Potential for Co-Infection of a Mosquito-Specific Flavivirus, Nhumirim Virus, to Block West Nile Virus Transmission in Mosquitoes

Autores
Goenaga, Silvina; Kenney, Joan L; Duggal, Nisha K; Delorey, Mark; Ebel, Gregory D; Zhang, Bo; Levis, Silvana; Enria, Delia; Brault, Aaron C
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Goenaga, Silvina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Kenney, Joan L. Centers for Disease Control and Prevention. Division of Vector-Borne Diseases, Fort Collins, Colorado; Estados Unidos.
Fil: Duggal, Nisha K. Centers for Disease Control and Prevention. Division of Vector-Borne Diseases, Fort Collins, Colorado; Estados Unidos.
Fil: Delorey, Mark. Centers for Disease Control and Prevention. Division of Vector-Borne Diseases, Fort Collins, Colorado; Estados Unidos.
Fil: Ebel, Gregory D. Colorado State University. Immunology and Pathology. Department of Microbiology, Fort Collins, Colorado; Estados Unidos.
Fil: Zhang, Bo. Chinese Academy of Sciences. Wuhan Institute of Virology, Wuhan, Hubei; China.
Fil: Levis, Silvana C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Enria, Delia A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina. Chinese Academy of Sciences. Wuhan Institute of Virology, Wuhan, Hubei; China.
Fil: Brault, Aaron C. Centers for Disease Control and Prevention. Division of Vector-Borne Diseases, Fort Collins, Colorado; Estados Unidos.
Nhumirim virus (NHUV) is an insect-specific virus that phylogenetically affiliates with dual-host mosquito-borne flaviviruses. Previous in vitro co-infection experiments demonstrated prior or concurrent infection of Aedes albopictus C6/36 mosquito cells with NHUV resulted in a 10,000-fold reduction in viral production of West Nile virus (WNV). This interference between WNV and NHUV was observed herein in an additional Ae. albopictus mosquito cell line, C7-10. A WNV 2K peptide (V9M) mutant capable of superinfection with a pre-established WNV infection demonstrated a comparable level of interference from NHUV as the parental WNV strain in C6/36 and C7-10 cells. Culex quinquefasciatus and Culex pipiens mosquitoes intrathoracically inoculated with NHUVandWNV, or solely withWNVas a control, were allowed to extrinsically incubate the viruses up to nine and 14 days, respectively, and transmissibility and replication of WNV was determined. The proportion of Cx. quinquefasciatus mosquitoes capable of transmitting WNV was significantly lower for the WNV/NHUV group than the WNV control at seven and nine days post inoculation (dpi), while no differences were observed in the Cx. pipiens inoculation group. By dpi nine, a 40% reduction in transmissibility in mosquitoes from the dual inoculation group was observed compared to the WNV-only control. These data indicate the potential that infection of some Culex spp. vectors with NHUV could serve as a barrier for efficient transmissibility of flaviviruses associated with human disease.
