A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient

Autores
Colli, Sandra; Furforo, Lilian; Rojo Pisarello, Eduardo; Maidana, Marcela; Martín, Carlos; Bordone, Javier; Slavutsky, Irma
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Colli, Sandra. Academia Nacional de Medicina. Instituto de Medicina Experimental. Laboratorio de Genética de Neoplasias Linfoides; Argentina.
Fil: Furforo, Lilian. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica; Argentina.
Fil: Rojo Pisarello, Eduardo. Hospital de Alta Complejidad "Presidente Juan Domingo Perón"; Formosa, Argentina.
Fil: Maidana, Marcela. Hospital de Alta Complejidad "Presidente Juan Domingo Perón"; Formosa, Argentina.
Fil: Martín, Carlos. Consultorio de Hematopatología; La Plata, Argentina.
Fil: Bordone, Javier. Consultorio de Hematopatología; La Plata, Argentina.
Fil: Slavutsky, Irma. Academia Nacional de Medicina. Instituto de Medicina Experimental. Laboratorio de Genética de Neoplasias Linfoides; Argentina.
Translocation t(4;11)(q21;p15) is a rare recurrent change associated to T-cell acute leukemia. In most cases, this alteration appears as the only abnormality or as part of a simple karyotype. In this report, we present the first case of T acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) with the unbalanced translocation der(11)t(4;11)(q21;p15) as part of a very complex karyotype with multiple chromosome abnormalities, most of them not previously described in the literature. FISH (fluorescence in situ hybridization) and spectral karyotype (HiSKY) analysis confirmed the presence of complex alterations. The patient, a 16-year-old male, showed poor response to treatment and short survival (11 months). A detailed review of previously reported cases with t(4;11)(q21;p15) is also provided. The description of this type of alterations may contribute to the identification of new molecular mechanism associated to neoplastic development.
Materia
Hibridación Fluorescente in Situ
Leucemia-Linfoma Linfoblástico de Células T Precursoras
Citogenética
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:123456789/1701
Acceder
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network_acronym_str SGCANLIS
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network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patientColli, SandraFurforo, LilianRojo Pisarello, EduardoMaidana, MarcelaMartín, CarlosBordone, JavierSlavutsky, IrmaHibridación Fluorescente in SituLeucemia-Linfoma Linfoblástico de Células T PrecursorasCitogenéticaFil: Colli, Sandra. Academia Nacional de Medicina. Instituto de Medicina Experimental. Laboratorio de Genética de Neoplasias Linfoides; Argentina.Fil: Furforo, Lilian. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica; Argentina.Fil: Rojo Pisarello, Eduardo. Hospital de Alta Complejidad "Presidente Juan Domingo Perón"; Formosa, Argentina.Fil: Maidana, Marcela. Hospital de Alta Complejidad "Presidente Juan Domingo Perón"; Formosa, Argentina.Fil: Martín, Carlos. Consultorio de Hematopatología; La Plata, Argentina.Fil: Bordone, Javier. Consultorio de Hematopatología; La Plata, Argentina.Fil: Slavutsky, Irma. Academia Nacional de Medicina. Instituto de Medicina Experimental. Laboratorio de Genética de Neoplasias Linfoides; Argentina.Translocation t(4;11)(q21;p15) is a rare recurrent change associated to T-cell acute leukemia. In most cases, this alteration appears as the only abnormality or as part of a simple karyotype. In this report, we present the first case of T acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) with the unbalanced translocation der(11)t(4;11)(q21;p15) as part of a very complex karyotype with multiple chromosome abnormalities, most of them not previously described in the literature. FISH (fluorescence in situ hybridization) and spectral karyotype (HiSKY) analysis confirmed the presence of complex alterations. The patient, a 16-year-old male, showed poor response to treatment and short survival (11 months). A detailed review of previously reported cases with t(4;11)(q21;p15) is also provided. The description of this type of alterations may contribute to the identification of new molecular mechanism associated to neoplastic development.2016-04info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf2210-7762http://sgc.anlis.gob.ar/handle/123456789/170110.1016/j.cancergen.2016.01.001Cancer geneticsenginfo:eu-repo/semantics/openAccessreponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLIS2025-09-04T11:17:20Zoai:sgc.anlis.gob.ar:123456789/1701Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-04 11:17:21.148Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
title A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
spellingShingle A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
Colli, Sandra
Hibridación Fluorescente in Situ
Leucemia-Linfoma Linfoblástico de Células T Precursoras
Citogenética
title_short A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
title_full A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
title_fullStr A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
title_full_unstemmed A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
title_sort A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
dc.creator.none.fl_str_mv Colli, Sandra
Furforo, Lilian
Rojo Pisarello, Eduardo
Maidana, Marcela
Martín, Carlos
Bordone, Javier
Slavutsky, Irma
author Colli, Sandra
author_facet Colli, Sandra
Furforo, Lilian
Rojo Pisarello, Eduardo
Maidana, Marcela
Martín, Carlos
Bordone, Javier
Slavutsky, Irma
author_role author
author2 Furforo, Lilian
Rojo Pisarello, Eduardo
Maidana, Marcela
Martín, Carlos
Bordone, Javier
Slavutsky, Irma
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Hibridación Fluorescente in Situ
Leucemia-Linfoma Linfoblástico de Células T Precursoras
Citogenética
topic Hibridación Fluorescente in Situ
Leucemia-Linfoma Linfoblástico de Células T Precursoras
Citogenética
dc.description.none.fl_txt_mv Fil: Colli, Sandra. Academia Nacional de Medicina. Instituto de Medicina Experimental. Laboratorio de Genética de Neoplasias Linfoides; Argentina.
Fil: Furforo, Lilian. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica; Argentina.
Fil: Rojo Pisarello, Eduardo. Hospital de Alta Complejidad "Presidente Juan Domingo Perón"; Formosa, Argentina.
Fil: Maidana, Marcela. Hospital de Alta Complejidad "Presidente Juan Domingo Perón"; Formosa, Argentina.
Fil: Martín, Carlos. Consultorio de Hematopatología; La Plata, Argentina.
Fil: Bordone, Javier. Consultorio de Hematopatología; La Plata, Argentina.
Fil: Slavutsky, Irma. Academia Nacional de Medicina. Instituto de Medicina Experimental. Laboratorio de Genética de Neoplasias Linfoides; Argentina.
Translocation t(4;11)(q21;p15) is a rare recurrent change associated to T-cell acute leukemia. In most cases, this alteration appears as the only abnormality or as part of a simple karyotype. In this report, we present the first case of T acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) with the unbalanced translocation der(11)t(4;11)(q21;p15) as part of a very complex karyotype with multiple chromosome abnormalities, most of them not previously described in the literature. FISH (fluorescence in situ hybridization) and spectral karyotype (HiSKY) analysis confirmed the presence of complex alterations. The patient, a 16-year-old male, showed poor response to treatment and short survival (11 months). A detailed review of previously reported cases with t(4;11)(q21;p15) is also provided. The description of this type of alterations may contribute to the identification of new molecular mechanism associated to neoplastic development.
description Fil: Colli, Sandra. Academia Nacional de Medicina. Instituto de Medicina Experimental. Laboratorio de Genética de Neoplasias Linfoides; Argentina.
publishDate 2016
dc.date.none.fl_str_mv 2016-04
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 2210-7762
http://sgc.anlis.gob.ar/handle/123456789/1701
10.1016/j.cancergen.2016.01.001
identifier_str_mv 2210-7762
10.1016/j.cancergen.2016.01.001
url http://sgc.anlis.gob.ar/handle/123456789/1701
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cancer genetics
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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score 12.623145

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