Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children

Autores
Viboud, Gloria I.; Jouve, Mabel J.; Binsztein, Norma; Vergara, Marta; Rivas, Marta; Quiroga, Marina; Svennerholm, Ann-Mari
Año de publicación
1999
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Viboud, Gloria I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Jouve, Mabel J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Binsztein, Norma. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Vergara, Marta. Universidad Nacional de Misiones. Cátedra de Bacteriología; Argentina.
Fil: Rivas, Marta. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Quiroga, Marina. Universidad Nacional de Misiones. Cátedra de Bacteriología; Argentina.
Fil: Svennerholm, Ann-Mari. University of Göteborg. Department of Medical Microbiology and Immunology; Suiza.
In a follow-up study, enterotoxigenic Escherichia coli (ETEC) infections in 145 children from two communities located in northeastern Argentina were monitored for 2 years. The occurrence of diarrhea was monitored by weekly household visits. Of 730 fecal specimens collected, 137 (19%) corresponded to diarrheal episodes. ETEC was isolated from a significantly higher proportion of symptomatic (18.3%) than asymptomatic (13.3%) children (P 5 0.04541). Individuals of up to 24 months of age were found to have a higher risk of developing ETEC diarrhea than older children (odds ratio [OR], 3.872; P 5 0.00021). When the toxin profiles were considered, only heat stable enterotoxin (ST)-producing ETEC was directly associated with diarrhea (P 5 0.00035). Fifty-five percent of the ETEC isolated from symptomatic children and 19% of the ETEC isolated from asymptomatic children expressed one of the colonization factors (CFs) investigated, i.e., CF antigen I (CFA/I), CFA/II, CFA/III, and CFA/IV; coli surface antigens CS7 and CS17; and putative CFs PCFO159, PCFO166, and PCFO20, indicating a clear association between diarrhea and ETEC strains that carry these factors (P 5 0.0000034). The most frequently identified CFs were CFA/IV (16%), CFA/I (10%), and CS17 (9%). CFs were mostly associated with ETEC strains that produce ST and both heat-labile enterotoxin and ST. Logistic regression analysis, applied to remove confounding effects, revealed that the expression of CFs was associated with illness independently of the toxin type (OR, 4.81; P 5 0.0003). When each CF was considered separately, CS17 was the only factor independently associated with illness (OR, 16.6; P 5 0.0151). Most CFs (the exception was CFA/IV) fell within a limited array of serotypes, while the CF-negative isolates belonged to many different O:H types. These results demonstrate that some CFs are risk factors for the development of ETEC diarrhea.
Fuente
Journal of Clinical Microbiology 1999; 37(9): 2829–2833.
Materia
Infecciones por Escherichia coli
Estudios de Cohortes
Lactante
Argentina
Escherichia coli
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:123456789/306

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oai_identifier_str oai:sgc.anlis.gob.ar:123456789/306
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network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean ChildrenViboud, Gloria I.Jouve, Mabel J.Binsztein, NormaVergara, MartaRivas, MartaQuiroga, MarinaSvennerholm, Ann-MariInfecciones por Escherichia coliEstudios de CohortesLactanteArgentinaEscherichia coliFil: Viboud, Gloria I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.Fil: Jouve, Mabel J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.Fil: Binsztein, Norma. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.Fil: Vergara, Marta. Universidad Nacional de Misiones. Cátedra de Bacteriología; Argentina.Fil: Rivas, Marta. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.Fil: Quiroga, Marina. Universidad Nacional de Misiones. Cátedra de Bacteriología; Argentina.Fil: Svennerholm, Ann-Mari. University of Göteborg. Department of Medical Microbiology and Immunology; Suiza.In a follow-up study, enterotoxigenic Escherichia coli (ETEC) infections in 145 children from two communities located in northeastern Argentina were monitored for 2 years. The occurrence of diarrhea was monitored by weekly household visits. Of 730 fecal specimens collected, 137 (19%) corresponded to diarrheal episodes. ETEC was isolated from a significantly higher proportion of symptomatic (18.3%) than asymptomatic (13.3%) children (P 5 0.04541). Individuals of up to 24 months of age were found to have a higher risk of developing ETEC diarrhea than older children (odds ratio [OR], 3.872; P 5 0.00021). When the toxin profiles were considered, only heat stable enterotoxin (ST)-producing ETEC was directly associated with diarrhea (P 5 0.00035). Fifty-five percent of the ETEC isolated from symptomatic children and 19% of the ETEC isolated from asymptomatic children expressed one of the colonization factors (CFs) investigated, i.e., CF antigen I (CFA/I), CFA/II, CFA/III, and CFA/IV; coli surface antigens CS7 and CS17; and putative CFs PCFO159, PCFO166, and PCFO20, indicating a clear association between diarrhea and ETEC strains that carry these factors (P 5 0.0000034). The most frequently identified CFs were CFA/IV (16%), CFA/I (10%), and CS17 (9%). CFs were mostly associated with ETEC strains that produce ST and both heat-labile enterotoxin and ST. Logistic regression analysis, applied to remove confounding effects, revealed that the expression of CFs was associated with illness independently of the toxin type (OR, 4.81; P 5 0.0003). When each CF was considered separately, CS17 was the only factor independently associated with illness (OR, 16.6; P 5 0.0151). Most CFs (the exception was CFA/IV) fell within a limited array of serotypes, while the CF-negative isolates belonged to many different O:H types. These results demonstrate that some CFs are risk factors for the development of ETEC diarrhea.American Society for Microbiology1999-09info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1098-660Xhttp://sgc.anlis.gob.ar/handle/123456789/306http://jcm.asm.org/content/37/9/2829.full.pdf+html10.1128/JCM.37.9.2829-2833.1999Journal of Clinical Microbiology 1999; 37(9): 2829–2833.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISJournal of clinical microbiologyARGenginfo:eu-repo/semantics/openAccess2025-09-29T14:29:57Zoai:sgc.anlis.gob.ar:123456789/306Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:29:57.852Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children
title Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children
spellingShingle Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children
Viboud, Gloria I.
