The pharmacokinetics of ceftazidime in lactating and non-lactating cows

Autores
Rule, R.; Quiroga, G. H.; Rubio, M.; Buschiazzo, Héctor Omar; Mordujovich de Buschiazzo, Perla
Año de publicación
1996
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The pharmacokinetics of ceftazidime (CAZ) were studied in lactating (LTG) and non-lactating (NLTG) cows. Two groups (LTG and NLTG) of 5 healthy dairy cows were given ceftazidime (10 mg/ kg body weight) intravenously (i.v.) and intramuscularly (i.m.). Serum and milk (LTG) and serum samples (NLTG) were collected over a 24-h period post-administration. CAZ concentrations in serum and milk were determined by high-performance liquid chromatography, and an interactive and weighted-non-linear least-squares regression analysis was used to perform the pharmacokinetic analysis. The pharmacokinetic profiles in LTG and NLTG cows which had received CAZ i.v. fitted a three-compartment model and a two-compartment model, respectively. The CAZ concentration-time curves in serum and the area under the curve were greater and more sustained (p<0.05) in the LTG cows by both routes, while the serum clearance (Cls=72.5±18.1 ml/h per kg) was lower (p<0.05) than that in the NLTG cows (Cls=185.9±44.2 ml/h per kg). CAZ given i.v. exhibited a relatively long half-life of elimination (t; 1/2 β (LTG)=1.1±0.2 h; t; 1/2 β (NLTG)=1.4±0.3 h). Compared with other cephalosporins, CAZ had good penetration into the mammary gland (47.7±38.2% for CAZ i.v.; 51.1±39.0% for CAZ i.m.). Finally, the bioavailability of CAZ (F(LTG)=98.9±36.8%; F(NLTG)=77.1±25.3%) was suitable for its use by the i.m. route in lactating and non-lactating cows.
Facultad de Ciencias Médicas
Comisión de Investigaciones Científicas de la provincia de Buenos Aires
Materia
Bioquímica
ceftazidime
cephalosporin
cattle
lactation
kinetics
milk
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/136155

id SEDICI_bb23c8b571cafdc458dc622922cf5c36
oai_identifier_str oai:sedici.unlp.edu.ar:10915/136155
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling The pharmacokinetics of ceftazidime in lactating and non-lactating cowsRule, R.Quiroga, G. H.Rubio, M.Buschiazzo, Héctor OmarMordujovich de Buschiazzo, PerlaBioquímicaceftazidimecephalosporincattlelactationkineticsmilkThe pharmacokinetics of ceftazidime (CAZ) were studied in lactating (LTG) and non-lactating (NLTG) cows. Two groups (LTG and NLTG) of 5 healthy dairy cows were given ceftazidime (10 mg/ kg body weight) intravenously (i.v.) and intramuscularly (i.m.). Serum and milk (LTG) and serum samples (NLTG) were collected over a 24-h period post-administration. CAZ concentrations in serum and milk were determined by high-performance liquid chromatography, and an interactive and weighted-non-linear least-squares regression analysis was used to perform the pharmacokinetic analysis. The pharmacokinetic profiles in LTG and NLTG cows which had received CAZ i.v. fitted a three-compartment model and a two-compartment model, respectively. The CAZ concentration-time curves in serum and the area under the curve were greater and more sustained (p<0.05) in the LTG cows by both routes, while the serum clearance (Cls=72.5±18.1 ml/h per kg) was lower (p<0.05) than that in the NLTG cows (Cls=185.9±44.2 ml/h per kg). CAZ given i.v. exhibited a relatively long half-life of elimination (t; 1/2 β (LTG)=1.1±0.2 h; t; 1/2 β (NLTG)=1.4±0.3 h). Compared with other cephalosporins, CAZ had good penetration into the mammary gland (47.7±38.2% for CAZ i.v.; 51.1±39.0% for CAZ i.m.). Finally, the bioavailability of CAZ (F(LTG)=98.9±36.8%; F(NLTG)=77.1±25.3%) was suitable for its use by the i.m. route in lactating and non-lactating cows.Facultad de Ciencias MédicasComisión de Investigaciones Científicas de la provincia de Buenos Aires1996info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf543-550http://sedici.unlp.edu.ar/handle/10915/136155enginfo:eu-repo/semantics/altIdentifier/issn/0165-7380info:eu-repo/semantics/altIdentifier/issn/1573-7446info:eu-repo/semantics/altIdentifier/doi/10.1007/bf00396297info:eu-repo/semantics/altIdentifier/pmid/8950835info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:31:57Zoai:sedici.unlp.edu.ar:10915/136155Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:31:58.259SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv The pharmacokinetics of ceftazidime in lactating and non-lactating cows
title The pharmacokinetics of ceftazidime in lactating and non-lactating cows
spellingShingle The pharmacokinetics of ceftazidime in lactating and non-lactating cows
Rule, R.
