Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections

Autores
Abascal, Estefanía; Herranz, Marta; Acosta, Fermín Eloy; Agapito, Juan; Cabibbe, Andrea M.; Monteserin, Johana; Ruiz Serrano, María Jesús; Gijón, Paloma; Fernández González, Francisco; Lozano, Nuria; Chiner Oms, Álvaro; Cáceres, Tatiana; Pintado, Pilar Gómez; Acín, Enrique; Valencia, Eddy; Muñoz, Patricia; Comas, Iñaki; Cirillo, Daniela M.; Ritacco, Gloria Viviana; Gotuzzo, Eduardo; García de Viedma, Darío
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR–clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002–5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.
Fil: Abascal, Estefanía. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Herranz, Marta. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Centro de Investigación Biomédica en Red. Enfermedades Respiratorias; España
Fil: Acosta, Fermín Eloy. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Agapito, Juan. Universidad Peruana Cayetano Heredia; Perú
Fil: Cabibbe, Andrea M.. San Raffaele Scientific Institute; Italia
Fil: Monteserin, Johana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Ruiz Serrano, María Jesús. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Centro de Investigación Biomédica en Red. Enfermedades Respiratorias; España
Fil: Gijón, Paloma. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Fernández González, Francisco. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Lozano, Nuria. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Chiner Oms, Álvaro. Universidad de Valencia; España
Fil: Cáceres, Tatiana. Universidad Peruana Cayetano Heredia; Perú
Fil: Pintado, Pilar Gómez. Ministerio del Interior; España
Fil: Acín, Enrique. Ministerio del Interior; España
Fil: Valencia, Eddy. Instituto Nacional de Salud de Perú; Perú
Fil: Muñoz, Patricia. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Centro de Investigación Biomédica en Red. Enfermedades Respiratorias; España
Fil: Comas, Iñaki. Consejo Superior de Investigaciones Científicas. Instituto de Biomedicina de Valencia; España. Centro de Investigación Biomédica en Red. Enfermedades Respiratorias; España
Fil: Cirillo, Daniela M.. San Raffaele Scientific Institute; Italia
Fil: Ritacco, Gloria Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Gotuzzo, Eduardo. Universidad Peruana Cayetano Heredia; Perú
Fil: García de Viedma, Darío. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Centro de Investigación Biomédica en Red. Enfermedades Respiratorias; España
Materia
MULTIDRUG RESISTANT TUBERCULOSIS
PRISON
CROSS-BORDER TRANSMISSION
MOLECULAR EPIDEMIOLOGY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/168357
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/168357
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infectionsAbascal, EstefaníaHerranz, MartaAcosta, Fermín EloyAgapito, JuanCabibbe, Andrea M.Monteserin, JohanaRuiz Serrano, María JesúsGijón, PalomaFernández González, FranciscoLozano, NuriaChiner Oms, ÁlvaroCáceres, TatianaPintado, Pilar GómezAcín, EnriqueValencia, EddyMuñoz, PatriciaComas, IñakiCirillo, Daniela M.Ritacco, Gloria VivianaGotuzzo, EduardoGarcía de Viedma, DaríoMULTIDRUG RESISTANT TUBERCULOSISPRISONCROSS-BORDER TRANSMISSIONMOLECULAR EPIDEMIOLOGYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR–clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002–5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.Fil: Abascal, Estefanía. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaFil: Herranz, Marta. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Centro de Investigación Biomédica en Red. Enfermedades Respiratorias; EspañaFil: Acosta, Fermín Eloy. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaFil: Agapito, Juan. Universidad Peruana Cayetano Heredia; PerúFil: Cabibbe, Andrea M.. San Raffaele Scientific Institute; ItaliaFil: Monteserin, Johana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: Ruiz Serrano, María Jesús. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Centro de Investigación Biomédica en Red. Enfermedades Respiratorias; EspañaFil: Gijón, Paloma. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaFil: Fernández González, Francisco. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaFil: Lozano, Nuria. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaFil: Chiner Oms, Álvaro. Universidad de Valencia; EspañaFil: Cáceres, Tatiana. Universidad Peruana Cayetano Heredia; PerúFil: Pintado, Pilar Gómez. Ministerio del Interior; EspañaFil: Acín, Enrique. Ministerio del Interior; EspañaFil: Valencia, Eddy. Instituto Nacional de Salud de Perú; PerúFil: Muñoz, Patricia. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Centro de Investigación Biomédica en Red. Enfermedades Respiratorias; EspañaFil: Comas, Iñaki. Consejo Superior de Investigaciones Científicas. Instituto de Biomedicina de Valencia; España. Centro de Investigación Biomédica en Red. Enfermedades Respiratorias; EspañaFil: Cirillo, Daniela M.. San Raffaele Scientific Institute; ItaliaFil: Ritacco, Gloria Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: Gotuzzo, Eduardo. Universidad Peruana Cayetano Heredia; PerúFil: García de Viedma, Darío. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Centro de Investigación Biomédica en Red. Enfermedades Respiratorias; EspañaNature Research2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/168357Abascal, Estefanía; Herranz, Marta; Acosta, Fermín Eloy; Agapito, Juan; Cabibbe, Andrea M.; et al.; Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-82045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41598-020-59373-winfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-59373-winfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-23T13:19:47Zoai:ri.conicet.gov.ar:11336/168357instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-23 13:19:47.482CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
title Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
spellingShingle Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
Abascal, Estefanía
MULTIDRUG RESISTANT TUBERCULOSIS
PRISON
CROSS-BORDER TRANSMISSION
MOLECULAR EPIDEMIOLOGY
title_short Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
title_full Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
title_fullStr Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
title_full_unstemmed Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
title_sort Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
dc.creator.none.fl_str_mv Abascal, Estefanía
Herranz, Marta
Acosta, Fermín Eloy
Agapito, Juan
Cabibbe, Andrea M.