Infecciones por Escherichia coli
Estudios de Cohortes
Lactante
Argentina
Escherichia coli
title_short Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children
title_full Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children
title_fullStr Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children
title_full_unstemmed Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children
title_sort Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children
dc.creator.none.fl_str_mv Viboud, Gloria I.
Jouve, Mabel J.
Binsztein, Norma
Vergara, Marta
Rivas, Marta
Quiroga, Marina
Svennerholm, Ann-Mari
author Viboud, Gloria I.
author_facet Viboud, Gloria I.
Jouve, Mabel J.
Binsztein, Norma
Vergara, Marta
Rivas, Marta
Quiroga, Marina
Svennerholm, Ann-Mari
author_role author
author2 Jouve, Mabel J.
Binsztein, Norma
Vergara, Marta
Rivas, Marta
Quiroga, Marina
Svennerholm, Ann-Mari
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Infecciones por Escherichia coli
Estudios de Cohortes
Lactante
Argentina
Escherichia coli
topic Infecciones por Escherichia coli
Estudios de Cohortes
Lactante
Argentina
Escherichia coli
dc.description.none.fl_txt_mv Fil: Viboud, Gloria I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Jouve, Mabel J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Binsztein, Norma. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Vergara, Marta. Universidad Nacional de Misiones. Cátedra de Bacteriología; Argentina.
Fil: Rivas, Marta. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Quiroga, Marina. Universidad Nacional de Misiones. Cátedra de Bacteriología; Argentina.
Fil: Svennerholm, Ann-Mari. University of Göteborg. Department of Medical Microbiology and Immunology; Suiza.
In a follow-up study, enterotoxigenic Escherichia coli (ETEC) infections in 145 children from two communities located in northeastern Argentina were monitored for 2 years. The occurrence of diarrhea was monitored by weekly household visits. Of 730 fecal specimens collected, 137 (19%) corresponded to diarrheal episodes. ETEC was isolated from a significantly higher proportion of symptomatic (18.3%) than asymptomatic (13.3%) children (P 5 0.04541). Individuals of up to 24 months of age were found to have a higher risk of developing ETEC diarrhea than older children (odds ratio [OR], 3.872; P 5 0.00021). When the toxin profiles were considered, only heat stable enterotoxin (ST)-producing ETEC was directly associated with diarrhea (P 5 0.00035). Fifty-five percent of the ETEC isolated from symptomatic children and 19% of the ETEC isolated from asymptomatic children expressed one of the colonization factors (CFs) investigated, i.e., CF antigen I (CFA/I), CFA/II, CFA/III, and CFA/IV; coli surface antigens CS7 and CS17; and putative CFs PCFO159, PCFO166, and PCFO20, indicating a clear association between diarrhea and ETEC strains that carry these factors (P 5 0.0000034). The most frequently identified CFs were CFA/IV (16%), CFA/I (10%), and CS17 (9%). CFs were mostly associated with ETEC strains that produce ST and both heat-labile enterotoxin and ST. Logistic regression analysis, applied to remove confounding effects, revealed that the expression of CFs was associated with illness independently of the toxin type (OR, 4.81; P 5 0.0003). When each CF was considered separately, CS17 was the only factor independently associated with illness (OR, 16.6; P 5 0.0151). Most CFs (the exception was CFA/IV) fell within a limited array of serotypes, while the CF-negative isolates belonged to many different O:H types. These results demonstrate that some CFs are risk factors for the development of ETEC diarrhea.
description Fil: Viboud, Gloria I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
publishDate 1999
dc.date.none.fl_str_mv 1999-09
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1098-660X
http://sgc.anlis.gob.ar/handle/123456789/306
http://jcm.asm.org/content/37/9/2829.full.pdf+html
10.1128/JCM.37.9.2829-2833.1999
identifier_str_mv 1098-660X
10.1128/JCM.37.9.2829-2833.1999
url http://sgc.anlis.gob.ar/handle/123456789/306
http://jcm.asm.org/content/37/9/2829.full.pdf+html
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of clinical microbiology
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv ARG
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv Journal of Clinical Microbiology 1999; 37(9): 2829–2833.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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