A mechanistic model of the neural entropy increase elicited by psychedelic drugs

Autores
Herzog, Rubén; Mediano, Pedro A. M.; Rosas, Fernando E.; Carhart-Harris, Robin; Sanz Perl Hernandez, Yonatan; Tagliazucchi, Enzo Rodolfo; Cofre, Rodrigo
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both acute alterations in consciousness and long-term effects. However, no clear mechanistic explanation for this entropy increase has been put forward so far. We sought to do this here by building upon a recent whole-brain model of serotonergic neuromodulation, to study the entropic effects of 5HT2A-R activation. Our results reproduce the overall entropy increase observed in previous experiments in vivo, providing the first model-based explanation for this phenomenon. We also found that entropy changes were not uniform across the brain: entropy increased in some regions and decreased in others, suggesting a topographical reconfiguration mediated by 5HT2A-R activation. Interestingly, at the whole-brain level, this reconfiguration was not well explained by 5HT2A-R density, but related closely to the topological properties of the brain’s anatomical connectivity. These results help us understand the mechanisms underlying the psychedelic state and, more generally, the pharmacological modulation of whole-brain activity.
Fil: Herzog, Rubén. Universidad de Valparaíso; Chile
Fil: Mediano, Pedro A. M.. University of Cambridge; Estados Unidos
Fil: Rosas, Fernando E.. Imperial College London; Reino Unido
Fil: Carhart-Harris, Robin. Imperial College London; Reino Unido
Fil: Sanz Perl Hernandez, Yonatan. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Cofre, Rodrigo. Universidad de Valparaíso; Chile
Materia
LSD
Neuroimaging
Modeling
Entropy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/146089
Acceder
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network_name_str CONICET Digital (CONICET)
spelling A mechanistic model of the neural entropy increase elicited by psychedelic drugsHerzog, RubénMediano, Pedro A. M.Rosas, Fernando E.Carhart-Harris, RobinSanz Perl Hernandez, YonatanTagliazucchi, Enzo RodolfoCofre, RodrigoLSDNeuroimagingModelingEntropyhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both acute alterations in consciousness and long-term effects. However, no clear mechanistic explanation for this entropy increase has been put forward so far. We sought to do this here by building upon a recent whole-brain model of serotonergic neuromodulation, to study the entropic effects of 5HT2A-R activation. Our results reproduce the overall entropy increase observed in previous experiments in vivo, providing the first model-based explanation for this phenomenon. We also found that entropy changes were not uniform across the brain: entropy increased in some regions and decreased in others, suggesting a topographical reconfiguration mediated by 5HT2A-R activation. Interestingly, at the whole-brain level, this reconfiguration was not well explained by 5HT2A-R density, but related closely to the topological properties of the brain’s anatomical connectivity. These results help us understand the mechanisms underlying the psychedelic state and, more generally, the pharmacological modulation of whole-brain activity.Fil: Herzog, Rubén. Universidad de Valparaíso; ChileFil: Mediano, Pedro A. M.. University of Cambridge; Estados UnidosFil: Rosas, Fernando E.. Imperial College London; Reino UnidoFil: Carhart-Harris, Robin. Imperial College London; Reino UnidoFil: Sanz Perl Hernandez, Yonatan. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Cofre, Rodrigo. Universidad de Valparaíso; ChileNature Publishing Group2020-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/146089Herzog, Rubén; Mediano, Pedro A. M.; Rosas, Fernando E.; Carhart-Harris, Robin; Sanz Perl Hernandez, Yonatan; et al.; A mechanistic model of the neural entropy increase elicited by psychedelic drugs; Nature Publishing Group; Scientific Reports; 10; 1; 10-2020; 1-122045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-74060-6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:30:03Zoai:ri.conicet.gov.ar:11336/146089instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:30:03.901CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A mechanistic model of the neural entropy increase elicited by psychedelic drugs
title A mechanistic model of the neural entropy increase elicited by psychedelic drugs
spellingShingle A mechanistic model of the neural entropy increase elicited by psychedelic drugs
Herzog, Rubén
LSD
Neuroimaging
Modeling
Entropy
title_short A mechanistic model of the neural entropy increase elicited by psychedelic drugs
title_full A mechanistic model of the neural entropy increase elicited by psychedelic drugs
title_fullStr A mechanistic model of the neural entropy increase elicited by psychedelic drugs
title_full_unstemmed A mechanistic model of the neural entropy increase elicited by psychedelic drugs
title_sort A mechanistic model of the neural entropy increase elicited by psychedelic drugs
dc.creator.none.fl_str_mv Herzog, Rubén
Mediano, Pedro A. M.
