A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient

Autores
Colli, Sandra; Furforo, Lilian; Rojo Pisarello, Eduardo; Maidana, Marcela; Martín, Carlos; Bordone, Javier; Slavutsky, Irma Rosa
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Translocation t(4;11)(q21;p15) is a rare recurrent change associated to T-cell acute leukemia. In most cases, this alteration appears as the only abnormality or as part of a simple karyotype. In this report, we present the first case of T acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) with the unbalanced translocation der(11)t(4;11)(q21;p15) as part of a very complex karyotype with multiple chromosome abnormalities, most of them not previously described in the literature. FISH (fluorescence in situ hybridization) and spectral karyotype (HiSKY) analysis confirmed the presence of complex alterations. The patient, a 16-year-old male, showed poor response to treatment and short survival (11 months). A detailed review of previously reported cases with t(4;11)(q21;p15) is also provided. The description of this type of alterations may contribute to the identification of new molecular mechanism associated to neoplastic development.
Fil: Colli, Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Furforo, Lilian. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán". Centro Nacional de Genética Médica; Argentina
Fil: Rojo Pisarello, Eduardo. Hospital de Alta Complejidad “Presidente Juan Domingo Perón"; Argentina
Fil: Maidana, Marcela. Hospital de Alta Complejidad “Presidente Juan Domingo Perón"; Argentina
Fil: Martín, Carlos. Consultorio de Hematopatología; Argentina
Fil: Bordone, Javier. Hospital de Alta Complejidad “Presidente Juan Domingo Perón"; Argentina
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
Cytogenetics
Fish
Spectral Karyotype
T-Cell Acute Leukemia/Lymphoma
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/52607
Acceder
id CONICETDig_44d9583be31bd3a65736d8ee9f39de8a
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patientColli, SandraFurforo, LilianRojo Pisarello, EduardoMaidana, MarcelaMartín, CarlosBordone, JavierSlavutsky, Irma RosaCytogeneticsFishSpectral KaryotypeT-Cell Acute Leukemia/Lymphomahttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Translocation t(4;11)(q21;p15) is a rare recurrent change associated to T-cell acute leukemia. In most cases, this alteration appears as the only abnormality or as part of a simple karyotype. In this report, we present the first case of T acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) with the unbalanced translocation der(11)t(4;11)(q21;p15) as part of a very complex karyotype with multiple chromosome abnormalities, most of them not previously described in the literature. FISH (fluorescence in situ hybridization) and spectral karyotype (HiSKY) analysis confirmed the presence of complex alterations. The patient, a 16-year-old male, showed poor response to treatment and short survival (11 months). A detailed review of previously reported cases with t(4;11)(q21;p15) is also provided. The description of this type of alterations may contribute to the identification of new molecular mechanism associated to neoplastic development.Fil: Colli, Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Furforo, Lilian. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán". Centro Nacional de Genética Médica; ArgentinaFil: Rojo Pisarello, Eduardo. Hospital de Alta Complejidad “Presidente Juan Domingo Perón"; ArgentinaFil: Maidana, Marcela. Hospital de Alta Complejidad “Presidente Juan Domingo Perón"; ArgentinaFil: Martín, Carlos. Consultorio de Hematopatología; ArgentinaFil: Bordone, Javier. Hospital de Alta Complejidad “Presidente Juan Domingo Perón"; ArgentinaFil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaElsevier Inc2016-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/52607Colli, Sandra; Furforo, Lilian; Rojo Pisarello, Eduardo; Maidana, Marcela; Martín, Carlos; et al.; A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient; Elsevier Inc; Cancer Genetics; 209; 4; 4-2016; 166-1702210-7770CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cancergen.2016.01.001info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2210776216000144info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:39Zoai:ri.conicet.gov.ar:11336/52607instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:39.658CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
title A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
