Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits
- Autores
- Zanuzzi, Carolina Natalia; Nishida, Fabián; Portiansky, Enrique Leo; Fontana, Paula Andrea; Gimeno, Eduardo Juan; Barbeito, Claudio Gustavo
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Vitamin D regulates mineral homeostases and enterocyte proliferation and differentiation. Hypervitaminosis D generates changes in cell proliferation, differentiation and apoptosis in several organs. We analysed morphometric parameters and proliferative and apoptotic indices in the intestinal epithelium of rabbits with hypervitaminosis D induced by the chronic treatment with the calcinogenic plant Solanum glaucophyllum. Rabbits were treated for 15 or 30 days. A group was treated for 15 days and led to possible recovery for 30 days. Another group was nutritionally restricted for 30 days. Morphological, morphometric, proliferative and apoptotic changes were found in the treated animals. Mild atrophy and reduced proliferation was found in the jejunum and ileum. Apoptosis increased in the crypts of the ileum and in the superficial epithelium and crypts of the rectum. Most of the alterations were partially recovered. The possible involvement in these changes of the hypervitaminosis D-like state induced by S. glaucophyllum is discussed.
Facultad de Ciencias Veterinarias - Materia
-
Ciencias Veterinarias
1,25-Dihydroxyvitamin D3
Intestine
Rabbit
Proliferation
Apoptosis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/107721
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Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbitsZanuzzi, Carolina NataliaNishida, FabiánPortiansky, Enrique LeoFontana, Paula AndreaGimeno, Eduardo JuanBarbeito, Claudio GustavoCiencias Veterinarias1,25-Dihydroxyvitamin D3IntestineRabbitProliferationApoptosisVitamin D regulates mineral homeostases and enterocyte proliferation and differentiation. Hypervitaminosis D generates changes in cell proliferation, differentiation and apoptosis in several organs. We analysed morphometric parameters and proliferative and apoptotic indices in the intestinal epithelium of rabbits with hypervitaminosis D induced by the chronic treatment with the calcinogenic plant <i>Solanum glaucophyllum</i>. Rabbits were treated for 15 or 30 days. A group was treated for 15 days and led to possible recovery for 30 days. Another group was nutritionally restricted for 30 days. Morphological, morphometric, proliferative and apoptotic changes were found in the treated animals. Mild atrophy and reduced proliferation was found in the jejunum and ileum. Apoptosis increased in the crypts of the ileum and in the superficial epithelium and crypts of the rectum. Most of the alterations were partially recovered. The possible involvement in these changes of the hypervitaminosis D-like state induced by <i>S. glaucophyllum</i> is discussed.Facultad de Ciencias Veterinarias2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/107721enginfo:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7125838&blobtype=pdfinfo:eu-repo/semantics/altIdentifier/issn/0034-5288info:eu-repo/semantics/altIdentifier/pmid/21862088info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rvsc.2011.07.018info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:23:52Zoai:sedici.unlp.edu.ar:10915/107721Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:23:53.094SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits |
title |
Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits |
spellingShingle |
Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits Zanuzzi, Carolina Natalia Ciencias Veterinarias 1,25-Dihydroxyvitamin D3 Intestine Rabbit Proliferation Apoptosis |
title_short |
Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits |
title_full |
Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits |
title_fullStr |
Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits |
title_full_unstemmed |
Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits |
title_sort |
Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits |
dc.creator.none.fl_str_mv |
Zanuzzi, Carolina Natalia Nishida, Fabián Portiansky, Enrique Leo Fontana, Paula Andrea Gimeno, Eduardo Juan Barbeito, Claudio Gustavo |
author |
Zanuzzi, Carolina Natalia |
author_facet |
Zanuzzi, Carolina Natalia Nishida, Fabián Portiansky, Enrique Leo Fontana, Paula Andrea Gimeno, Eduardo Juan Barbeito, Claudio Gustavo |
author_role |
author |
author2 |
Nishida, Fabián Portiansky, Enrique Leo Fontana, Paula Andrea Gimeno, Eduardo Juan Barbeito, Claudio Gustavo |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Ciencias Veterinarias 1,25-Dihydroxyvitamin D3 Intestine Rabbit Proliferation Apoptosis |
topic |
Ciencias Veterinarias 1,25-Dihydroxyvitamin D3 Intestine Rabbit Proliferation Apoptosis |
dc.description.none.fl_txt_mv |
Vitamin D regulates mineral homeostases and enterocyte proliferation and differentiation. Hypervitaminosis D generates changes in cell proliferation, differentiation and apoptosis in several organs. We analysed morphometric parameters and proliferative and apoptotic indices in the intestinal epithelium of rabbits with hypervitaminosis D induced by the chronic treatment with the calcinogenic plant <i>Solanum glaucophyllum</i>. Rabbits were treated for 15 or 30 days. A group was treated for 15 days and led to possible recovery for 30 days. Another group was nutritionally restricted for 30 days. Morphological, morphometric, proliferative and apoptotic changes were found in the treated animals. Mild atrophy and reduced proliferation was found in the jejunum and ileum. Apoptosis increased in the crypts of the ileum and in the superficial epithelium and crypts of the rectum. Most of the alterations were partially recovered. The possible involvement in these changes of the hypervitaminosis D-like state induced by <i>S. glaucophyllum</i> is discussed. Facultad de Ciencias Veterinarias |
description |
Vitamin D regulates mineral homeostases and enterocyte proliferation and differentiation. Hypervitaminosis D generates changes in cell proliferation, differentiation and apoptosis in several organs. We analysed morphometric parameters and proliferative and apoptotic indices in the intestinal epithelium of rabbits with hypervitaminosis D induced by the chronic treatment with the calcinogenic plant <i>Solanum glaucophyllum</i>. Rabbits were treated for 15 or 30 days. A group was treated for 15 days and led to possible recovery for 30 days. Another group was nutritionally restricted for 30 days. Morphological, morphometric, proliferative and apoptotic changes were found in the treated animals. Mild atrophy and reduced proliferation was found in the jejunum and ileum. Apoptosis increased in the crypts of the ileum and in the superficial epithelium and crypts of the rectum. Most of the alterations were partially recovered. The possible involvement in these changes of the hypervitaminosis D-like state induced by <i>S. glaucophyllum</i> is discussed. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/107721 |
url |
http://sedici.unlp.edu.ar/handle/10915/107721 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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openAccess |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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