Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children
- Autores
- Viboud, Gloria I.; Jouve, Mabel J.; Binsztein, Norma; Vergara, Marta; Rivas, Marta; Quiroga, Marina; Svennerholm, Ann-Mari
- Año de publicación
- 1999
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Viboud, Gloria I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Jouve, Mabel J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Binsztein, Norma. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Vergara, Marta. Universidad Nacional de Misiones. Cátedra de Bacteriología; Argentina.
Fil: Rivas, Marta. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Quiroga, Marina. Universidad Nacional de Misiones. Cátedra de Bacteriología; Argentina.
Fil: Svennerholm, Ann-Mari. University of Göteborg. Department of Medical Microbiology and Immunology; Suiza.
In a follow-up study, enterotoxigenic Escherichia coli (ETEC) infections in 145 children from two communities located in northeastern Argentina were monitored for 2 years. The occurrence of diarrhea was monitored by weekly household visits. Of 730 fecal specimens collected, 137 (19%) corresponded to diarrheal episodes. ETEC was isolated from a significantly higher proportion of symptomatic (18.3%) than asymptomatic (13.3%) children (P 5 0.04541). Individuals of up to 24 months of age were found to have a higher risk of developing ETEC diarrhea than older children (odds ratio [OR], 3.872; P 5 0.00021). When the toxin profiles were considered, only heat stable enterotoxin (ST)-producing ETEC was directly associated with diarrhea (P 5 0.00035). Fifty-five percent of the ETEC isolated from symptomatic children and 19% of the ETEC isolated from asymptomatic children expressed one of the colonization factors (CFs) investigated, i.e., CF antigen I (CFA/I), CFA/II, CFA/III, and CFA/IV; coli surface antigens CS7 and CS17; and putative CFs PCFO159, PCFO166, and PCFO20, indicating a clear association between diarrhea and ETEC strains that carry these factors (P 5 0.0000034). The most frequently identified CFs were CFA/IV (16%), CFA/I (10%), and CS17 (9%). CFs were mostly associated with ETEC strains that produce ST and both heat-labile enterotoxin and ST. Logistic regression analysis, applied to remove confounding effects, revealed that the expression of CFs was associated with illness independently of the toxin type (OR, 4.81; P 5 0.0003). When each CF was considered separately, CS17 was the only factor independently associated with illness (OR, 16.6; P 5 0.0151). Most CFs (the exception was CFA/IV) fell within a limited array of serotypes, while the CF-negative isolates belonged to many different O:H types. These results demonstrate that some CFs are risk factors for the development of ETEC diarrhea. - Fuente
- Journal of Clinical Microbiology 1999; 37(9): 2829–2833.
- Materia
-
Infecciones por Escherichia coli
Estudios de Cohortes
Lactante
Argentina
Escherichia coli - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Repositorio
- Institución
- Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
- OAI Identificador
- oai:sgc.anlis.gob.ar:Publications/123456789/306
Ver los metadatos del registro completo
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Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean ChildrenViboud, Gloria I.Jouve, Mabel J.Binsztein, NormaVergara, MartaRivas, MartaQuiroga, MarinaSvennerholm, Ann-MariInfecciones por Escherichia coliEstudios de CohortesLactanteArgentinaEscherichia coliFil: Viboud, Gloria I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.Fil: Jouve, Mabel J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.Fil: Binsztein, Norma. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.Fil: Vergara, Marta. Universidad Nacional de Misiones. Cátedra de Bacteriología; Argentina.Fil: Rivas, Marta. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.Fil: Quiroga, Marina. Universidad Nacional de Misiones. Cátedra de Bacteriología; Argentina.Fil: Svennerholm, Ann-Mari. University of Göteborg. Department of Medical Microbiology and Immunology; Suiza.In a follow-up study, enterotoxigenic Escherichia coli (ETEC) infections in 145 children from two communities located in northeastern Argentina were monitored for 2 years. The occurrence of diarrhea was monitored by weekly household visits. Of 730 fecal specimens collected, 137 (19%) corresponded to diarrheal episodes. ETEC was isolated from a significantly higher proportion of symptomatic (18.3%) than asymptomatic (13.3%) children (P 5 0.04541). Individuals of up to 24 months of age were found to have a higher risk of developing ETEC diarrhea than older children (odds ratio [OR], 3.872; P 5 0.00021). When the toxin profiles were considered, only heat stable enterotoxin (ST)-producing ETEC was directly associated with diarrhea (P 5 0.00035). Fifty-five percent of the ETEC isolated from symptomatic children and 19% of the ETEC isolated from asymptomatic children expressed one of the colonization factors (CFs) investigated, i.e., CF antigen I (CFA/I), CFA/II, CFA/III, and CFA/IV; coli surface antigens CS7 and CS17; and putative CFs PCFO159, PCFO166, and PCFO20, indicating a clear association between diarrhea and ETEC strains that carry these factors (P 5 0.0000034). The most frequently identified CFs were CFA/IV (16%), CFA/I (10%), and CS17 (9%). CFs were mostly associated with ETEC strains that produce ST and both heat-labile enterotoxin and ST. Logistic regression analysis, applied to remove confounding effects, revealed that the expression of CFs was associated with illness independently of the toxin type (OR, 4.81; P 5 0.0003). When each CF was considered separately, CS17 was the only factor independently associated with illness (OR, 16.6; P 5 0.0151). Most CFs (the exception was CFA/IV) fell within a limited array of serotypes, while the CF-negative isolates belonged to many different O:H types. These results demonstrate that some CFs are risk factors for the development of ETEC diarrhea.American Society for Microbiology1999-09info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1098-660Xhttp://sgc.anlis.gob.ar/handle/123456789/306http://jcm.asm.org/content/37/9/2829.full.pdf+html10.1128/JCM.37.9.2829-2833.1999Journal of Clinical Microbiology 1999; 37(9): 2829–2833.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISJournal of clinical microbiologyARGenginfo:eu-repo/semantics/openAccess2025-09-29T14:29:57Zoai:sgc.anlis.gob.ar:Publications/123456789/306Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:29:57.855Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false |
