Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats
- Autores
- Rule, R.; Villagra, S.; Barrena Chiantelassa, Jorge Pablo; Lacchini, Raul Alfredo; Reynaldi, Francisco José
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The aim of this work was to determine the pharmacokinetics of intravenous (iv) and intramuscular (im) ceftazidime administered to lactating (LTG; n = 6) and non-lactating (NLTG; n=6) healthy Creole goats in 2 trials (T1 and T2). During T1 and T2, goats randomly received a single dose of im or iv ceftazidime (10 mg/kg). Serum concentration of iv ceftazidime in NLTG and LTG goats is best described by 2 and 3 compartment models, respectively. The pharmacokinetic parameters of iv and im ceftazidime administered to LTG and NLTG showed statistically significant differences (P<0.05) in the constants (λz, T1 vs T2 [iv] 0.5±0.1 vs 0.3±0.1 /h; T1 vs T2 [im] 0.5±0.2 vs 0.3±0.1 /h) and in the mean times (t1/2, T 1 vs T 2 [iv] 1.6±0.3 vs 2.3±0.6 h; T 1 vs T 2 [im] 1.6±0.7 vs 2.6±0.9 h) of elimination. The bioavailability of ceftazidime in LTG and NLTG was 113.0 ± 17.8 and 96.0 ± 18.0 %, respectively. Ceftazidime concentration in milk at 2 h was: iv = 1.9 ± 0.2 and im = 2.4 ± 0.5 μg/m ; the penetration in milk was iv = 18.3 ± 13.5 and im = 14.3 ± 10.6 %. Ninety-six hours after iv and im administration, residues of the drug were not found in milk. In conclusion, ceftazidime, when administered to goats, showed high concentration times in serum, good penetration into milk and a bioavailability that makes it suitable to be used by the im route.
Fil: Rule, R.. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Fil: Villagra, S.. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Fil: Barrena Chiantelassa, Jorge Pablo. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Departamento de Producción Agropecuaria y Forestal; Argentina
Fil: Lacchini, Raul Alfredo. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Departamento de Producción Agropecuaria y Forestal; Argentina
Fil: Reynaldi, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina - Materia
-
CEFTAZIDIME
GOAT
MILK
PHARMACOKINETICS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/114372
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Pharmacokinetics of ceftazidime administered to lactating and non-lactating goatsRule, R.Villagra, S.Barrena Chiantelassa, Jorge PabloLacchini, Raul AlfredoReynaldi, Francisco JoséCEFTAZIDIMEGOATMILKPHARMACOKINETICShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The aim of this work was to determine the pharmacokinetics of intravenous (iv) and intramuscular (im) ceftazidime administered to lactating (LTG; n = 6) and non-lactating (NLTG; n=6) healthy Creole goats in 2 trials (T1 and T2). During T1 and T2, goats randomly received a single dose of im or iv ceftazidime (10 mg/kg). Serum concentration of iv ceftazidime in NLTG and LTG goats is best described by 2 and 3 compartment models, respectively. The pharmacokinetic parameters of iv and im ceftazidime administered to LTG and NLTG showed statistically significant differences (P<0.05) in the constants (λz, T1 vs T2 [iv] 0.5±0.1 vs 0.3±0.1 /h; T1 vs T2 [im] 0.5±0.2 vs 0.3±0.1 /h) and in the mean times (t1/2, T 1 vs T 2 [iv] 1.6±0.3 vs 2.3±0.6 h; T 1 vs T 2 [im] 1.6±0.7 vs 2.6±0.9 h) of elimination. The bioavailability of ceftazidime in LTG and NLTG was 113.0 ± 17.8 and 96.0 ± 18.0 %, respectively. Ceftazidime concentration in milk at 2 h was: iv = 1.9 ± 0.2 and im = 2.4 ± 0.5 μg/m ; the penetration in milk was iv = 18.3 ± 13.5 and im = 14.3 ± 10.6 %. Ninety-six hours after iv and im administration, residues of the drug were not found in milk. In conclusion, ceftazidime, when administered to goats, showed high concentration times in serum, good penetration into milk and a bioavailability that makes it suitable to be used by the im route.Fil: Rule, R.. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Villagra, S.. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Barrena Chiantelassa, Jorge Pablo. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Departamento de Producción Agropecuaria y Forestal; ArgentinaFil: Lacchini, Raul Alfredo. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Departamento de Producción Agropecuaria y Forestal; ArgentinaFil: Reynaldi, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaSouth African Veterinary Association2011-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/114372Rule, R.; Villagra, S.; Barrena Chiantelassa, Jorge Pablo; Lacchini, Raul Alfredo; Reynaldi, Francisco José; Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats; South African Veterinary Association; Journal of the South African Veterinary Association-Tydskrif van die Suid-Afrikaanse Veterinere Vereniging; 82; 4; 3-2011; 219-2230038-28092224-9435CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://jsava.co.za/index.php/jsava/article/view/77info:eu-repo/semantics/altIdentifier/doi/10.4102/jsava.v82i4.77info:eu-repo/semantics/altIdentifier/url/http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1019-91282011000400006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:57:55Zoai:ri.conicet.gov.ar:11336/114372instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:57:55.397CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats |
title |
Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats |
spellingShingle |
Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats Rule, R. CEFTAZIDIME GOAT MILK PHARMACOKINETICS |
title_short |
Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats |
title_full |
Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats |
title_fullStr |
Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats |
title_full_unstemmed |
Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats |
title_sort |
Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats |
dc.creator.none.fl_str_mv |
Rule, R. Villagra, S. Barrena Chiantelassa, Jorge Pablo Lacchini, Raul Alfredo Reynaldi, Francisco José |
author |
Rule, R. |
author_facet |
Rule, R. Villagra, S. Barrena Chiantelassa, Jorge Pablo Lacchini, Raul Alfredo Reynaldi, Francisco José |
author_role |
author |
author2 |
Villagra, S. Barrena Chiantelassa, Jorge Pablo Lacchini, Raul Alfredo Reynaldi, Francisco José |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
CEFTAZIDIME GOAT MILK PHARMACOKINETICS |
topic |
CEFTAZIDIME GOAT MILK PHARMACOKINETICS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
The aim of this work was to determine the pharmacokinetics of intravenous (iv) and intramuscular (im) ceftazidime administered to lactating (LTG; n = 6) and non-lactating (NLTG; n=6) healthy Creole goats in 2 trials (T1 and T2). During T1 and T2, goats randomly received a single dose of im or iv ceftazidime (10 mg/kg). Serum concentration of iv ceftazidime in NLTG and LTG goats is best described by 2 and 3 compartment models, respectively. The pharmacokinetic parameters of iv and im ceftazidime administered to LTG and NLTG showed statistically significant differences (P<0.05) in the constants (λz, T1 vs T2 [iv] 0.5±0.1 vs 0.3±0.1 /h; T1 vs T2 [im] 0.5±0.2 vs 0.3±0.1 /h) and in the mean times (t1/2, T 1 vs T 2 [iv] 1.6±0.3 vs 2.3±0.6 h; T 1 vs T 2 [im] 1.6±0.7 vs 2.6±0.9 h) of elimination. The bioavailability of ceftazidime in LTG and NLTG was 113.0 ± 17.8 and 96.0 ± 18.0 %, respectively. Ceftazidime concentration in milk at 2 h was: iv = 1.9 ± 0.2 and im = 2.4 ± 0.5 μg/m ; the penetration in milk was iv = 18.3 ± 13.5 and im = 14.3 ± 10.6 %. Ninety-six hours after iv and im administration, residues of the drug were not found in milk. In conclusion, ceftazidime, when administered to goats, showed high concentration times in serum, good penetration into milk and a bioavailability that makes it suitable to be used by the im route. Fil: Rule, R.. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina Fil: Villagra, S.. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina Fil: Barrena Chiantelassa, Jorge Pablo. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Departamento de Producción Agropecuaria y Forestal; Argentina Fil: Lacchini, Raul Alfredo. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Departamento de Producción Agropecuaria y Forestal; Argentina Fil: Reynaldi, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina |
description |
The aim of this work was to determine the pharmacokinetics of intravenous (iv) and intramuscular (im) ceftazidime administered to lactating (LTG; n = 6) and non-lactating (NLTG; n=6) healthy Creole goats in 2 trials (T1 and T2). During T1 and T2, goats randomly received a single dose of im or iv ceftazidime (10 mg/kg). Serum concentration of iv ceftazidime in NLTG and LTG goats is best described by 2 and 3 compartment models, respectively. The pharmacokinetic parameters of iv and im ceftazidime administered to LTG and NLTG showed statistically significant differences (P<0.05) in the constants (λz, T1 vs T2 [iv] 0.5±0.1 vs 0.3±0.1 /h; T1 vs T2 [im] 0.5±0.2 vs 0.3±0.1 /h) and in the mean times (t1/2, T 1 vs T 2 [iv] 1.6±0.3 vs 2.3±0.6 h; T 1 vs T 2 [im] 1.6±0.7 vs 2.6±0.9 h) of elimination. The bioavailability of ceftazidime in LTG and NLTG was 113.0 ± 17.8 and 96.0 ± 18.0 %, respectively. Ceftazidime concentration in milk at 2 h was: iv = 1.9 ± 0.2 and im = 2.4 ± 0.5 μg/m ; the penetration in milk was iv = 18.3 ± 13.5 and im = 14.3 ± 10.6 %. Ninety-six hours after iv and im administration, residues of the drug were not found in milk. In conclusion, ceftazidime, when administered to goats, showed high concentration times in serum, good penetration into milk and a bioavailability that makes it suitable to be used by the im route. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/114372 Rule, R.; Villagra, S.; Barrena Chiantelassa, Jorge Pablo; Lacchini, Raul Alfredo; Reynaldi, Francisco José; Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats; South African Veterinary Association; Journal of the South African Veterinary Association-Tydskrif van die Suid-Afrikaanse Veterinere Vereniging; 82; 4; 3-2011; 219-223 0038-2809 2224-9435 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/114372 |
identifier_str_mv |
Rule, R.; Villagra, S.; Barrena Chiantelassa, Jorge Pablo; Lacchini, Raul Alfredo; Reynaldi, Francisco José; Pharmacokinetics of ceftazidime administered to lactating and non-lactating goats; South African Veterinary Association; Journal of the South African Veterinary Association-Tydskrif van die Suid-Afrikaanse Veterinere Vereniging; 82; 4; 3-2011; 219-223 0038-2809 2224-9435 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://jsava.co.za/index.php/jsava/article/view/77 info:eu-repo/semantics/altIdentifier/doi/10.4102/jsava.v82i4.77 info:eu-repo/semantics/altIdentifier/url/http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1019-91282011000400006 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
South African Veterinary Association |
publisher.none.fl_str_mv |
South African Veterinary Association |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |