The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease
- Autores
- El-Sayed, Najib M.; Myler, Peter J.; Bartholomeu, Daniella C.; Nilsson, Daniel; Aggarwal, Gautam; Tran, Anh-Nhi; Ghedin, Elodie; Worthey, Elizabeth A.; Delcher, Arthur L.; Blandin, Gaëlle; Westenberger, Scott J.; Caler, Elisabet; Cerqueira, Gustavo C.; Branche, Carole; Haas, Brian; Anupama, Atashi; Arner, Erik; Åslund, Lena; Attipoe, Philip; Bontempi, Esteban; Bringaud, Frédéric; Burton, Peter; Cadag, Eithon; Campbell, David A.; Carrington, Mark; Crabtree, Jonathan; Darban, Hamid; Da Silveira, Jose Franco; De Jong, Pieter; Edwards, Kimberly; Englund, Paul T.; Fazelina, Gholam; Feldblyum, Tamara; Ferella, Marcela; Frasch, Alberto Carlos C.; Gull, Keith; Horn, David; Hou, Lihua; Huang, Yiting; Kindlund, Ellen; Klingbeil, Michele; Kluge, Sindy; Koo, Hean; Lacerda, Daniela; Levin, Mariano Jorge; Lorenzi, Hernan; Louie, Tin; Machado, Carlos Renato; McCulloch, Richard; McKenna, Alan; Mizuno, Yumi; Mottram, Jeremy C.; Nelson, Siri; Ochaya, Stephen; Osoegawa, Kazutoyo; Pai, Grace; Parsons, Marilyn; Pentony, Martin; Pettersson, Ulf; Pop, Mihai; Ramirez, Jose Luis; Rinta, Joel; Robertson, Laura; Salzberg, Steven L.; Sanchez, Daniel Oscar; Seyler, Amber; Sharma, Reuben; Shetty, Jyoti; Simpson, Anjana J.; Sisk, Ellen; Tammi, Martti T.; Tarleton, Rick; Teixeira, Santuza; Van Aken, Susan; Vogt, Christy; Ward, Pauline N.; Wickstead, Bill; Wortman, Jennifer; White, Owen; Fraser, Claire M.; Stuart, Kenneth D.; Andersson, Björn
- Año de publicación
- 2005
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
Fil: El-Sayed, Najib M.. The George Washington University; Estados Unidos. The Institute for Genomic Research; Estados Unidos
Fil: Myler, Peter J.. University of Washington; Estados Unidos. Seattle Biomedical Research Institute; Estados Unidos. University Of Washington School Of Public Health And Community Medicine; Estados Unidos
Fil: Bartholomeu, Daniella C.. The Institute for Genomic Research; Estados Unidos
Fil: Nilsson, Daniel. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Aggarwal, Gautam. Seattle Biomedical Research Institute; Estados Unidos
Fil: Tran, Anh-Nhi. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Ghedin, Elodie. The George Washington University; Estados Unidos. The Institute for Genomic Research; Estados Unidos
Fil: Worthey, Elizabeth A.. Seattle Biomedical Research Institute; Estados Unidos
Fil: Delcher, Arthur L.. The Institute for Genomic Research; Estados Unidos
Fil: Blandin, Gaëlle. The Institute for Genomic Research; Estados Unidos
Fil: Westenberger, Scott J.. The Institute for Genomic Research; Estados Unidos. University of California at Los Angeles; Estados Unidos
Fil: Caler, Elisabet. The Institute for Genomic Research; Estados Unidos
Fil: Cerqueira, Gustavo C.. The Institute for Genomic Research; Estados Unidos. Universidade Federal de Minas Gerais; Brasil
Fil: Branche, Carole. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Haas, Brian. The Institute for Genomic Research; Estados Unidos
Fil: Anupama, Atashi. Seattle Biomedical Research Institute; Estados Unidos
Fil: Arner, Erik. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Åslund, Lena. Uppsala Universitet; Suecia
Fil: Attipoe, Philip. Seattle Biomedical Research Institute; Estados Unidos
Fil: Bontempi, Esteban. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Bringaud, Frédéric. Centre National de la Recherche Scientifique; Francia
Fil: Burton, Peter. University of Glasgow; Reino Unido
Fil: Cadag, Eithon. Seattle Biomedical Research Institute; Estados Unidos
Fil: Campbell, David A.. University of California at Los Angeles; Estados Unidos
