Treatments for acute lymphoblastic leukemia: A comparison between Tisagenlecleucel and Clofarabine
- Autores
- Carmona, Rocío Guadalupe; Montivero, Malena; Quattrocchi, Georgina; Zarelli, Valeria; Giai, Constanza; Quintero, Cristián Andrés
- Año de publicación
- 2025
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Carmona, Rocío Guadalupe. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; Argentina
Fil: Montivero, Malena. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; Argentina
Fil: Quattrocchi, Georgina. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; Argentina
Fil: Zarelli, Valeria. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; Argentina
Fil: Zarelli, Valeria. Universidad Juan Agustín Maza. Laboratorio de Genética, Ambiente y Reproducción; Argentina
Fil: Giai, Constanza. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; Argentina
Fil: Giai, Constanza. Universidad Juan Agustín Maza. Laboratorio de Biología Molecular y Celular; Argentina
Fil: Quintero, Cristián Andrés. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; Argentina
Fil: Quintero, Cristián Andrés. Universidad Juan Agustín Maza. Laboratorio de Biología Molecular y Celular; Argentina
Background: Acute lymphoblastic leukemia (ALL) is a heterogeneous hematological malignancy predominantly affecting individuals under 20 years of age. Traditional chemotherapy, such as clofarabine, has shown efficacy; however, novel immunotherapeutic strategies like tisagenlecleucel (Kymriah®) have significantly altered the treatment paradigm. Aim: This study aimed to perform a comparative analysis of tisagenlecleucel, a CAR-T cell therapy, and clofarabine, a second-generation purine nucleoside analog, evaluating their mechanisms of action, therapeutic benefits, limitations, and clinical applicability across diverse patient populations. Methods: A systematic comparative evaluation was conducted, encompassing pharmacological characteristics, mechanisms of action, treatment protocols, efficacy, safety profiles, and clinical indications of both agents. The análisis considered pharmacokinetic and pharmacodynamic data and included patient demographic variables. Results: Tisagenlecleucel demonstrated high efficacy in refractory B-cell ALL, with durable responses and a blood half-life of 128 days, but with notable immune-related adverse effects such as cytokine release syndrome. Clofarabine, effective across a broader patient population, acts via multiple antitumor mechanisms but carries significant toxicity risks, including infection and sepsis. Discussion: The therapies present distinct clinical profiles: tisagenlecleucel offers targeted immunotherapy with high specificity but requires specialized infrastructure and management of immune toxicities. Clofarabine is more widely accessible and applicable, but is associated with conventional chemotherapy-related side effects. Treatment accessibility and cost differ markedly between the two. Conclusions: Therapy selection should be personalized based on patient-specific factors and institutional resources. Tisagenlecleucel is ideal for pediatric and young adult patients with relapsed/refractory B-cell ALL in CAR-T-capable centers, while clofarabine remains a viable option for broader ALL populations, particularly when genetic therapies are not feasible. Further research is needed to optimize therapeutic strategies and improve access to advanced treatments. - Materia
-
tisagenlecleucel
clofarabina
leucemia linfoblástica aguda - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Maza
- OAI Identificador
- oai:repositorio.umaza.edu.ar:00261/3607
Ver los metadatos del registro completo
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Treatments for acute lymphoblastic leukemia: A comparison between Tisagenlecleucel and ClofarabineCarmona, Rocío GuadalupeMontivero, MalenaQuattrocchi, GeorginaZarelli, ValeriaGiai, ConstanzaQuintero, Cristián Andréstisagenlecleucelclofarabinaleucemia linfoblástica agudaFil: Carmona, Rocío Guadalupe. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; ArgentinaFil: Montivero, Malena. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; ArgentinaFil: Quattrocchi, Georgina. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; ArgentinaFil: Zarelli, Valeria. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; ArgentinaFil: Zarelli, Valeria. Universidad Juan Agustín Maza. Laboratorio de Genética, Ambiente y Reproducción; ArgentinaFil: Giai, Constanza. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; ArgentinaFil: Giai, Constanza. Universidad Juan Agustín Maza. Laboratorio de Biología Molecular y Celular; ArgentinaFil: Quintero, Cristián Andrés. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; ArgentinaFil: Quintero, Cristián Andrés. Universidad Juan Agustín Maza. Laboratorio de Biología Molecular y Celular; ArgentinaBackground: Acute lymphoblastic leukemia (ALL) is a heterogeneous hematological malignancy predominantly affecting individuals under 20 years of age. Traditional chemotherapy, such as clofarabine, has shown efficacy; however, novel immunotherapeutic strategies like tisagenlecleucel (Kymriah®) have significantly altered the treatment paradigm. Aim: This study aimed to perform a comparative analysis of tisagenlecleucel, a CAR-T cell therapy, and clofarabine, a second-generation purine nucleoside analog, evaluating their mechanisms of action, therapeutic benefits, limitations, and clinical applicability across diverse patient populations. Methods: A systematic comparative evaluation was conducted, encompassing pharmacological characteristics, mechanisms of action, treatment protocols, efficacy, safety profiles, and clinical indications of both agents. The análisis considered pharmacokinetic and pharmacodynamic data and included patient demographic variables. Results: Tisagenlecleucel demonstrated high efficacy in refractory B-cell ALL, with durable responses and a blood half-life of 128 days, but with notable immune-related adverse effects such as cytokine release syndrome. Clofarabine, effective across a broader patient population, acts via multiple antitumor mechanisms but carries significant toxicity risks, including infection and sepsis. Discussion: The therapies present distinct clinical profiles: tisagenlecleucel offers targeted immunotherapy with high specificity but requires specialized infrastructure and management of immune toxicities. Clofarabine is more widely accessible and applicable, but is associated with conventional chemotherapy-related side effects. Treatment accessibility and cost differ markedly between the two. Conclusions: Therapy selection should be personalized based on patient-specific factors and institutional resources. Tisagenlecleucel is ideal for pediatric and young adult patients with relapsed/refractory B-cell ALL in CAR-T-capable centers, while clofarabine remains a viable option for broader ALL populations, particularly when genetic therapies are not feasible. Further research is needed to optimize therapeutic strategies and improve access to advanced treatments.2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfCarmona, R. G., Montivero, M., Quattrocchi, G., Zarelli, V., Giai, C., & Quintero, C. A. (2025). Treatments for acute lymphoblastic leukemia: A comparison between tisagenlecleucel and clofarabine. Southern Journal of Sciences, 33(39), 25–31. https://doi.org/10.48141/2764-5959.04.v33.n39.2025_QUINTEROS_pgs_25_31https://repositorio.umaza.edu.ar/handle/00261/3607enginfo:eu-repo/semantics/altIdentifier/url/10.48141/2764-5959.04.v33.n39.2025_QUINTEROS_pgs_25_31.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/reponame:UMaza Digitalinstname:Universidad Maza2025-09-29T14:29:18Zoai:repositorio.umaza.edu.ar:00261/3607instacron:UMAZAInstitucionalhttp://repositorio.umaza.edu.ar/Universidad privadaNo correspondehttp://repositorio.umaza.edu.ar/oaicienciaytecnica@umaza.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:44192025-09-29 14:29:18.495UMaza Digital - Universidad Mazafalse |
dc.title.none.fl_str_mv |
Treatments for acute lymphoblastic leukemia: A comparison between Tisagenlecleucel and Clofarabine |
title |
Treatments for acute lymphoblastic leukemia: A comparison between Tisagenlecleucel and Clofarabine |
spellingShingle |
Treatments for acute lymphoblastic leukemia: A comparison between Tisagenlecleucel and Clofarabine Carmona, Rocío Guadalupe tisagenlecleucel clofarabina leucemia linfoblástica aguda |
title_short |
Treatments for acute lymphoblastic leukemia: A comparison between Tisagenlecleucel and Clofarabine |
title_full |
Treatments for acute lymphoblastic leukemia: A comparison between Tisagenlecleucel and Clofarabine |
title_fullStr |
Treatments for acute lymphoblastic leukemia: A comparison between Tisagenlecleucel and Clofarabine |
title_full_unstemmed |
Treatments for acute lymphoblastic leukemia: A comparison between Tisagenlecleucel and Clofarabine |
title_sort |
Treatments for acute lymphoblastic leukemia: A comparison between Tisagenlecleucel and Clofarabine |
dc.creator.none.fl_str_mv |
Carmona, Rocío Guadalupe Montivero, Malena Quattrocchi, Georgina Zarelli, Valeria Giai, Constanza Quintero, Cristián Andrés |
author |
Carmona, Rocío Guadalupe |
author_facet |
Carmona, Rocío Guadalupe Montivero, Malena Quattrocchi, Georgina Zarelli, Valeria Giai, Constanza Quintero, Cristián Andrés |
author_role |
author |
author2 |
