Large-scale purification of pachydictyol A from the brown alga Dictyota dichotoma obtained from algal wash and evaluation of its antifouling activity against the freshwater...

Autores: Siless, Gastón E.; García, Mónica Teresita; Pérez, Miriam Cristina; Blustein, Guillermo; Palermo, Jorge A.
Año de publicación: 2017
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: A scalable procedure was developed for the extraction and purification of pachydictyol A, the main diterpenoid isolated from the brown alga Dictyota dichotoma. The organic extract of this species is a complex mixture of a large variety of diterpenes, and in this work, the protocol was employed successfully for the purification of gram quantities of this compound from Patagonian D. dichotoma collected from algal wash. Pachydictyol A, together with other minor diterpenoids, was tested for antifouling activity against the invading freshwater mussel Limnoperna fortunei, using a byssal thread formation assay. The results obtained in the study showed a potent antifouling activity for pachydictyol A at 4.7 μg cm⁻² disk load. As for the other diterpenoids, dictyoxide was also considerably active, while dictyol C and dictyotadiol had a considerably lower activity. Taking into account the large biomass of algal wash and the abundance of D. dichotoma, together with the effectiveness of the purification protocol, these results show that pachydictyol A and dictyoxide have a good chance to become natural, non-toxic, and ecologically friendly additives in antifouling paints for the protection of submersed structures against L. fortunei.
Centro de Investigación y Desarrollo en Tecnología de Pinturas
Facultad de Ciencias Naturales y Museo
Facultad de Ciencias Agrarias y Forestales
Materia: Química
Pachydictyol A
Dictyota dichotoma
Phaeophyceae
Limnoperna fortunei
Antifouling activity
Algal wash
Nivel de accesibilidad: acceso abierto
Condiciones de uso: http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Institución: Universidad Nacional de La Plata
OAI Identificador: oai:sedici.unlp.edu.ar:10915/103329

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spelling Large-scale purification of pachydictyol A from the brown alga Dictyota dichotoma obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk Limnoperna fortuneiSiless, Gastón E.García, Mónica TeresitaPérez, Miriam CristinaBlustein, GuillermoPalermo, Jorge A.QuímicaPachydictyol ADictyota dichotomaPhaeophyceaeLimnoperna fortuneiAntifouling activityAlgal washA scalable procedure was developed for the extraction and purification of pachydictyol A, the main diterpenoid isolated from the brown alga Dictyota dichotoma. The organic extract of this species is a complex mixture of a large variety of diterpenes, and in this work, the protocol was employed successfully for the purification of gram quantities of this compound from Patagonian D. dichotoma collected from algal wash. Pachydictyol A, together with other minor diterpenoids, was tested for antifouling activity against the invading freshwater mussel Limnoperna fortunei, using a byssal thread formation assay. The results obtained in the study showed a potent antifouling activity for pachydictyol A at 4.7 μg cm−2 disk load. As for the other diterpenoids, dictyoxide was also considerably active, while dictyol C and dictyotadiol had a considerably lower activity. Taking into account the large biomass of algal wash and the abundance of D. dichotoma, together with the effectiveness of the purification protocol, these results show that pachydictyol A and dictyoxide have a good chance to become natural, non-toxic, and ecologically friendly additives in antifouling paints for the protection of submersed structures against L. fortunei.Centro de Investigación y Desarrollo en Tecnología de PinturasFacultad de Ciencias Naturales y MuseoFacultad de Ciencias Agrarias y Forestales2017-09-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf629-636http://sedici.unlp.edu.ar/handle/10915/103329enginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10811-017-1261-9info:eu-repo/semantics/altIdentifier/issn/1573-5176info:eu-repo/semantics/altIdentifier/doi/10.1007/s10811-017-1261-9info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:22:24Zoai:sedici.unlp.edu.ar:10915/103329Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:22:24.446SEDICI (UNLP) - Universidad Nacional de La Platafalse