Fil: Carrington, Mark. University of Cambridge; Estados Unidos
Fil: Crabtree, Jonathan. The Institute for Genomic Research; Estados Unidos
Fil: Darban, Hamid. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Da Silveira, Jose Franco. Universidade Federal de Sao Paulo; Brasil
Fil: De Jong, Pieter. Children's Hospital Oakland Research Institute; Estados Unidos
Fil: Edwards, Kimberly. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Englund, Paul T.. The Johns Hopkins School Of Medicine; Estados Unidos
Fil: Fazelina, Gholam. Seattle Biomedical Research Institute; Estados Unidos
Fil: Feldblyum, Tamara. The Institute for Genomic Research; Estados Unidos
Fil: Ferella, Marcela. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Frasch, Alberto Carlos C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Gull, Keith. University of Oxford; Reino Unido
Fil: Horn, David. London School of Hygiene and Tropical Medicine; Reino Unido
Fil: Hou, Lihua. The Institute for Genomic Research; Estados Unidos
Fil: Huang, Yiting. Seattle Biomedical Research Institute; Estados Unidos
Fil: Kindlund, Ellen. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Klingbeil, Michele. University Of Massachusetts; Estados Unidos
Fil: Kluge, Sindy. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Koo, Hean. The Institute for Genomic Research; Estados Unidos
Fil: Lacerda, Daniela. Fundación Oswaldo Cruz; Brasil. The Institute for Genomic Research; Estados Unidos
Fil: Levin, Mariano Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Lorenzi, Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Louie, Tin. Seattle Biomedical Research Institute; Estados Unidos
Fil: Machado, Carlos Renato. Universidade Federal de Minas Gerais; Brasil
Fil: McCulloch, Richard. University of Glasgow; Reino Unido
Fil: McKenna, Alan. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Mizuno, Yumi. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Mottram, Jeremy C.. University of Glasgow; Reino Unido
Fil: Nelson, Siri. Seattle Biomedical Research Institute; Estados Unidos
Fil: Ochaya, Stephen. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Osoegawa, Kazutoyo. Children's Hospital Oakland Research Institute; Estados Unidos
Fil: Pai, Grace. The Institute for Genomic Research; Estados Unidos
Fil: Parsons, Marilyn. Seattle Biomedical Research Institute; Estados Unidos. University Of Washington School Of Public Health And Community Medicine; Estados Unidos
Fil: Pentony, Martin. Seattle Biomedical Research Institute; Estados Unidos
Fil: Pettersson, Ulf. Uppsala Universitet; Suecia
Fil: Pop, Mihai. The Institute for Genomic Research; Estados Unidos
Fil: Ramirez, Jose Luis. Universidad Central de Venezuela, Facultad de Ciencias; Venezuela
Fil: Rinta, Joel. Seattle Biomedical Research Institute; Estados Unidos
Fil: Robertson, Laura. Seattle Biomedical Research Institute; Estados Unidos
Fil: Salzberg, Steven L.. The Institute for Genomic Research; Estados Unidos
Fil: Sanchez, Daniel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Seyler, Amber. Seattle Biomedical Research Institute; Estados Unidos
Fil: Sharma, Reuben. University of Cambridge; Estados Unidos
Fil: Shetty, Jyoti. The Institute for Genomic Research; Estados Unidos
Fil: Simpson, Anjana J.. The Institute for Genomic Research; Estados Unidos
Fil: Sisk, Ellen. Seattle Biomedical Research Institute; Estados Unidos
Fil: Tammi, Martti T.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. National University Of Singapore; Singapur
Fil: Tarleton, Rick. University of Georgia; Estados Unidos
Fil: Teixeira, Santuza. Universidade Federal de Minas Gerais; Brasil
