Circulating Epstein-Barr virus (EBV) in HIV-infected patients and its relation with primary brain lymphoma

Autores
Fellner, María Dolores; Durand, Karina; Correa, Rita Mariel; Redini, Liliana; Yampolsky, Claudio; Colobraro, Antonio; Sevlever, Gustavo; Teyssie, Angelica R.; Benetucci, Jorge; Picconi, María Alejandra
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Fellner, María Dolores. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Durand, Karina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Correa, Rita Mariel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Redini, Liliana. FUNDAI. Laboratorio de Retrovirus y Virus asociados; Argentina.
Fil: Yampolsky, Claudio. Sanatorio Guemes. Servicio de Neurocirugía; Argentina.
Fil: Colobraro, Antonio. Instituto FLENI. Servicio de Patología; Argentina.
Fil: Sevlever, Gustavo. Instituto FLENI. Servicio de Patología; Argentina.
Fil: Teyssié, Angélica R. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Benetucci, Jorge. FUNDAI. Laboratorio de Retrovirus y Virus asociados; Argentina.
Fil: Picconi, María Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
OBJECTIVE To analyze Epstein-Barr virus (EBV) load at different HIV infection stages and its relation with brain lymphoma. DESIGN A cross-sectional study was conducted on 172 HIV-infected individuals: 62 asymptomatic HIV carriers (group A), 30 HIV progressors (group B), 73 AIDS patients (group C), seven AIDS patients with brain lymphoma (group C-BL); and 26 blood donors (group BD) as healthy carriers. EBV load was measured in peripheral blood mononuclear cells (PBMC) and plasma samples using a semi-quantitative PCR method. RESULTS PBMC-EBV levels in HIV-infected patients were higher than in the blood donors (p<0.05). No differences in PBMC-EBV loads were found in groups A, B, or C (p>0.05), while the C-BL group had significantly lower levels (p<0.05). Similar PBMC-EBV loads were seen in HIV-infected patients with CD4+ T cell counts higher than 50/mm(3) (p>0.05), while significantly lower levels were found in cases with less than 50 cells/mm(3) (p<0.05). In all HIV-infected patients, plasma-EBV load was lower than, or similar to, PBMC-EBV load, unlike 2/7 HIV-positive brain lymphoma patients. CONCLUSIONS During HIV infection PBMC-EBV load rises in comparison to healthy carriers, but decreases when immunosuppression progresses and CD4+ T cell count becomes <50/mm(3). Circulating EBV is mainly cell-associated in the HIV-infected population. Neither PBMC-EBV nor plasma-EBV loads would be useful to diagnose brain lymphoma in AIDS patients.
Fuente
International Journal of Infectious Diseases, 2007, 11(2), 172-178.
Materia
Herpesvirus Humano 4
VIH
Linfoma
Nivel de accesibilidad
acceso abierto
Condiciones de uso
none
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:123456789/426
Acceder
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oai_identifier_str oai:sgc.anlis.gob.ar:123456789/426
network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Circulating Epstein-Barr virus (EBV) in HIV-infected patients and its relation with primary brain lymphomaFellner, María DoloresDurand, KarinaCorrea, Rita MarielRedini, LilianaYampolsky, ClaudioColobraro, AntonioSevlever, GustavoTeyssie, Angelica R.Benetucci, JorgePicconi, María AlejandraHerpesvirus Humano 4VIHLinfomaFil: Fellner, María Dolores. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.Fil: Durand, Karina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.Fil: Correa, Rita Mariel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.Fil: Redini, Liliana. FUNDAI. Laboratorio de Retrovirus y Virus asociados; Argentina.Fil: Yampolsky, Claudio. Sanatorio Guemes. Servicio de Neurocirugía; Argentina.Fil: Colobraro, Antonio. Instituto FLENI. Servicio de Patología; Argentina.Fil: Sevlever, Gustavo. Instituto FLENI. Servicio de Patología; Argentina.Fil: Teyssié, Angélica R. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.Fil: Benetucci, Jorge. FUNDAI. Laboratorio de Retrovirus y Virus asociados; Argentina.Fil: Picconi, María Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.OBJECTIVE To analyze Epstein-Barr virus (EBV) load at different HIV infection stages and its relation with brain lymphoma. DESIGN A cross-sectional study was conducted on 172 HIV-infected individuals: 62 asymptomatic HIV carriers (group A), 30 HIV progressors (group B), 73 AIDS patients (group C), seven AIDS patients with brain lymphoma (group C-BL); and 26 blood donors (group BD) as healthy carriers. EBV load was measured in peripheral blood mononuclear cells (PBMC) and plasma samples using a semi-quantitative PCR method. RESULTS PBMC-EBV levels in HIV-infected patients were higher than in the blood donors (p<0.05). No differences in PBMC-EBV loads were found in groups A, B, or C (p>0.05), while the C-BL group had significantly lower levels (p<0.05). Similar PBMC-EBV loads were seen in HIV-infected patients with CD4+ T cell counts higher than 50/mm(3) (p>0.05), while significantly lower levels were found in cases with less than 50 cells/mm(3) (p<0.05). In all HIV-infected patients, plasma-EBV load was lower than, or similar to, PBMC-EBV load, unlike 2/7 HIV-positive brain lymphoma patients. CONCLUSIONS During HIV infection PBMC-EBV load rises in comparison to healthy carriers, but decreases when immunosuppression progresses and CD4+ T cell count becomes <50/mm(3). Circulating EBV is mainly cell-associated in the HIV-infected population. Neither PBMC-EBV nor plasma-EBV loads would be useful to diagnose brain lymphoma in AIDS patients.2007info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1201-9712http://sgc.anlis.gob.ar/handle/123456789/426https://www.ijidonline.com/action/showPdf?pii=S1201-9712%2806%2900084-1International Journal of Infectious Diseases, 2007, 11(2), 172-178.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseasesnoneinfo:eu-repo/semantics/openAccesseng2025-10-23T11:19:44Zoai:sgc.anlis.gob.ar:123456789/426Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-10-23 11:19:45.247Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Circulating Epstein-Barr virus (EBV) in HIV-infected patients and its relation with primary brain lymphoma
