Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats

Autores
Pallarés, María Eugenia; Monteleone, Melisa Carolina; Pastor, Verónica Estela; Grillo Balboa, Jazmín; Alzamendi, Ana; Brocco, Marcela Adriana; Antonelli, Marta Cristina
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Prenatal stress (PS) is a major risk factor for the development of emotional disorders in adulthood that may be mediated by an altered hypothalamic-pituitary-adrenal axis response to stress. Although the early onset of stress-related disorders is recognized as a major public health problem, to date, there are relatively few studies that have examined the incidence of early-life stressors in younger individuals. In this study, we assessed PS impact on the stress-coping response of juvenile offspring in behavioral tests and in the induced molecular changes in the hippocampus. Furthermore, we assessed if pregnancy stress could be driving changes in patterns of maternal behavior during early lactation. We found that PS modified stress-coping abilities of both sex offspring. In the hippocampus, PS increased the expression of bdnf-IV and crfr1 and induced sex difference changes on glucocorticoids and BDNF mRNA receptor levels. PS changed the hippocampal epigenetic landscape mainly in male offspring. Stress during pregnancy enhanced pup-directed behavior of stressed dams. Our study indicates that exposure to PS, in addition to enhanced maternal behavior, induces dynamic neurobehavioral variations at juvenile ages of the offspring that should be considered adaptive or maladaptive, depending on the characteristics of the confronting environment. Our present results highlight the importance to further explore risk factors that appear early in life that will be important to allow timely prevention strategies to later vulnerability to stress-related disorders.
Instituto Multidisciplinario de Biología Celular
Materia
Biología
Prenatal stress
Maternal behavior
Juvenile ofspring
Sex diferences
Stress-coping response
Hippocampus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/138540

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spelling Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile RatsPallarés, María EugeniaMonteleone, Melisa CarolinaPastor, Verónica EstelaGrillo Balboa, JazmínAlzamendi, AnaBrocco, Marcela AdrianaAntonelli, Marta CristinaBiologíaPrenatal stressMaternal behaviorJuvenile ofspringSex diferencesStress-coping responseHippocampusPrenatal stress (PS) is a major risk factor for the development of emotional disorders in adulthood that may be mediated by an altered hypothalamic-pituitary-adrenal axis response to stress. Although the early onset of stress-related disorders is recognized as a major public health problem, to date, there are relatively few studies that have examined the incidence of early-life stressors in younger individuals. In this study, we assessed PS impact on the stress-coping response of juvenile offspring in behavioral tests and in the induced molecular changes in the hippocampus. Furthermore, we assessed if pregnancy stress could be driving changes in patterns of maternal behavior during early lactation. We found that PS modified stress-coping abilities of both sex offspring. In the hippocampus, PS increased the expression of <i>bdnf</i>-IV and <i>crfr1</i> and induced sex difference changes on glucocorticoids and BDNF mRNA receptor levels. PS changed the hippocampal epigenetic landscape mainly in male offspring. Stress during pregnancy enhanced pup-directed behavior of stressed dams. Our study indicates that exposure to PS, in addition to enhanced maternal behavior, induces dynamic neurobehavioral variations at juvenile ages of the offspring that should be considered adaptive or maladaptive, depending on the characteristics of the confronting environment. Our present results highlight the importance to further explore risk factors that appear early in life that will be important to allow timely prevention strategies to later vulnerability to stress-related disorders.Instituto Multidisciplinario de Biología Celular2021-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf5837-5856http://sedici.unlp.edu.ar/handle/10915/138540enginfo:eu-repo/semantics/altIdentifier/issn/1559-1182info:eu-repo/semantics/altIdentifier/issn/0893-7648info:eu-repo/semantics/altIdentifier/doi/10.1007/s12035-021-02527-2info:eu-repo/semantics/altIdentifier/pmid/34409559info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:03Zoai:sedici.unlp.edu.ar:10915/138540Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:03.351SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats
title Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats
spellingShingle Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats
Pallarés, María Eugenia
Biología
Prenatal stress
Maternal behavior
Juvenile ofspring
Sex diferences
Stress-coping response
Hippocampus
title_short Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats
title_full Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats
title_fullStr Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats
title_full_unstemmed Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats
title_sort Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats
dc.creator.none.fl_str_mv Pallarés, María Eugenia
Monteleone, Melisa Carolina
Pastor, Verónica Estela
Grillo Balboa, Jazmín
Alzamendi, Ana
Brocco, Marcela Adriana
Antonelli, Marta Cristina
author Pallarés, María Eugenia
author_facet Pallarés, María Eugenia
Monteleone, Melisa Carolina
Pastor, Verónica Estela
Grillo Balboa, Jazmín
Alzamendi, Ana
Brocco, Marcela Adriana
Antonelli, Marta Cristina
author_role author
author2 Monteleone, Melisa Carolina
Pastor, Verónica Estela
Grillo Balboa, Jazmín
Alzamendi, Ana
Brocco, Marcela Adriana
Antonelli, Marta Cristina
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Biología
Prenatal stress
Maternal behavior
Juvenile ofspring
Sex diferences
Stress-coping response
Hippocampus
topic Biología
Prenatal stress
Maternal behavior
Juvenile ofspring
Sex diferences
Stress-coping response
Hippocampus
dc.description.none.fl_txt_mv Prenatal stress (PS) is a major risk factor for the development of emotional disorders in adulthood that may be mediated by an altered hypothalamic-pituitary-adrenal axis response to stress. Although the early onset of stress-related disorders is recognized as a major public health problem, to date, there are relatively few studies that have examined the incidence of early-life stressors in younger individuals. In this study, we assessed PS impact on the stress-coping response of juvenile offspring in behavioral tests and in the induced molecular changes in the hippocampus. Furthermore, we assessed if pregnancy stress could be driving changes in patterns of maternal behavior during early lactation. We found that PS modified stress-coping abilities of both sex offspring. In the hippocampus, PS increased the expression of <i>bdnf</i>-IV and <i>crfr1</i> and induced sex difference changes on glucocorticoids and BDNF mRNA receptor levels. PS changed the hippocampal epigenetic landscape mainly in male offspring. Stress during pregnancy enhanced pup-directed behavior of stressed dams. Our study indicates that exposure to PS, in addition to enhanced maternal behavior, induces dynamic neurobehavioral variations at juvenile ages of the offspring that should be considered adaptive or maladaptive, depending on the characteristics of the confronting environment. Our present results highlight the importance to further explore risk factors that appear early in life that will be important to allow timely prevention strategies to later vulnerability to stress-related disorders.
Instituto Multidisciplinario de Biología Celular
description Prenatal stress (PS) is a major risk factor for the development of emotional disorders in adulthood that may be mediated by an altered hypothalamic-pituitary-adrenal axis response to stress. Although the early onset of stress-related disorders is recognized as a major public health problem, to date, there are relatively few studies that have examined the incidence of early-life stressors in younger individuals. In this study, we assessed PS impact on the stress-coping response of juvenile offspring in behavioral tests and in the induced molecular changes in the hippocampus. Furthermore, we assessed if pregnancy stress could be driving changes in patterns of maternal behavior during early lactation. We found that PS modified stress-coping abilities of both sex offspring. In the hippocampus, PS increased the expression of <i>bdnf</i>-IV and <i>crfr1</i> and induced sex difference changes on glucocorticoids and BDNF mRNA receptor levels. PS changed the hippocampal epigenetic landscape mainly in male offspring. Stress during pregnancy enhanced pup-directed behavior of stressed dams. Our study indicates that exposure to PS, in addition to enhanced maternal behavior, induces dynamic neurobehavioral variations at juvenile ages of the offspring that should be considered adaptive or maladaptive, depending on the characteristics of the confronting environment. Our present results highlight the importance to further explore risk factors that appear early in life that will be important to allow timely prevention strategies to later vulnerability to stress-related disorders.
publishDate 2021
dc.date.none.fl_str_mv 2021-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/138540
url http://sedici.unlp.edu.ar/handle/10915/138540
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1559-1182
info:eu-repo/semantics/altIdentifier/issn/0893-7648
info:eu-repo/semantics/altIdentifier/doi/10.1007/s12035-021-02527-2
info:eu-repo/semantics/altIdentifier/pmid/34409559
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
5837-5856
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
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instname_str Universidad Nacional de La Plata
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institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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