Fil: Van Aken, Susan. The Institute for Genomic Research; Estados Unidos
Fil: Vogt, Christy. Seattle Biomedical Research Institute; Estados Unidos
Fil: Ward, Pauline N.. University of Glasgow; Reino Unido
Fil: Wickstead, Bill. Sir William Dunn School Of Pathology; Reino Unido
Fil: Wortman, Jennifer. The Institute for Genomic Research; Estados Unidos
Fil: White, Owen. The Institute for Genomic Research; Estados Unidos
Fil: Fraser, Claire M.. The Institute for Genomic Research; Estados Unidos
Fil: Stuart, Kenneth D.. Seattle Biomedical Research Institute; Estados Unidos. University Of Washington School Of Public Health And Community Medicine; Estados Unidos
Fil: Andersson, Björn. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/80500
Ver los metadatos del registro completo
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The genome sequence of Trypanosoma cruzi, etiologic agent of chagas diseaseEl-Sayed, Najib M.Myler, Peter J.Bartholomeu, Daniella C.Nilsson, DanielAggarwal, GautamTran, Anh-NhiGhedin, ElodieWorthey, Elizabeth A.Delcher, Arthur L.Blandin, GaëlleWestenberger, Scott J.Caler, ElisabetCerqueira, Gustavo C.Branche, CaroleHaas, BrianAnupama, AtashiArner, ErikÅslund, LenaAttipoe, PhilipBontempi, EstebanBringaud, FrédéricBurton, PeterCadag, EithonCampbell, David A.Carrington, MarkCrabtree, JonathanDarban, HamidDa Silveira, Jose FrancoDe Jong, PieterEdwards, KimberlyEnglund, Paul T.Fazelina, GholamFeldblyum, TamaraFerella, MarcelaFrasch, Alberto Carlos C.Gull, KeithHorn, DavidHou, LihuaHuang, YitingKindlund, EllenKlingbeil, MicheleKluge, SindyKoo, HeanLacerda, DanielaLevin, Mariano JorgeLorenzi, HernanLouie, TinMachado, Carlos RenatoMcCulloch, RichardMcKenna, AlanMizuno, YumiMottram, Jeremy C.Nelson, SiriOchaya, StephenOsoegawa, KazutoyoPai, GraceParsons, MarilynPentony, MartinPettersson, UlfPop, MihaiRamirez, Jose LuisRinta, JoelRobertson, LauraSalzberg, Steven L.Sanchez, Daniel OscarSeyler, AmberSharma, ReubenShetty, JyotiSimpson, Anjana J.Sisk, EllenTammi, Martti T.Tarleton, RickTeixeira, SantuzaVan Aken, SusanVogt, ChristyWard, Pauline N.Wickstead, BillWortman, JenniferWhite, OwenFraser, Claire M.Stuart, Kenneth D.Andersson, Björnhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.Fil: El-Sayed, Najib M.. The George Washington University; Estados Unidos. The Institute for Genomic Research; Estados UnidosFil: Myler, Peter J.. University of Washington; Estados Unidos. Seattle Biomedical Research Institute; Estados Unidos. University Of Washington School Of Public Health And Community Medicine; Estados UnidosFil: Bartholomeu, Daniella C.. The Institute for Genomic Research; Estados UnidosFil: Nilsson, Daniel. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Aggarwal, Gautam. Seattle Biomedical Research Institute; Estados UnidosFil: Tran, Anh-Nhi. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Ghedin, Elodie. The George Washington University; Estados Unidos. The Institute for Genomic Research; Estados UnidosFil: Worthey, Elizabeth A.. Seattle Biomedical Research Institute; Estados UnidosFil: Delcher, Arthur L.. The Institute for Genomic Research; Estados UnidosFil: Blandin, Gaëlle. The Institute for Genomic Research; Estados UnidosFil: Westenberger, Scott J.. The Institute for Genomic Research; Estados Unidos. University of California at Los Angeles; Estados UnidosFil: Caler, Elisabet. The Institute for Genomic Research; Estados UnidosFil: Cerqueira, Gustavo C.. The Institute for Genomic Research; Estados Unidos. Universidade Federal de Minas Gerais; BrasilFil: Branche, Carole. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Haas, Brian. The Institute for Genomic Research; Estados UnidosFil: Anupama, Atashi. Seattle Biomedical Research Institute; Estados UnidosFil: Arner, Erik. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Åslund, Lena. Uppsala Universitet; SueciaFil: Attipoe, Philip. Seattle Biomedical Research Institute; Estados UnidosFil: Bontempi, Esteban. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; ArgentinaFil: Bringaud, Frédéric. Centre National de la Recherche Scientifique; FranciaFil: Burton, Peter. University of Glasgow; Reino UnidoFil: Cadag, Eithon. Seattle Biomedical Research Institute; Estados UnidosFil: Campbell, David A.. University of California at Los Angeles; Estados UnidosFil: Carrington, Mark. University of Cambridge; Estados UnidosFil: Crabtree, Jonathan. The Institute for Genomic Research; Estados UnidosFil: Darban, Hamid. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Da Silveira, Jose Franco. Universidade Federal de Sao Paulo; BrasilFil: De Jong, Pieter. Children's Hospital Oakland Research Institute; Estados UnidosFil: Edwards, Kimberly. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Englund, Paul T.. The Johns Hopkins School Of Medicine; Estados UnidosFil: Fazelina, Gholam. Seattle Biomedical Research Institute; Estados UnidosFil: Feldblyum, Tamara. The Institute for Genomic Research; Estados UnidosFil: Ferella, Marcela. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Frasch, Alberto Carlos C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Gull, Keith. University of Oxford; Reino UnidoFil: Horn, David. London School of Hygiene and Tropical Medicine; Reino UnidoFil: Hou, Lihua. The Institute for Genomic Research; Estados UnidosFil: Huang, Yiting. Seattle Biomedical Research Institute; Estados UnidosFil: Kindlund, Ellen. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Klingbeil, Michele. University Of Massachusetts; Estados UnidosFil: Kluge, Sindy. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Koo, Hean. The Institute for Genomic Research; Estados UnidosFil: Lacerda, Daniela. Fundación Oswaldo Cruz; Brasil. The Institute for Genomic Research; Estados UnidosFil: Levin, Mariano Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Lorenzi, Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Louie, Tin. Seattle Biomedical Research Institute; Estados UnidosFil: Machado, Carlos Renato. Universidade Federal de Minas Gerais; BrasilFil: McCulloch, Richard. University of Glasgow; Reino UnidoFil: McKenna, Alan. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Mizuno, Yumi. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Mottram, Jeremy C.. University of Glasgow; Reino UnidoFil: Nelson, Siri. Seattle Biomedical Research Institute; Estados UnidosFil: Ochaya, Stephen. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Osoegawa, Kazutoyo. Children's Hospital Oakland Research Institute; Estados UnidosFil: Pai, Grace. The Institute for Genomic Research; Estados UnidosFil: Parsons, Marilyn. Seattle Biomedical Research Institute; Estados Unidos. University Of Washington School Of Public Health And Community Medicine; Estados UnidosFil: Pentony, Martin. Seattle Biomedical Research Institute; Estados UnidosFil: Pettersson, Ulf. Uppsala Universitet; SueciaFil: Pop, Mihai. The Institute for Genomic Research; Estados UnidosFil: Ramirez, Jose Luis. Universidad Central de Venezuela, Facultad de Ciencias; VenezuelaFil: Rinta, Joel. Seattle Biomedical Research Institute; Estados UnidosFil: Robertson, Laura. Seattle Biomedical Research Institute; Estados UnidosFil: Salzberg, Steven L.. The Institute for Genomic Research; Estados UnidosFil: Sanchez, Daniel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Seyler, Amber. Seattle Biomedical Research Institute; Estados UnidosFil: Sharma, Reuben. University of Cambridge; Estados UnidosFil: Shetty, Jyoti. The Institute for Genomic Research; Estados UnidosFil: Simpson, Anjana J.. The Institute for Genomic Research; Estados UnidosFil: Sisk, Ellen. Seattle Biomedical Research Institute; Estados UnidosFil: Tammi, Martti T.