Bordetella biofilms: a lifestyle leading to persistent infections
- Autores
- Cattelan, Natalia; Dubey, Purnima; Arnal, Laura; Yantorno, Osvaldo Miguel; Deora, Rajendar
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Bordetella bronchiseptica and B. pertussis are Gram-negative bacteria that cause respiratory diseases in animals and humans. The current incidence of whooping cough or pertussis caused by B. pertussis has reached levels not observed since the 1950s. Although pertussis is traditionally known as an acute childhood disease, it has recently resurged in vaccinated adolescents and adults. These individuals often become silent carriers, facilitating bacterial circulation and transmission. Similarly, vaccinated and non-vaccinated animals continue to be carriers of B. bronchiseptica and shed bacteria resulting in disease outbreaks. The persistence mechanisms of these bacteria remain poorly characterized. It has been proposed that adoption of a biofilm lifestyle allows persistent colonization of the mammalian respiratory tract. The history of Bordetella biofilm research is only a decade long and there is no single review article that has exclusively focused on this area. We systematically discuss the role of Bordetella factors in biofilm development in vitro and in the mouse respiratory tract. We further outline the implications of biofilms to bacterial persistence and transmission in humans and for the design of new acellular pertussis vaccines.
Centro de Investigación y Desarrollo en Fermentaciones Industriales - Materia
-
Ciencias Médicas
biofilm
Bordetella
animal model
transmission
vaccine - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/106748
Ver los metadatos del registro completo
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Bordetella biofilms: a lifestyle leading to persistent infectionsCattelan, NataliaDubey, PurnimaArnal, LauraYantorno, Osvaldo MiguelDeora, RajendarCiencias MédicasbiofilmBordetellaanimal modeltransmissionvaccineBordetella bronchiseptica and B. pertussis are Gram-negative bacteria that cause respiratory diseases in animals and humans. The current incidence of whooping cough or pertussis caused by B. pertussis has reached levels not observed since the 1950s. Although pertussis is traditionally known as an acute childhood disease, it has recently resurged in vaccinated adolescents and adults. These individuals often become silent carriers, facilitating bacterial circulation and transmission. Similarly, vaccinated and non-vaccinated animals continue to be carriers of B. bronchiseptica and shed bacteria resulting in disease outbreaks. The persistence mechanisms of these bacteria remain poorly characterized. It has been proposed that adoption of a biofilm lifestyle allows persistent colonization of the mammalian respiratory tract. The history of Bordetella biofilm research is only a decade long and there is no single review article that has exclusively focused on this area. We systematically discuss the role of Bordetella factors in biofilm development in vitro and in the mouse respiratory tract. We further outline the implications of biofilms to bacterial persistence and transmission in humans and for the design of new acellular pertussis vaccines.Centro de Investigación y Desarrollo en Fermentaciones Industriales2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/106748enginfo:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4830220&blobtype=pdfinfo:eu-repo/semantics/altIdentifier/issn/2049-632Xinfo:eu-repo/semantics/altIdentifier/pmid/26586694info:eu-repo/semantics/altIdentifier/doi/10.1093/femspd/ftv108info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:23:56Zoai:sedici.unlp.edu.ar:10915/106748Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:23:56.838SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Bordetella biofilms: a lifestyle leading to persistent infections |
title |
Bordetella biofilms: a lifestyle leading to persistent infections |
spellingShingle |
Bordetella biofilms: a lifestyle leading to persistent infections Cattelan, Natalia Ciencias Médicas biofilm Bordetella animal model transmission vaccine |
title_short |
Bordetella biofilms: a lifestyle leading to persistent infections |
title_full |
Bordetella biofilms: a lifestyle leading to persistent infections |
title_fullStr |
Bordetella biofilms: a lifestyle leading to persistent infections |
title_full_unstemmed |
Bordetella biofilms: a lifestyle leading to persistent infections |
title_sort |
Bordetella biofilms: a lifestyle leading to persistent infections |
dc.creator.none.fl_str_mv |
Cattelan, Natalia Dubey, Purnima Arnal, Laura Yantorno, Osvaldo Miguel Deora, Rajendar |
author |
Cattelan, Natalia |
author_facet |
Cattelan, Natalia Dubey, Purnima Arnal, Laura Yantorno, Osvaldo Miguel Deora, Rajendar |
author_role |
author |
author2 |
Dubey, Purnima Arnal, Laura Yantorno, Osvaldo Miguel Deora, Rajendar |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Ciencias Médicas biofilm Bordetella animal model transmission vaccine |
topic |
Ciencias Médicas biofilm Bordetella animal model transmission vaccine |
dc.description.none.fl_txt_mv |
Bordetella bronchiseptica and B. pertussis are Gram-negative bacteria that cause respiratory diseases in animals and humans. The current incidence of whooping cough or pertussis caused by B. pertussis has reached levels not observed since the 1950s. Although pertussis is traditionally known as an acute childhood disease, it has recently resurged in vaccinated adolescents and adults. These individuals often become silent carriers, facilitating bacterial circulation and transmission. Similarly, vaccinated and non-vaccinated animals continue to be carriers of B. bronchiseptica and shed bacteria resulting in disease outbreaks. The persistence mechanisms of these bacteria remain poorly characterized. It has been proposed that adoption of a biofilm lifestyle allows persistent colonization of the mammalian respiratory tract. The history of Bordetella biofilm research is only a decade long and there is no single review article that has exclusively focused on this area. We systematically discuss the role of Bordetella factors in biofilm development in vitro and in the mouse respiratory tract. We further outline the implications of biofilms to bacterial persistence and transmission in humans and for the design of new acellular pertussis vaccines. Centro de Investigación y Desarrollo en Fermentaciones Industriales |
description |
Bordetella bronchiseptica and B. pertussis are Gram-negative bacteria that cause respiratory diseases in animals and humans. The current incidence of whooping cough or pertussis caused by B. pertussis has reached levels not observed since the 1950s. Although pertussis is traditionally known as an acute childhood disease, it has recently resurged in vaccinated adolescents and adults. These individuals often become silent carriers, facilitating bacterial circulation and transmission. Similarly, vaccinated and non-vaccinated animals continue to be carriers of B. bronchiseptica and shed bacteria resulting in disease outbreaks. The persistence mechanisms of these bacteria remain poorly characterized. It has been proposed that adoption of a biofilm lifestyle allows persistent colonization of the mammalian respiratory tract. The history of Bordetella biofilm research is only a decade long and there is no single review article that has exclusively focused on this area. We systematically discuss the role of Bordetella factors in biofilm development in vitro and in the mouse respiratory tract. We further outline the implications of biofilms to bacterial persistence and transmission in humans and for the design of new acellular pertussis vaccines. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 |
dc.type.none.fl_str_mv |
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article |
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http://sedici.unlp.edu.ar/handle/10915/106748 |
url |
http://sedici.unlp.edu.ar/handle/10915/106748 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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openAccess |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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