Mathematical models: a precious tool for research in physiology
- Autores
- Lascano, Elena Catalina; Mattiazzi, Alicia Ramona; Negroni, Jorge Antonio
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- reseña artículo
- Estado
- versión publicada
- Descripción
- The use of mathematical models in science has increased in the last decades, since it is clear that they constitute an essential tool for the progress of experimental research. The main goal of this review is to present to the experimental physiologists some background on the different steps that are usually followed to develop a model. Probably more important, we aim to provide some basic thoughts to highlight the importance and need of mathematical modeling for scientific discovery and progress. The review also recapitulates the evolution of myocyte and Ca²⁺ handling models, the parallel work done in the interpretation of cardiac force generation, the integration of myocyte and force models into mechano-electric representations, and the construction of multi-scale models by assembling ventricular models with the mathematical descriptions of the circulatory system.
Sociedad Argentina de Fisiología - Materia
-
Ciencias Médicas
mathematical models
cardiac myocyte
multiscale models
intracellular calcium - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/127761
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Mathematical models: a precious tool for research in physiologyLascano, Elena CatalinaMattiazzi, Alicia RamonaNegroni, Jorge AntonioCiencias Médicasmathematical modelscardiac myocytemultiscale modelsintracellular calciumThe use of mathematical models in science has increased in the last decades, since it is clear that they constitute an essential tool for the progress of experimental research. The main goal of this review is to present to the experimental physiologists some background on the different steps that are usually followed to develop a model. Probably more important, we aim to provide some basic thoughts to highlight the importance and need of mathematical modeling for scientific discovery and progress. The review also recapitulates the evolution of myocyte and Ca²⁺ handling models, the parallel work done in the interpretation of cardiac force generation, the integration of myocyte and force models into mechano-electric representations, and the construction of multi-scale models by assembling ventricular models with the mathematical descriptions of the circulatory system.Sociedad Argentina de Fisiología2015info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf12-22http://sedici.unlp.edu.ar/handle/10915/127761enginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/archive/id/75info:eu-repo/semantics/altIdentifier/issn/1669-5402info:eu-repo/semantics/altIdentifier/issn/1669-5410info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:30:53Zoai:sedici.unlp.edu.ar:10915/127761Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:30:54.055SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Mathematical models: a precious tool for research in physiology |
title |
Mathematical models: a precious tool for research in physiology |
spellingShingle |
Mathematical models: a precious tool for research in physiology Lascano, Elena Catalina Ciencias Médicas mathematical models cardiac myocyte multiscale models intracellular calcium |
title_short |
Mathematical models: a precious tool for research in physiology |
title_full |
Mathematical models: a precious tool for research in physiology |
title_fullStr |
Mathematical models: a precious tool for research in physiology |
title_full_unstemmed |
Mathematical models: a precious tool for research in physiology |
title_sort |
Mathematical models: a precious tool for research in physiology |
dc.creator.none.fl_str_mv |
Lascano, Elena Catalina Mattiazzi, Alicia Ramona Negroni, Jorge Antonio |
author |
Lascano, Elena Catalina |
author_facet |
Lascano, Elena Catalina Mattiazzi, Alicia Ramona Negroni, Jorge Antonio |
author_role |
author |
author2 |
Mattiazzi, Alicia Ramona Negroni, Jorge Antonio |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Ciencias Médicas mathematical models cardiac myocyte multiscale models intracellular calcium |
topic |
Ciencias Médicas mathematical models cardiac myocyte multiscale models intracellular calcium |
dc.description.none.fl_txt_mv |
The use of mathematical models in science has increased in the last decades, since it is clear that they constitute an essential tool for the progress of experimental research. The main goal of this review is to present to the experimental physiologists some background on the different steps that are usually followed to develop a model. Probably more important, we aim to provide some basic thoughts to highlight the importance and need of mathematical modeling for scientific discovery and progress. The review also recapitulates the evolution of myocyte and Ca²⁺ handling models, the parallel work done in the interpretation of cardiac force generation, the integration of myocyte and force models into mechano-electric representations, and the construction of multi-scale models by assembling ventricular models with the mathematical descriptions of the circulatory system. Sociedad Argentina de Fisiología |
description |
The use of mathematical models in science has increased in the last decades, since it is clear that they constitute an essential tool for the progress of experimental research. The main goal of this review is to present to the experimental physiologists some background on the different steps that are usually followed to develop a model. Probably more important, we aim to provide some basic thoughts to highlight the importance and need of mathematical modeling for scientific discovery and progress. The review also recapitulates the evolution of myocyte and Ca²⁺ handling models, the parallel work done in the interpretation of cardiac force generation, the integration of myocyte and force models into mechano-electric representations, and the construction of multi-scale models by assembling ventricular models with the mathematical descriptions of the circulatory system. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Revision http://purl.org/coar/resource_type/c_dcae04bc info:ar-repo/semantics/resenaArticulo |
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review |
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publishedVersion |
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http://sedici.unlp.edu.ar/handle/10915/127761 |
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http://sedici.unlp.edu.ar/handle/10915/127761 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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openAccess |
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http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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application/pdf 12-22 |
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