Genomic features of attenuated Junín virus vaccine strain candidate

Autores
Goñi, Sandra Elizabeth; Iserte, Javier Alonso; Ambrosio, Ana Maria; Romanowski, Víctor; Ghiringhelli, Pablo Daniel; Lozano, Mario Enrique
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper, we report the nucleotide sequences of L RNA of Candid #1 and examine the relationship to its more virulent ancestors Junin virus XJ#44 and XJ 13 (prototype) and other closely and distantly related arenaviruses. Comparisons of the nucleotide and amino acid sequences of L and Z genes of Candid #1 and its progenitor strains revealed twelve point mutations in the L polypeptide that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype. In contrast, Z ORF was completely conserved among all strains.
Instituto de Biotecnología y Biología Molecular
Materia
Biología
Arenaviridae
Junin
Attenuation
Molecular markers
L RNA
Genomic
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/138396
Acceder
id SEDICI_e11f68483d9c78afa3eb0b3a312b65fb
oai_identifier_str oai:sedici.unlp.edu.ar:10915/138396
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Genomic features of attenuated Junín virus vaccine strain candidateGoñi, Sandra ElizabethIserte, Javier AlonsoAmbrosio, Ana MariaRomanowski, VíctorGhiringhelli, Pablo DanielLozano, Mario EnriqueBiologíaArenaviridaeJuninAttenuationMolecular markersL RNAGenomicJunin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper, we report the nucleotide sequences of L RNA of Candid #1 and examine the relationship to its more virulent ancestors Junin virus XJ#44 and XJ 13 (prototype) and other closely and distantly related arenaviruses. Comparisons of the nucleotide and amino acid sequences of L and Z genes of Candid #1 and its progenitor strains revealed twelve point mutations in the L polypeptide that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype. In contrast, Z ORF was completely conserved among all strains.Instituto de Biotecnología y Biología Molecular2006-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf37-41http://sedici.unlp.edu.ar/handle/10915/138396enginfo:eu-repo/semantics/altIdentifier/issn/0920-8569info:eu-repo/semantics/altIdentifier/issn/1572-994Xinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s11262-005-5843-2info:eu-repo/semantics/altIdentifier/pmid/16525733info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2026-02-26T11:19:12Zoai:sedici.unlp.edu.ar:10915/138396Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292026-02-26 11:19:12.836SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Genomic features of attenuated Junín virus vaccine strain candidate
title Genomic features of attenuated Junín virus vaccine strain candidate
spellingShingle Genomic features of attenuated Junín virus vaccine strain candidate
Goñi, Sandra Elizabeth
Biología
Arenaviridae
Junin
Attenuation
Molecular markers
L RNA
Genomic
title_short Genomic features of attenuated Junín virus vaccine strain candidate
title_full Genomic features of attenuated Junín virus vaccine strain candidate
title_fullStr Genomic features of attenuated Junín virus vaccine strain candidate
title_full_unstemmed Genomic features of attenuated Junín virus vaccine strain candidate
title_sort Genomic features of attenuated Junín virus vaccine strain candidate
dc.creator.none.fl_str_mv Goñi, Sandra Elizabeth
Iserte, Javier Alonso
Ambrosio, Ana Maria
Romanowski, Víctor
Ghiringhelli, Pablo Daniel
Lozano, Mario Enrique
author Goñi, Sandra Elizabeth
author_facet Goñi, Sandra Elizabeth
Iserte, Javier Alonso
Ambrosio, Ana Maria
Romanowski, Víctor
Ghiringhelli, Pablo Daniel
Lozano, Mario Enrique
author_role author
author2 Iserte, Javier Alonso
Ambrosio, Ana Maria
Romanowski, Víctor
Ghiringhelli, Pablo Daniel
Lozano, Mario Enrique
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Biología
Arenaviridae
Junin
Attenuation
Molecular markers
L RNA
Genomic
topic Biología
Arenaviridae
Junin
Attenuation
Molecular markers
L RNA
Genomic
dc.description.none.fl_txt_mv Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper, we report the nucleotide sequences of L RNA of Candid #1 and examine the relationship to its more virulent ancestors Junin virus XJ#44 and XJ 13 (prototype) and other closely and distantly related arenaviruses. Comparisons of the nucleotide and amino acid sequences of L and Z genes of Candid #1 and its progenitor strains revealed twelve point mutations in the L polypeptide that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype. In contrast, Z ORF was completely conserved among all strains.
Instituto de Biotecnología y Biología Molecular
description Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper, we report the nucleotide sequences of L RNA of Candid #1 and examine the relationship to its more virulent ancestors Junin virus XJ#44 and XJ 13 (prototype) and other closely and distantly related arenaviruses. Comparisons of the nucleotide and amino acid sequences of L and Z genes of Candid #1 and its progenitor strains revealed twelve point mutations in the L polypeptide that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype. In contrast, Z ORF was completely conserved among all strains.
publishDate 2006
dc.date.none.fl_str_mv 2006-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/138396
url http://sedici.unlp.edu.ar/handle/10915/138396
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0920-8569
info:eu-repo/semantics/altIdentifier/issn/1572-994X
info:eu-repo/semantics/altIdentifier/doi/10.1007/s11262-005-5843-2
info:eu-repo/semantics/altIdentifier/pmid/16525733
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
37-41
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
_version_ 1858282205054238720
score 12.665996

Publicaciones similares