Buenos Aires cohort of men who have sex with men: Prevalence, incidence, risk factors, and molecular genotyping of HIV type 1

Autores
Segura, Marcela; Sosa-Estani, Sergio Alejandro; Marone, Rubén; Bautista, Christian T.; Pando, María de los Ángeles; Eyzaguirre, Lindsay; Sánchez, José L.; Carr, Jean K.; Montano, Silvia M.; Weissenbacher, Mercedes Crecencia; Avila, Maria Mercedes
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The prevalence, incidence, risk factors, and molecular genotyping of HIV-1 infection among men who have sex with men (MSM) were assessed through a prospective cohort study. The study was conducted in Buenos Aires from February 2003 to December 2004. Sociodemographic, sexual risk behavior data, and blood samples for HIV testing were collected at baseline and at 6 and 12 months. Cox regression analysis was applied to determine risk factors associated with HIV seroconversion. HIV-positive samples were analyzed by partial (pro/RT) and full-length genome sequencing. Of 811 HIV-negative participants evaluated at baseline, 327 volunteers that fulfilled the inclusion criteria were enrolled. Retention rates at 6 and 12 months were 97.2% and 91.5%, respectively. Twelve MSM seroconverted for HIV infection [incidence rate = 3.9 (95% CI = 2.0-6.7) per 100 person-years]. HIV seroconversion was associated with a greater number of different sexual contacts in the preceding 6 months (≥10, hazard ratio = 3.3, 95% CI: 1.1-10.4). By partial pro/RT genotyping analysis, 83% HIV-positive samples were subtype B and 17% samples were BF recombinants, most of these being unique recombinant forms. This study describes for the first time the recruitment and follow-up of a cohort of MSM in Argentina. Retention rates and HIV incidence rate were high. These data should be considered as a promising potential population for HIV vaccine trials.
Fil: Segura, Marcela. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina
Fil: Sosa-Estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Marone, Rubén. No especifíca;
Fil: Bautista, Christian T.. Naval Medical Research Center Detachment; Perú
Fil: Pando, María de los Ángeles. University of Maryland; Estados Unidos. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Eyzaguirre, Lindsay. University of Maryland; Estados Unidos
Fil: Sánchez, José L.. No especifíca;
Fil: Carr, Jean K.. University of Maryland; Estados Unidos
Fil: Montano, Silvia M.. Naval Medical Research Center Detachment; Perú
Fil: Weissenbacher, Mercedes Crecencia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Avila, Maria Mercedes. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Materia
HIV
MSM
Cohort
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/163025
Acceder
id CONICETDig_6cb47cca3a6b991ce19fb58f27177dfe
oai_identifier_str oai:ri.conicet.gov.ar:11336/163025
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Buenos Aires cohort of men who have sex with men: Prevalence, incidence, risk factors, and molecular genotyping of HIV type 1Segura, MarcelaSosa-Estani, Sergio AlejandroMarone, RubénBautista, Christian T.Pando, María de los ÁngelesEyzaguirre, LindsaySánchez, José L.Carr, Jean K.Montano, Silvia M.Weissenbacher, Mercedes CrecenciaAvila, Maria MercedesHIVMSMCohorthttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The prevalence, incidence, risk factors, and molecular genotyping of HIV-1 infection among men who have sex with men (MSM) were assessed through a prospective cohort study. The study was conducted in Buenos Aires from February 2003 to December 2004. Sociodemographic, sexual risk behavior data, and blood samples for HIV testing were collected at baseline and at 6 and 12 months. Cox regression analysis was applied to determine risk factors associated with HIV seroconversion. HIV-positive samples were analyzed by partial (pro/RT) and full-length genome sequencing. Of 811 HIV-negative participants evaluated at baseline, 327 volunteers that fulfilled the inclusion criteria were enrolled. Retention rates at 6 and 12 months were 