Insulin resistance: the linchpin between prediabetes and cardiovascular disease

Autores
Salazar, Martín R.; Carbajal, Horacio Antonio; Espeche, Walter Gastón; Aizpurúa, Marcelo; Leiva Sisnieguez, Carlos Enrique; Leiva Sisnieguez, Betty Cecilia; Stavile, Rodolfo Nicolás; March, Carlos E.; Reaven, Gerald M.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to test the hypothesis that cardiovascular disease occurs to the greatest extent in persons with prediabetes mellitus who are also insulin resistant. In 2003, 664 non-diabetic women (n = 457) and men (n = 207), aged 52 ± 16 and 53 ± 15 years, were surveyed during a programme for cardiovascular disease prevention. Fasting plasma glucose concentrations defined participants as having normal fasting plasma glucose (fasting plasma glucose <5.6 mmol/L) or prediabetes mellitus (fasting plasma glucose ⩾ 5.6 and <7.0 mmol/L). The tertile of prediabetes mellitus subjects with the highest fasting plasma insulin concentration was classified as insulin resistant. Baseline cardiovascular disease risk factors were accentuated in prediabetes mellitus versus normal fasting glucose, particularly in prediabetes mellitus/insulin resistant. In 2012, 86% of the sample were surveyed again, and the crude incidence for cardiovascular disease was higher in subjects with prediabetes mellitus versus normal fasting glucose (13.7 vs 6.0/100 persons/10 years; age- and sex-adjusted hazard ratio = 1.88, p = 0.052). In prediabetes mellitus, the crude incidences were 22.9 versus 9.6/100 persons/10 years in insulin resistant versus non-insulin resistant persons (age- and sex-adjusted hazard ratio = 2.36, p = 0.040). In conclusion, cardiovascular disease risk was accentuated in prediabetes mellitus/insulin resistant individuals, with a relative risk approximately twice as high compared to prediabetes mellitus/non-insulin resistant subjects.
Facultad de Ciencias Médicas
Materia
Ciencias Médicas
Prediabetes
Cardiovascular disease
Insulin resistance
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/136298
Acceder
id SEDICI_d7bc49a832fa13e97194b76504e9055e
oai_identifier_str oai:sedici.unlp.edu.ar:10915/136298
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Insulin resistance: the linchpin between prediabetes and cardiovascular diseaseSalazar, Martín R.Carbajal, Horacio AntonioEspeche, Walter GastónAizpurúa, MarceloLeiva Sisnieguez, Carlos EnriqueLeiva Sisnieguez, Betty CeciliaStavile, Rodolfo NicolásMarch, Carlos E.Reaven, Gerald M.Ciencias MédicasPrediabetesCardiovascular diseaseInsulin resistanceThe aim of this study was to test the hypothesis that cardiovascular disease occurs to the greatest extent in persons with prediabetes mellitus who are also insulin resistant. In 2003, 664 non-diabetic women (n = 457) and men (n = 207), aged 52 ± 16 and 53 ± 15 years, were surveyed during a programme for cardiovascular disease prevention. Fasting plasma glucose concentrations defined participants as having normal fasting plasma glucose (fasting plasma glucose <5.6 mmol/L) or prediabetes mellitus (fasting plasma glucose ⩾ 5.6 and <7.0 mmol/L). The tertile of prediabetes mellitus subjects with the highest fasting plasma insulin concentration was classified as insulin resistant. Baseline cardiovascular disease risk factors were accentuated in prediabetes mellitus versus normal fasting glucose, particularly in prediabetes mellitus/insulin resistant. In 2012, 86% of the sample were surveyed again, and the crude incidence for cardiovascular disease was higher in subjects with prediabetes mellitus versus normal fasting glucose (13.7 vs 6.0/100 persons/10 years; age- and sex-adjusted hazard ratio = 1.88, p = 0.052). In prediabetes mellitus, the crude incidences were 22.9 versus 9.6/100 persons/10 years in insulin resistant versus non-insulin resistant persons (age- and sex-adjusted hazard ratio = 2.36, p = 0.040). In conclusion, cardiovascular disease risk was accentuated in prediabetes mellitus/insulin resistant individuals, with a relative risk approximately twice as high compared to prediabetes mellitus/non-insulin resistant subjects.Facultad de Ciencias Médicas2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf157-163http://sedici.unlp.edu.ar/handle/10915/136298enginfo:eu-repo/semantics/altIdentifier/issn/1752-8984info:eu-repo/semantics/altIdentifier/issn/1479-1641info:eu-repo/semantics/altIdentifier/doi/10.1177/1479164115610057info:eu-repo/semantics/altIdentifier/pmid/26802220info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:24:10Zoai:sedici.unlp.edu.ar:10915/136298Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:24:10.992SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Insulin resistance: the linchpin between prediabetes and cardiovascular disease
title Insulin resistance: the linchpin between prediabetes and cardiovascular disease
spellingShingle Insulin resistance: the linchpin between prediabetes and cardiovascular disease
Salazar, Martín R.
