The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease

• Autores: El-Sayed, Najib M.; Myler, Peter J.; Bartholomeu, Daniella C.; Nilsson, Daniel; Aggarwal, Gautam; Tran, Anh-Nhi; Ghedin, Elodie; Worthey, Elizabeth A.; Delcher, Arthur L.; Blandin, Gaëlle; Westenberger, Scott J.; Caler, Elisabet; Cerqueira, Gustavo C.; Haas, Carole Branched Brian; Anupama, Atashi; Arner, Erik; Åslund, Lena; Attipoe, Philip; Bontempi, Esteban; Bringaud, Frédéric; Burton, Peter; Cadag, Eithon; Campbell, David A.; Carrington, Mark; Crabtree, Jonathan; Darban, Hamid; Silveira, Jose Franco da; Jong, Pieter de; Edwards, Kimberly; Englund, Paul T.; Fazelina, Gholam; Feldblyum, Tamara; Ferella, Marcela; Frasch, Alberto Carlos; Gull, Keith; Horn, David; Hou, Lihua; Huang, Yiting; Kindlund, Ellen; Klingbeil, Michele; Kluge, Sindy; Koo, Hean; Lacerda, Daniela; Levin, Mariano J.; Lorenzi, Hernan; Louie, Tin; Machado, Carlos Renato; McCulloch, Richard; McKenna, Alan; Mizuno, Yumi; Mottram, Jeremy C.; Nelson, Siri; Ochaya, Stephen; Osoegawa, Kazutoyo; Pai, Grace; Parsons, Marilyn; Pentony, Martin; Pettersson, Ulf; Pop, Mihai; Ramirez, Jose Luis; Rinta, Joel; Robertson, Laura; Salzberg, Steven L.; Seyler, Amber; Sharma, Reuben; Shetty, Jyoti; Simpson, Anjana J.; Sisk, Ellen; Tammi, Martti T.; Tarleton, Rick; Teixeira, Santuza; Aken, Susan Van; Vogt, Christy; Ward, Pauline N.; Wickstead, Bill; Wortman, Jennifer; White, Owen; Fraser, Claire M.; Stuart, Kenneth D.; Andersson, Björn
• Año de publicación: 2005
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Science 2005; 309(5733): 409–415.
• Materia: Trypanosoma cruzi; Enfermedad de Chagas; Genoma de Protozoarios; Genoma
• Institución: Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"

Fil: El-Sayed, Najib M. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Myler, Peter J. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Bartholomeu, Daniella C. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Nilsson, Daniel. Karolinska Institutet. Center for Genomics and Bioinformatics; Suecia.
Fil: Aggarwal, Gautam. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Tran, Anh-Nhi. Karolinska Institutet. Center for Genomics and Bioinformatics; Suecia.
Fil: Ghedin, Elodie. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Worthey, Elizabeth A. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Delcher, Arthur L. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Blandin, Gaëlle. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Westenberger, Scott J. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Caler, Elisabet. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Cerqueira, Gustavo C. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Haas, Carole Branched Brian. Karolinska Institutet. Center for Genomics and Bioinformatics; Suecia.
Fil: Anupama, Atashi. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Arner, Erik. Karolinska Institutet. Center for Genomics and Bioinformatics; Suecia.
Fil: Åslund, Lena. Uppsala University. Department of Genetics and Pathology; Suecia.
Fil: Attipoe, Philip. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Bontempi, Esteban. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Bringaud, Frédéric. Université Victor Segalen Bordeaux II. Laboratoire de Génomique Fonctionnelle des Trypanosomatides; Francia.
Fil: Burton, Peter. University of Glasgow. Wellcome Centre for Molecular Parasitology; Reino Unido.
Fil: Cadag, Eithon. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Campbell, David A. University of California. Department of Microbiology; Estados Unidos.
Fil: Carrington, Mark. University of Cambridge. Department of Biochemistry; Reino Unido.
Fil: Crabtree, Jonathan. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Darban, Hamid. Karolinska Institutet. Center for Genomics and Bioinformatics; Suecia.