97.2% and 91.5%, respectively. Twelve MSM seroconverted for HIV infection [incidence rate = 3.9 (95% CI = 2.0-6.7) per 100 person-years]. HIV seroconversion was associated with a greater number of different sexual contacts in the preceding 6 months (≥10, hazard ratio = 3.3, 95% CI: 1.1-10.4). By partial pro/RT genotyping analysis, 83% HIV-positive samples were subtype B and 17% samples were BF recombinants, most of these being unique recombinant forms. This study describes for the first time the recruitment and follow-up of a cohort of MSM in Argentina. Retention rates and HIV incidence rate were high. These data should be considered as a promising potential population for HIV vaccine trials.Fil: Segura, Marcela. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; ArgentinaFil: Sosa-Estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Marone, Rubén. No especifíca;Fil: Bautista, Christian T.. Naval Medical Research Center Detachment; PerúFil: Pando, María de los Ángeles. University of Maryland; Estados Unidos. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Eyzaguirre, Lindsay. University of Maryland; Estados UnidosFil: Sánchez, José L.. No especifíca;Fil: Carr, Jean K.. University of Maryland; Estados UnidosFil: Montano, Silvia M.. Naval Medical Research Center Detachment; PerúFil: Weissenbacher, Mercedes Crecencia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Avila, Maria Mercedes. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaMary Ann Liebert2007-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/163025Segura, Marcela; Sosa-Estani, Sergio Alejandro; Marone, Rubén; Bautista, Christian T.; Pando, María de los Ángeles; et al.; Buenos Aires cohort of men who have sex with men: Prevalence, incidence, risk factors, and molecular genotyping of HIV type 1; Mary Ann Liebert; Aids Research and Human Retroviruses; 23; 11; 12-2007; 1322-13290889-2229CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1089/aid.2007.0063info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:31Zoai:ri.conicet.gov.ar:11336/163025instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:31.916CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Buenos Aires cohort of men who have sex with men: Prevalence, incidence, risk factors, and molecular genotyping of HIV type 1
title Buenos Aires cohort of men who have sex with men: Prevalence, incidence, risk factors, and molecular genotyping of HIV type 1
spellingShingle Buenos Aires cohort of men who have sex with men: Prevalence, incidence, risk factors, and molecular genotyping of HIV type 1
Segura, Marcela
HIV
MSM
Cohort
title_short Buenos Aires cohort of men who have sex with men: Prevalence, incidence, risk factors, and molecular genotyping of HIV type 1
title_full Buenos Aires cohort of men who have sex with men: Prevalence, incidence, risk factors, and molecular genotyping of HIV type 1
title_fullStr Buenos Aires cohort of men who have sex with men: Prevalence, incidence, risk factors, and molecular genotyping of HIV type 1
title_full_unstemmed Buenos Aires cohort of men who have sex with men: Prevalence, incidence, risk factors, and molecular genotyping of HIV type 1
title_sort Buenos Aires cohort of men who have sex with men: Prevalence, incidence, risk factors, and molecular genotyping of HIV type 1
dc.creator.none.fl_str_mv Segura, Marcela
Sosa-Estani, Sergio Alejandro
Marone, Rubén
Bautista, Christian T.
Pando, María de los Ángeles
Eyzaguirre, Lindsay
Sánchez, José L.
Carr, Jean K.
Montano, Silvia M.
Weissenbacher, Mercedes Crecencia
Avila, Maria Mercedes
author Segura, Marcela
author_facet Segura, Marcela
Sosa-Estani, Sergio Alejandro
Marone, Rubén
Bautista, Christian T.
Pando, María de los Ángeles
Eyzaguirre, Lindsay
Sánchez, José L.
Carr, Jean K.
Montano, Silvia M.
Weissenbacher, Mercedes Crecencia
Avila, Maria Mercedes
author_role author
author2 Sosa-Estani, Sergio Alejandro
Marone, Rubén
Bautista, Christian T.
Pando, María de los Ángeles
Eyzaguirre, Lindsay
Sánchez, José L.
Carr, Jean K.
Montano, Silvia M.
