Protocol for the Production of a Vaccine Against Argentinian Hemorrhagic Fever

Autores
Ambrosio, Ana María; Mariani, Mauricio; Maiza, Andrea; Gamboa, Graciela; Fossa, Sebastián; Bottale, Alejandro Javier
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Ambrosio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Mariani, Mauricio. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Maiza, Andrea. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Gamboa, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Fossa, Sebastián Edgardo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Bottale, Alejando Javier. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Argentinian hemorrhagic Fever (AHF) is a febrile, acute disease caused by Junín virus (JUNV), a member of the Arenaviridae. Different approaches to obtain an effective antigen to prevent AHF using complete live or inactivated virus, as well as molecular constructs, have reached diverse development stages. This chapter refers to JUNV live attenuated vaccine strain Candid #1, currently used in Argentina to prevent AHF. A general standardized protocol used at Instituto Nacional de Enfermedades Virales Humanas (Pergamino, Pcia. Buenos Aires, Argentina) to manufacture the tissue culture derived Candid #1 vaccine is described. Intermediate stages like viral seeds and cell culture bank management, bulk vaccine manufacture, and finished product processing are also separately presented in terms of Production and Quality Control/Quality Assurance requirements, under the Adminitracion Nacional de Medicamentos, Alimentos y Tecnología Medica (ANMAT), the Argentine national regulatory authority.
Fuente
Methods in Molecular Biology 2018;1604:305-329.
Materia
Fiebre Hemorrágica Americana
Arenaviridae
Virus Junin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
none
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:Publications/123456789/2117
Acceder
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oai_identifier_str oai:sgc.anlis.gob.ar:Publications/123456789/2117
network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Protocol for the Production of a Vaccine Against Argentinian Hemorrhagic FeverAmbrosio, Ana MaríaMariani, MauricioMaiza, AndreaGamboa, GracielaFossa, SebastiánBottale, Alejandro JavierFiebre Hemorrágica AmericanaArenaviridaeVirus JuninFil: Ambrosio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: Mariani, Mauricio. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: Maiza, Andrea. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: Gamboa, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: Fossa, Sebastián Edgardo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: Bottale, Alejando Javier. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Argentinian hemorrhagic Fever (AHF) is a febrile, acute disease caused by Junín virus (JUNV), a member of the Arenaviridae. Different approaches to obtain an effective antigen to prevent AHF using complete live or inactivated virus, as well as molecular constructs, have reached diverse development stages. This chapter refers to JUNV live attenuated vaccine strain Candid #1, currently used in Argentina to prevent AHF. A general standardized protocol used at Instituto Nacional de Enfermedades Virales Humanas (Pergamino, Pcia. Buenos Aires, Argentina) to manufacture the tissue culture derived Candid #1 vaccine is described. Intermediate stages like viral seeds and cell culture bank management, bulk vaccine manufacture, and finished product processing are also separately presented in terms of Production and Quality Control/Quality Assurance requirements, under the Adminitracion Nacional de Medicamentos, Alimentos y Tecnología Medica (ANMAT), the Argentine national regulatory authority.Humana Press2018info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1064-3745http://sgc.anlis.gob.ar/handle/123456789/211710.1007/978-1-4939-6981-4_24Methods in Molecular Biology 2018;1604:305-329.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISMethods in molecular biology (Clifton, N.J.)noneinfo:eu-repo/semantics/openAccesseng2025-09-29T14:30:39Zoai:sgc.anlis.gob.ar:Publications/123456789/2117Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:30:39.941Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Protocol for the Production of a Vaccine Against Argentinian Hemorrhagic Fever
title Protocol for the Production of a Vaccine Against Argentinian Hemorrhagic Fever
spellingShingle Protocol for the Production of a Vaccine Against Argentinian Hemorrhagic Fever
Ambrosio, Ana María
Fiebre Hemorrágica Americana
Arenaviridae
Virus Junin
title_short Protocol for the Production of a Vaccine Against Argentinian Hemorrhagic Fever
title_full Protocol for the Production of a Vaccine Against Argentinian Hemorrhagic Fever
title_fullStr Protocol for the Production of a Vaccine Against Argentinian Hemorrhagic Fever
title_full_unstemmed Protocol for the Production of a Vaccine Against Argentinian Hemorrhagic Fever
title_sort Protocol for the Production of a Vaccine Against Argentinian Hemorrhagic Fever
dc.creator.none.fl_str_mv Ambrosio, Ana María
Mariani, Mauricio
Maiza, Andrea
Gamboa, Graciela
Fossa, Sebastián
Bottale, Alejandro Javier
author Ambrosio, Ana María
author_facet Ambrosio, Ana María
Mariani, Mauricio
Maiza, Andrea
Gamboa, Graciela
Fossa, Sebastián
Bottale, Alejandro Javier
author_role author
author2 Mariani, Mauricio
Maiza, Andrea
Gamboa, Graciela
Fossa, Sebastián
Bottale, Alejandro Javier
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Fiebre Hemorrágica Americana
Arenaviridae
Virus Junin
topic Fiebre Hemorrágica Americana
Arenaviridae
Virus Junin
dc.description.none.fl_txt_mv Fil: Ambrosio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Mariani, Mauricio. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Maiza, Andrea. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Gamboa, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Fossa, Sebastián Edgardo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Bottale, Alejando Javier. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Argentinian hemorrhagic Fever (AHF) is a febrile, acute disease caused by Junín virus (JUNV), a member of the Arenaviridae. Different approaches to obtain an effective antigen to prevent AHF using complete live or inactivated virus, as well as molecular constructs, have reached diverse development stages. This chapter refers to JUNV live attenuated vaccine strain Candid #1, currently used in Argentina to prevent AHF. A general standardized protocol used at Instituto Nacional de Enfermedades Virales Humanas (Pergamino, Pcia. Buenos Aires, Argentina) to manufacture the tissue culture derived Candid #1 vaccine is described. Intermediate stages like viral seeds and cell culture bank management, bulk vaccine manufacture, and finished product processing are also separately presented in terms of Production and Quality Control/Quality Assurance requirements, under the Adminitracion Nacional de Medicamentos, Alimentos y Tecnología Medica (ANMAT), the Argentine national regulatory authority.
description Fil: Ambrosio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1064-3745
http://sgc.anlis.gob.ar/handle/123456789/2117
10.1007/978-1-4939-6981-4_24
identifier_str_mv 1064-3745
10.1007/978-1-4939-6981-4_24
url http://sgc.anlis.gob.ar/handle/123456789/2117
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Methods in molecular biology (Clifton, N.J.)
dc.rights.none.fl_str_mv none
info:eu-repo/semantics/openAccess
rights_invalid_str_mv none
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Humana Press
publisher.none.fl_str_mv Humana Press
dc.source.none.fl_str_mv Methods in Molecular Biology 2018;1604:305-329.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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score 12.559606

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