dc.title.none.fl_str_mv Large-scale purification of pachydictyol A from the brown alga Dictyota dichotoma obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk Limnoperna fortunei

title Large-scale purification of pachydictyol A from the brown alga Dictyota dichotoma obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk Limnoperna fortunei

spellingShingle Large-scale purification of pachydictyol A from the brown alga Dictyota dichotoma obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk Limnoperna fortunei
Siless, Gastón E.
Química
Pachydictyol A
Dictyota dichotoma
Phaeophyceae
Limnoperna fortunei
Antifouling activity
Algal wash

title_short Large-scale purification of pachydictyol A from the brown alga Dictyota dichotoma obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk Limnoperna fortunei

title_full Large-scale purification of pachydictyol A from the brown alga Dictyota dichotoma obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk Limnoperna fortunei

title_fullStr Large-scale purification of pachydictyol A from the brown alga Dictyota dichotoma obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk Limnoperna fortunei

title_full_unstemmed Large-scale purification of pachydictyol A from the brown alga Dictyota dichotoma obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk Limnoperna fortunei

title_sort Large-scale purification of pachydictyol A from the brown alga Dictyota dichotoma obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk Limnoperna fortunei

dc.creator.none.fl_str_mv Siless, Gastón E.
García, Mónica Teresita
Pérez, Miriam Cristina
Blustein, Guillermo
Palermo, Jorge A.

author Siless, Gastón E.

author_facet Siless, Gastón E.
García, Mónica Teresita
Pérez, Miriam Cristina
Blustein, Guillermo
Palermo, Jorge A.

author_role author

author2 García, Mónica Teresita
Pérez, Miriam Cristina
Blustein, Guillermo
Palermo, Jorge A.

author2_role author
author
author
author

dc.subject.none.fl_str_mv Química
Pachydictyol A
Dictyota dichotoma
Phaeophyceae
Limnoperna fortunei
Antifouling activity
Algal wash

topic Química
Pachydictyol A
Dictyota dichotoma
Phaeophyceae
Limnoperna fortunei
Antifouling activity
Algal wash

dc.description.none.fl_txt_mv A scalable procedure was developed for the extraction and purification of pachydictyol A, the main diterpenoid isolated from the brown alga Dictyota dichotoma. The organic extract of this species is a complex mixture of a large variety of diterpenes, and in this work, the protocol was employed successfully for the purification of gram quantities of this compound from Patagonian D. dichotoma collected from algal wash. Pachydictyol A, together with other minor diterpenoids, was tested for antifouling activity against the invading freshwater mussel Limnoperna fortunei, using a byssal thread formation assay. The results obtained in the study showed a potent antifouling activity for pachydictyol A at 4.7 μg cm−2 disk load. As for the other diterpenoids, dictyoxide was also considerably active, while dictyol C and dictyotadiol had a considerably lower activity. Taking into account the large biomass of algal wash and the abundance of D. dichotoma, together with the effectiveness of the purification protocol, these results show that pachydictyol A and dictyoxide have a good chance to become natural, non-toxic, and ecologically friendly additives in antifouling paints for the protection of submersed structures against L. fortunei.
Centro de Investigación y Desarrollo en Tecnología de Pinturas
Facultad de Ciencias Naturales y Museo
Facultad de Ciencias Agrarias y Forestales

description A scalable procedure was developed for the extraction and purification of pachydictyol A, the main diterpenoid isolated from the brown alga Dictyota dichotoma. The organic extract of this species is a complex mixture of a large variety of diterpenes, and in this work, the protocol was employed successfully for the purification of gram quantities of this compound from Patagonian D. dichotoma collected from algal wash. Pachydictyol A, together with other minor diterpenoids, was tested for antifouling activity against the invading freshwater mussel Limnoperna fortunei, using a byssal thread formation assay. The results obtained in the study showed a potent antifouling activity for pachydictyol A at 4.7 μg cm−2 disk load. As for the other diterpenoids, dictyoxide was also considerably active, while dictyol C and dictyotadiol had a considerably lower activity. Taking into account the large biomass of algal wash and the abundance of D. dichotoma, together with the effectiveness of the purification protocol, these results show that pachydictyol A and dictyoxide have a good chance to become natural, non-toxic, and ecologically friendly additives in antifouling paints for the protection of submersed structures against L. fortunei.

