Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistance

Autores
Gomez Rosso, Leonardo Adrián; Meroño, Tomás; Giunta, Gustavo Ariel; Boero, Laura Estela; Schreier, Laura Ester; Cuniberti, Luis Alberto; Brites, Fernando Daniel
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background and aims: Several studies have been carried out to characterize the different alterations associated with hypertriglyceridemia (HTG) and to identify this dyslipemia as an independent risk factor for cardiovascular disease (CVD). HTG is frequently, but not always, associated with insulin resistance (IR). The present study was aimed to evaluate if the alterations observed in biomarkers of CVD were similar in HTG states independently of IR. Methods: HTG was defined as triglycerides ≥1.69 mmol/l and IR as HOMA-IR ≥3.1. HTG-IR patients (n= 15) were compared with HTG subjects without IR (WIR) (n= 15) and with normotriglyceridemic (NTG)-WIR individuals (n= 30). Results: Both HTG groups shared the increment in VLDL-C and non-HDL-C, HDL enrichment in triglycerides and depletion in phospholipids, the decrease in adiponectin concentration, and the increase in CETP activity. HDL-C and VCAM-1 levels were altered only in HTG-IR patients in comparison with the other groups, while oxidized LDL was only higher in HTG-IR than the control group. Multiple regression analysis identified triglycerides as the independent predictor of HDL-C, CETP activity and oxidized LDL levels. Conclusion: The increase in triglycerides is the major determinant factor of the atherogenic modifications observed, while IR would be an amplifier factor.
Fil: Gomez Rosso, Leonardo Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Meroño, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Giunta, Gustavo Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Lípidos; Argentina
Fil: Boero, Laura Estela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Cuniberti, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Lípidos; Argentina
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
HYPERTRIGLYCERIDEMIA
INSULIN RESISTANCE
OXIDIZED LOW DENSITY LIPOPROTEIN
CARDIOVASCULAR DISEASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/243255
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/243255
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistanceGomez Rosso, Leonardo AdriánMeroño, TomásGiunta, Gustavo ArielBoero, Laura EstelaSchreier, Laura EsterCuniberti, Luis AlbertoBrites, Fernando DanielHYPERTRIGLYCERIDEMIAINSULIN RESISTANCEOXIDIZED LOW DENSITY LIPOPROTEINCARDIOVASCULAR DISEASEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background and aims: Several studies have been carried out to characterize the different alterations associated with hypertriglyceridemia (HTG) and to identify this dyslipemia as an independent risk factor for cardiovascular disease (CVD). HTG is frequently, but not always, associated with insulin resistance (IR). The present study was aimed to evaluate if the alterations observed in biomarkers of CVD were similar in HTG states independently of IR. Methods: HTG was defined as triglycerides ≥1.69 mmol/l and IR as HOMA-IR ≥3.1. HTG-IR patients (n= 15) were compared with HTG subjects without IR (WIR) (n= 15) and with normotriglyceridemic (NTG)-WIR individuals (n= 30). Results: Both HTG groups shared the increment in VLDL-C and non-HDL-C, HDL enrichment in triglycerides and depletion in phospholipids, the decrease in adiponectin concentration, and the increase in CETP activity. HDL-C and VCAM-1 levels were altered only in HTG-IR patients in comparison with the other groups, while oxidized LDL was only higher in HTG-IR than the control group. Multiple regression analysis identified triglycerides as the independent predictor of HDL-C, CETP activity and oxidized LDL levels. Conclusion: The increase in triglycerides is the major determinant factor of the atherogenic modifications observed, while IR would be an amplifier factor.Fil: Gomez Rosso, Leonardo Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Meroño, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Giunta, Gustavo Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Lípidos; ArgentinaFil: Boero, Laura Estela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Cuniberti, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Lípidos; ArgentinaFil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science2012-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/243255Gomez Rosso, Leonardo Adrián; Meroño, Tomás; Giunta, Gustavo Ariel; Boero, Laura Estela; Schreier, Laura Ester; et al.; Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistance; Elsevier Science; Clinica Chimica Acta; 413; 5-6; 3-2012; 620-6240009-8981CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cca.2011.12.007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:10:28Zoai:ri.conicet.gov.ar:11336/243255instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:10:28.902CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistance
title Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistance
spellingShingle Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistance
Gomez Rosso, Leonardo Adrián
HYPERTRIGLYCERIDEMIA
INSULIN RESISTANCE
OXIDIZED LOW DENSITY LIPOPROTEIN
