Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats

Autores
Rule, R.; Villagra, S.; Barrena Chiantelassa, Jorge Pablo; Lacchini, Raul Alfredo; Reynaldi, Francisco José
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this work was to determine the pharmacokinetics of intravenous (iv) and intramuscular (im) ceftazidime administered to lactating (LTG; n = 6) and non-lactating (NLTG; n=6) healthy Creole goats in 2 trials (T1 and T2). During T1 and T2, goats randomly received a single dose of im or iv ceftazidime (10 mg/kg). Serum concentration of iv ceftazidime in NLTG and LTG goats is best described by 2 and 3 compartment models, respectively. The pharmacokinetic parameters of iv and im ceftazidime administered to LTG and NLTG showed statistically significant differences (P<0.05) in the constants (λz, T1 vs T2 [iv] 0.5±0.1 vs 0.3±0.1 /h; T1 vs T2 [im] 0.5±0.2 vs 0.3±0.1 /h) and in the mean times (t1/2, T 1 vs T 2 [iv] 1.6±0.3 vs 2.3±0.6 h; T 1 vs T 2 [im] 1.6±0.7 vs 2.6±0.9 h) of elimination. The bioavailability of ceftazidime in LTG and NLTG was 113.0 ± 17.8 and 96.0 ± 18.0 %, respectively. Ceftazidime concentration in milk at 2 h was: iv = 1.9 ± 0.2 and im = 2.4 ± 0.5 μg/m ; the penetration in milk was iv = 18.3 ± 13.5 and im = 14.3 ± 10.6 %. Ninety-six hours after iv and im administration, residues of the drug were not found in milk. In conclusion, ceftazidime, when administered to goats, showed high concentration times in serum, good penetration into milk and a bioavailability that makes it suitable to be used by the im route.
Fil: Rule, R.. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Fil: Villagra, S.. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Fil: Barrena Chiantelassa, Jorge Pablo. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Departamento de Producción Agropecuaria y Forestal; Argentina
Fil: Lacchini, Raul Alfredo. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Departamento de Producción Agropecuaria y Forestal; Argentina
Fil: Reynaldi, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Materia
CEFTAZIDIME
GOAT
MILK
PHARMACOKINETICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/114372
Acceder
id CONICETDig_008b468eac15b6a615d53f5023af5204
oai_identifier_str oai:ri.conicet.gov.ar:11336/114372
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pharmacokinetics of ceftazidime administered to lactating and non-lactating goatsRule, R.Villagra, S.Barrena Chiantelassa, Jorge PabloLacchini, Raul AlfredoReynaldi, Francisco JoséCEFTAZIDIMEGOATMILKPHARMACOKINETICShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The aim of this work was to determine the pharmacokinetics of intravenous (iv) and intramuscular (im) ceftazidime administered to lactating (LTG; n = 6) and non-lactating (NLTG; n=6) healthy Creole goats in 2 trials (T1 and T2). During T1 and T2, goats randomly received a single dose of im or iv ceftazidime (10 mg/kg). Serum concentration of iv ceftazidime in NLTG and LTG goats is best described by 2 and 3 compartment models, respectively. The pharmacokinetic parameters of iv and im ceftazidime administered to LTG and NLTG showed statistically significant differences (P<0.05) in the constants (λz, T1 vs T2 [iv] 0.5±0.1 vs 0.3±0.1 /h; T1 vs T2 [im] 0.5±0.2 vs 0.3±0.1 /h) and in the mean times (t1/2, T 1 vs T 2 [iv] 1.6±0.3 vs 2.3±0.6 h; T 1 vs T 2 [im] 1.6±0.7 vs 2.6±0.9 h) of elimination. The bioavailability of ceftazidime in LTG and NLTG was 113.0 ± 17.8 and 96.0 ± 18.0 %, respectively. Ceftazidime concentration in milk at 2 h was: iv = 1.9 ± 0.2 and im = 2.4 ± 0.5 μg/m ; the penetration in milk was iv = 18.3 ± 13.5 and im = 14.3 ± 10.6 %. Ninety-six hours after iv and im administration, residues of the drug were not found in milk. In conclusion, ceftazidime, when administered to goats, showed high concentration times in serum, good penetration into milk and a bioavailability that makes it suitable to be used by the im route.Fil: Rule, R.. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Villagra, S.. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Barrena Chiantelassa, Jorge Pablo. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Departamento de Producción Agropecuaria y Forestal; ArgentinaFil: Lacchini, Raul Alfredo. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Departamento de Producción Agropecuaria y Forestal; ArgentinaFil: Reynaldi, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaSouth African Veterinary Association2011-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/114372Rule, R.; Villagra, S.; Barrena Chiantelassa, Jorge Pablo; Lacchini, Raul Alfredo; Reynaldi, Francisco José; Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats; South African Veterinary Association; Journal of the South African Veterinary Association-Tydskrif van die Suid-Afrikaanse Veterinere Vereniging; 82; 4; 3-2011; 219-2230038-28092224-9435CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://jsava.co.za/index.php/jsava/article/view/77info:eu-repo/semantics/altIdentifier/doi/10.4102/jsava.v82i4.77info:eu-repo/semantics/altIdentifier/url/http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1019-91282011000400006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:53:19Zoai:ri.conicet.gov.ar:11336/114372instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:53:19.602CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats
title Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats
spellingShingle Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats
Rule, R.
CEFTAZIDIME
GOAT
MILK
PHARMACOKINETICS
title_short Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats
title_full Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats
title_fullStr Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats
title_full_unstemmed Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats
title_sort Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats
dc.creator.none.fl_str_mv Rule, R.