Fuente
Viruses 2015;7(11):5801-5812
Materia
Control de Mosquitos
Presas
Flavivirus
Fiebre del Nilo Occidental
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:123456789/2143

id SGCANLIS_73f9efe08c8ba104dd7a601bf8fa429b
oai_identifier_str oai:sgc.anlis.gob.ar:123456789/2143
network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Potential for Co-Infection of a Mosquito-Specific Flavivirus, Nhumirim Virus, to Block West Nile Virus Transmission in MosquitoesGoenaga, SilvinaKenney, Joan LDuggal, Nisha KDelorey, MarkEbel, Gregory DZhang, BoLevis, SilvanaEnria, DeliaBrault, Aaron CControl de MosquitosPresasFlavivirusFiebre del Nilo OccidentalFil: Goenaga, Silvina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: Kenney, Joan L. Centers for Disease Control and Prevention. Division of Vector-Borne Diseases, Fort Collins, Colorado; Estados Unidos.Fil: Duggal, Nisha K. Centers for Disease Control and Prevention. Division of Vector-Borne Diseases, Fort Collins, Colorado; Estados Unidos.Fil: Delorey, Mark. Centers for Disease Control and Prevention. Division of Vector-Borne Diseases, Fort Collins, Colorado; Estados Unidos.Fil: Ebel, Gregory D. Colorado State University. Immunology and Pathology. Department of Microbiology, Fort Collins, Colorado; Estados Unidos.Fil: Zhang, Bo. Chinese Academy of Sciences. Wuhan Institute of Virology, Wuhan, Hubei; China.Fil: Levis, Silvana C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: Enria, Delia A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina. Chinese Academy of Sciences. Wuhan Institute of Virology, Wuhan, Hubei; China.Fil: Brault, Aaron C. Centers for Disease Control and Prevention. Division of Vector-Borne Diseases, Fort Collins, Colorado; Estados Unidos.Nhumirim virus (NHUV) is an insect-specific virus that phylogenetically affiliates with dual-host mosquito-borne flaviviruses. Previous in vitro co-infection experiments demonstrated prior or concurrent infection of Aedes albopictus C6/36 mosquito cells with NHUV resulted in a 10,000-fold reduction in viral production of West Nile virus (WNV). This interference between WNV and NHUV was observed herein in an additional Ae. albopictus mosquito cell line, C7-10. A WNV 2K peptide (V9M) mutant capable of superinfection with a pre-established WNV infection demonstrated a comparable level of interference from NHUV as the parental WNV strain in C6/36 and C7-10 cells. Culex quinquefasciatus and Culex pipiens mosquitoes intrathoracically inoculated with NHUVandWNV, or solely withWNVas a control, were allowed to extrinsically incubate the viruses up to nine and 14 days, respectively, and transmissibility and replication of WNV was determined. The proportion of Cx. quinquefasciatus mosquitoes capable of transmitting WNV was significantly lower for the WNV/NHUV group than the WNV control at seven and nine days post inoculation (dpi), while no differences were observed in the Cx. pipiens inoculation group. By dpi nine, a 40% reduction in transmissibility in mosquitoes from the dual inoculation group was observed compared to the WNV-only control. These data indicate the potential that infection of some Culex spp. vectors with NHUV could serve as a barrier for efficient transmissibility of flaviviruses associated with human disease.2015-11-11info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1999-4915http://sgc.anlis.gob.ar/handle/123456789/214310.3390/v7112911Viruses 2015;7(11):5801-5812reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISVirusesenginfo:eu-repo/semantics/openAccess2025-09-04T11:18:15Zoai:sgc.anlis.gob.ar:123456789/2143Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-04 11:18:15.453Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Potential for Co-Infection of a Mosquito-Specific Flavivirus, Nhumirim Virus, to Block West Nile Virus Transmission in Mosquitoes
title Potential for Co-Infection of a Mosquito-Specific Flavivirus, Nhumirim Virus, to Block West Nile Virus Transmission in Mosquitoes
spellingShingle Potential for Co-Infection of a Mosquito-Specific Flavivirus, Nhumirim Virus, to Block West Nile Virus Transmission in Mosquitoes
Goenaga, Silvina
Control de Mosquitos
Presas
Flavivirus
Fiebre del Nilo Occidental
title_short Potential for Co-Infection of a Mosquito-Specific Flavivirus, Nhumirim Virus, to Block West Nile Virus Transmission in Mosquitoes
title_full Potential for Co-Infection of a Mosquito-Specific Flavivirus, Nhumirim Virus, to Block West Nile Virus Transmission in Mosquitoes
title_fullStr Potential for Co-Infection of a Mosquito-Specific Flavivirus, Nhumirim Virus, to Block West Nile Virus Transmission in Mosquitoes
title_full_unstemmed Potential for Co-Infection of a Mosquito-Specific Flavivirus, Nhumirim Virus, to Block West Nile Virus Transmission in Mosquitoes
title_sort Potential for Co-Infection of a Mosquito-Specific Flavivirus, Nhumirim Virus, to Block West Nile Virus Transmission in Mosquitoes
dc.creator.none.fl_str_mv Goenaga, Silvina
Kenney, Joan L
Duggal, Nisha K
Delorey, Mark
Ebel, Gregory D
Zhang, Bo
Levis, Silvana
Enria, Delia
Brault, Aaron C
author Goenaga, Silvina
author_facet Goenaga, Silvina
Kenney, Joan L
Duggal, Nisha K
Delorey, Mark
Ebel, Gregory D
Zhang, Bo
Levis, Silvana
Enria, Delia
Brault, Aaron C
author_role author
author2 Kenney, Joan L
Duggal, Nisha K
Delorey, Mark
Ebel, Gregory D
Zhang, Bo
Levis, Silvana
Enria, Delia
Brault, Aaron C
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Control de Mosquitos
Presas
Flavivirus
Fiebre del Nilo Occidental
topic Control de Mosquitos
Presas
Flavivirus
Fiebre del Nilo Occidental
dc.description.none.fl_txt_mv Fil: Goenaga, Silvina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Kenney, Joan L. Centers for Disease Control and Prevention. Division of Vector-Borne Diseases, Fort Collins, Colorado; Estados Unidos.