CARDIOVASCULAR DISEASE
title_short Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistance
title_full Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistance
title_fullStr Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistance
title_full_unstemmed Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistance
title_sort Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistance
dc.creator.none.fl_str_mv Gomez Rosso, Leonardo Adrián
Meroño, Tomás
Giunta, Gustavo Ariel
Boero, Laura Estela
Schreier, Laura Ester
Cuniberti, Luis Alberto
Brites, Fernando Daniel
author Gomez Rosso, Leonardo Adrián
author_facet Gomez Rosso, Leonardo Adrián
Meroño, Tomás
Giunta, Gustavo Ariel
Boero, Laura Estela
Schreier, Laura Ester
Cuniberti, Luis Alberto
Brites, Fernando Daniel
author_role author
author2 Meroño, Tomás
Giunta, Gustavo Ariel
Boero, Laura Estela
Schreier, Laura Ester
Cuniberti, Luis Alberto
Brites, Fernando Daniel
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv HYPERTRIGLYCERIDEMIA
INSULIN RESISTANCE
OXIDIZED LOW DENSITY LIPOPROTEIN
CARDIOVASCULAR DISEASE
topic HYPERTRIGLYCERIDEMIA
INSULIN RESISTANCE
OXIDIZED LOW DENSITY LIPOPROTEIN
CARDIOVASCULAR DISEASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background and aims: Several studies have been carried out to characterize the different alterations associated with hypertriglyceridemia (HTG) and to identify this dyslipemia as an independent risk factor for cardiovascular disease (CVD). HTG is frequently, but not always, associated with insulin resistance (IR). The present study was aimed to evaluate if the alterations observed in biomarkers of CVD were similar in HTG states independently of IR. Methods: HTG was defined as triglycerides ≥1.69 mmol/l and IR as HOMA-IR ≥3.1. HTG-IR patients (n= 15) were compared with HTG subjects without IR (WIR) (n= 15) and with normotriglyceridemic (NTG)-WIR individuals (n= 30). Results: Both HTG groups shared the increment in VLDL-C and non-HDL-C, HDL enrichment in triglycerides and depletion in phospholipids, the decrease in adiponectin concentration, and the increase in CETP activity. HDL-C and VCAM-1 levels were altered only in HTG-IR patients in comparison with the other groups, while oxidized LDL was only higher in HTG-IR than the control group. Multiple regression analysis identified triglycerides as the independent predictor of HDL-C, CETP activity and oxidized LDL levels. Conclusion: The increase in triglycerides is the major determinant factor of the atherogenic modifications observed, while IR would be an amplifier factor.
Fil: Gomez Rosso, Leonardo Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Meroño, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Giunta, Gustavo Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Lípidos; Argentina
Fil: Boero, Laura Estela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Cuniberti, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Lípidos; Argentina
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Background and aims: Several studies have been carried out to characterize the different alterations associated with hypertriglyceridemia (HTG) and to identify this dyslipemia as an independent risk factor for cardiovascular disease (CVD). HTG is frequently, but not always, associated with insulin resistance (IR). The present study was aimed to evaluate if the alterations observed in biomarkers of CVD were similar in HTG states independently of IR. Methods: HTG was defined as triglycerides ≥1.69 mmol/l and IR as HOMA-IR ≥3.1. HTG-IR patients (n= 15) were compared with HTG subjects without IR (WIR) (n= 15) and with normotriglyceridemic (NTG)-WIR individuals (n= 30). Results: Both HTG groups shared the increment in VLDL-C and non-HDL-C, HDL enrichment in triglycerides and depletion in phospholipids, the decrease in adiponectin concentration, and the increase in CETP activity. HDL-C and VCAM-1 levels were altered only in HTG-IR patients in comparison with the other groups, while oxidized LDL was only higher in HTG-IR than the control group. Multiple regression analysis identified triglycerides as the independent predictor of HDL-C, CETP activity and oxidized LDL levels. Conclusion: The increase in triglycerides is the major determinant factor of the atherogenic modifications observed, while IR would be an amplifier factor.
publishDate 2012
dc.date.none.fl_str_mv 2012-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/243255
Gomez Rosso, Leonardo Adrián; Meroño, Tomás; Giunta, Gustavo Ariel; Boero, Laura Estela; Schreier, Laura Ester; et al.; Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistance; Elsevier Science; Clinica Chimica Acta; 413; 5-6; 3-2012; 620-624
0009-8981
CONICET Digital
CONICET
url http://hdl.handle.net/11336/243255
identifier_str_mv Gomez Rosso, Leonardo Adrián; Meroño, Tomás; Giunta, Gustavo Ariel; Boero, Laura Estela; Schreier, Laura Ester; et al.; Atherogenic alterations in hypertriglyceridemic patients would not depend on insulin resistance; Elsevier Science; Clinica Chimica Acta; 413; 5-6; 3-2012; 620-624
0009-8981
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cca.2011.12.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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