Phylodynamics of vampire bat-transmitted rabies in Argentina

• Autores: Torres, Carolina; Lema, Cristina L.; Gury Dohmen, Federico; Beltran, Fernando; Novaro, Laura; Russo, Susana; Freire, María Cecilia; Velasco-Villa, A; Mbayed, Viviana Andrea; Cisterna, Daniel M
• Año de publicación: 2014
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Molecular Ecology 2014;23(9):2340-2352
• Materia: Argentina; Filogeografía; Virus de la Rabia; Quirópteros
• Institución: Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"

Fil: Torres, Carolina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Virología; Argentina.
Fil: Lema, Cristina L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología. Servicio de Neurovirosis; Argentina
Fil: Gury Dohmen, Federico. Instituto de Zoonosis "Dr. Luis Pasteur", Ciudad Autónoma de Buenos Aires; Argentina.
Fil: Beltran, Fernando. Instituto de Zoonosis "Dr. Luis Pasteur", Ciudad Autónoma de Buenos Aires; Argentina.
Fil: Novaro, Laura. Servicio Nacional de Sanidad y Calidad Agroalimentaria. DILAB, Ciudad Autónoma de Buenos Aires; Argentina.
Fil: Russo, Susana. Servicio Nacional de Sanidad y Calidad Agroalimentaria. DILAB, Ciudad Autónoma de Buenos Aires; Argentina.
Fil: Freire, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología. Servicio de Neurovirosis; Argentina
Fil: Velasco-Villa, A. Centers for Disease Control and Prevention, Atlanta, Georgia; Estados Unidos.
Fil: Mbayed, Viviana Andrea. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Virología; Argentina.
Fil: Cisterna, Daniel M. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología. Servicio de Neurovirosis; Argentina.
Common vampire bat populations distributed from Mexico to Argentina are important rabies reservoir hosts in Latin America. The aim of this work was to analyse the population structure of the rabies virus (RABV) variants associated with vampire bats in the Americas and to study their phylodynamic pattern within Argentina. The phylogenetic analysis based on all available vampire bat‐related N gene sequences showed both a geographical and a temporal structure. The two largest groups of RABV variants from Argentina were isolated from northwestern Argentina and from the central western zone of northeastern Argentina, corresponding to livestock areas with different climatic, topographic and biogeographical conditions, which determined their dissemination and evolutionary patterns. In addition, multiple introductions of the infection into Argentina, possibly from Brazil, were detected. The phylodynamic analysis suggests that RABV transmission dynamics is characterized by initial epizootic waves followed by local enzootic cycles with variable persistence. Anthropogenic interventions in the ecosystem should be assessed taking into account not only the environmental impact but also the potential risk of disease spreading through dissemination of current RABV lineages or the emergence of novel ones associated with vampire bats.