publishDate 2017

dc.date.none.fl_str_mv 2017-09-12

dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/103329

url http://sedici.unlp.edu.ar/handle/10915/103329

dc.language.none.fl_str_mv eng

language eng

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info:eu-repo/semantics/altIdentifier/issn/1573-5176
info:eu-repo/semantics/altIdentifier/doi/10.1007/s10811-017-1261-9

dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)

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rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)

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spelling	Large-scale purification of pachydictyol A from the brown alga <i>Dictyota dichotoma</i> obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk <i>Limnoperna fortunei</i>Siless, Gastón E.García, Mónica TeresitaPérez, Miriam CristinaBlustein, GuillermoPalermo, Jorge A.QuímicaPachydictyol ADictyota dichotomaPhaeophyceaeLimnoperna fortuneiAntifouling activityAlgal washA scalable procedure was developed for the extraction and purification of pachydictyol A, the main diterpenoid isolated from the brown alga <i>Dictyota dichotoma</i>. The organic extract of this species is a complex mixture of a large variety of diterpenes, and in this work, the protocol was employed successfully for the purification of gram quantities of this compound from Patagonian D. dichotoma collected from algal wash. Pachydictyol A, together with other minor diterpenoids, was tested for antifouling activity against the invading freshwater mussel <i>Limnoperna fortunei</i>, using a byssal thread formation assay. The results obtained in the study showed a potent antifouling activity for pachydictyol A at 4.7 μg cm<sup>−2</sup> disk load. As for the other diterpenoids, dictyoxide was also considerably active, while dictyol C and dictyotadiol had a considerably lower activity. Taking into account the large biomass of algal wash and the abundance of <i>D. dichotoma</sup>, together with the effectiveness of the purification protocol, these results show that pachydictyol A and dictyoxide have a good chance to become natural, non-toxic, and ecologically friendly additives in antifouling paints for the protection of submersed structures against <i>L. fortunei</i>.Centro de Investigación y Desarrollo en Tecnología de PinturasFacultad de Ciencias Naturales y MuseoFacultad de Ciencias Agrarias y Forestales2017-09-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf629-636http://sedici.unlp.edu.ar/handle/10915/103329enginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10811-017-1261-9info:eu-repo/semantics/altIdentifier/issn/1573-5176info:eu-repo/semantics/altIdentifier/doi/10.1007/s10811-017-1261-9info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:22:24Zoai:sedici.unlp.edu.ar:10915/103329Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:22:24.446SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv	Large-scale purification of pachydictyol A from the brown alga <i>Dictyota dichotoma</i> obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk <i>Limnoperna fortunei</i>
title	Large-scale purification of pachydictyol A from the brown alga <i>Dictyota dichotoma</i> obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk <i>Limnoperna fortunei</i>
spellingShingle	Large-scale purification of pachydictyol A from the brown alga <i>Dictyota dichotoma</i> obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk <i>Limnoperna fortunei</i> Siless, Gastón E. Química Pachydictyol A Dictyota dichotoma Phaeophyceae Limnoperna fortunei Antifouling activity Algal wash
title_short	Large-scale purification of pachydictyol A from the brown alga <i>Dictyota dichotoma</i> obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk <i>Limnoperna fortunei</i>
title_full	Large-scale purification of pachydictyol A from the brown alga <i>Dictyota dichotoma</i> obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk <i>Limnoperna fortunei</i>
title_fullStr	Large-scale purification of pachydictyol A from the brown alga <i>Dictyota dichotoma</i> obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk <i>Limnoperna fortunei</i>
