Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy study

Autores
Petruk, Ariel Alcides; Alvarez, Rosa Maria Susana
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Previous reports from our laboratory have shown that thyroid hormones induce changes in the fluidity and permeability of phospholipid bilayers and modify the transmembrane dipolar organization according to their iodine content. The interactions of T2, T3, and T4 with a model membrane of dilauroylphosphatidylcholine in the liquid-crystalline phase were analyzed by confocal Raman spectroscopy. Insights into the nature of the hormone effects on the membrane properties, as well as the structural adaptations of the hormones in response to the lipid environment were derived from the spectral changes. The series of progressive iodine substituents on the ring-β allowed us to correlate the hormone effects according to the number and the orientation of the iodine atoms. T4 was responsible for producing the highest alteration in the hydrophobic region of the membrane.
Fil: Petruk, Ariel Alcides. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; Argentina
Fil: Alvarez, Rosa Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; Argentina
Materia
Thyroid Hormones
Phospholipids
Vibrational Analysis
Confocal Raman Microscopy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/21993
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy studyPetruk, Ariel AlcidesAlvarez, Rosa Maria SusanaThyroid HormonesPhospholipidsVibrational AnalysisConfocal Raman Microscopyhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Previous reports from our laboratory have shown that thyroid hormones induce changes in the fluidity and permeability of phospholipid bilayers and modify the transmembrane dipolar organization according to their iodine content. The interactions of T2, T3, and T4 with a model membrane of dilauroylphosphatidylcholine in the liquid-crystalline phase were analyzed by confocal Raman spectroscopy. Insights into the nature of the hormone effects on the membrane properties, as well as the structural adaptations of the hormones in response to the lipid environment were derived from the spectral changes. The series of progressive iodine substituents on the ring-β allowed us to correlate the hormone effects according to the number and the orientation of the iodine atoms. T4 was responsible for producing the highest alteration in the hydrophobic region of the membrane.Fil: Petruk, Ariel Alcides. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; ArgentinaFil: Alvarez, Rosa Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; ArgentinaWiley2012-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21993Petruk, Ariel Alcides; Alvarez, Rosa Maria Susana; Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy study; Wiley; Journal Of Raman Spectroscopy; 44; 3; 11-2012; 346-3540377-0486CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/jrs.4205info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/jrs.4205/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:10Zoai:ri.conicet.gov.ar:11336/21993instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:11.04CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy study
title Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy study
spellingShingle Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy study
Petruk, Ariel Alcides
Thyroid Hormones
Phospholipids
Vibrational Analysis
Confocal Raman Microscopy
title_short Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy study
title_full Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy study
title_fullStr Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy study
title_full_unstemmed Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy study
title_sort Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy study
dc.creator.none.fl_str_mv Petruk, Ariel Alcides
Alvarez, Rosa Maria Susana
author Petruk, Ariel Alcides
author_facet Petruk, Ariel Alcides
Alvarez, Rosa Maria Susana
author_role author
author2 Alvarez, Rosa Maria Susana
author2_role author
dc.subject.none.fl_str_mv Thyroid Hormones
Phospholipids
Vibrational Analysis
Confocal Raman Microscopy
topic Thyroid Hormones
Phospholipids
Vibrational Analysis
Confocal Raman Microscopy
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Previous reports from our laboratory have shown that thyroid hormones induce changes in the fluidity and permeability of phospholipid bilayers and modify the transmembrane dipolar organization according to their iodine content. The interactions of T2, T3, and T4 with a model membrane of dilauroylphosphatidylcholine in the liquid-crystalline phase were analyzed by confocal Raman spectroscopy. Insights into the nature of the hormone effects on the membrane properties, as well as the structural adaptations of the hormones in response to the lipid environment were derived from the spectral changes. The series of progressive iodine substituents on the ring-β allowed us to correlate the hormone effects according to the number and the orientation of the iodine atoms. T4 was responsible for producing the highest alteration in the hydrophobic region of the membrane.
Fil: Petruk, Ariel Alcides. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; Argentina
Fil: Alvarez, Rosa Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; Argentina
description Previous reports from our laboratory have shown that thyroid hormones induce changes in the fluidity and permeability of phospholipid bilayers and modify the transmembrane dipolar organization according to their iodine content. The interactions of T2, T3, and T4 with a model membrane of dilauroylphosphatidylcholine in the liquid-crystalline phase were analyzed by confocal Raman spectroscopy. Insights into the nature of the hormone effects on the membrane properties, as well as the structural adaptations of the hormones in response to the lipid environment were derived from the spectral changes. The series of progressive iodine substituents on the ring-β allowed us to correlate the hormone effects according to the number and the orientation of the iodine atoms. T4 was responsible for producing the highest alteration in the hydrophobic region of the membrane.
publishDate 2012
dc.date.none.fl_str_mv 2012-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/21993
Petruk, Ariel Alcides; Alvarez, Rosa Maria Susana; Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy study; Wiley; Journal Of Raman Spectroscopy; 44; 3; 11-2012; 346-354
0377-0486
CONICET Digital
CONICET
url http://hdl.handle.net/11336/21993
identifier_str_mv Petruk, Ariel Alcides; Alvarez, Rosa Maria Susana; Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy study; Wiley; Journal Of Raman Spectroscopy; 44; 3; 11-2012; 346-354
0377-0486
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/jrs.4205
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/jrs.4205/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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