Mathematical models: a precious tool for research in physiology

Autores
Lascano, Elena C.; Mattiazzi, Ramona Alicia; Negroni, Jorge A.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The use of mathematical models in science has increased in the last decades, since it is clear that they constitute an essential tool for the progress of experimental research. The main goal of this review is to present to the experimental physiologists some background on the different steps that are usually followed to develop a model. Probably more important, we aim to provide some basic thoughts to highlight the importance and need of mathematical modeling for scientific discovery and progress. The review also recapitulates the evolution of myocyte and Ca2+ handling models, the parallel work done in the interpretation of cardiac force generation, the integration of myocyte and force models into mechano-electric representations, and the construction of multi-scale models by assembling ventricular models with the mathematical descriptions of the circulatory system.
Fil: Lascano, Elena C.. Universidad Favaloro; Argentina
Fil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Negroni, Jorge A.. Universidad Favaloro; Argentina
Materia
Mathematical Models
Cardiac Myocyte
Intracellular Calcium
Multiscale Models
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11934
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/11934
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mathematical models: a precious tool for research in physiologyLascano, Elena C.Mattiazzi, Ramona AliciaNegroni, Jorge A.Mathematical ModelsCardiac MyocyteIntracellular CalciumMultiscale Modelshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The use of mathematical models in science has increased in the last decades, since it is clear that they constitute an essential tool for the progress of experimental research. The main goal of this review is to present to the experimental physiologists some background on the different steps that are usually followed to develop a model. Probably more important, we aim to provide some basic thoughts to highlight the importance and need of mathematical modeling for scientific discovery and progress. The review also recapitulates the evolution of myocyte and Ca2+ handling models, the parallel work done in the interpretation of cardiac force generation, the integration of myocyte and force models into mechano-electric representations, and the construction of multi-scale models by assembling ventricular models with the mathematical descriptions of the circulatory system.Fil: Lascano, Elena C.. Universidad Favaloro; ArgentinaFil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Negroni, Jorge A.. Universidad Favaloro; ArgentinaSociedad Argentina de Fisiología2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11934Lascano, Elena C.; Mattiazzi, Ramona Alicia; Negroni, Jorge A.; Mathematical models: a precious tool for research in physiology; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 8; 2; 3-2015; 12-221669-5410enginfo:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/archive/id/75info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:45:24Zoai:ri.conicet.gov.ar:11336/11934instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:45:24.299CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mathematical models: a precious tool for research in physiology
title Mathematical models: a precious tool for research in physiology
spellingShingle Mathematical models: a precious tool for research in physiology
Lascano, Elena C.
Mathematical Models
Cardiac Myocyte
Intracellular Calcium
Multiscale Models
title_short Mathematical models: a precious tool for research in physiology
title_full Mathematical models: a precious tool for research in physiology
title_fullStr Mathematical models: a precious tool for research in physiology
title_full_unstemmed Mathematical models: a precious tool for research in physiology
title_sort Mathematical models: a precious tool for research in physiology
dc.creator.none.fl_str_mv Lascano, Elena C.
Mattiazzi, Ramona Alicia
Negroni, Jorge A.
author Lascano, Elena C.
author_facet Lascano, Elena C.
Mattiazzi, Ramona Alicia
Negroni, Jorge A.
author_role author
author2 Mattiazzi, Ramona Alicia
Negroni, Jorge A.
author2_role author
author
dc.subject.none.fl_str_mv Mathematical Models
Cardiac Myocyte
Intracellular Calcium
Multiscale Models
topic Mathematical Models
Cardiac Myocyte
Intracellular Calcium
Multiscale Models
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The use of mathematical models in science has increased in the last decades, since it is clear that they constitute an essential tool for the progress of experimental research. The main goal of this review is to present to the experimental physiologists some background on the different steps that are usually followed to develop a model. Probably more important, we aim to provide some basic thoughts to highlight the importance and need of mathematical modeling for scientific discovery and progress. The review also recapitulates the evolution of myocyte and Ca2+ handling models, the parallel work done in the interpretation of cardiac force generation, the integration of myocyte and force models into mechano-electric representations, and the construction of multi-scale models by assembling ventricular models with the mathematical descriptions of the circulatory system.
Fil: Lascano, Elena C.. Universidad Favaloro; Argentina
Fil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Negroni, Jorge A.. Universidad Favaloro; Argentina
description The use of mathematical models in science has increased in the last decades, since it is clear that they constitute an essential tool for the progress of experimental research. The main goal of this review is to present to the experimental physiologists some background on the different steps that are usually followed to develop a model. Probably more important, we aim to provide some basic thoughts to highlight the importance and need of mathematical modeling for scientific discovery and progress. The review also recapitulates the evolution of myocyte and Ca2+ handling models, the parallel work done in the interpretation of cardiac force generation, the integration of myocyte and force models into mechano-electric representations, and the construction of multi-scale models by assembling ventricular models with the mathematical descriptions of the circulatory system.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11934
Lascano, Elena C.; Mattiazzi, Ramona Alicia; Negroni, Jorge A.; Mathematical models: a precious tool for research in physiology; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 8; 2; 3-2015; 12-22
1669-5410
url http://hdl.handle.net/11336/11934
identifier_str_mv Lascano, Elena C.; Mattiazzi, Ramona Alicia; Negroni, Jorge A.; Mathematical models: a precious tool for research in physiology; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 8; 2; 3-2015; 12-22
1669-5410
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/archive/id/75
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Fisiología
publisher.none.fl_str_mv Sociedad Argentina de Fisiología
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613424072359936
score 13.070432

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