Ciencias Médicas
Prediabetes
Cardiovascular disease
Insulin resistance
title_short Insulin resistance: the linchpin between prediabetes and cardiovascular disease
title_full Insulin resistance: the linchpin between prediabetes and cardiovascular disease
title_fullStr Insulin resistance: the linchpin between prediabetes and cardiovascular disease
title_full_unstemmed Insulin resistance: the linchpin between prediabetes and cardiovascular disease
title_sort Insulin resistance: the linchpin between prediabetes and cardiovascular disease
dc.creator.none.fl_str_mv Salazar, Martín R.
Carbajal, Horacio Antonio
Espeche, Walter Gastón
Aizpurúa, Marcelo
Leiva Sisnieguez, Carlos Enrique
Leiva Sisnieguez, Betty Cecilia
Stavile, Rodolfo Nicolás
March, Carlos E.
Reaven, Gerald M.
author Salazar, Martín R.
author_facet Salazar, Martín R.
Carbajal, Horacio Antonio
Espeche, Walter Gastón
Aizpurúa, Marcelo
Leiva Sisnieguez, Carlos Enrique
Leiva Sisnieguez, Betty Cecilia
Stavile, Rodolfo Nicolás
March, Carlos E.
Reaven, Gerald M.
author_role author
author2 Carbajal, Horacio Antonio
Espeche, Walter Gastón
Aizpurúa, Marcelo
Leiva Sisnieguez, Carlos Enrique
Leiva Sisnieguez, Betty Cecilia
Stavile, Rodolfo Nicolás
March, Carlos E.
Reaven, Gerald M.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Prediabetes
Cardiovascular disease
Insulin resistance
topic Ciencias Médicas
Prediabetes
Cardiovascular disease
Insulin resistance
dc.description.none.fl_txt_mv The aim of this study was to test the hypothesis that cardiovascular disease occurs to the greatest extent in persons with prediabetes mellitus who are also insulin resistant. In 2003, 664 non-diabetic women (n = 457) and men (n = 207), aged 52 ± 16 and 53 ± 15 years, were surveyed during a programme for cardiovascular disease prevention. Fasting plasma glucose concentrations defined participants as having normal fasting plasma glucose (fasting plasma glucose <5.6 mmol/L) or prediabetes mellitus (fasting plasma glucose ⩾ 5.6 and <7.0 mmol/L). The tertile of prediabetes mellitus subjects with the highest fasting plasma insulin concentration was classified as insulin resistant. Baseline cardiovascular disease risk factors were accentuated in prediabetes mellitus versus normal fasting glucose, particularly in prediabetes mellitus/insulin resistant. In 2012, 86% of the sample were surveyed again, and the crude incidence for cardiovascular disease was higher in subjects with prediabetes mellitus versus normal fasting glucose (13.7 vs 6.0/100 persons/10 years; age- and sex-adjusted hazard ratio = 1.88, p = 0.052). In prediabetes mellitus, the crude incidences were 22.9 versus 9.6/100 persons/10 years in insulin resistant versus non-insulin resistant persons (age- and sex-adjusted hazard ratio = 2.36, p = 0.040). In conclusion, cardiovascular disease risk was accentuated in prediabetes mellitus/insulin resistant individuals, with a relative risk approximately twice as high compared to prediabetes mellitus/non-insulin resistant subjects.
Facultad de Ciencias Médicas
description The aim of this study was to test the hypothesis that cardiovascular disease occurs to the greatest extent in persons with prediabetes mellitus who are also insulin resistant. In 2003, 664 non-diabetic women (n = 457) and men (n = 207), aged 52 ± 16 and 53 ± 15 years, were surveyed during a programme for cardiovascular disease prevention. Fasting plasma glucose concentrations defined participants as having normal fasting plasma glucose (fasting plasma glucose <5.6 mmol/L) or prediabetes mellitus (fasting plasma glucose ⩾ 5.6 and <7.0 mmol/L). The tertile of prediabetes mellitus subjects with the highest fasting plasma insulin concentration was classified as insulin resistant. Baseline cardiovascular disease risk factors were accentuated in prediabetes mellitus versus normal fasting glucose, particularly in prediabetes mellitus/insulin resistant. In 2012, 86% of the sample were surveyed again, and the crude incidence for cardiovascular disease was higher in subjects with prediabetes mellitus versus normal fasting glucose (13.7 vs 6.0/100 persons/10 years; age- and sex-adjusted hazard ratio = 1.88, p = 0.052). In prediabetes mellitus, the crude incidences were 22.9 versus 9.6/100 persons/10 years in insulin resistant versus non-insulin resistant persons (age- and sex-adjusted hazard ratio = 2.36, p = 0.040). In conclusion, cardiovascular disease risk was accentuated in prediabetes mellitus/insulin resistant individuals, with a relative risk approximately twice as high compared to prediabetes mellitus/non-insulin resistant subjects.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/136298
url http://sedici.unlp.edu.ar/handle/10915/136298
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1752-8984
info:eu-repo/semantics/altIdentifier/issn/1479-1641
info:eu-repo/semantics/altIdentifier/doi/10.1177/1479164115610057
info:eu-repo/semantics/altIdentifier/pmid/26802220
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
157-163
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
_version_ 1846064296239300608
score 13.22299

Publicaciones similares