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. National University Of Singapore; SingapurFil: Tarleton, Rick. University of Georgia; Estados UnidosFil: Teixeira, Santuza. Universidade Federal de Minas Gerais; BrasilFil: Van Aken, Susan. The Institute for Genomic Research; Estados UnidosFil: Vogt, Christy. Seattle Biomedical Research Institute; Estados UnidosFil: Ward, Pauline N.. University of Glasgow; Reino UnidoFil: Wickstead, Bill. Sir William Dunn School Of Pathology; Reino UnidoFil: Wortman, Jennifer. The Institute for Genomic Research; Estados UnidosFil: White, Owen. The Institute for Genomic Research; Estados UnidosFil: Fraser, Claire M.. The Institute for Genomic Research; Estados UnidosFil: Stuart, Kenneth D.. Seattle Biomedical Research Institute; Estados Unidos. University Of Washington School Of Public Health And Community Medicine; Estados UnidosFil: Andersson, Björn. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaAmerican Association for the Advancement of Science2005-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/80500El-Sayed, Najib M.; Myler, Peter J.; Bartholomeu, Daniella C.; Nilsson, Daniel; Aggarwal, Gautam; et al.; The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease; American Association for the Advancement of Science; Science; 309; 5733; 7-2005; 409-4150036-8075CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1126/science.1112631info:eu-repo/semantics/altIdentifier/url/https://science.sciencemag.org/content/309/5733/409info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:05:06Zoai:ri.conicet.gov.ar:11336/80500instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:05:06.765CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease |
| title |
The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease |
| spellingShingle |
The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease El-Sayed, Najib M. |
| title_short |
The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease |
| title_full |
The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease |
| title_fullStr |
The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease |
| title_full_unstemmed |
The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease |
| title_sort |
The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease |
| dc.creator.none.fl_str_mv |
El-Sayed, Najib M. Myler, Peter J. Bartholomeu, Daniella C. Nilsson, Daniel Aggarwal, Gautam Tran, Anh-Nhi Ghedin, Elodie Worthey, Elizabeth A. Delcher, Arthur L. Blandin, Gaëlle Westenberger, Scott J. Caler, Elisabet Cerqueira, Gustavo C. Branche, Carole Haas, Brian Anupama, Atashi Arner, Erik Åslund, Lena Attipoe, Philip Bontempi, Esteban Bringaud, Frédéric Burton, Peter Cadag, Eithon Campbell, David A. Carrington, Mark Crabtree, Jonathan Darban, Hamid Da Silveira, Jose Franco De Jong, Pieter Edwards, Kimberly Englund, Paul T. Fazelina, Gholam Feldblyum, Tamara Ferella, Marcela Frasch, Alberto Carlos C. Gull, Keith Horn, David Hou, Lihua Huang, Yiting Kindlund, Ellen Klingbeil, Michele Kluge, Sindy Koo, Hean Lacerda, Daniela Levin, Mariano Jorge Lorenzi, Hernan Louie, Tin Machado, Carlos Renato McCulloch, Richard McKenna, Alan Mizuno, Yumi Mottram, Jeremy C. Nelson, Siri Ochaya, Stephen Osoegawa, Kazutoyo Pai, Grace Parsons, Marilyn Pentony, Martin Pettersson, Ulf Pop, Mihai Ramirez, Jose Luis Rinta, Joel Robertson, Laura Salzberg, Steven L. Sanchez, Daniel Oscar Seyler, Amber Sharma, Reuben Shetty, Jyoti Simpson, Anjana J. Sisk, Ellen Tammi, Martti T. Tarleton, Rick Teixeira, Santuza Van Aken, Susan Vogt, Christy Ward, Pauline N. Wickstead, Bill Wortman, Jennifer White, Owen Fraser, Claire M. Stuart, Kenneth D. Andersson, Björn |
