Effects of maternal stress during different periods of pregnancy on the early neurobehavioral response of rats

Autores
Kvarik, Timea; Mammel, Barbara; Reglodi, Dora; Antonelli, Marta Cristina; Farkas, Jozsef; Tamas, Andrea; Ertl, Tibor; Atlasz, Tamas; Bodzai, Greta; Kiss, Peter; Gyarmati, Judit
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Several studies focus on the effects of prenatal stress in adulthood. Relatively little is known about the early neurodevelopmental consequences of such experiences and their predictive value. Thus we examined the early neurobehavioral responses of offspring whose mothers were exposed to restraint stress. Methods and results: Pregnant rats were exposed to 60 minutes restraint stress twice a day for seven days in different periods of pregnancy (early/mid and late phase). After birth, offspring were examined for the maturation of neural signs and reflexes daily for 3 weeks. Mid-pregnancy stress resulted in a subtle faster development in the appearance of eyelid and auditory startle reflexes, and in the disappearance of crossed extensor reflex. Pups exposed to stress in the last week of intrauterine life displayed a delay in air righting and showed a slight enhancement in the appearance of auditory startle. Conclusion: Based on our present findings, the deleterious consequences of prenatal stress are not apparent during the early developmental stages at least not detectable with the battery of test most widely used to examine neurobehavioral development. However, these findings draw the attention of the need of careful awareness in later ages in spite of the normal neurobehavioral development of newborns exposed to prenatal stress.
Fil: Kvarik, Timea. University of Pécs; Hungría
Fil: Mammel, Barbara. University of Pécs; Hungría
Fil: Reglodi, Dora. University of Pécs; Hungría
Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Farkas, Jozsef. University of Pécs; Hungría
Fil: Tamas, Andrea. University of Pécs; Hungría
Fil: Ertl, Tibor. University of Pécs; Hungría
Fil: Atlasz, Tamas. University of Pécs; Hungría
Fil: Bodzai, Greta. University of Pécs; Hungría
Fil: Kiss, Peter. University of Pécs; Hungría
Fil: Gyarmati, Judit. University of Pécs; Hungría
Materia
RESTRAINT STRESS PRENATAL
MATERNAL
NEROBEHAVIORAL
DEVELOPMENT
RAT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/17824
Acceder
id CONICETDig_8699123b080b5b20a1db5730eb3d2ec4
oai_identifier_str oai:ri.conicet.gov.ar:11336/17824
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of maternal stress during different periods of pregnancy on the early neurobehavioral response of ratsKvarik, TimeaMammel, BarbaraReglodi, DoraAntonelli, Marta CristinaFarkas, JozsefTamas, AndreaErtl, TiborAtlasz, TamasBodzai, GretaKiss, PeterGyarmati, JuditRESTRAINT STRESS PRENATALMATERNALNEROBEHAVIORALDEVELOPMENTRAThttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Several studies focus on the effects of prenatal stress in adulthood. Relatively little is known about the early neurodevelopmental consequences of such experiences and their predictive value. Thus we examined the early neurobehavioral responses of offspring whose mothers were exposed to restraint stress. Methods and results: Pregnant rats were exposed to 60 minutes restraint stress twice a day for seven days in different periods of pregnancy (early/mid and late phase). After birth, offspring were examined for the maturation of neural signs and reflexes daily for 3 weeks. Mid-pregnancy stress resulted in a subtle faster development in the appearance of eyelid and auditory startle reflexes, and in the disappearance of crossed extensor reflex. Pups exposed to stress in the last week of intrauterine life displayed a delay in air righting and showed a slight enhancement in the appearance of auditory startle. Conclusion: Based on our present findings, the deleterious consequences of prenatal stress are not apparent during the early developmental stages at least not detectable with the battery of test most widely used to examine neurobehavioral development. However, these findings draw the attention of the need of careful awareness in later ages in spite of the normal neurobehavioral development of newborns exposed to prenatal stress.Fil: Kvarik, Timea. University of Pécs; HungríaFil: Mammel, Barbara. University of Pécs; HungríaFil: Reglodi, Dora. University of Pécs; HungríaFil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Farkas, Jozsef. University of Pécs; HungríaFil: Tamas, Andrea. University of Pécs; HungríaFil: Ertl, Tibor. University of Pécs; HungríaFil: Atlasz, Tamas. University of Pécs; HungríaFil: Bodzai, Greta. University of Pécs; HungríaFil: Kiss, Peter. University of Pécs; HungríaFil: Gyarmati, Judit. University of Pécs; HungríaInsight Medical Publishing2016-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/17824Kvarik, Timea; Mammel, Barbara; Reglodi, Dora; Antonelli, Marta Cristina; Farkas, Jozsef; et al.; Effects of maternal stress during different periods of pregnancy on the early neurobehavioral response of rats; Insight Medical Publishing; Journal of Neurology and Neuroscience; 7; 2; 2-2016; 1-82171-6625enginfo:eu-repo/semantics/altIdentifier/url/http://www.jneuro.com/neurology-neuroscience/effects-of-maternal-stress-during-different-periods-of-pregnancy-on-the-early-neurobehavioral-response-of-rats.php?aid=8703info:eu-repo/semantics/altIdentifier/doi/10.21767/2171-6625.100080info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:27:29Zoai:ri.conicet.gov.ar:11336/17824instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:27:29.37CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of maternal stress during different periods of pregnancy on the early neurobehavioral response of rats
title Effects of maternal stress during different periods of pregnancy on the early neurobehavioral response of rats
spellingShingle Effects of maternal stress during different periods of pregnancy on the early neurobehavioral response of rats
Kvarik, Timea