Villagra, S.
Barrena Chiantelassa, Jorge Pablo
Lacchini, Raul Alfredo
Reynaldi, Francisco José
author Rule, R.
author_facet Rule, R.
Villagra, S.
Barrena Chiantelassa, Jorge Pablo
Lacchini, Raul Alfredo
Reynaldi, Francisco José
author_role author
author2 Villagra, S.
Barrena Chiantelassa, Jorge Pablo
Lacchini, Raul Alfredo
Reynaldi, Francisco José
author2_role author
author
author
author
dc.subject.none.fl_str_mv CEFTAZIDIME
GOAT
MILK
PHARMACOKINETICS
topic CEFTAZIDIME
GOAT
MILK
PHARMACOKINETICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The aim of this work was to determine the pharmacokinetics of intravenous (iv) and intramuscular (im) ceftazidime administered to lactating (LTG; n = 6) and non-lactating (NLTG; n=6) healthy Creole goats in 2 trials (T1 and T2). During T1 and T2, goats randomly received a single dose of im or iv ceftazidime (10 mg/kg). Serum concentration of iv ceftazidime in NLTG and LTG goats is best described by 2 and 3 compartment models, respectively. The pharmacokinetic parameters of iv and im ceftazidime administered to LTG and NLTG showed statistically significant differences (P<0.05) in the constants (λz, T1 vs T2 [iv] 0.5±0.1 vs 0.3±0.1 /h; T1 vs T2 [im] 0.5±0.2 vs 0.3±0.1 /h) and in the mean times (t1/2, T 1 vs T 2 [iv] 1.6±0.3 vs 2.3±0.6 h; T 1 vs T 2 [im] 1.6±0.7 vs 2.6±0.9 h) of elimination. The bioavailability of ceftazidime in LTG and NLTG was 113.0 ± 17.8 and 96.0 ± 18.0 %, respectively. Ceftazidime concentration in milk at 2 h was: iv = 1.9 ± 0.2 and im = 2.4 ± 0.5 μg/m ; the penetration in milk was iv = 18.3 ± 13.5 and im = 14.3 ± 10.6 %. Ninety-six hours after iv and im administration, residues of the drug were not found in milk. In conclusion, ceftazidime, when administered to goats, showed high concentration times in serum, good penetration into milk and a bioavailability that makes it suitable to be used by the im route.
Fil: Rule, R.. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Fil: Villagra, S.. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Fil: Barrena Chiantelassa, Jorge Pablo. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Departamento de Producción Agropecuaria y Forestal; Argentina
Fil: Lacchini, Raul Alfredo. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Departamento de Producción Agropecuaria y Forestal; Argentina
Fil: Reynaldi, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
description The aim of this work was to determine the pharmacokinetics of intravenous (iv) and intramuscular (im) ceftazidime administered to lactating (LTG; n = 6) and non-lactating (NLTG; n=6) healthy Creole goats in 2 trials (T1 and T2). During T1 and T2, goats randomly received a single dose of im or iv ceftazidime (10 mg/kg). Serum concentration of iv ceftazidime in NLTG and LTG goats is best described by 2 and 3 compartment models, respectively. The pharmacokinetic parameters of iv and im ceftazidime administered to LTG and NLTG showed statistically significant differences (P<0.05) in the constants (λz, T1 vs T2 [iv] 0.5±0.1 vs 0.3±0.1 /h; T1 vs T2 [im] 0.5±0.2 vs 0.3±0.1 /h) and in the mean times (t1/2, T 1 vs T 2 [iv] 1.6±0.3 vs 2.3±0.6 h; T 1 vs T 2 [im] 1.6±0.7 vs 2.6±0.9 h) of elimination. The bioavailability of ceftazidime in LTG and NLTG was 113.0 ± 17.8 and 96.0 ± 18.0 %, respectively. Ceftazidime concentration in milk at 2 h was: iv = 1.9 ± 0.2 and im = 2.4 ± 0.5 μg/m ; the penetration in milk was iv = 18.3 ± 13.5 and im = 14.3 ± 10.6 %. Ninety-six hours after iv and im administration, residues of the drug were not found in milk. In conclusion, ceftazidime, when administered to goats, showed high concentration times in serum, good penetration into milk and a bioavailability that makes it suitable to be used by the im route.
publishDate 2011
dc.date.none.fl_str_mv 2011-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/114372
Rule, R.; Villagra, S.; Barrena Chiantelassa, Jorge Pablo; Lacchini, Raul Alfredo; Reynaldi, Francisco José; Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats; South African Veterinary Association; Journal of the South African Veterinary Association-Tydskrif van die Suid-Afrikaanse Veterinere Vereniging; 82; 4; 3-2011; 219-223
0038-2809
2224-9435
CONICET Digital
CONICET
url http://hdl.handle.net/11336/114372
identifier_str_mv Rule, R.; Villagra, S.; Barrena Chiantelassa, Jorge Pablo; Lacchini, Raul Alfredo; Reynaldi, Francisco José; Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats; South African Veterinary Association; Journal of the South African Veterinary Association-Tydskrif van die Suid-Afrikaanse Veterinere Vereniging; 82; 4; 3-2011; 219-223
0038-2809
2224-9435
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://jsava.co.za/index.php/jsava/article/view/77
info:eu-repo/semantics/altIdentifier/doi/10.4102/jsava.v82i4.77
info:eu-repo/semantics/altIdentifier/url/http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1019-91282011000400006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv South African Veterinary Association
publisher.none.fl_str_mv South African Veterinary Association
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083063812980736
score 13.22299

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