Formation of semi-crystalline fraction, in which all diethylene glycol (DEG) is contained, during its extraction from human tissues: the probable cause of false negative results in...

Autores
Giannuzzi, Leda; Ferrari, Luis Alberto
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Diethylene glycol (DEG) can be found in commercial products such as antifreeze, brake fluid, and lubricants. In addition, DEG has been found as a contaminant of raw materials in the production of pharmaceuticals. At least ten mass DEG poisoning events have occurred over the past 70 years. The first and largest outbreak, which resulted in 105 deaths, occurred in the United States in 1937. In 1967, a mass poisoning occurred in South Africa in which 7 children died. In 1992 in Argentina, 29 people died after consuming propolis syrups that contained high DEG concentrations; the drug was widely commercialized in Argentina to treat mild upper respiratory tract infections. Thereafter, pediatric medicinal syrups contaminated with DEG caused the deaths of 33 children in India in 1998, and 85 children in Haiti in 1995–1996. The most recent outbreak took place in Panama in 2006, in which more than 100 people died due to DEG poisoning. In spite of these repeated mass DEG poisonings, only a few analytical methods for DEG analysis, by gas chromatography (GC) and GC–mass spectrometry (MS), have been reported. There is a pressing need to establish and improve the methods for analysis of DEG, especially for postmortem human samples. As a result of our extensive experience in analysis of DEG in postmortem samples, we hereby report an important characteristic of DEG that we observed during sample extraction.
Facultad de Ciencias Exactas
Materia
Ciencias Exactas
Química
Diethylene glycol (DEG)
analysis of DEG
postmortem samples
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/145140

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network_name_str SEDICI (UNLP)
spelling Formation of semi-crystalline fraction, in which all diethylene glycol (DEG) is contained, during its extraction from human tissues: the probable cause of false negative results in fatal DEG poisoning casesGiannuzzi, LedaFerrari, Luis AlbertoCiencias ExactasQuímicaDiethylene glycol (DEG)analysis of DEGpostmortem samplesDiethylene glycol (DEG) can be found in commercial products such as antifreeze, brake fluid, and lubricants. In addition, DEG has been found as a contaminant of raw materials in the production of pharmaceuticals. At least ten mass DEG poisoning events have occurred over the past 70 years. The first and largest outbreak, which resulted in 105 deaths, occurred in the United States in 1937. In 1967, a mass poisoning occurred in South Africa in which 7 children died. In 1992 in Argentina, 29 people died after consuming propolis syrups that contained high DEG concentrations; the drug was widely commercialized in Argentina to treat mild upper respiratory tract infections. Thereafter, pediatric medicinal syrups contaminated with DEG caused the deaths of 33 children in India in 1998, and 85 children in Haiti in 1995–1996. The most recent outbreak took place in Panama in 2006, in which more than 100 people died due to DEG poisoning. In spite of these repeated mass DEG poisonings, only a few analytical methods for DEG analysis, by gas chromatography (GC) and GC–mass spectrometry (MS), have been reported. There is a pressing need to establish and improve the methods for analysis of DEG, especially for postmortem human samples. As a result of our extensive experience in analysis of DEG in postmortem samples, we hereby report an important characteristic of DEG that we observed during sample extraction.Facultad de Ciencias Exactas2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf59-61http://sedici.unlp.edu.ar/handle/10915/145140enginfo:eu-repo/semantics/altIdentifier/issn/1860-8965info:eu-repo/semantics/altIdentifier/issn/1860-8973info:eu-repo/semantics/altIdentifier/doi/10.1007/s11419-012-0154-5info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:16Zoai:sedici.unlp.edu.ar:10915/145140Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:17.248SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Formation of semi-crystalline fraction, in which all diethylene glycol (DEG) is contained, during its extraction from human tissues: the probable cause of false negative results in fatal DEG poisoning cases
title Formation of semi-crystalline fraction, in which all diethylene glycol (DEG) is contained, during its extraction from human tissues: the probable cause of false negative results in fatal DEG poisoning cases
spellingShingle Formation of semi-crystalline fraction, in which all diethylene glycol (DEG) is contained, during its extraction from human tissues: the probable cause of false negative results in fatal DEG poisoning cases
Giannuzzi, Leda
Ciencias Exactas
Química
Diethylene glycol (DEG)
analysis of DEG
postmortem samples