Weissenbacher, Mercedes Crecencia
Avila, Maria Mercedes
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HIV
MSM
Cohort
topic HIV
MSM
Cohort
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The prevalence, incidence, risk factors, and molecular genotyping of HIV-1 infection among men who have sex with men (MSM) were assessed through a prospective cohort study. The study was conducted in Buenos Aires from February 2003 to December 2004. Sociodemographic, sexual risk behavior data, and blood samples for HIV testing were collected at baseline and at 6 and 12 months. Cox regression analysis was applied to determine risk factors associated with HIV seroconversion. HIV-positive samples were analyzed by partial (pro/RT) and full-length genome sequencing. Of 811 HIV-negative participants evaluated at baseline, 327 volunteers that fulfilled the inclusion criteria were enrolled. Retention rates at 6 and 12 months were 97.2% and 91.5%, respectively. Twelve MSM seroconverted for HIV infection [incidence rate = 3.9 (95% CI = 2.0-6.7) per 100 person-years]. HIV seroconversion was associated with a greater number of different sexual contacts in the preceding 6 months (≥10, hazard ratio = 3.3, 95% CI: 1.1-10.4). By partial pro/RT genotyping analysis, 83% HIV-positive samples were subtype B and 17% samples were BF recombinants, most of these being unique recombinant forms. This study describes for the first time the recruitment and follow-up of a cohort of MSM in Argentina. Retention rates and HIV incidence rate were high. These data should be considered as a promising potential population for HIV vaccine trials.
Fil: Segura, Marcela. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina
Fil: Sosa-Estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Marone, Rubén. No especifíca;
Fil: Bautista, Christian T.. Naval Medical Research Center Detachment; Perú
Fil: Pando, María de los Ángeles. University of Maryland; Estados Unidos. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Eyzaguirre, Lindsay. University of Maryland; Estados Unidos
Fil: Sánchez, José L.. No especifíca;
Fil: Carr, Jean K.. University of Maryland; Estados Unidos
Fil: Montano, Silvia M.. Naval Medical Research Center Detachment; Perú
Fil: Weissenbacher, Mercedes Crecencia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Avila, Maria Mercedes. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Cátedra de Microbiología, Parasitología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
description The prevalence, incidence, risk factors, and molecular genotyping of HIV-1 infection among men who have sex with men (MSM) were assessed through a prospective cohort study. The study was conducted in Buenos Aires from February 2003 to December 2004. Sociodemographic, sexual risk behavior data, and blood samples for HIV testing were collected at baseline and at 6 and 12 months. Cox regression analysis was applied to determine risk factors associated with HIV seroconversion. HIV-positive samples were analyzed by partial (pro/RT) and full-length genome sequencing. Of 811 HIV-negative participants evaluated at baseline, 327 volunteers that fulfilled the inclusion criteria were enrolled. Retention rates at 6 and 12 months were 97.2% and 91.5%, respectively. Twelve MSM seroconverted for HIV infection [incidence rate = 3.9 (95% CI = 2.0-6.7) per 100 person-years]. HIV seroconversion was associated with a greater number of different sexual contacts in the preceding 6 months (≥10, hazard ratio = 3.3, 95% CI: 1.1-10.4). By partial pro/RT genotyping analysis, 83% HIV-positive samples were subtype B and 17% samples were BF recombinants, most of these being unique recombinant forms. This study describes for the first time the recruitment and follow-up of a cohort of MSM in Argentina. Retention rates and HIV incidence rate were high. These data should be considered as a promising potential population for HIV vaccine trials.
publishDate 2007
dc.date.none.fl_str_mv 2007-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/163025
Segura, Marcela; Sosa-Estani, Sergio Alejandro; Marone, Rubén; Bautista, Christian T.; Pando, María de los Ángeles; et al.; Buenos Aires cohort of men who have sex with men: Prevalence, incidence, risk factors, and molecular genotyping of HIV type 1; Mary Ann Liebert; Aids Research and Human Retroviruses; 23; 11; 12-2007; 1322-1329
0889-2229
CONICET Digital
CONICET
url http://hdl.handle.net/11336/163025
identifier_str_mv Segura, Marcela; Sosa-Estani, Sergio Alejandro; Marone, Rubén; Bautista, Christian T.; Pando, María de los Ángeles; et al.; Buenos Aires cohort of men who have sex with men: Prevalence, incidence, risk factors, and molecular genotyping of HIV type 1; Mary Ann Liebert; Aids Research and Human Retroviruses; 23; 11; 12-2007; 1322-1329
0889-2229
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1089/aid.2007.0063
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269915172569088
score 13.13397

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