Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration

Autores
Pérez, Denisa Soledad; Soraci, Alejandro Luis; Tapia, Maria Ofelia
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A HPLC-MS/MS method, which was suitable to be used in withdrawal time studies, was validated for the determination of fosfomycin in swine muscle, liver, kidney and skin-fat. Therefore, the withdrawal time of fosfomycin in swines, considering a MRL of 0.5 μg/mL was studied. Forty-eight pigs were assigned to two groups; in group one, fosfomycin was orally administered daily with 30 mg⁄kg bw and to the other group a dose of 15 mg⁄kg bw of the antibiotic was intramuscularly administered. Pigs were slaughtered 24, 48, 72 and 96 hours later of oral treatment withdrawn and post intramuscular treatment. The longer WDT was 2.95 days for the PO administration and 1.73 days for the IM administration; therefore, WDTs of 3 days and 2 days, respectively, could be assigned as a precautionary principle for public health, without a significant economic impact for the swine producer.
Fil: Pérez, Denisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Tapia, Maria Ofelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Materia
HPLC MS-MS
FOSFOMYCIN
SWINE TISSUES
WITHDRAWAL TIME
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/4669
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular AdministrationPérez, Denisa SoledadSoraci, Alejandro LuisTapia, Maria OfeliaHPLC MS-MSFOSFOMYCINSWINE TISSUESWITHDRAWAL TIMEhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4A HPLC-MS/MS method, which was suitable to be used in withdrawal time studies, was validated for the determination of fosfomycin in swine muscle, liver, kidney and skin-fat. Therefore, the withdrawal time of fosfomycin in swines, considering a MRL of 0.5 μg/mL was studied. Forty-eight pigs were assigned to two groups; in group one, fosfomycin was orally administered daily with 30 mg⁄kg bw and to the other group a dose of 15 mg⁄kg bw of the antibiotic was intramuscularly administered. Pigs were slaughtered 24, 48, 72 and 96 hours later of oral treatment withdrawn and post intramuscular treatment. The longer WDT was 2.95 days for the PO administration and 1.73 days for the IM administration; therefore, WDTs of 3 days and 2 days, respectively, could be assigned as a precautionary principle for public health, without a significant economic impact for the swine producer.Fil: Pérez, Denisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; ArgentinaFil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; ArgentinaFil: Tapia, Maria Ofelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; ArgentinaGlobal Researchers Journals2013-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4669Pérez, Denisa Soledad; Soraci, Alejandro Luis; Tapia, Maria Ofelia; Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration; Global Researchers Journals; Journal of Animal Production Advances; 3; 4; 4-2013; 107-1192251-7677enginfo:eu-repo/semantics/altIdentifier/url/http://www.scopemed.org/?mno=32949info:eu-repo/semantics/altIdentifier/doi/10.5455/japa.20130407054809info:eu-repo/semantics/altIdentifier/issn/2251-7677info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:19Zoai:ri.conicet.gov.ar:11336/4669instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:19.424CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration
title Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration
spellingShingle Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration
Pérez, Denisa Soledad
HPLC MS-MS
FOSFOMYCIN
SWINE TISSUES
WITHDRAWAL TIME
title_short Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration
title_full Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration
title_fullStr Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration
title_full_unstemmed Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration
title_sort Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration
dc.creator.none.fl_str_mv Pérez, Denisa Soledad
Soraci, Alejandro Luis
Tapia, Maria Ofelia
author Pérez, Denisa Soledad
author_facet Pérez, Denisa Soledad
Soraci, Alejandro Luis
Tapia, Maria Ofelia
author_role author
author2 Soraci, Alejandro Luis
Tapia, Maria Ofelia
author2_role author
author
dc.subject.none.fl_str_mv HPLC MS-MS
FOSFOMYCIN
SWINE TISSUES
WITHDRAWAL TIME
topic HPLC MS-MS
FOSFOMYCIN
SWINE TISSUES
WITHDRAWAL TIME
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv A HPLC-MS/MS method, which was suitable to be used in withdrawal time studies, was validated for the determination of fosfomycin in swine muscle, liver, kidney and skin-fat. Therefore, the withdrawal time of fosfomycin in swines, considering a MRL of 0.5 μg/mL was studied. Forty-eight pigs were assigned to two groups; in group one, fosfomycin was orally administered daily with 30 mg⁄kg bw and to the other group a dose of 15 mg⁄kg bw of the antibiotic was intramuscularly administered. Pigs were slaughtered 24, 48, 72 and 96 hours later of oral treatment withdrawn and post intramuscular treatment. The longer WDT was 2.95 days for the PO administration and 1.73 days for the IM administration; therefore, WDTs of 3 days and 2 days, respectively, could be assigned as a precautionary principle for public health, without a significant economic impact for the swine producer.
Fil: Pérez, Denisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
Fil: Tapia, Maria Ofelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina
description A HPLC-MS/MS method, which was suitable to be used in withdrawal time studies, was validated for the determination of fosfomycin in swine muscle, liver, kidney and skin-fat. Therefore, the withdrawal time of fosfomycin in swines, considering a MRL of 0.5 μg/mL was studied. Forty-eight pigs were assigned to two groups; in group one, fosfomycin was orally administered daily with 30 mg⁄kg bw and to the other group a dose of 15 mg⁄kg bw of the antibiotic was intramuscularly administered. Pigs were slaughtered 24, 48, 72 and 96 hours later of oral treatment withdrawn and post intramuscular treatment. The longer WDT was 2.95 days for the PO administration and 1.73 days for the IM administration; therefore, WDTs of 3 days and 2 days, respectively, could be assigned as a precautionary principle for public health, without a significant economic impact for the swine producer.
publishDate 2013
dc.date.none.fl_str_mv 2013-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/4669
Pérez, Denisa Soledad; Soraci, Alejandro Luis; Tapia, Maria Ofelia; Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration; Global Researchers Journals; Journal of Animal Production Advances; 3; 4; 4-2013; 107-119
2251-7677
url http://hdl.handle.net/11336/4669
identifier_str_mv Pérez, Denisa Soledad; Soraci, Alejandro Luis; Tapia, Maria Ofelia; Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration; Global Researchers Journals; Journal of Animal Production Advances; 3; 4; 4-2013; 107-119
2251-7677
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.scopemed.org/?mno=32949
info:eu-repo/semantics/altIdentifier/doi/10.5455/japa.20130407054809
info:eu-repo/semantics/altIdentifier/issn/2251-7677
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Global Researchers Journals
publisher.none.fl_str_mv Global Researchers Journals
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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