title Circulating Epstein-Barr virus (EBV) in HIV-infected patients and its relation with primary brain lymphoma
spellingShingle Circulating Epstein-Barr virus (EBV) in HIV-infected patients and its relation with primary brain lymphoma
Fellner, María Dolores
Herpesvirus Humano 4
VIH
Linfoma
title_short Circulating Epstein-Barr virus (EBV) in HIV-infected patients and its relation with primary brain lymphoma
title_full Circulating Epstein-Barr virus (EBV) in HIV-infected patients and its relation with primary brain lymphoma
title_fullStr Circulating Epstein-Barr virus (EBV) in HIV-infected patients and its relation with primary brain lymphoma
title_full_unstemmed Circulating Epstein-Barr virus (EBV) in HIV-infected patients and its relation with primary brain lymphoma
title_sort Circulating Epstein-Barr virus (EBV) in HIV-infected patients and its relation with primary brain lymphoma
dc.creator.none.fl_str_mv Fellner, María Dolores
Durand, Karina
Correa, Rita Mariel
Redini, Liliana
Yampolsky, Claudio
Colobraro, Antonio
Sevlever, Gustavo
Teyssie, Angelica R.
Benetucci, Jorge
Picconi, María Alejandra
author Fellner, María Dolores
author_facet Fellner, María Dolores
Durand, Karina
Correa, Rita Mariel
Redini, Liliana
Yampolsky, Claudio
Colobraro, Antonio
Sevlever, Gustavo
Teyssie, Angelica R.
Benetucci, Jorge
Picconi, María Alejandra
author_role author
author2 Durand, Karina
Correa, Rita Mariel
Redini, Liliana
Yampolsky, Claudio
Colobraro, Antonio
Sevlever, Gustavo
Teyssie, Angelica R.
Benetucci, Jorge
Picconi, María Alejandra
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Herpesvirus Humano 4
VIH
Linfoma
topic Herpesvirus Humano 4
VIH
Linfoma
dc.description.none.fl_txt_mv Fil: Fellner, María Dolores. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Durand, Karina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Correa, Rita Mariel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Redini, Liliana. FUNDAI. Laboratorio de Retrovirus y Virus asociados; Argentina.
Fil: Yampolsky, Claudio. Sanatorio Guemes. Servicio de Neurocirugía; Argentina.
Fil: Colobraro, Antonio. Instituto FLENI. Servicio de Patología; Argentina.
Fil: Sevlever, Gustavo. Instituto FLENI. Servicio de Patología; Argentina.
Fil: Teyssié, Angélica R. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Benetucci, Jorge. FUNDAI. Laboratorio de Retrovirus y Virus asociados; Argentina.
Fil: Picconi, María Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
OBJECTIVE To analyze Epstein-Barr virus (EBV) load at different HIV infection stages and its relation with brain lymphoma. DESIGN A cross-sectional study was conducted on 172 HIV-infected individuals: 62 asymptomatic HIV carriers (group A), 30 HIV progressors (group B), 73 AIDS patients (group C), seven AIDS patients with brain lymphoma (group C-BL); and 26 blood donors (group BD) as healthy carriers. EBV load was measured in peripheral blood mononuclear cells (PBMC) and plasma samples using a semi-quantitative PCR method. RESULTS PBMC-EBV levels in HIV-infected patients were higher than in the blood donors (p<0.05). No differences in PBMC-EBV loads were found in groups A, B, or C (p>0.05), while the C-BL group had significantly lower levels (p<0.05). Similar PBMC-EBV loads were seen in HIV-infected patients with CD4+ T cell counts higher than 50/mm(3) (p>0.05), while significantly lower levels were found in cases with less than 50 cells/mm(3) (p<0.05). In all HIV-infected patients, plasma-EBV load was lower than, or similar to, PBMC-EBV load, unlike 2/7 HIV-positive brain lymphoma patients. CONCLUSIONS During HIV infection PBMC-EBV load rises in comparison to healthy carriers, but decreases when immunosuppression progresses and CD4+ T cell count becomes <50/mm(3). Circulating EBV is mainly cell-associated in the HIV-infected population. Neither PBMC-EBV nor plasma-EBV loads would be useful to diagnose brain lymphoma in AIDS patients.
description Fil: Fellner, María Dolores. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
publishDate 2007
dc.date.none.fl_str_mv 2007
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1201-9712
http://sgc.anlis.gob.ar/handle/123456789/426
https://www.ijidonline.com/action/showPdf?pii=S1201-9712%2806%2900084-1
identifier_str_mv 1201-9712
url http://sgc.anlis.gob.ar/handle/123456789/426
https://www.ijidonline.com/action/showPdf?pii=S1201-9712%2806%2900084-1
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
dc.rights.none.fl_str_mv none
info:eu-repo/semantics/openAccess
rights_invalid_str_mv none
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv International Journal of Infectious Diseases, 2007, 11(2), 172-178.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
_version_ 1846788001850458112
score 12.471625

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