title_short Formation of semi-crystalline fraction, in which all diethylene glycol (DEG) is contained, during its extraction from human tissues: the probable cause of false negative results in fatal DEG poisoning cases
title_full Formation of semi-crystalline fraction, in which all diethylene glycol (DEG) is contained, during its extraction from human tissues: the probable cause of false negative results in fatal DEG poisoning cases
title_fullStr Formation of semi-crystalline fraction, in which all diethylene glycol (DEG) is contained, during its extraction from human tissues: the probable cause of false negative results in fatal DEG poisoning cases
title_full_unstemmed Formation of semi-crystalline fraction, in which all diethylene glycol (DEG) is contained, during its extraction from human tissues: the probable cause of false negative results in fatal DEG poisoning cases
title_sort Formation of semi-crystalline fraction, in which all diethylene glycol (DEG) is contained, during its extraction from human tissues: the probable cause of false negative results in fatal DEG poisoning cases
dc.creator.none.fl_str_mv Giannuzzi, Leda
Ferrari, Luis Alberto
author Giannuzzi, Leda
author_facet Giannuzzi, Leda
Ferrari, Luis Alberto
author_role author
author2 Ferrari, Luis Alberto
author2_role author
dc.subject.none.fl_str_mv Ciencias Exactas
Química
Diethylene glycol (DEG)
analysis of DEG
postmortem samples
topic Ciencias Exactas
Química
Diethylene glycol (DEG)
analysis of DEG
postmortem samples
dc.description.none.fl_txt_mv Diethylene glycol (DEG) can be found in commercial products such as antifreeze, brake fluid, and lubricants. In addition, DEG has been found as a contaminant of raw materials in the production of pharmaceuticals. At least ten mass DEG poisoning events have occurred over the past 70 years. The first and largest outbreak, which resulted in 105 deaths, occurred in the United States in 1937. In 1967, a mass poisoning occurred in South Africa in which 7 children died. In 1992 in Argentina, 29 people died after consuming propolis syrups that contained high DEG concentrations; the drug was widely commercialized in Argentina to treat mild upper respiratory tract infections. Thereafter, pediatric medicinal syrups contaminated with DEG caused the deaths of 33 children in India in 1998, and 85 children in Haiti in 1995–1996. The most recent outbreak took place in Panama in 2006, in which more than 100 people died due to DEG poisoning. In spite of these repeated mass DEG poisonings, only a few analytical methods for DEG analysis, by gas chromatography (GC) and GC–mass spectrometry (MS), have been reported. There is a pressing need to establish and improve the methods for analysis of DEG, especially for postmortem human samples. As a result of our extensive experience in analysis of DEG in postmortem samples, we hereby report an important characteristic of DEG that we observed during sample extraction.
Facultad de Ciencias Exactas
description Diethylene glycol (DEG) can be found in commercial products such as antifreeze, brake fluid, and lubricants. In addition, DEG has been found as a contaminant of raw materials in the production of pharmaceuticals. At least ten mass DEG poisoning events have occurred over the past 70 years. The first and largest outbreak, which resulted in 105 deaths, occurred in the United States in 1937. In 1967, a mass poisoning occurred in South Africa in which 7 children died. In 1992 in Argentina, 29 people died after consuming propolis syrups that contained high DEG concentrations; the drug was widely commercialized in Argentina to treat mild upper respiratory tract infections. Thereafter, pediatric medicinal syrups contaminated with DEG caused the deaths of 33 children in India in 1998, and 85 children in Haiti in 1995–1996. The most recent outbreak took place in Panama in 2006, in which more than 100 people died due to DEG poisoning. In spite of these repeated mass DEG poisonings, only a few analytical methods for DEG analysis, by gas chromatography (GC) and GC–mass spectrometry (MS), have been reported. There is a pressing need to establish and improve the methods for analysis of DEG, especially for postmortem human samples. As a result of our extensive experience in analysis of DEG in postmortem samples, we hereby report an important characteristic of DEG that we observed during sample extraction.
publishDate 2013
dc.date.none.fl_str_mv 2013-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/145140
url http://sedici.unlp.edu.ar/handle/10915/145140
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1860-8965
info:eu-repo/semantics/altIdentifier/issn/1860-8973
info:eu-repo/semantics/altIdentifier/doi/10.1007/s11419-012-0154-5
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
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instname:Universidad Nacional de La Plata
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