The need of a neonatal preparation for Chagas disease

• Autores: Sosa-Estani, Sergio; Belizán, José M.; Althabe, Fernando; Rubinstein, Aldofo
• Año de publicación: 2005
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: PLoS medicine 2005; 2(11):e387.
• Materia: Recién Nacido; Enfermedad de Chagas
• Institución: Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"

Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación en Endemo-Epidemias; Argentina.
Fil: Belizan, Jose M. Department of Mother and Child Health Research, Institute for Clinical Effectiveness and Health Policy (IECS), Buenos Aires; Argentina.
Fil: Althabe, Fernando. Department of Mother and Child Health Research, Institute for Clinical Effectiveness and Health Policy (IECS), Buenos Aires; Argentina.
Fil: Rubinstein, Aldofo. Institute for Clinical Effectiveness and Health Policy, Buenos Aires; Argentina.
We have read about the efforts and initiatives related to the design of drugs for parasitic diseases in McKerrow's article [1] with interest and expectation. One of the pressing needs in this area is for a neonatal preparation for Chagas disease. Satisfactory achievements have been made in Argentina in relation to the transmission of the disease by vectors and through blood transfusion [2,3]. Vertical transmission is now the great challenge in eradicating Chagas disease. Around 800–1,300 neonates infected with Trypanosmoma cruzi are born every year in our country [4]. Almost 99% of all births occur in hospital, thus allowing the detection of infants born with parasites immediately after birth. The initiation of treatment of these neonates before they and their mothers leave the hospital is a good strategy to obtain high treatment coverage. The later attendance of mothers with their children to health-care facilities is quite unpredictable and irregular. Also, it is difficult to link information about maternal and neonatal parasitic status obtained at birth with later attendance at other health-care facilities.