| author |
El-Sayed, Najib M. |
| author_facet |
El-Sayed, Najib M. Myler, Peter J. Bartholomeu, Daniella C. Nilsson, Daniel Aggarwal, Gautam Tran, Anh-Nhi Ghedin, Elodie Worthey, Elizabeth A. Delcher, Arthur L. Blandin, Gaëlle Westenberger, Scott J. Caler, Elisabet Cerqueira, Gustavo C. Branche, Carole Haas, Brian Anupama, Atashi Arner, Erik Åslund, Lena Attipoe, Philip Bontempi, Esteban Bringaud, Frédéric Burton, Peter Cadag, Eithon Campbell, David A. Carrington, Mark Crabtree, Jonathan Darban, Hamid Da Silveira, Jose Franco De Jong, Pieter Edwards, Kimberly Englund, Paul T. Fazelina, Gholam Feldblyum, Tamara Ferella, Marcela Frasch, Alberto Carlos C. Gull, Keith Horn, David Hou, Lihua Huang, Yiting Kindlund, Ellen Klingbeil, Michele Kluge, Sindy Koo, Hean Lacerda, Daniela Levin, Mariano Jorge Lorenzi, Hernan Louie, Tin Machado, Carlos Renato McCulloch, Richard McKenna, Alan Mizuno, Yumi Mottram, Jeremy C. Nelson, Siri Ochaya, Stephen Osoegawa, Kazutoyo Pai, Grace Parsons, Marilyn Pentony, Martin Pettersson, Ulf Pop, Mihai Ramirez, Jose Luis Rinta, Joel Robertson, Laura Salzberg, Steven L. Sanchez, Daniel Oscar Seyler, Amber Sharma, Reuben Shetty, Jyoti Simpson, Anjana J. Sisk, Ellen Tammi, Martti T. Tarleton, Rick Teixeira, Santuza Van Aken, Susan Vogt, Christy Ward, Pauline N. Wickstead, Bill Wortman, Jennifer White, Owen Fraser, Claire M. Stuart, Kenneth D. Andersson, Björn |
| author_role |
author |
| author2 |
Myler, Peter J. Bartholomeu, Daniella C. Nilsson, Daniel Aggarwal, Gautam Tran, Anh-Nhi Ghedin, Elodie Worthey, Elizabeth A. Delcher, Arthur L. Blandin, Gaëlle Westenberger, Scott J. Caler, Elisabet Cerqueira, Gustavo C. Branche, Carole Haas, Brian Anupama, Atashi Arner, Erik Åslund, Lena Attipoe, Philip Bontempi, Esteban Bringaud, Frédéric Burton, Peter Cadag, Eithon Campbell, David A. Carrington, Mark Crabtree, Jonathan Darban, Hamid Da Silveira, Jose Franco De Jong, Pieter Edwards, Kimberly Englund, Paul T. Fazelina, Gholam Feldblyum, Tamara Ferella, Marcela Frasch, Alberto Carlos C. Gull, Keith Horn, David Hou, Lihua Huang, Yiting Kindlund, Ellen Klingbeil, Michele Kluge, Sindy Koo, Hean Lacerda, Daniela Levin, Mariano Jorge Lorenzi, Hernan Louie, Tin Machado, Carlos Renato McCulloch, Richard McKenna, Alan Mizuno, Yumi Mottram, Jeremy C. Nelson, Siri Ochaya, Stephen Osoegawa, Kazutoyo Pai, Grace Parsons, Marilyn Pentony, Martin Pettersson, Ulf Pop, Mihai Ramirez, Jose Luis Rinta, Joel Robertson, Laura Salzberg, Steven L. Sanchez, Daniel Oscar Seyler, Amber Sharma, Reuben Shetty, Jyoti Simpson, Anjana J. Sisk, Ellen Tammi, Martti T. Tarleton, Rick Teixeira, Santuza Van Aken, Susan Vogt, Christy Ward, Pauline N. Wickstead, Bill Wortman, Jennifer White, Owen Fraser, Claire M. Stuart, Kenneth D. Andersson, Björn |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention. Fil: El-Sayed, Najib M.. The George Washington University; Estados Unidos. The Institute for Genomic Research; Estados Unidos Fil: Myler, Peter J.. University of Washington; Estados Unidos. Seattle Biomedical Research Institute; Estados Unidos. University Of Washington School Of Public Health And Community Medicine; Estados Unidos Fil: Bartholomeu, Daniella C.. The Institute for Genomic Research; Estados Unidos Fil: Nilsson, Daniel. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Aggarwal, Gautam. Seattle Biomedical Research Institute; Estados Unidos Fil: Tran, Anh-Nhi. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Ghedin, Elodie. The George Washington University; Estados Unidos. The Institute for Genomic Research; Estados Unidos Fil: Worthey, Elizabeth A.. Seattle Biomedical Research Institute; Estados Unidos Fil: Delcher, Arthur L.. The Institute for Genomic Research; Estados Unidos Fil: Blandin, Gaëlle. The Institute for Genomic Research; Estados Unidos Fil: Westenberger, Scott J.. The Institute for Genomic Research; Estados Unidos. University of California at Los Angeles; Estados Unidos Fil: Caler, Elisabet. The Institute for Genomic Research; Estados Unidos Fil: Cerqueira, Gustavo C.. The Institute for Genomic Research; Estados Unidos. Universidade Federal de Minas Gerais; Brasil Fil: Branche, Carole. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Haas, Brian. The Institute for Genomic Research; Estados Unidos Fil: Anupama, Atashi. Seattle Biomedical Research Institute; Estados Unidos Fil: Arner, Erik. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Åslund, Lena. Uppsala Universitet; Suecia Fil: Attipoe, Philip. Seattle Biomedical Research Institute; Estados Unidos Fil: Bontempi, Esteban. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina Fil: Bringaud, Frédéric. Centre National de la Recherche Scientifique; Francia Fil: Burton, Peter. University of Glasgow; Reino Unido Fil: Cadag, Eithon. Seattle Biomedical Research Institute; Estados Unidos Fil: Campbell, David A.. University of California at Los Angeles; Estados Unidos Fil: Carrington, Mark. University of Cambridge; Estados Unidos Fil: Crabtree, Jonathan. The Institute for Genomic Research; Estados Unidos Fil: Darban, Hamid. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Da Silveira, Jose Franco. Universidade Federal de Sao Paulo; Brasil Fil: De Jong, Pieter. Children's Hospital Oakland Research Institute; Estados Unidos Fil: Edwards, Kimberly. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Englund, Paul T.. The Johns Hopkins School Of Medicine; Estados Unidos Fil: Fazelina, Gholam. Seattle Biomedical Research Institute; Estados Unidos Fil: Feldblyum, Tamara. The Institute for Genomic Research; Estados Unidos Fil: Ferella, Marcela. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Frasch, Alberto Carlos C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina Fil: Gull, Keith. University of Oxford; Reino Unido Fil: Horn, David. London School of Hygiene and Tropical Medicine; Reino Unido Fil: Hou, Lihua. The Institute for Genomic Research; Estados Unidos Fil: Huang, Yiting. Seattle Biomedical Research Institute; Estados Unidos Fil: Kindlund, Ellen. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Klingbeil, Michele. University Of Massachusetts; Estados Unidos Fil: Kluge, Sindy. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Koo, Hean. The Institute for Genomic Research; Estados Unidos Fil: Lacerda, Daniela. Fundación Oswaldo Cruz; Brasil. The Institute for Genomic Research; Estados Unidos Fil: Levin, Mariano Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Lorenzi, Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Louie, Tin. Seattle Biomedical Research Institute; Estados Unidos Fil: Machado, Carlos Renato. Universidade Federal de Minas Gerais; Brasil Fil: McCulloch, Richard. University of Glasgow; Reino Unido Fil: McKenna, Alan. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Mizuno, Yumi. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Mottram, Jeremy C.. University of Glasgow; Reino Unido Fil: Nelson, Siri. Seattle Biomedical Research Institute; Estados Unidos Fil: Ochaya, Stephen. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Osoegawa, Kazutoyo. Children's Hospital Oakland Research Institute; Estados Unidos Fil: Pai, Grace. The Institute for Genomic Research; Estados Unidos Fil: Parsons, Marilyn. Seattle Biomedical Research Institute; Estados Unidos. University Of Washington School Of Public Health And Community Medicine; Estados Unidos Fil: Pentony, Martin. Seattle Biomedical Research Institute; Estados Unidos Fil: Pettersson, Ulf. Uppsala Universitet; Suecia Fil: Pop, Mihai. The Institute for Genomic Research; Estados Unidos Fil: Ramirez, Jose Luis. Universidad Central de Venezuela, Facultad de Ciencias; Venezuela Fil: Rinta, Joel. Seattle Biomedical Research Institute; Estados Unidos Fil: Robertson, Laura. Seattle Biomedical Research Institute; Estados Unidos Fil: Salzberg, Steven L.. The Institute for Genomic Research; Estados Unidos Fil: Sanchez, Daniel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina Fil: Seyler, Amber. Seattle Biomedical Research Institute; Estados Unidos Fil: Sharma, Reuben. University of Cambridge; Estados Unidos Fil: Shetty, Jyoti. The Institute for Genomic Research; Estados Unidos Fil: Simpson, Anjana J.. The Institute for Genomic Research; Estados Unidos Fil: Sisk, Ellen. Seattle Biomedical Research Institute; Estados Unidos Fil: Tammi, Martti T.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. National University Of Singapore; Singapur Fil: Tarleton, Rick. University of Georgia; Estados Unidos Fil: Teixeira, Santuza. Universidade Federal de Minas Gerais; Brasil Fil: Van Aken, Susan. The Institute for Genomic Research; Estados Unidos Fil: Vogt, Christy. Seattle Biomedical Research Institute; Estados Unidos Fil: Ward, Pauline N.. University of Glasgow; Reino Unido Fil: Wickstead, Bill. Sir William Dunn School Of Pathology; Reino Unido Fil: Wortman, Jennifer. The Institute for Genomic Research; Estados Unidos Fil: White, Owen. The Institute for Genomic Research; Estados Unidos Fil: Fraser, Claire M.. The Institute for Genomic Research; Estados Unidos Fil: Stuart, Kenneth D.. Seattle Biomedical Research Institute; Estados Unidos. University Of Washington School Of Public Health And Community Medicine; Estados Unidos Fil: Andersson, Björn. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia |
| description |
Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention. |
| publishDate |
2005 |
| dc.date.none.fl_str_mv |
2005-07 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/80500 El-Sayed, Najib M.; Myler, Peter J.; Bartholomeu, Daniella C.; Nilsson, Daniel; Aggarwal, Gautam; et al.; The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease; American Association for the Advancement of Science; Science; 309; 5733; 7-2005; 409-415 0036-8075 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/80500 |
| identifier_str_mv |
El-Sayed, Najib M.; Myler, Peter J.; Bartholomeu, Daniella C.; Nilsson, Daniel; Aggarwal, Gautam; et al.; The genome sequence of Trypanosoma cruzi, etiologic agent of chagas disease; American Association for the Advancement of Science; Science; 309; 5733; 7-2005; 409-415 0036-8075 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1126/science.1112631 info:eu-repo/semantics/altIdentifier/url/https://science.sciencemag.org/content/309/5733/409 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
American Association for the Advancement of Science |
| publisher.none.fl_str_mv |
American Association for the Advancement of Science |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1846083193499811840 |
| score |
12.891075 |