Pharmacokinetics and tissue residues of an oxytetracycline/diclofenac combination in cattle

Autores
Mestorino, Olga Nora; Mariño Hernández, E.; Marchetti, María Laura; Errecalde, Jorge Eduardo
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Eight male cattle were given a combined dose containing 20 mg/kg oxytetracycline and 0.5 mg/kg diclofenac intramuscularly. Blood samples were drawn at different times until 168 h after administration. Two experimental animals were slaughtered by humane means at weekly intervals up to 28 days after administration. Samples of muscle, injection zone tissue, liver, kidney and fat were obtained. Oxytetracycline and diclofenac concentrations were determined by high performance liquid chromatography. Kinetic analysis was performed by linear regression using the CSTRIP programme. Plasma oxytetracycline concentration showed a maximum (Cmax) of 3.89 ± 1.48 μg/ml and a prolonged elimination half-life (T½b: 47.73 ± 18.33 h). The diclofenac plasma profile showed high Cmax (577.62 ± 238.40 ng/ml), and its T½b was also prolonged (30.48 ± 9.42 h). Oxytetracycline concentrations were measurable in liver and adipose tissue until day 21 after administration, but all tissue samples were negative for diclofenac at 21 days. The long elimination half-life of diclofenac was an unexpected finding; its T½b in humans is 1.1 h.
Facultad de Ciencias Veterinarias
Materia
Ciencias Veterinarias
Antimicrobial
Cattle
Diclofenac
Non-steroidal anti-inflammatory
Oxytetracycline
Pharmacokinetics
Residue
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/191486
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/191486
network_acronym_str SEDICI
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network_name_str SEDICI (UNLP)
spelling Pharmacokinetics and tissue residues of an oxytetracycline/diclofenac combination in cattleMestorino, Olga NoraMariño Hernández, E.Marchetti, María LauraErrecalde, Jorge EduardoCiencias VeterinariasAntimicrobialCattleDiclofenacNon-steroidal anti-inflammatoryOxytetracyclinePharmacokineticsResidueEight male cattle were given a combined dose containing 20 mg/kg oxytetracycline and 0.5 mg/kg diclofenac intramuscularly. Blood samples were drawn at different times until 168 h after administration. Two experimental animals were slaughtered by humane means at weekly intervals up to 28 days after administration. Samples of muscle, injection zone tissue, liver, kidney and fat were obtained. Oxytetracycline and diclofenac concentrations were determined by high performance liquid chromatography. Kinetic analysis was performed by linear regression using the CSTRIP programme. Plasma oxytetracycline concentration showed a maximum (Cmax) of 3.89 ± 1.48 μg/ml and a prolonged elimination half-life (T½b: 47.73 ± 18.33 h). The diclofenac plasma profile showed high Cmax (577.62 ± 238.40 ng/ml), and its T½b was also prolonged (30.48 ± 9.42 h). Oxytetracycline concentrations were measurable in liver and adipose tissue until day 21 after administration, but all tissue samples were negative for diclofenac at 21 days. The long elimination half-life of diclofenac was an unexpected finding; its T½b in humans is 1.1 h.Facultad de Ciencias Veterinarias2007info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf679-690http://sedici.unlp.edu.ar/handle/10915/191486enginfo:eu-repo/semantics/altIdentifier/issn/0253-1933info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2026-03-26T09:21:36Zoai:sedici.unlp.edu.ar:10915/191486Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292026-03-26 09:21:37.262SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Pharmacokinetics and tissue residues of an oxytetracycline/diclofenac combination in cattle
title Pharmacokinetics and tissue residues of an oxytetracycline/diclofenac combination in cattle
spellingShingle Pharmacokinetics and tissue residues of an oxytetracycline/diclofenac combination in cattle
Mestorino, Olga Nora
Ciencias Veterinarias
Antimicrobial
Cattle
Diclofenac
Non-steroidal anti-inflammatory
Oxytetracycline
Pharmacokinetics
Residue
title_short Pharmacokinetics and tissue residues of an oxytetracycline/diclofenac combination in cattle
title_full Pharmacokinetics and tissue residues of an oxytetracycline/diclofenac combination in cattle
title_fullStr Pharmacokinetics and tissue residues of an oxytetracycline/diclofenac combination in cattle
title_full_unstemmed Pharmacokinetics and tissue residues of an oxytetracycline/diclofenac combination in cattle
title_sort Pharmacokinetics and tissue residues of an oxytetracycline/diclofenac combination in cattle
dc.creator.none.fl_str_mv Mestorino, Olga Nora
Mariño Hernández, E.
