Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling

Autores
Coronel Oliveros, Carlos; Gónzalez Gómez, Raúl; Ranasinghe, Kamalini; Sainz Ballesteros, Agustín; Legaz, Agustina; Fittipaldi, Sol; Cruzat, Josephine; Herzog, Rubén; Yener, Gorsev; Parra, Mario; Aguillon, David; Lopera, Francisco; Santamaria Garcia, Hernando; Moguilner, Sebastián; Medel, Vicente; Orio, Patricio; Whelan, Robert; Tagliazucchi, Enzo Rodolfo; Prado, Pavel; Ibañez, Agustín
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
INTRODUCTION: Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) lack mechanistic biophysical modeling in diverse, underrepresented populations. Electroencephalography (EEG) is a high temporal resolution, cost-effective technique for studying dementia globally, but lacks mechanistic models and produces non-replicable results. METHODS:We developed a generative whole-brain model that combines EEG sourcelevel metaconnectivity, anatomical priors, and a perturbational approach. This model was applied to Global South participants (AD, bvFTD, and healthy controls). RESULTS: Metaconnectivity outperformed pairwise connectivity and revealed more viscous dynamics in patients, with altered metaconnectivity patterns associated with multimodal disease presentation. The biophysical model showed that connectome disintegration and hypoexcitability triggered altered metaconnectivity dynamics and identified critical regions for brain stimulation. We replicated the main results in a second subset of participants for validation with unharmonized, heterogeneous recording settings. DISCUSSION: The results provide a novel agenda for developing mechanistic modelinspired characterization and therapies in clinical, translational, and computational neuroscience settings.
Fil: Coronel Oliveros, Carlos. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile. Trinity College Dublin; Irlanda. Universidad de Valparaíso; Chile
Fil: Gónzalez Gómez, Raúl. Universidad Adolfo Ibañez; Chile
Fil: Ranasinghe, Kamalini. University of California; Estados Unidos
Fil: Sainz Ballesteros, Agustín. Universidad Adolfo Ibañez; Chile
Fil: Legaz, Agustina. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fittipaldi, Sol. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile. University of California; Estados Unidos. Trinity College Dublin; Irlanda
Fil: Cruzat, Josephine. Universidad Adolfo Ibañez; Chile
Fil: Herzog, Rubén. Universidad Adolfo Ibañez; Chile
Fil: Yener, Gorsev. Dokuz Eylül University; Turquía. Izmir University of Economics; Turquía
Fil: Parra, Mario. University of Strathclyde; Reino Unido
Fil: Aguillon, David. Universidad de Antioquia; Colombia
Fil: Lopera, Francisco. Universidad de Antioquia; Colombia
Fil: Santamaria Garcia, Hernando. Pontificia Universidad Javeriana; Colombia. Hospital Universitario San Ignacio; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Moguilner, Sebastián. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina
Fil: Medel, Vicente. Universidad Adolfo Ibañez; Chile. The University of Sydney; Australia. Universidad de Chile; Chile
Fil: Orio, Patricio. Universidad de Valparaíso; Chile
Fil: Whelan, Robert. Trinity College Dublin; Irlanda. University of California; Estados Unidos
Fil: Tagliazucchi, Enzo Rodolfo. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Prado, Pavel. Universidad Adolfo Ibañez; Chile. Universidad San Sebastián; Chile
Fil: Ibañez, Agustín. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Trinity College Dublin; Irlanda. University of California; Estados Unidos
Materia
NEUROIMAGING
DEMENTIA
AGING
MODELING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/267071
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modelingCoronel Oliveros, CarlosGónzalez Gómez, RaúlRanasinghe, KamaliniSainz Ballesteros, AgustínLegaz, AgustinaFittipaldi, SolCruzat, JosephineHerzog, RubénYener, GorsevParra, MarioAguillon, DavidLopera, FranciscoSantamaria Garcia, HernandoMoguilner, SebastiánMedel, VicenteOrio, PatricioWhelan, RobertTagliazucchi, Enzo RodolfoPrado, PavelIbañez, AgustínNEUROIMAGINGDEMENTIAAGINGMODELINGhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1INTRODUCTION: Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) lack mechanistic biophysical modeling in diverse, underrepresented populations. Electroencephalography (EEG) is a high temporal resolution, cost-effective technique for studying dementia globally, but lacks mechanistic models and produces non-replicable results. METHODS:We developed a generative whole-brain model that combines EEG sourcelevel metaconnectivity, anatomical priors, and a perturbational approach. This model was applied to Global South participants (AD, bvFTD, and healthy controls). RESULTS: Metaconnectivity outperformed pairwise connectivity and revealed more viscous dynamics in patients, with altered metaconnectivity patterns associated with multimodal disease presentation. The biophysical model showed that connectome disintegration and hypoexcitability triggered altered metaconnectivity dynamics and identified critical regions for brain stimulation. We replicated the main results in a second subset of participants for validation with unharmonized, heterogeneous recording settings. DISCUSSION: The results provide a novel agenda for developing mechanistic modelinspired characterization and therapies in clinical, translational, and computational neuroscience settings.Fil: Coronel Oliveros, Carlos. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile. Trinity College Dublin; Irlanda. Universidad de Valparaíso; ChileFil: Gónzalez Gómez, Raúl. Universidad Adolfo Ibañez; ChileFil: Ranasinghe, Kamalini. University of California; Estados UnidosFil: Sainz Ballesteros, Agustín. Universidad Adolfo Ibañez; ChileFil: Legaz, Agustina. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fittipaldi, Sol. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile. University of California; Estados Unidos. Trinity College Dublin; IrlandaFil: Cruzat, Josephine. Universidad Adolfo Ibañez; ChileFil: Herzog, Rubén. Universidad Adolfo Ibañez; ChileFil: Yener, Gorsev. Dokuz Eylül University; Turquía. Izmir University of Economics; TurquíaFil: Parra, Mario. University of Strathclyde; Reino UnidoFil: Aguillon, David. Universidad de Antioquia; ColombiaFil: Lopera, Francisco. Universidad de Antioquia; ColombiaFil: Santamaria Garcia, Hernando. Pontificia Universidad Javeriana; Colombia. Hospital Universitario San Ignacio; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Moguilner, Sebastián. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; ArgentinaFil: Medel, Vicente. Universidad Adolfo Ibañez; Chile. The University of Sydney; Australia. Universidad de Chile; ChileFil: Orio, Patricio. Universidad de Valparaíso; ChileFil: Whelan, Robert. Trinity College Dublin; Irlanda. University of California; Estados UnidosFil: Tagliazucchi, Enzo Rodolfo. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Prado, Pavel. Universidad Adolfo Ibañez; Chile. Universidad San Sebastián; ChileFil: Ibañez, Agustín. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Trinity College Dublin; Irlanda. University of California; Estados UnidosElsevier Science Inc.2024-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/267071Coronel Oliveros, Carlos; Gónzalez Gómez, Raúl; Ranasinghe, Kamalini; Sainz Ballesteros, Agustín; Legaz, Agustina; et al.; Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling; Elsevier Science Inc.; Alzheimers & Dementia; 20; 5; 3-2024; 3228-32501552-5260CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13788info:eu-repo/semantics/altIdentifier/doi/10.1002/alz.13788info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:47Zoai:ri.conicet.gov.ar:11336/267071instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:47.653CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling
title Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling
spellingShingle Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling
Coronel Oliveros, Carlos
NEUROIMAGING
DEMENTIA
AGING
MODELING
title_short Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling
title_full Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling
title_fullStr Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling
title_full_unstemmed Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling
title_sort Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling
dc.creator.none.fl_str_mv Coronel Oliveros, Carlos
Gónzalez Gómez, Raúl
Ranasinghe, Kamalini
Sainz Ballesteros, Agustín
Legaz, Agustina
Fittipaldi, Sol
Cruzat, Josephine
Herzog, Rubén
Yener, Gorsev
Parra, Mario
Aguillon, David
Lopera, Francisco
Santamaria Garcia, Hernando
Moguilner, Sebastián
Medel, Vicente
Orio, Patricio
Whelan, Robert
Tagliazucchi, Enzo Rodolfo
Prado, Pavel
Ibañez, Agustín
author Coronel Oliveros, Carlos
author_facet Coronel Oliveros, Carlos
Gónzalez Gómez, Raúl
Ranasinghe, Kamalini
Sainz Ballesteros, Agustín
Legaz, Agustina
Fittipaldi, Sol
Cruzat, Josephine
Herzog, Rubén
Yener, Gorsev
Parra, Mario
Aguillon, David
Lopera, Francisco
Santamaria Garcia, Hernando
Moguilner, Sebastián
Medel, Vicente
Orio, Patricio
Whelan, Robert
Tagliazucchi, Enzo Rodolfo
Prado, Pavel
Ibañez, Agustín
author_role author
author2 Gónzalez Gómez, Raúl
Ranasinghe, Kamalini
Sainz Ballesteros, Agustín
Legaz, Agustina
Fittipaldi, Sol
Cruzat, Josephine
Herzog, Rubén
Yener, Gorsev
Parra, Mario
Aguillon, David
Lopera, Francisco
Santamaria Garcia, Hernando
Moguilner, Sebastián
Medel, Vicente
Orio, Patricio
Whelan, Robert
Tagliazucchi, Enzo Rodolfo
Prado, Pavel
Ibañez, Agustín
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv NEUROIMAGING
DEMENTIA
AGING
MODELING
topic NEUROIMAGING
DEMENTIA
AGING
MODELING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv INTRODUCTION: Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) lack mechanistic biophysical modeling in diverse, underrepresented populations. Electroencephalography (EEG) is a high temporal resolution, cost-effective technique for studying dementia globally, but lacks mechanistic models and produces non-replicable results. METHODS:We developed a generative whole-brain model that combines EEG sourcelevel metaconnectivity, anatomical priors, and a perturbational approach. This model was applied to Global South participants (AD, bvFTD, and healthy controls). RESULTS: Metaconnectivity outperformed pairwise connectivity and revealed more viscous dynamics in patients, with altered metaconnectivity patterns associated with multimodal disease presentation. The biophysical model showed that connectome disintegration and hypoexcitability triggered altered metaconnectivity dynamics and identified critical regions for brain stimulation. We replicated the main results in a second subset of participants for validation with unharmonized, heterogeneous recording settings. DISCUSSION: The results provide a novel agenda for developing mechanistic modelinspired characterization and therapies in clinical, translational, and computational neuroscience settings.