Bioquímica
ceftazidime
cephalosporin
cattle
lactation
kinetics
milk
title_short The pharmacokinetics of ceftazidime in lactating and non-lactating cows
title_full The pharmacokinetics of ceftazidime in lactating and non-lactating cows
title_fullStr The pharmacokinetics of ceftazidime in lactating and non-lactating cows
title_full_unstemmed The pharmacokinetics of ceftazidime in lactating and non-lactating cows
title_sort The pharmacokinetics of ceftazidime in lactating and non-lactating cows
dc.creator.none.fl_str_mv Rule, R.
Quiroga, G. H.
Rubio, M.
Buschiazzo, Héctor Omar
Mordujovich de Buschiazzo, Perla
author Rule, R.
author_facet Rule, R.
Quiroga, G. H.
Rubio, M.
Buschiazzo, Héctor Omar
Mordujovich de Buschiazzo, Perla
author_role author
author2 Quiroga, G. H.
Rubio, M.
Buschiazzo, Héctor Omar
Mordujovich de Buschiazzo, Perla
author2_role author
author
author
author
dc.subject.none.fl_str_mv Bioquímica
ceftazidime
cephalosporin
cattle
lactation
kinetics
milk
topic Bioquímica
ceftazidime
cephalosporin
cattle
lactation
kinetics
milk
dc.description.none.fl_txt_mv The pharmacokinetics of ceftazidime (CAZ) were studied in lactating (LTG) and non-lactating (NLTG) cows. Two groups (LTG and NLTG) of 5 healthy dairy cows were given ceftazidime (10 mg/ kg body weight) intravenously (i.v.) and intramuscularly (i.m.). Serum and milk (LTG) and serum samples (NLTG) were collected over a 24-h period post-administration. CAZ concentrations in serum and milk were determined by high-performance liquid chromatography, and an interactive and weighted-non-linear least-squares regression analysis was used to perform the pharmacokinetic analysis. The pharmacokinetic profiles in LTG and NLTG cows which had received CAZ i.v. fitted a three-compartment model and a two-compartment model, respectively. The CAZ concentration-time curves in serum and the area under the curve were greater and more sustained (p<0.05) in the LTG cows by both routes, while the serum clearance (Cls=72.5±18.1 ml/h per kg) was lower (p<0.05) than that in the NLTG cows (Cls=185.9±44.2 ml/h per kg). CAZ given i.v. exhibited a relatively long half-life of elimination (t; 1/2 β (LTG)=1.1±0.2 h; t; 1/2 β (NLTG)=1.4±0.3 h). Compared with other cephalosporins, CAZ had good penetration into the mammary gland (47.7±38.2% for CAZ i.v.; 51.1±39.0% for CAZ i.m.). Finally, the bioavailability of CAZ (F(LTG)=98.9±36.8%; F(NLTG)=77.1±25.3%) was suitable for its use by the i.m. route in lactating and non-lactating cows.
Facultad de Ciencias Médicas
Comisión de Investigaciones Científicas de la provincia de Buenos Aires
description The pharmacokinetics of ceftazidime (CAZ) were studied in lactating (LTG) and non-lactating (NLTG) cows. Two groups (LTG and NLTG) of 5 healthy dairy cows were given ceftazidime (10 mg/ kg body weight) intravenously (i.v.) and intramuscularly (i.m.). Serum and milk (LTG) and serum samples (NLTG) were collected over a 24-h period post-administration. CAZ concentrations in serum and milk were determined by high-performance liquid chromatography, and an interactive and weighted-non-linear least-squares regression analysis was used to perform the pharmacokinetic analysis. The pharmacokinetic profiles in LTG and NLTG cows which had received CAZ i.v. fitted a three-compartment model and a two-compartment model, respectively. The CAZ concentration-time curves in serum and the area under the curve were greater and more sustained (p<0.05) in the LTG cows by both routes, while the serum clearance (Cls=72.5±18.1 ml/h per kg) was lower (p<0.05) than that in the NLTG cows (Cls=185.9±44.2 ml/h per kg). CAZ given i.v. exhibited a relatively long half-life of elimination (t; 1/2 β (LTG)=1.1±0.2 h; t; 1/2 β (NLTG)=1.4±0.3 h). Compared with other cephalosporins, CAZ had good penetration into the mammary gland (47.7±38.2% for CAZ i.v.; 51.1±39.0% for CAZ i.m.). Finally, the bioavailability of CAZ (F(LTG)=98.9±36.8%; F(NLTG)=77.1±25.3%) was suitable for its use by the i.m. route in lactating and non-lactating cows.
publishDate 1996
dc.date.none.fl_str_mv 1996
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/136155
url http://sedici.unlp.edu.ar/handle/10915/136155
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0165-7380
info:eu-repo/semantics/altIdentifier/issn/1573-7446
info:eu-repo/semantics/altIdentifier/doi/10.1007/bf00396297
info:eu-repo/semantics/altIdentifier/pmid/8950835
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
543-550
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
_version_ 1844616199462191104
score 13.070432