Buenos Aires cohort of men who have sex with men: prevalence, incidence, risk factors, and molecular genotyping of HIV type 1

• Autores: Segura, Marcela; Sosa-Estani, Sergio; Marone, Rubén; Bautista, Christian; Pando, María A.; Eyzaguirre, Lindsay; Sánchez, José L; Carr, Jean K; Montano, Silvia M; Weissenbacher, Mercedes C.; Avila, María M.
• Año de publicación: 2007
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: VIH-1; Infecciones por VIH; Homosexualidad Masculina; Argentina
• Institución: Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"

Fil: Segura, Marcela. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología, Parasitología e Inmunología. Centro Nacional de Referencias para el SIDA; Argentina.
Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación de Endemoepidemias; Argentina.
Fil: Marone, Rubén. NEXO Asociación Civil; Argentina.
Fil: Bautista, Christian. U.S. Naval Medical Research Center Detachment; Perú.
Fil: Pando, María A. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología, Parasitología e Inmunología. Centro Nacional de Referencias para el SIDA; Argentina.
Fil: Eyzaguirre, Lindsay. University of Maryland Biotechnology Institute. Institute of Human Virology. Division of Epidemiology and Prevention; Estados Unidos.
Fil: Sánchez, José L. Department of Defense Global Emerging Infections Surveillance and Response System; Estados Unidos.
Fil: Carr, Jean K. University of Maryland Biotechnology Institute. Institute of Human Virology. Division of Epidemiology and Prevention; Estados Unidos.
Fil: Montano, Silvia M. U.S. Naval Medical Research Center Detachment; Perú.
Fil: Weissenbacher, Mercedes C. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología, Parasitología e Inmunología. Centro Nacional de Referencias para el SIDA; Argentina.
Fil: Avila, María M. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología, Parasitología e Inmunología. Centro Nacional de Referencias para el SIDA; Argentina.
The prevalence, incidence, risk factors, and molecular genotyping of HIV-1 infection among men who have sex with men (MSM) were assessed through a prospective cohort study. The study was conducted in Buenos Aires from February 2003 to December 2004. Sociodemographic, sexual risk behavior data, and blood samples for HIV testing were collected at baseline and at 6 and 12 months. Cox regression analysis was applied to determine risk factors associated with HIV seroconversion. HIV-positive samples were analyzed by partial (pro/RT) and full-length genome sequencing. Of 811 HIV-negative participants evaluated at baseline, 327 volunteers that fulfilled the inclusion criteria were enrolled. Retention rates at 6 and 12 months were 97.2% and 91.5%, respectively. Twelve MSM seroconverted for HIV infection [incidence rate = 3.9 (95% CI = 2.0-6.7) per 100 person-years]. HIV seroconversion was associated with a greater number of different sexual contacts in the preceding 6 months (> or =10, hazard ratio = 3.3, 95% CI: 1.1-10.4). By partial pro/RT genotyping analysis, 83% HIV-positive samples were subtype B and 17% samples were BF recombinants, most of these being unique recombinant forms. This study describes for the first time the recruitment and follow-up of a cohort of MSM in Argentina. Retention rates and HIV incidence rate were high. These data should be considered as a promising potential population for HIV vaccine trials.