Marchetti, María Laura
Errecalde, Jorge Eduardo
author Mestorino, Olga Nora
author_facet Mestorino, Olga Nora
Mariño Hernández, E.
Marchetti, María Laura
Errecalde, Jorge Eduardo
author_role author
author2 Mariño Hernández, E.
Marchetti, María Laura
Errecalde, Jorge Eduardo
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Veterinarias
Antimicrobial
Cattle
Diclofenac
Non-steroidal anti-inflammatory
Oxytetracycline
Pharmacokinetics
Residue
topic Ciencias Veterinarias
Antimicrobial
Cattle
Diclofenac
Non-steroidal anti-inflammatory
Oxytetracycline
Pharmacokinetics
Residue
dc.description.none.fl_txt_mv Eight male cattle were given a combined dose containing 20 mg/kg oxytetracycline and 0.5 mg/kg diclofenac intramuscularly. Blood samples were drawn at different times until 168 h after administration. Two experimental animals were slaughtered by humane means at weekly intervals up to 28 days after administration. Samples of muscle, injection zone tissue, liver, kidney and fat were obtained. Oxytetracycline and diclofenac concentrations were determined by high performance liquid chromatography. Kinetic analysis was performed by linear regression using the CSTRIP programme. Plasma oxytetracycline concentration showed a maximum (Cmax) of 3.89 ± 1.48 μg/ml and a prolonged elimination half-life (T½b: 47.73 ± 18.33 h). The diclofenac plasma profile showed high Cmax (577.62 ± 238.40 ng/ml), and its T½b was also prolonged (30.48 ± 9.42 h). Oxytetracycline concentrations were measurable in liver and adipose tissue until day 21 after administration, but all tissue samples were negative for diclofenac at 21 days. The long elimination half-life of diclofenac was an unexpected finding; its T½b in humans is 1.1 h.
Facultad de Ciencias Veterinarias
description Eight male cattle were given a combined dose containing 20 mg/kg oxytetracycline and 0.5 mg/kg diclofenac intramuscularly. Blood samples were drawn at different times until 168 h after administration. Two experimental animals were slaughtered by humane means at weekly intervals up to 28 days after administration. Samples of muscle, injection zone tissue, liver, kidney and fat were obtained. Oxytetracycline and diclofenac concentrations were determined by high performance liquid chromatography. Kinetic analysis was performed by linear regression using the CSTRIP programme. Plasma oxytetracycline concentration showed a maximum (Cmax) of 3.89 ± 1.48 μg/ml and a prolonged elimination half-life (T½b: 47.73 ± 18.33 h). The diclofenac plasma profile showed high Cmax (577.62 ± 238.40 ng/ml), and its T½b was also prolonged (30.48 ± 9.42 h). Oxytetracycline concentrations were measurable in liver and adipose tissue until day 21 after administration, but all tissue samples were negative for diclofenac at 21 days. The long elimination half-life of diclofenac was an unexpected finding; its T½b in humans is 1.1 h.
publishDate 2007
dc.date.none.fl_str_mv 2007
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/191486
url http://sedici.unlp.edu.ar/handle/10915/191486
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0253-1933
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
679-690
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 12.977003

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