Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells
- Autores
- Grumelli, Sandra; Islan, Germán Abel; Castro, Guillermo Raúl
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- reseña artículo
- Estado
- versión publicada
- Descripción
- Recent studies in cystic fibrosis (CF) transmembrane regulator (CFTR) mutations and function have shed light on its involvement in disease progression. The extent of cell and tissue distribution of CFTR facilitates systemic dysfunction of ion transport in patients carrying a mutation in CFTR, however, its incidences as cofounding risk factor to develop other diseases is not well studied. In this review we differentiate the dysfunctions driven by CFTR mutations in cell of the immune system and their role in CF progression and examine the types of medical treatments available to patients up to date.
Centro de Investigación y Desarrollo en Fermentaciones Industriales - Materia
-
Ciencias Médicas
Cystic fibrosis
CFTR-deficiency
CF-immune response
Antibiotic therapies
Microbioma maintenance
Gene therapy - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/100520
Ver los metadatos del registro completo
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Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cellsGrumelli, SandraIslan, Germán AbelCastro, Guillermo RaúlCiencias MédicasCystic fibrosisCFTR-deficiencyCF-immune responseAntibiotic therapiesMicrobioma maintenanceGene therapyRecent studies in cystic fibrosis (CF) transmembrane regulator (CFTR) mutations and function have shed light on its involvement in disease progression. The extent of cell and tissue distribution of CFTR facilitates systemic dysfunction of ion transport in patients carrying a mutation in CFTR, however, its incidences as cofounding risk factor to develop other diseases is not well studied. In this review we differentiate the dysfunctions driven by CFTR mutations in cell of the immune system and their role in CF progression and examine the types of medical treatments available to patients up to date.Centro de Investigación y Desarrollo en Fermentaciones Industriales2016-08info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf39-51http://sedici.unlp.edu.ar/handle/10915/100520enginfo:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/49503info:eu-repo/semantics/altIdentifier/url/http://oatext.com/Consequences-of-cystic-fibrosis-transmembrane-regulator-mutations-on-inflammatory-cells.phpinfo:eu-repo/semantics/altIdentifier/issn/2398-3108info:eu-repo/semantics/altIdentifier/doi/10.15761/PCCM.1000110info:eu-repo/semantics/altIdentifier/hdl/11336/49503info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:12:00Zoai:sedici.unlp.edu.ar:10915/100520Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:12:00.776SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells |
title |
Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells |
spellingShingle |
Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells Grumelli, Sandra Ciencias Médicas Cystic fibrosis CFTR-deficiency CF-immune response Antibiotic therapies Microbioma maintenance Gene therapy |
title_short |
Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells |
title_full |
Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells |
title_fullStr |
Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells |
title_full_unstemmed |
Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells |
title_sort |
Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells |
dc.creator.none.fl_str_mv |
Grumelli, Sandra Islan, Germán Abel Castro, Guillermo Raúl |
author |
Grumelli, Sandra |
author_facet |
Grumelli, Sandra Islan, Germán Abel Castro, Guillermo Raúl |
author_role |
author |
author2 |
Islan, Germán Abel Castro, Guillermo Raúl |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Ciencias Médicas Cystic fibrosis CFTR-deficiency CF-immune response Antibiotic therapies Microbioma maintenance Gene therapy |
topic |
Ciencias Médicas Cystic fibrosis CFTR-deficiency CF-immune response Antibiotic therapies Microbioma maintenance Gene therapy |
dc.description.none.fl_txt_mv |
Recent studies in cystic fibrosis (CF) transmembrane regulator (CFTR) mutations and function have shed light on its involvement in disease progression. The extent of cell and tissue distribution of CFTR facilitates systemic dysfunction of ion transport in patients carrying a mutation in CFTR, however, its incidences as cofounding risk factor to develop other diseases is not well studied. In this review we differentiate the dysfunctions driven by CFTR mutations in cell of the immune system and their role in CF progression and examine the types of medical treatments available to patients up to date. Centro de Investigación y Desarrollo en Fermentaciones Industriales |
description |
Recent studies in cystic fibrosis (CF) transmembrane regulator (CFTR) mutations and function have shed light on its involvement in disease progression. The extent of cell and tissue distribution of CFTR facilitates systemic dysfunction of ion transport in patients carrying a mutation in CFTR, however, its incidences as cofounding risk factor to develop other diseases is not well studied. In this review we differentiate the dysfunctions driven by CFTR mutations in cell of the immune system and their role in CF progression and examine the types of medical treatments available to patients up to date. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Revision http://purl.org/coar/resource_type/c_dcae04bc info:ar-repo/semantics/resenaArticulo |
format |
review |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/100520 |
url |
http://sedici.unlp.edu.ar/handle/10915/100520 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/49503 info:eu-repo/semantics/altIdentifier/url/http://oatext.com/Consequences-of-cystic-fibrosis-transmembrane-regulator-mutations-on-inflammatory-cells.php info:eu-repo/semantics/altIdentifier/issn/2398-3108 info:eu-repo/semantics/altIdentifier/doi/10.15761/PCCM.1000110 info:eu-repo/semantics/altIdentifier/hdl/11336/49503 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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openAccess |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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application/pdf 39-51 |
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