spellingShingle A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
Colli, Sandra
Cytogenetics
Fish
Spectral Karyotype
T-Cell Acute Leukemia/Lymphoma
title_short A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
title_full A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
title_fullStr A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
title_full_unstemmed A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
title_sort A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
dc.creator.none.fl_str_mv Colli, Sandra
Furforo, Lilian
Rojo Pisarello, Eduardo
Maidana, Marcela
Martín, Carlos
Bordone, Javier
Slavutsky, Irma Rosa
author Colli, Sandra
author_facet Colli, Sandra
Furforo, Lilian
Rojo Pisarello, Eduardo
Maidana, Marcela
Martín, Carlos
Bordone, Javier
Slavutsky, Irma Rosa
author_role author
author2 Furforo, Lilian
Rojo Pisarello, Eduardo
Maidana, Marcela
Martín, Carlos
Bordone, Javier
Slavutsky, Irma Rosa
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Cytogenetics
Fish
Spectral Karyotype
T-Cell Acute Leukemia/Lymphoma
topic Cytogenetics
Fish
Spectral Karyotype
T-Cell Acute Leukemia/Lymphoma
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Translocation t(4;11)(q21;p15) is a rare recurrent change associated to T-cell acute leukemia. In most cases, this alteration appears as the only abnormality or as part of a simple karyotype. In this report, we present the first case of T acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) with the unbalanced translocation der(11)t(4;11)(q21;p15) as part of a very complex karyotype with multiple chromosome abnormalities, most of them not previously described in the literature. FISH (fluorescence in situ hybridization) and spectral karyotype (HiSKY) analysis confirmed the presence of complex alterations. The patient, a 16-year-old male, showed poor response to treatment and short survival (11 months). A detailed review of previously reported cases with t(4;11)(q21;p15) is also provided. The description of this type of alterations may contribute to the identification of new molecular mechanism associated to neoplastic development.
Fil: Colli, Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Furforo, Lilian. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán". Centro Nacional de Genética Médica; Argentina
Fil: Rojo Pisarello, Eduardo. Hospital de Alta Complejidad “Presidente Juan Domingo Perón"; Argentina
Fil: Maidana, Marcela. Hospital de Alta Complejidad “Presidente Juan Domingo Perón"; Argentina
Fil: Martín, Carlos. Consultorio de Hematopatología; Argentina
Fil: Bordone, Javier. Hospital de Alta Complejidad “Presidente Juan Domingo Perón"; Argentina
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description Translocation t(4;11)(q21;p15) is a rare recurrent change associated to T-cell acute leukemia. In most cases, this alteration appears as the only abnormality or as part of a simple karyotype. In this report, we present the first case of T acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) with the unbalanced translocation der(11)t(4;11)(q21;p15) as part of a very complex karyotype with multiple chromosome abnormalities, most of them not previously described in the literature. FISH (fluorescence in situ hybridization) and spectral karyotype (HiSKY) analysis confirmed the presence of complex alterations. The patient, a 16-year-old male, showed poor response to treatment and short survival (11 months). A detailed review of previously reported cases with t(4;11)(q21;p15) is also provided. The description of this type of alterations may contribute to the identification of new molecular mechanism associated to neoplastic development.
publishDate 2016
dc.date.none.fl_str_mv 2016-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/52607
Colli, Sandra; Furforo, Lilian; Rojo Pisarello, Eduardo; Maidana, Marcela; Martín, Carlos; et al.; A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient; Elsevier Inc; Cancer Genetics; 209; 4; 4-2016; 166-170
2210-7770
CONICET Digital
CONICET
url http://hdl.handle.net/11336/52607
identifier_str_mv Colli, Sandra; Furforo, Lilian; Rojo Pisarello, Eduardo; Maidana, Marcela; Martín, Carlos; et al.; A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient; Elsevier Inc; Cancer Genetics; 209; 4; 4-2016; 166-170
2210-7770
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cancergen.2016.01.001
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2210776216000144
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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