Mathematical models: a precious tool for research in physiology

Autores
Lascano, Elena Catalina; Mattiazzi, Alicia Ramona; Negroni, Jorge Antonio
Año de publicación
2015
Idioma
inglés
Tipo de recurso
reseña artículo
Estado
versión publicada
Descripción
The use of mathematical models in science has increased in the last decades, since it is clear that they constitute an essential tool for the progress of experimental research. The main goal of this review is to present to the experimental physiologists some background on the different steps that are usually followed to develop a model. Probably more important, we aim to provide some basic thoughts to highlight the importance and need of mathematical modeling for scientific discovery and progress. The review also recapitulates the evolution of myocyte and Ca²⁺ handling models, the parallel work done in the interpretation of cardiac force generation, the integration of myocyte and force models into mechano-electric representations, and the construction of multi-scale models by assembling ventricular models with the mathematical descriptions of the circulatory system.
Sociedad Argentina de Fisiología
Materia
Ciencias Médicas
mathematical models
cardiac myocyte
multiscale models
intracellular calcium
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/127761
Acceder
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network_name_str SEDICI (UNLP)
spelling Mathematical models: a precious tool for research in physiologyLascano, Elena CatalinaMattiazzi, Alicia RamonaNegroni, Jorge AntonioCiencias Médicasmathematical modelscardiac myocytemultiscale modelsintracellular calciumThe use of mathematical models in science has increased in the last decades, since it is clear that they constitute an essential tool for the progress of experimental research. The main goal of this review is to present to the experimental physiologists some background on the different steps that are usually followed to develop a model. Probably more important, we aim to provide some basic thoughts to highlight the importance and need of mathematical modeling for scientific discovery and progress. The review also recapitulates the evolution of myocyte and Ca²⁺ handling models, the parallel work done in the interpretation of cardiac force generation, the integration of myocyte and force models into mechano-electric representations, and the construction of multi-scale models by assembling ventricular models with the mathematical descriptions of the circulatory system.Sociedad Argentina de Fisiología2015info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf12-22http://sedici.unlp.edu.ar/handle/10915/127761enginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/archive/id/75info:eu-repo/semantics/altIdentifier/issn/1669-5402info:eu-repo/semantics/altIdentifier/issn/1669-5410info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:11:51Zoai:sedici.unlp.edu.ar:10915/127761Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:11:51.597SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Mathematical models: a precious tool for research in physiology
title Mathematical models: a precious tool for research in physiology
spellingShingle Mathematical models: a precious tool for research in physiology
Lascano, Elena Catalina
Ciencias Médicas
mathematical models
cardiac myocyte
multiscale models
intracellular calcium
title_short Mathematical models: a precious tool for research in physiology
title_full Mathematical models: a precious tool for research in physiology
title_fullStr Mathematical models: a precious tool for research in physiology
title_full_unstemmed Mathematical models: a precious tool for research in physiology
title_sort Mathematical models: a precious tool for research in physiology
dc.creator.none.fl_str_mv Lascano, Elena Catalina
Mattiazzi, Alicia Ramona
Negroni, Jorge Antonio
author Lascano, Elena Catalina
author_facet Lascano, Elena Catalina
Mattiazzi, Alicia Ramona
Negroni, Jorge Antonio
author_role author
author2 Mattiazzi, Alicia Ramona
Negroni, Jorge Antonio
author2_role author
author
dc.subject.none.fl_str_mv Ciencias Médicas
mathematical models
cardiac myocyte
multiscale models
intracellular calcium
topic Ciencias Médicas
mathematical models
cardiac myocyte
multiscale models
intracellular calcium
dc.description.none.fl_txt_mv The use of mathematical models in science has increased in the last decades, since it is clear that they constitute an essential tool for the progress of experimental research. The main goal of this review is to present to the experimental physiologists some background on the different steps that are usually followed to develop a model. Probably more important, we aim to provide some basic thoughts to highlight the importance and need of mathematical modeling for scientific discovery and progress. The review also recapitulates the evolution of myocyte and Ca²⁺ handling models, the parallel work done in the interpretation of cardiac force generation, the integration of myocyte and force models into mechano-electric representations, and the construction of multi-scale models by assembling ventricular models with the mathematical descriptions of the circulatory system.
Sociedad Argentina de Fisiología
description The use of mathematical models in science has increased in the last decades, since it is clear that they constitute an essential tool for the progress of experimental research. The main goal of this review is to present to the experimental physiologists some background on the different steps that are usually followed to develop a model. Probably more important, we aim to provide some basic thoughts to highlight the importance and need of mathematical modeling for scientific discovery and progress. The review also recapitulates the evolution of myocyte and Ca²⁺ handling models, the parallel work done in the interpretation of cardiac force generation, the integration of myocyte and force models into mechano-electric representations, and the construction of multi-scale models by assembling ventricular models with the mathematical descriptions of the circulatory system.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/review
info:eu-repo/semantics/publishedVersion
Revision
http://purl.org/coar/resource_type/c_dcae04bc
info:ar-repo/semantics/resenaArticulo
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status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/127761
url http://sedici.unlp.edu.ar/handle/10915/127761
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/issn/1669-5402
info:eu-repo/semantics/altIdentifier/issn/1669-5410
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
12-22
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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