Fil: Silveira, Jose Franco da. Universidade Federal de Sao Paulo. Departamento de Microbiologia; Brasil.
Fil: Jong, Pieter de. Children’s Hospital Oakland Research Institute. BACPAC Resources; Estados Unidos.
Fil: Edwards, Kimberly. Karolinska Institutet. Center for Genomics and Bioinformatics; Suecia.
Fil: Englund, Paul T. Johns Hopkins University School of Medicine. Department of Biological Chemistry; Estados Unidos.
Fil: Fazelina, Gholam. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Feldblyum, Tamara. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Ferella, Marcela. Karolinska Institutet. Center for Genomics and Bioinformatics; Suecia.
Fil: Frasch, Alberto Carlos. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina.
Fil: Gull, Keith. University of Oxford. Sir William Dunn School of Pathology; Reino Unido.
Fil: Horn, David. London School of Hygiene and Tropical Medicine; Reino Unido.
Fil: Hou, Lihua. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Huang, Yiting. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Kindlund, Ellen. Karolinska Institutet. Center for Genomics and Bioinformatics; Suecia.
Fil: Klingbeil, Michele. University of Massachusetts. Department of Microbiology; Estados Unidos.
Fil: Kluge, Sindy. Karolinska Institutet. Center for Genomics and Bioinformatics; Suecia.
Fil: Koo, Hean. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Lacerda, Daniela. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Levin, Mariano J. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET-CYTED project). Laboratorio de Biología Molecular de la Enfermedad de Chagas; Argentina.
Fil: Lorenzi, Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET-CYTED project). Laboratorio de Biología Molecular de la Enfermedad de Chagas; Argentina.
Fil: Louie, Tin. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Machado, Carlos Renato. Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia; Brasil.
Fil: McCulloch, Richard. University of Glasgow. Wellcome Centre for Molecular Parasitology; Reino Unido.
Fil: McKenna, Alan. Karolinska Institutet. Center for Genomics and Bioinformatics; Suecia.
Fil: Mizuno, Yumi. Karolinska Institutet. Center for Genomics and Bioinformatics; Suecia.
Fil: Mottram, Jeremy C. University of Glasgow. Wellcome Centre for Molecular Parasitology; Reino Unido.
Fil: Nelson, Siri. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Ochaya, Stephen. Karolinska Institutet. Center for Genomics and Bioinformatics; Suecia.
Fil: Osoegawa, Kazutoyo. Children’s Hospital Oakland Research Institute. BACPAC Resources; Estados Unidos.
Fil: Pai, Grace. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Parsons, Marilyn. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Pentony, Martin. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Pettersson, Ulf. Uppsala University. Department of Genetics and Pathology; Suecia.
Fil: Pop, Mihai. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Ramirez, Jose Luis. Universidad Central de Venezuela. Instituto de Biología Experimental; Venezuela.
Fil: Rinta, Joel. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Robertson, Laura. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Salzberg, Steven L. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Sanchez, Daniel O. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina.
Fil: Seyler, Amber. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Sharma, Reuben. University of Cambridge. Department of Biochemistry; Reino Unido.
Fil: Shetty, Jyoti. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Simpson, Anjana J. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Sisk, Ellen. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Tammi, Martti T. Karolinska Institutet. Center for Genomics and Bioinformatics; Suecia.
Fil: Tarleton, Rick. University of Georgia. Center for Tropical and Emerging Global Diseases; Estados Unidos.
Fil: Teixeira, Santuza. Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia; Brasil.
Fil: Aken, Susan Van. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Vogt, Christy. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Ward, Pauline N. University of Glasgow. Wellcome Centre for Molecular Parasitology; Reino Unido.
Fil: Wickstead, Bill. University of Oxford. Sir William Dunn School of Pathology; Reino Unido.
Fil: Wortman, Jennifer. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: White, Owen. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Fraser, Claire M. The Institute for Genomic Research. Department of Parasite Genomics; Estados Unidos.
Fil: Stuart, Kenneth D. Seattle Biomedical Research Institute; Estados Unidos.
Fil: Andersson, Björn. Karolinska Institutet. Center for Genomics and Bioinformatics; Suecia.
Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.