Montivero, Malena Quattrocchi, Georgina Zarelli, Valeria Giai, Constanza Quintero, Cristián Andrés |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
tisagenlecleucel clofarabina leucemia linfoblástica aguda |
topic |
tisagenlecleucel clofarabina leucemia linfoblástica aguda |
dc.description.none.fl_txt_mv |
Fil: Carmona, Rocío Guadalupe. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; Argentina Fil: Montivero, Malena. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; Argentina Fil: Quattrocchi, Georgina. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; Argentina Fil: Zarelli, Valeria. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; Argentina Fil: Zarelli, Valeria. Universidad Juan Agustín Maza. Laboratorio de Genética, Ambiente y Reproducción; Argentina Fil: Giai, Constanza. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; Argentina Fil: Giai, Constanza. Universidad Juan Agustín Maza. Laboratorio de Biología Molecular y Celular; Argentina Fil: Quintero, Cristián Andrés. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; Argentina Fil: Quintero, Cristián Andrés. Universidad Juan Agustín Maza. Laboratorio de Biología Molecular y Celular; Argentina Background: Acute lymphoblastic leukemia (ALL) is a heterogeneous hematological malignancy predominantly affecting individuals under 20 years of age. Traditional chemotherapy, such as clofarabine, has shown efficacy; however, novel immunotherapeutic strategies like tisagenlecleucel (Kymriah®) have significantly altered the treatment paradigm. Aim: This study aimed to perform a comparative analysis of tisagenlecleucel, a CAR-T cell therapy, and clofarabine, a second-generation purine nucleoside analog, evaluating their mechanisms of action, therapeutic benefits, limitations, and clinical applicability across diverse patient populations. Methods: A systematic comparative evaluation was conducted, encompassing pharmacological characteristics, mechanisms of action, treatment protocols, efficacy, safety profiles, and clinical indications of both agents. The análisis considered pharmacokinetic and pharmacodynamic data and included patient demographic variables. Results: Tisagenlecleucel demonstrated high efficacy in refractory B-cell ALL, with durable responses and a blood half-life of 128 days, but with notable immune-related adverse effects such as cytokine release syndrome. Clofarabine, effective across a broader patient population, acts via multiple antitumor mechanisms but carries significant toxicity risks, including infection and sepsis. Discussion: The therapies present distinct clinical profiles: tisagenlecleucel offers targeted immunotherapy with high specificity but requires specialized infrastructure and management of immune toxicities. Clofarabine is more widely accessible and applicable, but is associated with conventional chemotherapy-related side effects. Treatment accessibility and cost differ markedly between the two. Conclusions: Therapy selection should be personalized based on patient-specific factors and institutional resources. Tisagenlecleucel is ideal for pediatric and young adult patients with relapsed/refractory B-cell ALL in CAR-T-capable centers, while clofarabine remains a viable option for broader ALL populations, particularly when genetic therapies are not feasible. Further research is needed to optimize therapeutic strategies and improve access to advanced treatments. |
description |
Fil: Carmona, Rocío Guadalupe. Universidad Juan Agustín Maza. Facultad de Farmacia y Bioquímica; Argentina |
publishDate |
2025 |
dc.date.none.fl_str_mv |
2025 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
Carmona, R. G., Montivero, M., Quattrocchi, G., Zarelli, V., Giai, C., & Quintero, C. A. (2025). Treatments for acute lymphoblastic leukemia: A comparison between tisagenlecleucel and clofarabine. Southern Journal of Sciences, 33(39), 25–31. https://doi.org/10.48141/2764-5959.04.v33.n39.2025_QUINTEROS_pgs_25_31 https://repositorio.umaza.edu.ar/handle/00261/3607 |
identifier_str_mv |
Carmona, R. G., Montivero, M., Quattrocchi, G., Zarelli, V., Giai, C., & Quintero, C. A. (2025). Treatments for acute lymphoblastic leukemia: A comparison between tisagenlecleucel and clofarabine. Southern Journal of Sciences, 33(39), 25–31. https://doi.org/10.48141/2764-5959.04.v33.n39.2025_QUINTEROS_pgs_25_31 |
url |
https://repositorio.umaza.edu.ar/handle/00261/3607 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/10.48141/2764-5959.04.v33.n39.2025_QUINTEROS_pgs_25_31.pdf |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
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application/pdf application/pdf |
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