findings in the MRI presurgical evaluation. Numerical analysis was carried out in three different situations: awake and sleep interictal and also during the preictal stage. High levels of desynchronization ipsilateral to the epileptic side were present in mesial TLE patients. Lowlevels of desynchronization were present in the lateral TLE patient during the interictal stage and almost zero in the preictal stage. Implications of these findings in relation with seizure spreading are discussed.
Fil: Pastor, Jesús. Hospital Universitario and Instituto de Investigacion La Princesa; España
Fil: Navarrete, Eduardo G.. Hospital Universitario and Instituto de Investigacion La Princesa; España
Fil: Sola, Rafael G.. Hospital Universitario and Instituto de Investigacion La Princesa; España
Fil: Ortega, Guillermo José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Although temporal lobe epilepsy (TLE) is traditionally associated with both hypersynchronous activity in the form of interictalepileptic discharges and hippocampal sclerosis, recent findings suggest that desynchronization also plays a central role in thedynamics of this pathology. The objective of this work is to show the imbalance existing between mesial activities in patientssuffering from mesial TLE, with normal mesial structures. Foramen ovale recordings from six patients with mesial TLE and one with lateral TLE were analyzed through a cluster analysis and synchronization matrices. None of the patients present findings in the MRI presurgical evaluation. Numerical analysis was carried out in three different situations: awake and sleep interictal and also during the preictal stage. High levels of desynchronization ipsilateral to the epileptic side were present in mesial TLE patients. Lowlevels of desynchronization were present in the lateral TLE patient during the interictal stage and almost zero in the preictal stage. Implications of these findings in relation with seizure spreading are discussed.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/194458
Pastor, Jesús; Navarrete, Eduardo G.; Sola, Rafael G.; Ortega, Guillermo José; Extrahippocampal Desynchronization in Nonlesional Temporal Lobe Epilepsy; Hindawi Publishing Corporation; Epilepsy Research and Treatment; 2012; 1-2012; 1-9
2090-1348
CONICET Digital
CONICET
url http://hdl.handle.net/11336/194458
identifier_str_mv Pastor, Jesús; Navarrete, Eduardo G.; Sola, Rafael G.; Ortega, Guillermo José; Extrahippocampal Desynchronization in Nonlesional Temporal Lobe Epilepsy; Hindawi Publishing Corporation; Epilepsy Research and Treatment; 2012; 1-2012; 1-9
2090-1348
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ert/2012/823683/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2012/823683
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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