RESTRAINT STRESS PRENATAL
MATERNAL
NEROBEHAVIORAL
DEVELOPMENT
RAT
title_short Effects of maternal stress during different periods of pregnancy on the early neurobehavioral response of rats
title_full Effects of maternal stress during different periods of pregnancy on the early neurobehavioral response of rats
title_fullStr Effects of maternal stress during different periods of pregnancy on the early neurobehavioral response of rats
title_full_unstemmed Effects of maternal stress during different periods of pregnancy on the early neurobehavioral response of rats
title_sort Effects of maternal stress during different periods of pregnancy on the early neurobehavioral response of rats
dc.creator.none.fl_str_mv Kvarik, Timea
Mammel, Barbara
Reglodi, Dora
Antonelli, Marta Cristina
Farkas, Jozsef
Tamas, Andrea
Ertl, Tibor
Atlasz, Tamas
Bodzai, Greta
Kiss, Peter
Gyarmati, Judit
author Kvarik, Timea
author_facet Kvarik, Timea
Mammel, Barbara
Reglodi, Dora
Antonelli, Marta Cristina
Farkas, Jozsef
Tamas, Andrea
Ertl, Tibor
Atlasz, Tamas
Bodzai, Greta
Kiss, Peter
Gyarmati, Judit
author_role author
author2 Mammel, Barbara
Reglodi, Dora
Antonelli, Marta Cristina
Farkas, Jozsef
Tamas, Andrea
Ertl, Tibor
Atlasz, Tamas
Bodzai, Greta
Kiss, Peter
Gyarmati, Judit
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv RESTRAINT STRESS PRENATAL
MATERNAL
NEROBEHAVIORAL
DEVELOPMENT
RAT
topic RESTRAINT STRESS PRENATAL
MATERNAL
NEROBEHAVIORAL
DEVELOPMENT
RAT
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Several studies focus on the effects of prenatal stress in adulthood. Relatively little is known about the early neurodevelopmental consequences of such experiences and their predictive value. Thus we examined the early neurobehavioral responses of offspring whose mothers were exposed to restraint stress. Methods and results: Pregnant rats were exposed to 60 minutes restraint stress twice a day for seven days in different periods of pregnancy (early/mid and late phase). After birth, offspring were examined for the maturation of neural signs and reflexes daily for 3 weeks. Mid-pregnancy stress resulted in a subtle faster development in the appearance of eyelid and auditory startle reflexes, and in the disappearance of crossed extensor reflex. Pups exposed to stress in the last week of intrauterine life displayed a delay in air righting and showed a slight enhancement in the appearance of auditory startle. Conclusion: Based on our present findings, the deleterious consequences of prenatal stress are not apparent during the early developmental stages at least not detectable with the battery of test most widely used to examine neurobehavioral development. However, these findings draw the attention of the need of careful awareness in later ages in spite of the normal neurobehavioral development of newborns exposed to prenatal stress.
Fil: Kvarik, Timea. University of Pécs; Hungría
Fil: Mammel, Barbara. University of Pécs; Hungría
Fil: Reglodi, Dora. University of Pécs; Hungría
Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Farkas, Jozsef. University of Pécs; Hungría
Fil: Tamas, Andrea. University of Pécs; Hungría
Fil: Ertl, Tibor. University of Pécs; Hungría
Fil: Atlasz, Tamas. University of Pécs; Hungría
Fil: Bodzai, Greta. University of Pécs; Hungría
Fil: Kiss, Peter. University of Pécs; Hungría
Fil: Gyarmati, Judit. University of Pécs; Hungría
description Background: Several studies focus on the effects of prenatal stress in adulthood. Relatively little is known about the early neurodevelopmental consequences of such experiences and their predictive value. Thus we examined the early neurobehavioral responses of offspring whose mothers were exposed to restraint stress. Methods and results: Pregnant rats were exposed to 60 minutes restraint stress twice a day for seven days in different periods of pregnancy (early/mid and late phase). After birth, offspring were examined for the maturation of neural signs and reflexes daily for 3 weeks. Mid-pregnancy stress resulted in a subtle faster development in the appearance of eyelid and auditory startle reflexes, and in the disappearance of crossed extensor reflex. Pups exposed to stress in the last week of intrauterine life displayed a delay in air righting and showed a slight enhancement in the appearance of auditory startle. Conclusion: Based on our present findings, the deleterious consequences of prenatal stress are not apparent during the early developmental stages at least not detectable with the battery of test most widely used to examine neurobehavioral development. However, these findings draw the attention of the need of careful awareness in later ages in spite of the normal neurobehavioral development of newborns exposed to prenatal stress.
publishDate 2016
dc.date.none.fl_str_mv 2016-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/17824
Kvarik, Timea; Mammel, Barbara; Reglodi, Dora; Antonelli, Marta Cristina; Farkas, Jozsef; et al.; Effects of maternal stress during different periods of pregnancy on the early neurobehavioral response of rats; Insight Medical Publishing; Journal of Neurology and Neuroscience; 7; 2; 2-2016; 1-8
2171-6625
url http://hdl.handle.net/11336/17824
identifier_str_mv Kvarik, Timea; Mammel, Barbara; Reglodi, Dora; Antonelli, Marta Cristina; Farkas, Jozsef; et al.; Effects of maternal stress during different periods of pregnancy on the early neurobehavioral response of rats; Insight Medical Publishing; Journal of Neurology and Neuroscience; 7; 2; 2-2016; 1-8
2171-6625
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.jneuro.com/neurology-neuroscience/effects-of-maternal-stress-during-different-periods-of-pregnancy-on-the-early-neurobehavioral-response-of-rats.php?aid=8703
info:eu-repo/semantics/altIdentifier/doi/10.21767/2171-6625.100080
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Insight Medical Publishing
publisher.none.fl_str_mv Insight Medical Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083416467963904
score 13.22299

Publicaciones similares