title_full_unstemmed	Large-scale purification of pachydictyol A from the brown alga <i>Dictyota dichotoma</i> obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk <i>Limnoperna fortunei</i>
title_sort	Large-scale purification of pachydictyol A from the brown alga <i>Dictyota dichotoma</i> obtained from algal wash and evaluation of its antifouling activity against the freshwater mollusk <i>Limnoperna fortunei</i>
dc.creator.none.fl_str_mv	Siless, Gastón E. García, Mónica Teresita Pérez, Miriam Cristina Blustein, Guillermo Palermo, Jorge A.
author	Siless, Gastón E.
author_facet	Siless, Gastón E. García, Mónica Teresita Pérez, Miriam Cristina Blustein, Guillermo Palermo, Jorge A.
author_role	author
author2	García, Mónica Teresita Pérez, Miriam Cristina Blustein, Guillermo Palermo, Jorge A.
author2_role	author author author author
dc.subject.none.fl_str_mv	Química Pachydictyol A Dictyota dichotoma Phaeophyceae Limnoperna fortunei Antifouling activity Algal wash
topic	Química Pachydictyol A Dictyota dichotoma Phaeophyceae Limnoperna fortunei Antifouling activity Algal wash
dc.description.none.fl_txt_mv	A scalable procedure was developed for the extraction and purification of pachydictyol A, the main diterpenoid isolated from the brown alga <i>Dictyota dichotoma</i>. The organic extract of this species is a complex mixture of a large variety of diterpenes, and in this work, the protocol was employed successfully for the purification of gram quantities of this compound from Patagonian D. dichotoma collected from algal wash. Pachydictyol A, together with other minor diterpenoids, was tested for antifouling activity against the invading freshwater mussel <i>Limnoperna fortunei</i>, using a byssal thread formation assay. The results obtained in the study showed a potent antifouling activity for pachydictyol A at 4.7 μg cm<sup>−2</sup> disk load. As for the other diterpenoids, dictyoxide was also considerably active, while dictyol C and dictyotadiol had a considerably lower activity. Taking into account the large biomass of algal wash and the abundance of <i>D. dichotoma</sup>, together with the effectiveness of the purification protocol, these results show that pachydictyol A and dictyoxide have a good chance to become natural, non-toxic, and ecologically friendly additives in antifouling paints for the protection of submersed structures against <i>L. fortunei</i>. Centro de Investigación y Desarrollo en Tecnología de Pinturas Facultad de Ciencias Naturales y Museo Facultad de Ciencias Agrarias y Forestales
description	A scalable procedure was developed for the extraction and purification of pachydictyol A, the main diterpenoid isolated from the brown alga <i>Dictyota dichotoma</i>. The organic extract of this species is a complex mixture of a large variety of diterpenes, and in this work, the protocol was employed successfully for the purification of gram quantities of this compound from Patagonian D. dichotoma collected from algal wash. Pachydictyol A, together with other minor diterpenoids, was tested for antifouling activity against the invading freshwater mussel <i>Limnoperna fortunei</i>, using a byssal thread formation assay. The results obtained in the study showed a potent antifouling activity for pachydictyol A at 4.7 μg cm<sup>−2</sup> disk load. As for the other diterpenoids, dictyoxide was also considerably active, while dictyol C and dictyotadiol had a considerably lower activity. Taking into account the large biomass of algal wash and the abundance of <i>D. dichotoma</sup>, together with the effectiveness of the purification protocol, these results show that pachydictyol A and dictyoxide have a good chance to become natural, non-toxic, and ecologically friendly additives in antifouling paints for the protection of submersed structures against <i>L. fortunei</i>.
publishDate	2017
dc.date.none.fl_str_mv	2017-09-12
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language	eng
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