Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats
- Autores
- Pallarés, María Eugenia; Monteleone, Melisa Carolina; Pastor, Verónica Estela; Grillo Balboa, Jazmín; Alzamendi, Ana; Brocco, Marcela Adriana; Antonelli, Marta Cristina
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Prenatal stress (PS) is a major risk factor for the development of emotional disorders in adulthood that may be mediated by an altered hypothalamic-pituitary-adrenal axis response to stress. Although the early onset of stress-related disorders is recognized as a major public health problem, to date, there are relatively few studies that have examined the incidence of early-life stressors in younger individuals. In this study, we assessed PS impact on the stress-coping response of juvenile offspring in behavioral tests and in the induced molecular changes in the hippocampus. Furthermore, we assessed if pregnancy stress could be driving changes in patterns of maternal behavior during early lactation. We found that PS modified stress-coping abilities of both sex offspring. In the hippocampus, PS increased the expression of bdnf-IV and crfr1 and induced sex difference changes on glucocorticoids and BDNF mRNA receptor levels. PS changed the hippocampal epigenetic landscape mainly in male offspring. Stress during pregnancy enhanced pup-directed behavior of stressed dams. Our study indicates that exposure to PS, in addition to enhanced maternal behavior, induces dynamic neurobehavioral variations at juvenile ages of the offspring that should be considered adaptive or maladaptive, depending on the characteristics of the confronting environment. Our present results highlight the importance to further explore risk factors that appear early in life that will be important to allow timely prevention strategies to later vulnerability to stress-related disorders.
Instituto Multidisciplinario de Biología Celular - Materia
-
Biología
Prenatal stress
Maternal behavior
Juvenile ofspring
Sex diferences
Stress-coping response
Hippocampus - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/138540
Ver los metadatos del registro completo
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Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile RatsPallarés, María EugeniaMonteleone, Melisa CarolinaPastor, Verónica EstelaGrillo Balboa, JazmínAlzamendi, AnaBrocco, Marcela AdrianaAntonelli, Marta CristinaBiologíaPrenatal stressMaternal behaviorJuvenile ofspringSex diferencesStress-coping responseHippocampusPrenatal stress (PS) is a major risk factor for the development of emotional disorders in adulthood that may be mediated by an altered hypothalamic-pituitary-adrenal axis response to stress. Although the early onset of stress-related disorders is recognized as a major public health problem, to date, there are relatively few studies that have examined the incidence of early-life stressors in younger individuals. In this study, we assessed PS impact on the stress-coping response of juvenile offspring in behavioral tests and in the induced molecular changes in the hippocampus. Furthermore, we assessed if pregnancy stress could be driving changes in patterns of maternal behavior during early lactation. We found that PS modified stress-coping abilities of both sex offspring. In the hippocampus, PS increased the expression of <i>bdnf</i>-IV and <i>crfr1</i> and induced sex difference changes on glucocorticoids and BDNF mRNA receptor levels. PS changed the hippocampal epigenetic landscape mainly in male offspring. Stress during pregnancy enhanced pup-directed behavior of stressed dams. Our study indicates that exposure to PS, in addition to enhanced maternal behavior, induces dynamic neurobehavioral variations at juvenile ages of the offspring that should be considered adaptive or maladaptive, depending on the characteristics of the confronting environment. Our present results highlight the importance to further explore risk factors that appear early in life that will be important to allow timely prevention strategies to later vulnerability to stress-related disorders.Instituto Multidisciplinario de Biología Celular2021-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf5837-5856http://sedici.unlp.edu.ar/handle/10915/138540enginfo:eu-repo/semantics/altIdentifier/issn/1559-1182info:eu-repo/semantics/altIdentifier/issn/0893-7648info:eu-repo/semantics/altIdentifier/doi/10.1007/s12035-021-02527-2info:eu-repo/semantics/altIdentifier/pmid/34409559info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:03Zoai:sedici.unlp.edu.ar:10915/138540Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:03.351SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats |
title |
Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats |
spellingShingle |
Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats Pallarés, María Eugenia Biología Prenatal stress Maternal behavior Juvenile ofspring Sex diferences Stress-coping response Hippocampus |
title_short |
Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats |
title_full |
Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats |
title_fullStr |
Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats |
title_full_unstemmed |
Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats |
title_sort |
Early-Life Stress Reprograms Stress-Coping Abilities in Male and Female Juvenile Rats |
dc.creator.none.fl_str_mv |
Pallarés, María Eugenia Monteleone, Melisa Carolina Pastor, Verónica Estela Grillo Balboa, Jazmín Alzamendi, Ana Brocco, Marcela Adriana Antonelli, Marta Cristina |
author |
Pallarés, María Eugenia |
author_facet |
Pallarés, María Eugenia Monteleone, Melisa Carolina Pastor, Verónica Estela Grillo Balboa, Jazmín Alzamendi, Ana Brocco, Marcela Adriana Antonelli, Marta Cristina |
author_role |
author |
author2 |
Monteleone, Melisa Carolina Pastor, Verónica Estela Grillo Balboa, Jazmín Alzamendi, Ana Brocco, Marcela Adriana Antonelli, Marta Cristina |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Biología Prenatal stress Maternal behavior Juvenile ofspring Sex diferences Stress-coping response Hippocampus |
topic |
Biología Prenatal stress Maternal behavior Juvenile ofspring Sex diferences Stress-coping response Hippocampus |
dc.description.none.fl_txt_mv |
Prenatal stress (PS) is a major risk factor for the development of emotional disorders in adulthood that may be mediated by an altered hypothalamic-pituitary-adrenal axis response to stress. Although the early onset of stress-related disorders is recognized as a major public health problem, to date, there are relatively few studies that have examined the incidence of early-life stressors in younger individuals. In this study, we assessed PS impact on the stress-coping response of juvenile offspring in behavioral tests and in the induced molecular changes in the hippocampus. Furthermore, we assessed if pregnancy stress could be driving changes in patterns of maternal behavior during early lactation. We found that PS modified stress-coping abilities of both sex offspring. In the hippocampus, PS increased the expression of <i>bdnf</i>-IV and <i>crfr1</i> and induced sex difference changes on glucocorticoids and BDNF mRNA receptor levels. PS changed the hippocampal epigenetic landscape mainly in male offspring. Stress during pregnancy enhanced pup-directed behavior of stressed dams. Our study indicates that exposure to PS, in addition to enhanced maternal behavior, induces dynamic neurobehavioral variations at juvenile ages of the offspring that should be considered adaptive or maladaptive, depending on the characteristics of the confronting environment. Our present results highlight the importance to further explore risk factors that appear early in life that will be important to allow timely prevention strategies to later vulnerability to stress-related disorders. Instituto Multidisciplinario de Biología Celular |
description |
Prenatal stress (PS) is a major risk factor for the development of emotional disorders in adulthood that may be mediated by an altered hypothalamic-pituitary-adrenal axis response to stress. Although the early onset of stress-related disorders is recognized as a major public health problem, to date, there are relatively few studies that have examined the incidence of early-life stressors in younger individuals. In this study, we assessed PS impact on the stress-coping response of juvenile offspring in behavioral tests and in the induced molecular changes in the hippocampus. Furthermore, we assessed if pregnancy stress could be driving changes in patterns of maternal behavior during early lactation. We found that PS modified stress-coping abilities of both sex offspring. In the hippocampus, PS increased the expression of <i>bdnf</i>-IV and <i>crfr1</i> and induced sex difference changes on glucocorticoids and BDNF mRNA receptor levels. PS changed the hippocampal epigenetic landscape mainly in male offspring. Stress during pregnancy enhanced pup-directed behavior of stressed dams. Our study indicates that exposure to PS, in addition to enhanced maternal behavior, induces dynamic neurobehavioral variations at juvenile ages of the offspring that should be considered adaptive or maladaptive, depending on the characteristics of the confronting environment. Our present results highlight the importance to further explore risk factors that appear early in life that will be important to allow timely prevention strategies to later vulnerability to stress-related disorders. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/138540 |
url |
http://sedici.unlp.edu.ar/handle/10915/138540 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/1559-1182 info:eu-repo/semantics/altIdentifier/issn/0893-7648 info:eu-repo/semantics/altIdentifier/doi/10.1007/s12035-021-02527-2 info:eu-repo/semantics/altIdentifier/pmid/34409559 |
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info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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openAccess |
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http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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application/pdf 5837-5856 |
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