Fil: Coronel Oliveros, Carlos. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile. Trinity College Dublin; Irlanda. Universidad de Valparaíso; Chile
Fil: Gónzalez Gómez, Raúl. Universidad Adolfo Ibañez; Chile
Fil: Ranasinghe, Kamalini. University of California; Estados Unidos
Fil: Sainz Ballesteros, Agustín. Universidad Adolfo Ibañez; Chile
Fil: Legaz, Agustina. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fittipaldi, Sol. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile. University of California; Estados Unidos. Trinity College Dublin; Irlanda
Fil: Cruzat, Josephine. Universidad Adolfo Ibañez; Chile
Fil: Herzog, Rubén. Universidad Adolfo Ibañez; Chile
Fil: Yener, Gorsev. Dokuz Eylül University; Turquía. Izmir University of Economics; Turquía
Fil: Parra, Mario. University of Strathclyde; Reino Unido
Fil: Aguillon, David. Universidad de Antioquia; Colombia
Fil: Lopera, Francisco. Universidad de Antioquia; Colombia
Fil: Santamaria Garcia, Hernando. Pontificia Universidad Javeriana; Colombia. Hospital Universitario San Ignacio; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Moguilner, Sebastián. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina
Fil: Medel, Vicente. Universidad Adolfo Ibañez; Chile. The University of Sydney; Australia. Universidad de Chile; Chile
Fil: Orio, Patricio. Universidad de Valparaíso; Chile
Fil: Whelan, Robert. Trinity College Dublin; Irlanda. University of California; Estados Unidos
Fil: Tagliazucchi, Enzo Rodolfo. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Prado, Pavel. Universidad Adolfo Ibañez; Chile. Universidad San Sebastián; Chile
Fil: Ibañez, Agustín. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Trinity College Dublin; Irlanda. University of California; Estados Unidos
description INTRODUCTION: Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) lack mechanistic biophysical modeling in diverse, underrepresented populations. Electroencephalography (EEG) is a high temporal resolution, cost-effective technique for studying dementia globally, but lacks mechanistic models and produces non-replicable results. METHODS:We developed a generative whole-brain model that combines EEG sourcelevel metaconnectivity, anatomical priors, and a perturbational approach. This model was applied to Global South participants (AD, bvFTD, and healthy controls). RESULTS: Metaconnectivity outperformed pairwise connectivity and revealed more viscous dynamics in patients, with altered metaconnectivity patterns associated with multimodal disease presentation. The biophysical model showed that connectome disintegration and hypoexcitability triggered altered metaconnectivity dynamics and identified critical regions for brain stimulation. We replicated the main results in a second subset of participants for validation with unharmonized, heterogeneous recording settings. DISCUSSION: The results provide a novel agenda for developing mechanistic modelinspired characterization and therapies in clinical, translational, and computational neuroscience settings.
publishDate 2024
dc.date.none.fl_str_mv 2024-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/267071
Coronel Oliveros, Carlos; Gónzalez Gómez, Raúl; Ranasinghe, Kamalini; Sainz Ballesteros, Agustín; Legaz, Agustina; et al.; Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling; Elsevier Science Inc.; Alzheimers & Dementia; 20; 5; 3-2024; 3228-3250
1552-5260
CONICET Digital
CONICET
url http://hdl.handle.net/11336/267071
identifier_str_mv Coronel Oliveros, Carlos; Gónzalez Gómez, Raúl; Ranasinghe, Kamalini; Sainz Ballesteros, Agustín; Legaz, Agustina; et al.; Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling; Elsevier Science Inc.; Alzheimers & Dementia; 20; 5; 3-2024; 3228-3250
1552-5260
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13788
info:eu-repo/semantics/altIdentifier/doi/10.1002/alz.13788
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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