dc.title.none.fl_str_mv |
Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children |
title |
Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children |
spellingShingle |
Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children Viboud, Gloria I. Infecciones por Escherichia coli Estudios de Cohortes Lactante Argentina Escherichia coli |
title_short |
Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children |
title_full |
Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children |
title_fullStr |
Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children |
title_full_unstemmed |
Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children |
title_sort |
Prospective Cohort Study of Enterotoxigenic Escherichia coli Infections in Argentinean Children |
dc.creator.none.fl_str_mv |
Viboud, Gloria I. Jouve, Mabel J. Binsztein, Norma Vergara, Marta Rivas, Marta Quiroga, Marina Svennerholm, Ann-Mari |
author |
Viboud, Gloria I. |
author_facet |
Viboud, Gloria I. Jouve, Mabel J. Binsztein, Norma Vergara, Marta Rivas, Marta Quiroga, Marina Svennerholm, Ann-Mari |
author_role |
author |
author2 |
Jouve, Mabel J. Binsztein, Norma Vergara, Marta Rivas, Marta Quiroga, Marina Svennerholm, Ann-Mari |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Infecciones por Escherichia coli Estudios de Cohortes Lactante Argentina Escherichia coli |
topic |
Infecciones por Escherichia coli Estudios de Cohortes Lactante Argentina Escherichia coli |
dc.description.none.fl_txt_mv |
Fil: Viboud, Gloria I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina. Fil: Jouve, Mabel J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina. Fil: Binsztein, Norma. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina. Fil: Vergara, Marta. Universidad Nacional de Misiones. Cátedra de Bacteriología; Argentina. Fil: Rivas, Marta. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina. Fil: Quiroga, Marina. Universidad Nacional de Misiones. Cátedra de Bacteriología; Argentina. Fil: Svennerholm, Ann-Mari. University of Göteborg. Department of Medical Microbiology and Immunology; Suiza. In a follow-up study, enterotoxigenic Escherichia coli (ETEC) infections in 145 children from two communities located in northeastern Argentina were monitored for 2 years. The occurrence of diarrhea was monitored by weekly household visits. Of 730 fecal specimens collected, 137 (19%) corresponded to diarrheal episodes. ETEC was isolated from a significantly higher proportion of symptomatic (18.3%) than asymptomatic (13.3%) children (P 5 0.04541). Individuals of up to 24 months of age were found to have a higher risk of developing ETEC diarrhea than older children (odds ratio [OR], 3.872; P 5 0.00021). When the toxin profiles were considered, only heat stable enterotoxin (ST)-producing ETEC was directly associated with diarrhea (P 5 0.00035). Fifty-five percent of the ETEC isolated from symptomatic children and 19% of the ETEC isolated from asymptomatic children expressed one of the colonization factors (CFs) investigated, i.e., CF antigen I (CFA/I), CFA/II, CFA/III, and CFA/IV; coli surface antigens CS7 and CS17; and putative CFs PCFO159, PCFO166, and PCFO20, indicating a clear association between diarrhea and ETEC strains that carry these factors (P 5 0.0000034). The most frequently identified CFs were CFA/IV (16%), CFA/I (10%), and CS17 (9%). CFs were mostly associated with ETEC strains that produce ST and both heat-labile enterotoxin and ST. Logistic regression analysis, applied to remove confounding effects, revealed that the expression of CFs was associated with illness independently of the toxin type (OR, 4.81; P 5 0.0003). When each CF was considered separately, CS17 was the only factor independently associated with illness (OR, 16.6; P 5 0.0151). Most CFs (the exception was CFA/IV) fell within a limited array of serotypes, while the CF-negative isolates belonged to many different O:H types. These results demonstrate that some CFs are risk factors for the development of ETEC diarrhea. |
description |
Fil: Viboud, Gloria I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-09 |
dc.type.none.fl_str_mv |
info:ar-repo/semantics/articulo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
1098-660X http://sgc.anlis.gob.ar/handle/123456789/306 http://jcm.asm.org/content/37/9/2829.full.pdf+html 10.1128/JCM.37.9.2829-2833.1999 |
identifier_str_mv |
1098-660X 10.1128/JCM.37.9.2829-2833.1999 |
url |
http://sgc.anlis.gob.ar/handle/123456789/306 http://jcm.asm.org/content/37/9/2829.full.pdf+html |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of clinical microbiology |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.coverage.none.fl_str_mv |
ARG |
dc.publisher.none.fl_str_mv |
American Society for Microbiology |
publisher.none.fl_str_mv |
American Society for Microbiology |
dc.source.none.fl_str_mv |
Journal of Clinical Microbiology 1999; 37(9): 2829–2833. reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" instacron:ANLIS |
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Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
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Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
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