Monteserin, Johana
Ruiz Serrano, María Jesús
Gijón, Paloma
Fernández González, Francisco
Lozano, Nuria
Chiner Oms, Álvaro
Cáceres, Tatiana
Pintado, Pilar Gómez
Acín, Enrique
Valencia, Eddy
Muñoz, Patricia
Comas, Iñaki
Cirillo, Daniela M.
Ritacco, Gloria Viviana
Gotuzzo, Eduardo
García de Viedma, Darío
author Abascal, Estefanía
author_facet Abascal, Estefanía
Herranz, Marta
Acosta, Fermín Eloy
Agapito, Juan
Cabibbe, Andrea M.
Monteserin, Johana
Ruiz Serrano, María Jesús
Gijón, Paloma
Fernández González, Francisco
Lozano, Nuria
Chiner Oms, Álvaro
Cáceres, Tatiana
Pintado, Pilar Gómez
Acín, Enrique
Valencia, Eddy
Muñoz, Patricia
Comas, Iñaki
Cirillo, Daniela M.
Ritacco, Gloria Viviana
Gotuzzo, Eduardo
García de Viedma, Darío
author_role author
author2 Herranz, Marta
Acosta, Fermín Eloy
Agapito, Juan
Cabibbe, Andrea M.
Monteserin, Johana
Ruiz Serrano, María Jesús
Gijón, Paloma
Fernández González, Francisco
Lozano, Nuria
Chiner Oms, Álvaro
Cáceres, Tatiana
Pintado, Pilar Gómez
Acín, Enrique
Valencia, Eddy
Muñoz, Patricia
Comas, Iñaki
Cirillo, Daniela M.
Ritacco, Gloria Viviana
Gotuzzo, Eduardo
García de Viedma, Darío
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MULTIDRUG RESISTANT TUBERCULOSIS
PRISON
CROSS-BORDER TRANSMISSION
MOLECULAR EPIDEMIOLOGY
topic MULTIDRUG RESISTANT TUBERCULOSIS
PRISON
CROSS-BORDER TRANSMISSION
MOLECULAR EPIDEMIOLOGY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR–clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002–5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.
Fil: Abascal, Estefanía. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Herranz, Marta. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Centro de Investigación Biomédica en Red. Enfermedades Respiratorias; España
Fil: Acosta, Fermín Eloy. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Agapito, Juan. Universidad Peruana Cayetano Heredia; Perú
Fil: Cabibbe, Andrea M.. San Raffaele Scientific Institute; Italia
Fil: Monteserin, Johana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Ruiz Serrano, María Jesús. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Centro de Investigación Biomédica en Red. Enfermedades Respiratorias; España
Fil: Gijón, Paloma. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Fernández González, Francisco. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Lozano, Nuria. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Chiner Oms, Álvaro. Universidad de Valencia; España
Fil: Cáceres, Tatiana. Universidad Peruana Cayetano Heredia; Perú
Fil: Pintado, Pilar Gómez. Ministerio del Interior; España
Fil: Acín, Enrique. Ministerio del Interior; España
Fil: Valencia, Eddy. Instituto Nacional de Salud de Perú; Perú
Fil: Muñoz, Patricia. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Centro de Investigación Biomédica en Red. Enfermedades Respiratorias; España
Fil: Comas, Iñaki. Consejo Superior de Investigaciones Científicas. Instituto de Biomedicina de Valencia; España. Centro de Investigación Biomédica en Red. Enfermedades Respiratorias; España
Fil: Cirillo, Daniela M.. San Raffaele Scientific Institute; Italia
Fil: Ritacco, Gloria Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Gotuzzo, Eduardo. Universidad Peruana Cayetano Heredia; Perú
Fil: García de Viedma, Darío. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Centro de Investigación Biomédica en Red. Enfermedades Respiratorias; España
description It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR–clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002–5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.
publishDate 2020
dc.date.none.fl_str_mv 2020-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/168357
Abascal, Estefanía; Herranz, Marta; Acosta, Fermín Eloy; Agapito, Juan; Cabibbe, Andrea M.; et al.; Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-8
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/168357
identifier_str_mv Abascal, Estefanía; Herranz, Marta; Acosta, Fermín Eloy; Agapito, Juan; Cabibbe, Andrea M.; et al.; Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-8
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41598-020-59373-w
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-59373-w
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.952241

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