Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections

Autores
Abascal, Estefanía; Herranz, Marta; Acosta, Fermín; Agapito, Juan; Cabibbe, Andrea M; Monteserin, Johana; Ruiz Serrano, María Jesús; Gijón, Paloma; Fernández-González, Francisco; Lozano, Nuria; Chiner-Oms, Álvaro; Cáceres, Tatiana; Pintado, Pilar Gómez; Acín, Enrique; Valencia, Eddy; Muñoz, Patricia; Comas, Iñaki; Cirillo, Daniela M; Ritacco, Viviana; Gotuzzo, Eduardo; Garcia de Viedma, Dario
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Abascal, Estefanía. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España
Fil: Herranz, Marta. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España
Fil: Acosta, Fermín. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España
Fil: Agapito, Juan. TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima; Peru.
Fil: Cabibbe, Andrea M. Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan; Italia.
Fil: Monteserín, Johana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Epidemiología; Argentina.
Fil: Ruiz Serrano, María Jesús. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
Fil: Gijón, Paloma. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
Fil: Fernández-González, Francisco. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
Fil: Lozano, Nuria. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
Fil: Chiner-Oms, Álvaro. Unidad Mixta Genómica y Salud, Centro Superior de Investigación en Salud Pública (FISABIO)-Universitat de València; España.
Fil: Cáceres, Tatiana. TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima; Peru.
Fil: Gómez Pintado, Pilar. General Subdirection of Penitentiary Health - Penitentiary Institutions - Ministry of Interior of Spain; España.
Fil: Acín, Enrique. General Subdirection of Penitentiary Health - Penitentiary Institutions - Ministry of Interior of Spain; España.
Fil: Muñoz, Patricia. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España
Fil: Comas, Iñaki. Instituto de Biomedicina de Valencia (IBV) Consejo Superior de Investigaciones Científicas (CSIC); España.
Fil: Cirillo, Daniela M. Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan; Italia.
Fil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Epidemiología; Argentina.
Fil: Gotuzzo, Eduardo. TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima; Peru.
Fil: García de Viedma, Dario. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR-clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002-5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.
Fuente
Scientific reports 2020; 10(1):2704
Materia
Antibióticos Antituberculosos
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:Publications/123456789/1727
Acceder
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network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infectionsAbascal, EstefaníaHerranz, MartaAcosta, FermínAgapito, JuanCabibbe, Andrea MMonteserin, JohanaRuiz Serrano, María JesúsGijón, PalomaFernández-González, FranciscoLozano, NuriaChiner-Oms, ÁlvaroCáceres, TatianaPintado, Pilar GómezAcín, EnriqueValencia, EddyMuñoz, PatriciaComas, IñakiCirillo, Daniela MRitacco, VivianaGotuzzo, EduardoGarcia de Viedma, DarioAntibióticos AntituberculososFil: Abascal, Estefanía. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; EspañaFil: Herranz, Marta. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; EspañaFil: Acosta, Fermín. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; EspañaFil: Agapito, Juan. TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima; Peru.Fil: Cabibbe, Andrea M. Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan; Italia.Fil: Monteserín, Johana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Epidemiología; Argentina.Fil: Ruiz Serrano, María Jesús. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.Fil: Gijón, Paloma. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.Fil: Fernández-González, Francisco. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.Fil: Lozano, Nuria. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.Fil: Chiner-Oms, Álvaro. Unidad Mixta Genómica y Salud, Centro Superior de Investigación en Salud Pública (FISABIO)-Universitat de València; España.Fil: Cáceres, Tatiana. TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima; Peru.Fil: Gómez Pintado, Pilar. General Subdirection of Penitentiary Health - Penitentiary Institutions - Ministry of Interior of Spain; España.Fil: Acín, Enrique. General Subdirection of Penitentiary Health - Penitentiary Institutions - Ministry of Interior of Spain; España.Fil: Muñoz, Patricia. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; EspañaFil: Comas, Iñaki. Instituto de Biomedicina de Valencia (IBV) Consejo Superior de Investigaciones Científicas (CSIC); España.Fil: Cirillo, Daniela M. Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan; Italia.Fil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Epidemiología; Argentina.Fil: Gotuzzo, Eduardo. TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima; Peru.Fil: García de Viedma, Dario. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR-clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002-5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.2020info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf2045-2322http://sgc.anlis.gob.ar/handle/123456789/172710.1038/s41598-020-59373-wScientific reports 2020; 10(1):2704reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISScientific reportsenginfo:eu-repo/semantics/openAccess2025-09-04T11:17:20Zoai:sgc.anlis.gob.ar:Publications/123456789/1727Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-04 11:17:21.051Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
title Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
spellingShingle Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
Abascal, Estefanía
Antibióticos Antituberculosos
title_short Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
title_full Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
title_fullStr Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
title_full_unstemmed Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
title_sort Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
dc.creator.none.fl_str_mv Abascal, Estefanía
Herranz, Marta
Acosta, Fermín
Agapito, Juan
Cabibbe, Andrea M
Monteserin, Johana
Ruiz Serrano, María Jesús
Gijón, Paloma
Fernández-González, Francisco
Lozano, Nuria
Chiner-Oms, Álvaro
Cáceres, Tatiana
Pintado, Pilar Gómez
Acín, Enrique
Valencia, Eddy
Muñoz, Patricia
Comas, Iñaki
Cirillo, Daniela M
Ritacco, Viviana
Gotuzzo, Eduardo
Garcia de Viedma, Dario
author Abascal, Estefanía
author_facet Abascal, Estefanía
Herranz, Marta
Acosta, Fermín
Agapito, Juan
Cabibbe, Andrea M
Monteserin, Johana
Ruiz Serrano, María Jesús
Gijón, Paloma
Fernández-González, Francisco
Lozano, Nuria
Chiner-Oms, Álvaro
Cáceres, Tatiana
Pintado, Pilar Gómez
Acín, Enrique
Valencia, Eddy
Muñoz, Patricia
Comas, Iñaki
Cirillo, Daniela M
Ritacco, Viviana
Gotuzzo, Eduardo
Garcia de Viedma, Dario
author_role author
author2 Herranz, Marta
Acosta, Fermín
Agapito, Juan
Cabibbe, Andrea M
Monteserin, Johana
Ruiz Serrano, María Jesús
Gijón, Paloma
Fernández-González, Francisco
Lozano, Nuria
Chiner-Oms, Álvaro
Cáceres, Tatiana
Pintado, Pilar Gómez
Acín, Enrique
Valencia, Eddy
Muñoz, Patricia
Comas, Iñaki
Cirillo, Daniela M
Ritacco, Viviana
Gotuzzo, Eduardo
Garcia de Viedma, Dario
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Antibióticos Antituberculosos
topic Antibióticos Antituberculosos
dc.description.none.fl_txt_mv Fil: Abascal, Estefanía. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España
Fil: Herranz, Marta. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España
Fil: Acosta, Fermín. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España
Fil: Agapito, Juan. TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima; Peru.
Fil: Cabibbe, Andrea M. Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan; Italia.
Fil: Monteserín, Johana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Epidemiología; Argentina.
Fil: Ruiz Serrano, María Jesús. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
Fil: Gijón, Paloma. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
Fil: Fernández-González, Francisco. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
Fil: Lozano, Nuria. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
Fil: Chiner-Oms, Álvaro. Unidad Mixta Genómica y Salud, Centro Superior de Investigación en Salud Pública (FISABIO)-Universitat de València; España.
Fil: Cáceres, Tatiana. TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima; Peru.
Fil: Gómez Pintado, Pilar. General Subdirection of Penitentiary Health - Penitentiary Institutions - Ministry of Interior of Spain; España.
Fil: Acín, Enrique. General Subdirection of Penitentiary Health - Penitentiary Institutions - Ministry of Interior of Spain; España.
Fil: Muñoz, Patricia. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España
Fil: Comas, Iñaki. Instituto de Biomedicina de Valencia (IBV) Consejo Superior de Investigaciones Científicas (CSIC); España.
Fil: Cirillo, Daniela M. Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan; Italia.
Fil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Epidemiología; Argentina.
Fil: Gotuzzo, Eduardo. TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima; Peru.
Fil: García de Viedma, Dario. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR-clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002-5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.
description Fil: Abascal, Estefanía. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 2045-2322
http://sgc.anlis.gob.ar/handle/123456789/1727
10.1038/s41598-020-59373-w
identifier_str_mv 2045-2322
10.1038/s41598-020-59373-w
url http://sgc.anlis.gob.ar/handle/123456789/1727
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Scientific reports
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scientific reports 2020; 10(1):2704
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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