Rosas, Fernando E.
Carhart-Harris, Robin
Sanz Perl Hernandez, Yonatan
Tagliazucchi, Enzo Rodolfo
Cofre, Rodrigo
author Herzog, Rubén
author_facet Herzog, Rubén
Mediano, Pedro A. M.
Rosas, Fernando E.
Carhart-Harris, Robin
Sanz Perl Hernandez, Yonatan
Tagliazucchi, Enzo Rodolfo
Cofre, Rodrigo
author_role author
author2 Mediano, Pedro A. M.
Rosas, Fernando E.
Carhart-Harris, Robin
Sanz Perl Hernandez, Yonatan
Tagliazucchi, Enzo Rodolfo
Cofre, Rodrigo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv LSD
Neuroimaging
Modeling
Entropy
topic LSD
Neuroimaging
Modeling
Entropy
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both acute alterations in consciousness and long-term effects. However, no clear mechanistic explanation for this entropy increase has been put forward so far. We sought to do this here by building upon a recent whole-brain model of serotonergic neuromodulation, to study the entropic effects of 5HT2A-R activation. Our results reproduce the overall entropy increase observed in previous experiments in vivo, providing the first model-based explanation for this phenomenon. We also found that entropy changes were not uniform across the brain: entropy increased in some regions and decreased in others, suggesting a topographical reconfiguration mediated by 5HT2A-R activation. Interestingly, at the whole-brain level, this reconfiguration was not well explained by 5HT2A-R density, but related closely to the topological properties of the brain’s anatomical connectivity. These results help us understand the mechanisms underlying the psychedelic state and, more generally, the pharmacological modulation of whole-brain activity.
Fil: Herzog, Rubén. Universidad de Valparaíso; Chile
Fil: Mediano, Pedro A. M.. University of Cambridge; Estados Unidos
Fil: Rosas, Fernando E.. Imperial College London; Reino Unido
Fil: Carhart-Harris, Robin. Imperial College London; Reino Unido
Fil: Sanz Perl Hernandez, Yonatan. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Cofre, Rodrigo. Universidad de Valparaíso; Chile
description Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both acute alterations in consciousness and long-term effects. However, no clear mechanistic explanation for this entropy increase has been put forward so far. We sought to do this here by building upon a recent whole-brain model of serotonergic neuromodulation, to study the entropic effects of 5HT2A-R activation. Our results reproduce the overall entropy increase observed in previous experiments in vivo, providing the first model-based explanation for this phenomenon. We also found that entropy changes were not uniform across the brain: entropy increased in some regions and decreased in others, suggesting a topographical reconfiguration mediated by 5HT2A-R activation. Interestingly, at the whole-brain level, this reconfiguration was not well explained by 5HT2A-R density, but related closely to the topological properties of the brain’s anatomical connectivity. These results help us understand the mechanisms underlying the psychedelic state and, more generally, the pharmacological modulation of whole-brain activity.
publishDate 2020
dc.date.none.fl_str_mv 2020-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/146089
Herzog, Rubén; Mediano, Pedro A. M.; Rosas, Fernando E.; Carhart-Harris, Robin; Sanz Perl Hernandez, Yonatan; et al.; A mechanistic model of the neural entropy increase elicited by psychedelic drugs; Nature Publishing Group; Scientific Reports; 10; 1; 10-2020; 1-12
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/146089
identifier_str_mv Herzog, Rubén; Mediano, Pedro A. M.; Rosas, Fernando E.; Carhart-Harris, Robin; Sanz Perl Hernandez, Yonatan; et al.; A mechanistic model of the neural entropy increase elicited by psychedelic drugs; Nature Publishing Group; Scientific Reports; 10; 1; 10-2020; 1-12
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-74060-6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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