Fil: Duggal, Nisha K. Centers for Disease Control and Prevention. Division of Vector-Borne Diseases, Fort Collins, Colorado; Estados Unidos.
Fil: Delorey, Mark. Centers for Disease Control and Prevention. Division of Vector-Borne Diseases, Fort Collins, Colorado; Estados Unidos.
Fil: Ebel, Gregory D. Colorado State University. Immunology and Pathology. Department of Microbiology, Fort Collins, Colorado; Estados Unidos.
Fil: Zhang, Bo. Chinese Academy of Sciences. Wuhan Institute of Virology, Wuhan, Hubei; China.
Fil: Levis, Silvana C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Enria, Delia A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina. Chinese Academy of Sciences. Wuhan Institute of Virology, Wuhan, Hubei; China.
Fil: Brault, Aaron C. Centers for Disease Control and Prevention. Division of Vector-Borne Diseases, Fort Collins, Colorado; Estados Unidos.
Nhumirim virus (NHUV) is an insect-specific virus that phylogenetically affiliates with dual-host mosquito-borne flaviviruses. Previous in vitro co-infection experiments demonstrated prior or concurrent infection of Aedes albopictus C6/36 mosquito cells with NHUV resulted in a 10,000-fold reduction in viral production of West Nile virus (WNV). This interference between WNV and NHUV was observed herein in an additional Ae. albopictus mosquito cell line, C7-10. A WNV 2K peptide (V9M) mutant capable of superinfection with a pre-established WNV infection demonstrated a comparable level of interference from NHUV as the parental WNV strain in C6/36 and C7-10 cells. Culex quinquefasciatus and Culex pipiens mosquitoes intrathoracically inoculated with NHUVandWNV, or solely withWNVas a control, were allowed to extrinsically incubate the viruses up to nine and 14 days, respectively, and transmissibility and replication of WNV was determined. The proportion of Cx. quinquefasciatus mosquitoes capable of transmitting WNV was significantly lower for the WNV/NHUV group than the WNV control at seven and nine days post inoculation (dpi), while no differences were observed in the Cx. pipiens inoculation group. By dpi nine, a 40% reduction in transmissibility in mosquitoes from the dual inoculation group was observed compared to the WNV-only control. These data indicate the potential that infection of some Culex spp. vectors with NHUV could serve as a barrier for efficient transmissibility of flaviviruses associated with human disease.
description Fil: Goenaga, Silvina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
publishDate 2015
dc.date.none.fl_str_mv 2015-11-11
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1999-4915
http://sgc.anlis.gob.ar/handle/123456789/2143
10.3390/v7112911
identifier_str_mv 1999-4915
10.3390/v7112911
url http://sgc.anlis.gob.ar/handle/123456789/2143
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Viruses
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Viruses 2015;7(11):5801-5812
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
_version_ 1842344424083816448
score 12.623145